| MAP4K3/GLK inhibits Treg differentiation by direct phosphorylating IKKbeta and inducing IKKbeta-mediated FoxO1 nuclear export and Foxp3 downregulation. | MAP4K3/GLK inhibits Treg differentiation by direct phosphorylating IKKβ and inducing IKKβ-mediated FoxO1 nuclear export and Foxp3 downregulation.
Chi JN, Yang JY, Hsueh CH, Tsai CY, Chuang HC, Tan TH., Free PMC Article | 08/27/2022 |
| Ablation of glucokinase-expressing tanycytes impacts energy balance and increases adiposity in mice. | Ablation of glucokinase-expressing tanycytes impacts energy balance and increases adiposity in mice.
Rohrbach A, Caron E, Dali R, Brunner M, Pasquettaz R, Kolotuev I, Santoni F, Thorens B, Langlet F., Free PMC Article | 03/26/2022 |
| Biphasic dynamics of beta cell mass in a mouse model of congenital hyperinsulinism: implications for type 2 diabetes. | Biphasic dynamics of beta cell mass in a mouse model of congenital hyperinsulinism: implications for type 2 diabetes.
Tornovsky-Babeay S, Weinberg-Corem N, Ben-Haroush Schyr R, Avrahami D, Lavi J, Feleke E, Kaestner KH, Dor Y, Glaser B., Free PMC Article | 02/26/2022 |
| Glucokinase is required for high-starch diet-induced beta-cell mass expansion in mice. | Glucokinase is required for high-starch diet-induced β-cell mass expansion in mice.
Tsuchida K, Nakamura A, Miyoshi H, Yang K, Yamauchi Y, Kawata S, Omori K, Takahashi K, Kitao N, Nomoto H, Kameda H, Cho KY, Seino Y, Terauchi Y, Atsumi T., Free PMC Article | 01/29/2022 |
| Berberine alleviates hyperglycemia by targeting hepatic glucokinase in diabetic db/db mice. | Berberine alleviates hyperglycemia by targeting hepatic glucokinase in diabetic db/db mice.
Li M, Dang Y, Li Q, Zhou W, Zuo J, Yao Z, Zhang L, Ji G., Free PMC Article | 10/24/2020 |
| PASK regulated some of the genes and proteins responsible for glucose sensing, such as glucokinase. | PAS Kinase deficiency alters the glucokinase function and hepatic metabolism.
Pérez-García A, Dongil P, Hurtado-Carneiro V, Blazquez E, Sanz C, Alvarez E., Free PMC Article | 10/19/2019 |
| These data also imply an etiological role of GCK in diet-induced diabetes. | Impaired β-cell glucokinase as an underlying mechanism in diet-induced diabetes.
Lu B, Kurmi K, Munoz-Gomez M, Jacobus Ambuludi EJ, Tonne JM, Rakshit K, Hitosugi T, Kudva YC, Matveyenko AV, Ikeda Y., Free PMC Article | 12/22/2018 |
| Long-term treatment with octanoic acid increased cellular glucose uptake in MIN6 cells by up-regulating the expression of glucokinase (GK). | Octanoic acid potentiates glucose-stimulated insulin secretion and expression of glucokinase through the olfactory receptor in pancreatic β-cells.
Leem J, Shim HM, Cho H, Park JH. | 12/22/2018 |
| a nuclear import of glucokinase mediated by a redundant mechanism, involving a nuclear localization signal, and which is modulated by its SUMOylation, is reported. | Nuclear import of glucokinase in pancreatic beta-cells is mediated by a nuclear localization signal and modulated by SUMOylation.
Johansson BB, Fjeld K, Solheim MH, Shirakawa J, Zhang E, Keindl M, Hu J, Lindqvist A, Døskeland A, Mellgren G, Flatmark T, Njølstad PR, Kulkarni RN, Wierup N, Aukrust I, Bjørkhaug L. | 04/28/2018 |
| Glucokinase governs an alpha-cell metabolic pathway that suppresses secretion at or above normoglycemic levels; abnormal suppression of glucagon secretion deregulates hepatic glucose metabolism and, over time, induces a pre-diabetic phenotype. | α-cell glucokinase suppresses glucose-regulated glucagon secretion.
Basco D, Zhang Q, Salehi A, Tarasov A, Dolci W, Herrera P, Spiliotis I, Berney X, Tarussio D, Rorsman P, Thorens B., Free PMC Article | 03/10/2018 |
| GCK-dependent glycolysis regulates Treg cell migration. | Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis.
Kishore M, Cheung KCP, Fu H, Bonacina F, Wang G, Coe D, Ward EJ, Colamatteo A, Jangani M, Baragetti A, Matarese G, Smith DM, Haas R, Mauro C, Wraith DC, Okkenhaug K, Catapano AL, De Rosa V, Norata GD, Marelli-Berg FM., Free PMC Article | 12/9/2017 |
| GCK expression is regulated by nutrient-sensing O-linked beta-N-acetylglucosaminylation cycling in liver. | Glucokinase expression is regulated by glucose through O-GlcNAc glycosylation.
