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    KIR2DS2 killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2 [ Homo sapiens (human) ]

    Gene ID: 100132285, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Evaluation of the genetic diversity of KIR genes in patients with endometrial cancer.

    Evaluation of the genetic diversity of KIR genes in patients with endometrial cancer.
    Shiravani Z, Mirshekari K, Larki MH, Shafiee N, Haghshenas MR, Ghaderi A, Fattahi MJ.

    04/17/2024
    KIR2DS2 Expression Identifies NK Cells With Enhanced Anticancer Activity.

    KIR2DS2 Expression Identifies NK Cells With Enhanced Anticancer Activity.
    Blunt MD, Vallejo Pulido A, Fisher JG, Graham LV, Doyle ADP, Fulton R, Carter MJ, Polak M, Johnson PWM, Cragg MS, Forconi F, Khakoo SI., Free PMC Article

    07/23/2022
    Killer Cell Immunoglobulin-Like Receptor Haplotype B Modulates Susceptibility to EBV-Associated Classic Hodgkin Lymphoma.

    Killer Cell Immunoglobulin-Like Receptor Haplotype B Modulates Susceptibility to EBV-Associated Classic Hodgkin Lymphoma.
    Jiang P, Nolte IM, Hepkema BG, Stulp M, van den Berg A, Diepstra A., Free PMC Article

    03/19/2022
    Clinical and histopathological changes in different KIR gene profiles in chronic HCV Romanian patients.

    Clinical and histopathological changes in different KIR gene profiles in chronic HCV Romanian patients.
    Ursu LD, Calenic B, Diculescu M, Dima A, Stoian IT, Constantinescu I.

    07/10/2021
    The combination KIR2DS2/KIR2DL2/C1 correlated with severe Alzheimer's Disease status and an increased susceptibility to HHV-6A infection.

    KIR2DS2/KIR2DL2/HLA-C1 Haplotype Is Associated with Alzheimer's Disease: Implication for the Role of Herpesvirus Infections.
    Rizzo R, Bortolotti D, Gentili V, Rotola A, Bolzani S, Caselli E, Tola MR, Di Luca D.

    05/30/2020
    matching of KIR2DL1, 2DS1, and 2DS2 in donors with their HLA-C ligands in recipients is associated with increased GvHD, and holds potential for selection of HSCT donors.

    Prognostic role of KIR genes and HLA-C after hematopoietic stem cell transplantation in a patient cohort with acute myeloid leukemia from a consanguineous community.
    Gaafar A, Sheereen A, Almohareb F, Eldali A, Chaudhri N, Mohamed SY, Hanbali A, Shaheen M, Alfraih F, El Fakih R, Iqneibi A, Youniss R, Elhassan T, Hashmi S, Aljurf M, Alhussein K.

    09/28/2019
    The multivariate analysis revealed that the lack of KIR2DS2 (p = 0.035), the presence of KIR2DL3 (p = 0.075), and the presence of KIR2DL2HLA-C1 (p = 0.044) were risk factors for posttransplant cytomegalovirus infection.

    Killer Immunoglobulin-Like Receptor 2DS2 (KIR2DS2), KIR2DL2-HLA-C1, and KIR2DL3 as Genetic Markers for Stratifying the Risk of Cytomegalovirus Infection in Kidney Transplant Recipients.
    Deborska-Materkowska D, Perkowska-Ptasinska A, Sadowska-Jakubowicz A, Gozdowska J, Ciszek M, Pazik J, Ostaszewska A, Kosieradzki M, Nowak J, Durlik M., Free PMC Article

    06/8/2019
    Genotypes missing these two inhibitory KIR-HLA combinations in addition to missing activating KIRs 2DS2 and 2DS3 were more common in Vogt-Koyanagi-Harada disease (OR = 1.90, P = 0.002).

    KIR and HLA Genotypes Implicated in Reduced Killer Lymphocytes Immunity Are Associated with Vogt-Koyanagi-Harada Disease.
    Levinson RD, Yung M, Meguro A, Ashouri E, Yu F, Mizuki N, Ohno S, Rajalingam R., Free PMC Article

    07/29/2017
    KIR2DS2/HLA-C1 may correlate with Hashimoto thyroiditis in a Chinese population.

    KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR GENES AND THEIR HLA-C LIGANDS IN HASHIMOTO THYROIDITIS IN A CHINESE POPULATION.
    Li JT, Guo C, Li ML, Wei YQ, Hou YF, Jiao YL, Zhao YR, Sun H, Xu J, Cao MF, Feng L, Yu GN, Gao L, Liu YQ, Zhang BC, Zhao JJ, Zhang HQ.

    05/27/2017
    Loss of KIR2DS2 gene is associated with breast cancer.

    Association of the genetic diversity of killer cell immunoglobulin-like receptor genes and HLA-C ligand in Saudi women with breast cancer.
    Alomar SY, Alkhuriji A, Trayhyrn P, Alhetheel A, Al-Jurayyan A, Mansour L.

    05/20/2017
    association between KIR2DS2 and the response to methotrexate (MTX), moreover, the combination KIR2DL2+/KIR2DS2+ was more frequent in responders to MTX (p = 0.043).

    KIR2DL2 and KIR2DS2 as genetic markers to the methotrexate response in rheumatoid arthritis patients.
    Velarde-de la Cruz EE, Sánchez-Hernández PE, Muñoz-Valle JF, Palafox-Sánchez CA, Ramírez-de Los Santos S, Graciano-Machuca O, García-Iglesias T, Montoya-Buelna M, Ramírez-Dueñas MG.

    03/25/2017
    this study shows that the presence of KIR2DS2 was associated with a worsening of haematopoietic stem cell transplantation from HLA-matched sibling donor for treatment of myeloid malignancies

    Synergistic effect of KIR ligands missing and cytomegalovirus reactivation in improving outcomes of haematopoietic stem cell transplantation from HLA-matched sibling donor for treatment of myeloid malignancies.
    Cardozo DM, Marangon AV, da Silva RF, Aranha FJP, Visentainer JEL, Bonon SHA, Costa SCB, Miranda ECM, de Souza CA, Guimarães F.

    03/18/2017
    genetic polymorphism is associated with childhood acute lymphoblastic leukemia among north Indians

    Genetic associations of killer immunoglobulin like receptors and class I human leukocyte antigens on childhood acute lymphoblastic leukemia among north Indians.
    Misra MK, Prakash S, Moulik NR, Kumar A, Agrawal S.

    11/12/2016
    this study was to look for immunogenetic determinants in the pathogenesis of FMF and find out if KIR are related to susceptibility. An activator KIR gene, KIR2DS2, was significantly more frequent in FMF patients (p=0.036).

    Killer Cell Immunoglobulin-Like Receptor (KIR) Genotype Distribution in Familial Mediterranean Fever (FMF) Patients.
    Erken E, Goruroglu Ozturk O, Kudas O, Arslan Tas D, Demirtas A, Kibar F, Dinkci S, Erken E., Free PMC Article

    10/1/2016
    a significant increase in the frequency of KIR2DL2 (P = 0.019) as well as KIR2DS2 (P = 0.008) in patients with neuroblastoma compared with the healthy control group, was found.

    Increased frequencies of the killer immunoglobulin-like receptor genes KIR2DL2 and KIR2DS2 are associated with neuroblastoma.
    Keating SE, Ní Chorcora C, Dring MM, Stallings RL, O'Meara A, Gardiner CM.

    05/14/2016
    Single Nucleotide Polymorphism in KIR2DS2 gene is associated with Asthma and Atopic Dermatitis.

    Imputation of KIR Types from SNP Variation Data.
    Vukcevic D, Traherne JA, Næss S, Ellinghaus E, Kamatani Y, Dilthey A, Lathrop M, Karlsen TH, Franke A, Moffatt M, Cookson W, Trowsdale J, McVean G, Sawcer S, Leslie S., Free PMC Article

    01/16/2016
    genetic polymorphism is associated with chronic hepatitis C and levels of viremia in Poland

    Contribution of genes for killer cell immunoglobulin-like receptors (KIR) to the susceptibility to chronic hepatitis C virus infection and to viremia.
    Kuśnierczyk P, Mozer-Lisewska I, Zwolińska K, Kowala-Piaskowska AE, Bura M, Bereszyńska I, Pauli A, Żeromski J.

