| PRG4 represses the genesis and metastasis of osteosarcoma by inhibiting PDL1 expression. | PRG4 represses the genesis and metastasis of osteosarcoma by inhibiting PDL1 expression.
Zhang L, Ren H, Wu Y, Xue L, Bai Y, Wei D, Wu Q. | 07/1/2024 |
| Camptodactyly-Arthropathy-Coxa Vara-Pericarditis Syndrome: The First Familial Case in China and Novel Mutations of the Proteoglycan 4 Gene. | Camptodactyly-Arthropathy-Coxa Vara-Pericarditis Syndrome: The First Familial Case in China and Novel Mutations of the Proteoglycan 4 Gene.
Zhang JM, Gao FQ, Li CF, Kuang WY, Deng JH, Tan XH, Li C, Li SP. | 03/3/2023 |
| A novel mutation in the proteoglycan 4 gene causing CACP syndrome: two sisters report. | A novel mutation in the proteoglycan 4 gene causing CACP syndrome: two sisters report.
Bağrul İ, Ceylaner S, Yildiz YT, Tuncez S, Aydin EA, Bağlan E, Ozdel S, Bülbül M., Free PMC Article | 02/4/2023 |
| Recombinant Human Proteoglycan 4 (rhPRG4) Downregulates TNFalpha-Stimulated NFkappaB Activity and FAT10 Expression in Human Corneal Epithelial Cells. | Recombinant Human Proteoglycan 4 (rhPRG4) Downregulates TNFα-Stimulated NFκB Activity and FAT10 Expression in Human Corneal Epithelial Cells.
Menon NG, Suhail Y, Goyal R, Du W, Tanguay AP, Jay GD, Ghosh M, Kshitiz, Schmidt TA., Free PMC Article | 11/19/2022 |
| Proteoglycan 4 is present within the dura mater and produced by mesenchymal progenitor cells. | Proteoglycan 4 is present within the dura mater and produced by mesenchymal progenitor cells.
Mudigonda S, Shah S, Das N, Corpuz JM, Ninkovic N, Al-Jezani N, Underhill TM, Salo PT, Mitha AP, Lyons FG, Cho R, Schmidt TA, Dufour A, Krawetz RJ. | 09/10/2022 |
| Regulatory Mechanisms of Prg4 and Gdf5 Expression in Articular Cartilage and Functions in Osteoarthritis. | Regulatory Mechanisms of Prg4 and Gdf5 Expression in Articular Cartilage and Functions in Osteoarthritis.
Takahata Y, Hagino H, Kimura A, Urushizaki M, Yamamoto S, Wakamori K, Murakami T, Hata K, Nishimura R., Free PMC Article | 05/28/2022 |
| Recombinant Human Proteoglycan 4 Regulates Phagocytic Activation of Monocytes and Reduces IL-1beta Secretion by Urate Crystal Stimulated Gout PBMCs. | Recombinant Human Proteoglycan 4 Regulates Phagocytic Activation of Monocytes and Reduces IL-1β Secretion by Urate Crystal Stimulated Gout PBMCs.
ElSayed S, Jay GD, Cabezas R, Qadri M, Schmidt TA, Elsaid KA., Free PMC Article | 02/19/2022 |
| Proteoglycan 4 Modulates Osteogenic Smooth Muscle Cell Differentiation during Vascular Remodeling and Intimal Calcification. | Proteoglycan 4 Modulates Osteogenic Smooth Muscle Cell Differentiation during Vascular Remodeling and Intimal Calcification.
Seime T, Akbulut AC, Liljeqvist ML, Siika A, Jin H, Winski G, van Gorp RH, Karlöf E, Lengquist M, Buckler AJ, Kronqvist M, Waring OJ, Lindeman JHN, Biessen EAL, Maegdefessel L, Razuvaev A, Schurgers LJ, Hedin U, Matic L., Free PMC Article | 11/6/2021 |
| Interrelationship of MMP-9, Proteoglycan-4, and Inflammation in Osteoarthritis Patients Undergoing Total Hip Arthroplasty. | Interrelationship of MMP-9, Proteoglycan-4, and Inflammation in Osteoarthritis Patients Undergoing Total Hip Arthroplasty.
Slovacek H, Khanna R, Poredos P, Poredos P, Jezovnik M, Hoppensteadt D, Fareed J, Hopkinson W., Free PMC Article | 10/30/2021 |
| Proteoglycan 4 (PRG4) expression and function in dry eye associated inflammation. | Proteoglycan 4 (PRG4) expression and function in dry eye associated inflammation.
Menon NG, Goyal R, Lema C, Woods PS, Tanguay AP, Morin AA, Das N, Jay GD, Krawetz RJ, Dufour A, Shapiro LH, Redfern RL, Ghosh M, Schmidt TA., Free PMC Article | 10/2/2021 |
| Decrease of core 2 O-glycans on synovial lubricin in osteoarthritis reduces galectin-3 mediated crosslinking. | Decrease of core 2 O-glycans on synovial lubricin in osteoarthritis reduces galectin-3 mediated crosslinking.
Flowers SA, Thomsson KA, Ali L, Huang S, Mthembu Y, Regmi SC, Holgersson J, Schmidt TA, Rolfson O, Björkman LI, Sundqvist M, Karlsson-Bengtsson A, Jay GD, Eisler T, Krawetz R, Karlsson NG., Free PMC Article | 03/13/2021 |
| Inhibitory Effects of PRG4 on Migration and Proliferation of Human Venous Cells. | Inhibitory Effects of PRG4 on Migration and Proliferation of Human Venous Cells.
