| RAMP2-AS1 stabilized RAPM2 mRNA through TIA1 to inhibit the progression of non-small cell lung cancer. | RAMP2-AS1 stabilized RAPM2 mRNA through TIA1 to inhibit the progression of non-small cell lung cancer.
Wang S, Xu C, Shan Y, Zhang Y. | 02/1/2024 |
| Receptor Activity-Modifying Protein 2 (RAMP2) alters glucagon receptor trafficking in hepatocytes with functional effects on receptor signalling. | Receptor Activity-Modifying Protein 2 (RAMP2) alters glucagon receptor trafficking in hepatocytes with functional effects on receptor signalling.
McGlone ER, Manchanda Y, Jones B, Pickford P, Inoue A, Carling D, Bloom SR, Tan T, Tomas A., Free PMC Article | 03/26/2022 |
| Adrenomedullin-Receptor Activity-Modifying Protein 2 System Ameliorates Subretinal Fibrosis by Suppressing Epithelial-Mesenchymal Transition in Age-Related Macular Degeneration. | Adrenomedullin-Receptor Activity-Modifying Protein 2 System Ameliorates Subretinal Fibrosis by Suppressing Epithelial-Mesenchymal Transition in Age-Related Macular Degeneration.
Tanaka M, Kakihara S, Hirabayashi K, Imai A, Toriyama Y, Iesato Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Cui N, Wei Y, Zhao Y, Aruga K, Yamauchi A, Murata T, Shindo T. | 04/17/2021 |
| Based on the finding that an acylated chimeric ADM/ADM2 analog potently stimulates CLR/RAMP1 and 2 signaling, we hypothesized that the binding domain of this analog could have potent inhibitory activity on CLR/RAMP receptors. | Development of chimeric and bifunctional antagonists for CLR/RAMP receptors.
Chang CL, Hsu SYT., Free PMC Article | 01/25/2020 |
| Interactions between RAMP2 and CRF receptors: The effect of receptor subtypes, splice variants and cell context | Interactions between RAMP2 and CRF receptors: The effect of receptor subtypes, splice variants and cell context.
Bailey S, Harris M, Barkan K, Winfield I, Harper MT, Simms J, Ladds G, Wheatley M, Poyner D. | 12/14/2019 |
| Single nucleotide polymorphism of RAMP2 is associated with Stroke. | Genetic Variants of RAMP2 and CLR are Associated with Stroke.
Koyama T, Kuriyama N, Ozaki E, Matsui D, Watanabe I, Takeshita W, Iwai K, Watanabe Y, Nakatochi M, Shimanoe C, Tanaka K, Oze I, Ito H, Uemura H, Katsuura-Kamano S, Ibusuki R, Shimoshikiryo I, Takashima N, Kadota A, Kawai S, Sasakabe T, Okada R, Hishida A, Naito M, Kuriki K, Endoh K, Furusyo N, Ikezaki H, Suzuki S, Hosono A, Mikami H, Nakamura Y, Kubo M, Wakai K., Free PMC Article | 08/4/2018 |
| This work suggests that RAMP2 may modify the agonist activity and trafficking of the GCGR, with potential relevance to production of new peptide analogs with selective agonist activities. | RAMP2 Influences Glucagon Receptor Pharmacology via Trafficking and Signaling.
Cegla J, Jones BJ, Gardiner JV, Hodson DJ, Marjot T, McGlone ER, Tan TM, Bloom SR., Free PMC Article | 09/23/2017 |
| Data suggest that a single GlcNAc residue at CTR N130 (asparagine 130) is responsible for enhanced affinity of calcitonin for CTR ECD; the same appears to apply for enhanced affinity of amylin for RAMP2-CTR ECD. [GlcNAc = N-acetylglucosamine; CTR = calcitonin receptor; ECD = extracellular domain; RAMP2 = receptor (calcitonin) activity modifying protein 2]. | N-Glycosylation of Asparagine 130 in the Extracellular Domain of the Human Calcitonin Receptor Significantly Increases Peptide Hormone Affinity.
Lee SM, Booe JM, Gingell JJ, Sjoelund V, Hay DL, Pioszak AA., Free PMC Article | 07/29/2017 |
| interaction of RAMP2 or RAMP3 with CLR induces conformational variation in the juxtamembrane region, yielding distinct binding pockets, probably via an allosteric mechanism. | Receptor Activity-modifying Proteins 2 and 3 Generate Adrenomedullin Receptor Subtypes with Distinct Molecular Properties.
Watkins HA, Chakravarthy M, Abhayawardana RS, Gingell JJ, Garelja M, Pardamwar M, McElhinney JM, Lathbridge A, Constantine A, Harris PW, Yuen TY, Brimble MA, Barwell J, Poyner DR, Woolley MJ, Conner AC, Pioszak AA, Reynolds CA, Hay DL., Free PMC Article | 12/17/2016 |
| This study reveals the glucagon receptor as a previously unidentified target for GLP-1 receptor agonists and highlights a role for RAMP2 in regulating its pharmacology. | Modulation of Glucagon Receptor Pharmacology by Receptor Activity-modifying Protein-2 (RAMP2).
Weston C, Lu J, Li N, Barkan K, Richards GO, Roberts DJ, Skerry TM, Poyner D, Pardamwar M, Reynolds CA, Dowell SJ, Willars GB, Ladds G., Free PMC Article | 12/19/2015 |
| Data suggest that ligand binding of a G protein-coupled receptor (GPCR) may inform drug development targeting calcitonin receptor-like receptor (CLR):receptor activity-modifying proteins RAMP1/2 complexes. | Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor.
