| TRAP1 drives smooth muscle cell senescence and promotes atherosclerosis via HDAC3-primed histone H4 lysine 12 lactylation. | TRAP1 drives smooth muscle cell senescence and promotes atherosclerosis via HDAC3-primed histone H4 lysine 12 lactylation.
Li X, Chen M, Chen X, He X, Li X, Wei H, Tan Y, Min J, Azam T, Xue M, Zhang Y, Dong M, Yin Q, Zheng L, Jiang H, Huo D, Wang X, Chen S, Ji Y, Chen H., | 10/16/2024 |
| TRAP1 modulates mitochondrial biogenesis via PGC-1alpha/TFAM signalling pathway in colorectal cancer cells. | TRAP1 modulates mitochondrial biogenesis via PGC-1α/TFAM signalling pathway in colorectal cancer cells.
Bruno G, Pietrafesa M, Crispo F, Piscazzi A, Maddalena F, Giordano G, Conteduca V, Garofoli M, Porras A, Esposito F, Landriscina M., Free PMC Article | 09/23/2024 |
| Histone chaperone SSRP1 is required for apoptosis inhibition and mitochondrial function in HCC via transcriptional promotion of TRAP1. | Histone chaperone SSRP1 is required for apoptosis inhibition and mitochondrial function in HCC via transcriptional promotion of TRAP1.
Chen X, Li M, Wang D, Wang Q, Wei X, Liu X, Yang J, Kalvakolanu DV, Guo B, Zhang L. | 11/7/2023 |
| Cytosolic and mitochondrial translation elongation are coordinated through the molecular chaperone TRAP1 for the synthesis and import of mitochondrial proteins. | Cytosolic and mitochondrial translation elongation are coordinated through the molecular chaperone TRAP1 for the synthesis and import of mitochondrial proteins.
Avolio R, Agliarulo I, Criscuolo D, Sarnataro D, Auriemma M, De Lella S, Pennacchio S, Calice G, Ng MY, Giorgi C, Pinton P, Cooperman BS, Landriscina M, Esposito F, Matassa DS., Free PMC Article | 10/11/2023 |
| Analysis and functional relevance of the chaperone TRAP-1 interactome in the metabolic regulation and mitochondrial integrity of cancer cells. | Analysis and functional relevance of the chaperone TRAP-1 interactome in the metabolic regulation and mitochondrial integrity of cancer cells.
Dharaskar SP, Paithankar K, Amere Subbarao S., Free PMC Article | 05/17/2023 |
| The mitochondrial chaperone TRAP-1 regulates the glutamine metabolism in tumor cells. | The mitochondrial chaperone TRAP-1 regulates the glutamine metabolism in tumor cells.
Dharaskar SP, Amere Subbarao S. | 03/15/2023 |
| Metabolic targeting of NRF2 potentiates the efficacy of the TRAP1 inhibitor G-TPP through reduction of ROS detoxification in colorectal cancer. | Metabolic targeting of NRF2 potentiates the efficacy of the TRAP1 inhibitor G-TPP through reduction of ROS detoxification in colorectal cancer.
Tsai HY, Bronner MP, March JK, Valentine JF, Shroyer NF, Lai LA, Brentnall TA, Pan S, Chen R., Free PMC Article | 10/22/2022 |
| TRAP1 Chaperones the Metabolic Switch in Cancer. | TRAP1 Chaperones the Metabolic Switch in Cancer.
Wengert LA, Backe SJ, Bourboulia D, Mollapour M, Woodford MR., Free PMC Article | 07/2/2022 |
| TRAP1 regulates the response of colorectal cancer cells to hypoxia and inhibits ribosome biogenesis under conditions of oxygen deprivation. | TRAP1 regulates the response of colorectal cancer cells to hypoxia and inhibits ribosome biogenesis under conditions of oxygen deprivation.
Bruno G, Li Bergolis V, Piscazzi A, Crispo F, Condelli V, Zoppoli P, Maddalena F, Pietrafesa M, Giordano G, Matassa DS, Esposito F, Landriscina M., Free PMC Article | 05/14/2022 |
| HIF1alpha-dependent induction of the mitochondrial chaperone TRAP1 regulates bioenergetic adaptations to hypoxia. | HIF1α-dependent induction of the mitochondrial chaperone TRAP1 regulates bioenergetic adaptations to hypoxia.
Laquatra C, Sanchez-Martin C, Dinarello A, Cannino G, Minervini G, Moroni E, Schiavone M, Tosatto S, Argenton F, Colombo G, Bernardi P, Masgras I, Rasola A., Free PMC Article | 10/16/2021 |
| TRAP1 enhances Warburg metabolism through modulation of PFK1 expression/activity and favors resistance to EGFR inhibitors in human colorectal carcinomas. | TRAP1 enhances Warburg metabolism through modulation of PFK1 expression/activity and favors resistance to EGFR inhibitors in human colorectal carcinomas.
Maddalena F, Condelli V, Matassa DS, Pacelli C, Scrima R, Lettini G, Li Bergolis V, Pietrafesa M, Crispo F, Piscazzi A, Storto G, Capitanio N, Esposito F, Landriscina M., Free PMC Article | 09/4/2021 |
| TRAP1 is a predictive biomarker of platinum-based adjuvant chemotherapy benefits in patients with resected lung adenocarcinoma. | TRAP1 is a predictive biomarker of platinum-based adjuvant chemotherapy benefits in patients with resected lung adenocarcinoma.