Wang L, Kikuchi S, Schmidt TA, Hoofnagle M, Wight TN, Azuma N, Tang GL, Sobel M, Velamoor GR, Mokadam NA, Kenagy RD. | 10/31/2020 |
| FoxO play a key role in postnatal cartilage development, maturation, and modulate autophagy and proteoglycan 4 in osteoarthritis. | FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis.
Matsuzaki T, Alvarez-Garcia O, Mokuda S, Nagira K, Olmer M, Gamini R, Miyata K, Akasaki Y, Su AI, Asahara H, Lotz MK., Free PMC Article | 09/21/2019 |
| The role of PRG4 in regulation the inflammatory response and tissue homeostasis maintanance is reviewed. | Proteoglycan 4: From Mere Lubricant to Regulator of Tissue Homeostasis and Inflammation: Does proteoglycan 4 have the ability to buffer the inflammatory response?
Das N, Schmidt TA, Krawetz RJ, Dufour A. | 07/27/2019 |
| HA and PRG4 reduced alpha-SMA expression. | cAMP attenuates TGF-β's profibrotic responses in osteoarthritic synoviocytes: involvement of hyaluronan and PRG4.
Qadri MM, Jay GD, Ostrom RS, Zhang LX, Elsaid KA., Free PMC Article | 07/6/2019 |
| Inflammatory Biomarker Profiling in Total Joint Arthroplasty and Its Relevance to Circulating Levels of Lubricin, a Novel Proteoglycan. | Inflammatory Biomarker Profiling in Total Joint Arthroplasty and Its Relevance to Circulating Levels of Lubricin, a Novel Proteoglycan.
Galicia K, Thorson C, Banos A, Rondina M, Hopkinson W, Hoppensteadt D, Fareed J., Free PMC Article | 10/27/2018 |
| Intra-articular injection of human PRG4 in vivo in Prg4-/- mice prevented caspase-3 activation in superficial zone chondrocytes and was associated with a modest decrease in whole joint friction. | Friction-Induced Mitochondrial Dysregulation Contributes to Joint Deterioration in Prg4 Knockout Mice.
Waller KA, Zhang LX, Jay GD., Free PMC Article | 04/7/2018 |
| PRG4 plays an important anti-inflammatory role in regulating osteoarthritis synoviocyte proliferation. | The autocrine role of proteoglycan-4 (PRG4) in modulating osteoarthritic synoviocyte proliferation and expression of matrix degrading enzymes.
Alquraini A, Jamal M, Zhang L, Schmidt T, Jay GD, Elsaid KA., Free PMC Article | 03/3/2018 |
| IL6 and PRG4 represent potential novel tissue biomarkers of disease severity and prognosis in conjunctival fibrosis after glaucoma surgery. | Genotype-Phenotype Associations of IL6 and PRG4 With Conjunctival Fibrosis After Glaucoma Surgery.
Yu-Wai-Man C, Tagalakis AD, Meng J, Bouremel Y, Lee RMH, Virasami A, Hart SL, Khaw PT., Free PMC Article | 11/25/2017 |
| adult talar cartilage increases both PRG4 release and biosynthetic activity as immediate cellular response to injury | Implications of trauma and subsequent articulation on the release of Proteoglycan-4 and tissue response in adult human ankle cartilage.
Shekhawat VK, Schmid TM, Pennekamp PH, Pacione CA, Chubinskaya S, Wimmer MA. | 09/23/2017 |
| Double knockdown of PRG4 and IL-24 did not inhibit myxoid liposarcoma (MLS)- cell growth, and single knockdown of PRG4 remarkably increased IL-24 expression. These results suggest that the growth inhibitory effect of PRG4 knockdown is caused by induction of IL-24 expression, and PRG4 may contribute to maintain MLS cell growth through repression of IL-24 expression. | PRG4 expression in myxoid liposarcoma maintains tumor cell growth through suppression of an antitumor cytokine IL-24.
Oikawa K, Mizusaki A, Takanashi M, Ozaki T, Sato F, Kuroda M, Muragaki Y. | 06/10/2017 |
| lubricin expression may typify adaptive and neoplastic changes along a pathway toward fibroblast-like synoviocytes | Abundant lubricin expression suggests a link between synoviocytes, synovial tumors, and myxomas.
Solka KA, Schmid TM, Miller IJ. | 04/15/2017 |
| PRG4 binds to TLR2 and TLR4 and this binding mediates a novel anti-inflammatory role for PRG4. | The interaction of lubricin/proteoglycan 4 (PRG4) with toll-like receptors 2 and 4: an anti-inflammatory role of PRG4 in synovial fluid.
Alquraini A, Garguilo S, D'Souza G, Zhang LX, Schmidt TA, Jay GD, Elsaid KA., Free PMC Article | 08/13/2016 |
| Cartilage derived from MSCs expressed lubricin protein both in vitro and in vivo | Cartilage Derived from Bone Marrow Mesenchymal Stem Cells Expresses Lubricin In Vitro and In Vivo.
Nakagawa Y, Muneta T, Otabe K, Ozeki N, Mizuno M, Udo M, Saito R, Yanagisawa K, Ichinose S, Koga H, Tsuji K, Sekiya I., Free PMC Article | 07/30/2016 |
| no synovial fluid level differences detected between healthy knees and injured knees | Does intra-articular fracture change the lubricant content of synovial fluid?
Ceylan HH, Erdil M, Polat G, Kara D, Kilic E, Kocyigit A, Tuncay I., Free PMC Article | 03/12/2016 |