Booe JM, Walker CS, Barwell J, Kuteyi G, Simms J, Jamaluddin MA, Warner ML, Bill RM, Harris PW, Brimble MA, Poyner DR, Hay DL, Pioszak AA., Free PMC Article | 09/26/2015 |
| the AM system is widely expressed in human thymus from newborns; both AM1 receptor components CLR and RAMP2, but not RAMP3, are not associated with the plasma membrane of TECs and thymocytes but are located intracellularly, notably in the nucleus | Expression and distribution of the adrenomedullin system in newborn human thymus.
De Martin S, Paliuri G, Belloni A, Orso G, Zanarella E, Stellin G, Milanesi O, Basso G, Ruga EM, Frasson C, Gabbia D, Perdoncin G, Palatini P, Bova S., Free PMC Article | 01/31/2015 |
| Adrenomedullin-RAMP2 system suppresses ER stress-induced tubule cell death and is involved in kidney protection. | Adrenomedullin-RAMP2 system suppresses ER stress-induced tubule cell death and is involved in kidney protection.
Uetake R, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Iesato Y, Yoshizawa T, Koyama T, Yang L, Toriyama Y, Yamauchi A, Igarashi K, Tanaka M, Kuwabara T, Mori K, Yanagita M, Mukoyama M, Shindo T., Free PMC Article | 11/22/2014 |
| Data suggest isoforms of RAMP modulate accessibility of peptides to residues situated on CALCRL (calcitonin receptor-like receptor) N-terminal domain; RAMP3/RAMP2/RAMP1 appear to alter accessibility of specific residues at CALCRL-RAMP interface. | Receptor activity-modifying protein-dependent effects of mutations in the calcitonin receptor-like receptor: implications for adrenomedullin and calcitonin gene-related peptide pharmacology.
Watkins HA, Walker CS, Ly KN, Bailey RJ, Barwell J, Poyner DR, Hay DL., Free PMC Article | 10/11/2014 |
| RAMP2 gene expression increases with gestational age development in the fetal lung. | Adrenomedullin expression in the developing human fetal lung.
Ramos CG, Sun X, Johnson EB, Nelson HE, Gonzalez Bosc LV. | 07/19/2014 |
| The CRLR-RAMP2 interactions were confirmed for the full-length proteins on the cell surface by site-specific photo-crosslinking. | Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding.
Kusano S, Kukimoto-Niino M, Hino N, Ohsawa N, Okuda K, Sakamoto K, Shirouzu M, Shindo T, Yokoyama S., Free PMC Article | 06/2/2012 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| the hCRLR C-tail is crucial for adrenomedullin-evoked cAMP production and internalization of the CRLR/RAMP2, while the receptor internalization is dependent on the aforementioned GPCR kinases, but not Gs coupling. | Function of the cytoplasmic tail of human calcitonin receptor-like receptor in complex with receptor activity-modifying protein 2.
Kuwasako K, Kitamura K, Nagata S, Hikosaka T, Kato J. | 03/29/2010 |
| findings provided no significant linkage or association of adrenomedullin and CRLR-RAMP-2 genes with rheumatoid arthritis in the studied trio families | Lack of linkage and association of adrenomedullin and its receptor genes in French Caucasian rheumatoid arthritis trio families.
Michou L, Garnier S, Barbet S, Glikmans E, Ea HK, Uzan B, Asensio C, Ah Kioon MD, Lasbleiz S, Bardin T, Cornélis F, Lioté F, Michou L, Garnier S, Barbet S, Glikmans E, Ea HK, Uzan B, Asensio C, Ah Kioon MD, Lasbleiz S, Bardin T, Cornélis F, Lioté F. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesGene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. Lack of linkage and association of adrenomedullin and its receptor genes in French Caucasian rheumatoid arthritis trio families.
Michou L, Garnier S, Barbet S, Glikmans E, Ea HK, Uzan B, Asensio C, Ah Kioon MD, Lasbleiz S, Bardin T, Cornélis F, Lioté F, Michou L, Garnier S, Barbet S, Glikmans E, Ea HK, Uzan B, Asensio C, Ah Kioon MD, Lasbleiz S, Bardin T, Cornélis F, Lioté F. | 03/25/2009 |
| Data found that expressions of RAMP1, RAMP2 and RAMP3 mRNAs increased with the worsening of heart function, but the expressions of RAMP1 and RAMP2 mRNA decreased at level IV of heart failure. | [Increased atria expression of receptor activity-modifying proteins in heart failure patients].
Wang YF, Zhang J, Li J, Lan LQ, Yang ZM, Wang SR. | 01/21/2010 |
| Identification of RAMP2 residues for adrenomedullin receptors are reported. | Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide, adrenomedullin, and amylin receptor function.
Qi T, Christopoulos G, Bailey RJ, Christopoulos A, Sexton PM, Hay DL. | 01/21/2010 |
| The His residues of hRAMP2 and -3 differentially govern adrenomedullin receptor function. | Functions of the extracellular histidine residues of receptor activity-modifying proteins vary within adrenomedullin receptors.
Kuwasako K, Kitamura K, Nagata S, Kato J. | 01/21/2010 |
| RAMP2 is silenced by promoter hypermethylation in lung cancer | Frequent inactivation of RAMP2, EFEMP1 and Dutt1 in lung cancer by promoter hypermethylation.
Yue W, Dacic S, Sun Q, Landreneau R, Guo M, Zhou W, Siegfried JM, Yu J, Zhang L. | 01/21/2010 |
| This study reveals important functionality of the RAMP C-terminal domain and identifies key differences in the role of the RAMP C terminus for calcitonin receptor versus calcitonin receptor-like receptor-based receptors. | A critical role for the short intracellular C terminus in receptor activity-modifying protein function.
Udawela M, Christopoulos G, Morfis M, Christopoulos A, Ye S, Tilakaratne N, Sexton PM. | 01/21/2010 |