Kuchitsu Y, Nagashio R, Igawa S, Kusuhara S, Tsuchiya B, Ichinoe M, Satoh Y, Naoki K, Murakumo Y, Saegusa M, Sato Y. | 08/14/2021 |
| Knockdown of TRAP1 promotes cisplatin-induced apoptosis by promoting the ROS-dependent mitochondrial dysfunction in lung cancer cells. | Knockdown of TRAP1 promotes cisplatin-induced apoptosis by promoting the ROS-dependent mitochondrial dysfunction in lung cancer cells.
Zhang X, Dong Y, Gao M, Hao M, Ren H, Guo L, Guo H. | 07/17/2021 |
| Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1. | Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1.
Park HK, Yoon NG, Lee JE, Hu S, Yoon S, Kim SY, Hong JH, Nam D, Chae YC, Park JB, Kang BH., Free PMC Article | 07/3/2021 |
| TRAP1 chaperone protein mutations and autoinflammation. | TRAP1 chaperone protein mutations and autoinflammation.
Standing AS, Hong Y, Paisan-Ruiz C, Omoyinmi E, Medlar A, Stanescu H, Kleta R, Rowcenzio D, Hawkins P, Lachmann H, McDermott MF, Eleftheriou D, Klein N, Brogan PA., Free PMC Article | 05/15/2021 |
| Mitochondrial chaperone, TRAP1 modulates mitochondrial dynamics and promotes tumor metastasis. | Mitochondrial chaperone, TRAP1 modulates mitochondrial dynamics and promotes tumor metastasis.
Purushottam Dharaskar S, Paithankar K, Kanugovi Vijayavittal A, Shabbir Kara H, Amere Subbarao S. | 04/3/2021 |
| Mitochondrial chaperone, TRAP1 as a potential pharmacological target to combat cancer metabolism. | Mitochondrial chaperone, TRAP1 as a potential pharmacological target to combat cancer metabolism.
Ramkumar B, Dharaskar SP, Mounika G, Paithankar K, Sreedhar AS. | 02/27/2021 |
| TRAP1 Regulates Wnt/beta-Catenin Pathway through LRP5/6 Receptors Expression Modulation. | TRAP1 Regulates Wnt/β-Catenin Pathway through LRP5/6 Receptors Expression Modulation.
Lettini G, Condelli V, Pietrafesa M, Crispo F, Zoppoli P, Maddalena F, Laurenzana I, Sgambato A, Esposito F, Landriscina M., Free PMC Article | 02/27/2021 |
| The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis. | The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis.
Joshi A, Dai L, Liu Y, Lee J, Ghahhari NM, Segala G, Beebe K, Jenkins LM, Lyons GC, Bernasconi L, Tsai FTF, Agard DA, Neckers L, Picard D., Free PMC Article | 09/5/2020 |
| reviewed the recently identified functions of the molecular chaperone TRAP1 in cancer development and progression, as well as the discovery and recent advances in selective TRAP1 inhibitors as anticancer drug therapies | New insights into molecular chaperone TRAP1 as a feasible target for future cancer treatments.
Li XT, Li YS, Shi ZY, Guo XL. | 08/1/2020 |
| Data suggest that heat shock protein 75 (HSP75) may be important for maintenance of mitochondrial function in renal proximal tubular cells (HK2) cells under pathological conditions. | HSP75 inhibits TGF-β1-induced apoptosis by targeting mitochondria in human renal proximal tubular epithelial cells.
Chen JF, He Q, Dai MH, Kong W. | 07/4/2020 |
| The TRAP1 gene is associated with mucosal healing in Crohn's disease patients following infliximab therapy. | Association of TRAP1 with infliximab-induced mucosal healing in Crohn's disease.
Park SH, Hong M, Lee HS, Ye BD, Hwang SW, Jung S, Baek J, Moon JW, Kim BM, Oh SH, Kim KM, Lee I, Im CN, Liu J, McGovern DPB, Yang SK, Song K. | 06/6/2020 |
| Discovery and functional analysis of a TRAP1-SIRT3 complex in glioma stem cells identify potential target proteins for glioblastoma treatment | Interplay between TRAP1 and Sirtuin-3 Modulates Mitochondrial Respiration and Oxidative Stress to Maintain Stemness of Glioma Stem Cells.
Park HK, Hong JH, Oh YT, Kim SS, Yin J, Lee AJ, Chae YC, Kim JH, Park SH, Park CK, Park MJ, Park JB, Kang BH. | 01/4/2020 |
| Results demonstrated that TRAP1 gene polymorphisms may be associated with the systemic lupus erythematosus (SLE) susceptibility and glucocorticoids sensitivity in SLE patients. | Association study of TRAP1 gene polymorphisms with susceptibility and glucocorticoids efficacy of systemic lupus erythematosus.
Li S, Sun X, Xu J, Gu Y, Liu S, Xu S, Pan F, Tao J, Cai J, Liu S, Wang D, Qian L, Wang C, Liang C, Huang H, Pan H, Su H, Ye D, Zou Y. | 07/6/2019 |
| In the presence of magnesium, ATP hydrolysis by TRAP1, as with other Hsp90s, was noncooperative, whereas calcium binding resulted in cooperative hydrolysis by the two protomers within the Hsp90 dimer. The structural data suggested a mechanism for this cooperative behavior. | Calcium binding to a remote site can replace magnesium as cofactor for mitochondrial Hsp90 (TRAP1) ATPase activity.
Elnatan D, Agard DA., Free PMC Article | 03/9/2019 |