    12/26/2015
    KIR2DL2 and KIR2DS2 genotype is associated with protection against primary biliary cirrhosis in Han population.

    [Correlation analysis between killer cell immunoglobulin-like receptor gene polymorphism and primary biliary cirrhosis].
    Zheng L, Xu L, He M, Shi Q, Li X, Wang Y.

    08/22/2015
    CD4(+) CD28(-) cells exhibited increased KIR2DS2, reduced KIR2DL3 and increased DAP12 expression in HD-ESRD compared with NDD-CKD patients.

    Killer cell immunoglobulin receptor profile on CD4(+)  CD28(-) T cells and their pathogenic role in non-dialysis-dependent and dialysis-dependent chronic kidney disease patients.
    Zal B, Chitalia N, Ng YS, Trieu V, Javed S, Warrington R, Kaski JC, Banerjee D, Baboonian C., Free PMC Article

    07/4/2015
    Authors showed a significant increased correlation between KIR2DL2/DS2, type 2 diabetes and HLA-C1C1 genotype in the type 2 diabetes patients infected with human herpesvirus 8.

    High prevalence of HHV8 infection and specific killer cell immunoglobulin-like receptors allotypes in Sardinian patients with type 2 diabetes mellitus.
    Caselli E, Rizzo R, Ingianni A, Contini P, Pompei R, Di Luca D.

    04/4/2015
    NK cells with KIR2DS2 immunogenotype have a functional activation advantage to efficiently kill glioblastoma and prolong animal survival.

    NK cells with KIR2DS2 immunogenotype have a functional activation advantage to efficiently kill glioblastoma and prolong animal survival.
    Gras Navarro A, Kmiecik J, Leiss L, Zelkowski M, Engelsen A, Bruserud Ø, Zimmer J, Enger PØ, Chekenya M., Free PMC Article

    03/21/2015
    There is an association of the KIR2DS gene, especially KIR2DS2, with psoriatic arthritis.

    Killer-cell immunoglobulin-like receptor gene polymorphisms and susceptibility to psoriatic arthritis.
    Chandran V, Bull SB, Pellett FJ, Ayearst R, Pollock RA, Gladman DD.

    05/31/2014
    Activating killer cell immunoglobulin-like receptor 2DS2 binds to HLA-A*11.

    Activating killer cell immunoglobulin-like receptor 2DS2 binds to HLA-A*11.
    Liu J, Xiao Z, Ko HL, Shen M, Ren EC., Free PMC Article

    04/19/2014
    Analysis of this large cohort from Uganda in the context of other African populations reveals variations in KIR and HLA-C1 and C2 that are consistent with migrations within Africa and potential selection pressures on these genes.

    Killer cell immunoglobulin-like receptor (KIR) genes and their HLA-C ligands in a Ugandan population.
    Nakimuli A, Chazara O, Farrell L, Hiby SE, Tukwasibwe S, Knee O, Jayaraman J, Traherne JA, Elliott AM, Kaleebu P, Mirembe F, Moffett A., Free PMC Article

    12/7/2013
    Data indicate that increased frequency of the activating receptor KIR2DS1 and a reduced frequency of the KIR-ligand combination KIR2DS2/2DL2 absent/C1 present were significantly associated with chronic myeloid leukemia (CML).

    Homozygosity for killer immunoglobin-like receptor haplotype A predicts complete molecular response to treatment with tyrosine kinase inhibitors in chronic myeloid leukemia patients.
    La Nasa G, Caocci G, Littera R, Atzeni S, Vacca A, Mulas O, Langiu M, Greco M, Orrù S, Orrù N, Floris A, Carcassi C.

    06/29/2013
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