Baldini SF, Steenackers A, Olivier-Van Stichelen S, Mir AM, Mortuaire M, Lefebvre T, Guinez C. | 06/3/2017 |
| Absence of Gck expression did not prevent the glucose responsiveness of glucose-excited or glucose-inhibited Sf1 neurons in either sex. Thus Gck in the VMN plays a sex-specific role in the glucose-dependent control of autonomic nervous activity; this is, however, unrelated to the control of the firing activity of classical glucose-responsive neurons. | Sex-Specific Control of Fat Mass and Counterregulation by Hypothalamic Glucokinase.
Steinbusch LK, Picard A, Bonnet MS, Basco D, Labouèbe G, Thorens B. | 05/20/2017 |
| Using a mutant GCK gene (GCK 262) with a knocked out cytosine at position 2643 results in lower protein expression and more ubiquitination-led protein degradation compared with wild-type GCK (GCK 261) | Overexpression of a glucokinase point mutant in the treatment of diabetes mellitus.
Lu G, Teng X, Zheng Z, Zhang R, Peng L, Zheng F, Liu J, Huang H, Xiong H., Free PMC Article | 01/28/2017 |
| lncLGR facilitates the recruitment of hnRNPL to the GCK promoter and suppresses GCK transcription. | A Long Non-coding RNA, lncLGR, Regulates Hepatic Glucokinase Expression and Glycogen Storage during Fasting.
Ruan X, Li P, Cangelosi A, Yang L, Cao H., Free PMC Article | 12/17/2016 |
| Given that acetylated GKRP may affiliate with type-2 diabetes mellitus (T2DM), understanding the mechanism of GKRP acetylation in the liver could reveal novel targets within the GK-GKRP pathway, for treating T2DM and other metabolic pathologies. | Acetylation of glucokinase regulatory protein decreases glucose metabolism by suppressing glucokinase activity.
Park JM, Kim TH, Jo SH, Kim MY, Ahn YH., Free PMC Article | 10/1/2016 |
| These results suggest a mechanism for integrative control over GCK activation and, therefore, glucose metabolism and insulin secretion through regulation of cytoplasmic Ca(2+) levels. | Regulation of Glucokinase by Intracellular Calcium Levels in Pancreatic β Cells.
Markwardt ML, Seckinger KM, Rizzo MA., Free PMC Article | 06/28/2016 |
| GHR knockdown caused increased glucokinase mRNA and protein levels. | Growth Hormone Inhibits Hepatic De Novo Lipogenesis in Adult Mice.
Cordoba-Chacon J, Majumdar N, List EO, Diaz-Ruiz A, Frank SJ, Manzano A, Bartrons R, Puchowicz M, Kopchick JJ, Kineman RD., Free PMC Article | 11/21/2015 |
| results suggest that chronic suppression of hepatic glucokinase has a small influence on intertissue (liver-to-BAT as well as liver-to-beta-cell) metabolic communication | Roles of hepatic glucokinase in intertissue metabolic communication: Examination of novel liver-specific glucokinase knockout mice.
Hayashi H, Sato Y, Li Z, Yamamura K, Yoshizawa T, Yamagata K. | 08/22/2015 |
| Atf3-silencing reversed ethanol-mediated Gck down-regulation and beta-cell dysfunction, followed by the amelioration of impaired glucose tolerance and insulin resistance. | Chronic ethanol consumption inhibits glucokinase transcriptional activity by Atf3 and triggers metabolic syndrome in vivo.
Kim JY, Hwang JY, Lee DY, Song EH, Park KJ, Kim GH, Jeong EA, Lee YJ, Go MJ, Kim DJ, Lee SS, Kim BJ, Song J, Roh GS, Gao B, Kim WH., Free PMC Article | 12/20/2014 |
| Chronic treatment with glucose kinase activators in animal models of diabetes provided sustained lowering of blood glucose. | Chronic glucokinase activator treatment at clinically translatable exposures gives durable glucose lowering in two animal models of type 2 diabetes.
Baker DJ, Wilkinson GP, Atkinson AM, Jones HB, Coghlan M, Charles AD, Leighton B., Free PMC Article | 11/22/2014 |
| Suggest heterozygous glucokinase knockout mouse as a translatable model of human type 2 diabetes. | Characterization of the heterozygous glucokinase knockout mouse as a translational disease model for glucose control in type 2 diabetes.
Baker DJ, Atkinson AM, Wilkinson GP, Coope GJ, Charles AD, Leighton B., Free PMC Article | 11/22/2014 |
| In the liver-specific glucokinase knockout mouse reduced expression of glucokinase in the liver induces diabetic cardiomyopathy. | Long term liver specific glucokinase gene defect induced diabetic cardiomyopathy by up regulating NADPH oxidase and down regulating insulin receptor and p-AMPK.
Li H, Wang X, Mao Y, Hu R, Xu W, Lei Z, Zhou N, Jin L, Guo T, Li Z, Irwin DM, Niu G, Tan H., Free PMC Article | 08/30/2014 |
| Glucokinase is regulated by the ubiquitin-proteasome system to avoid misfolding and reduced activity of the enzyme. | The ubiquitin-proteasome system regulates the stability and activity of the glucose sensor glucokinase in pancreatic β-cells.
Hofmeister-Brix A, Lenzen S, Baltrusch S. | 01/11/2014 |
| IRS-2 signalling is important for maintaining the activity of liver glucokinase. | Insulin-receptor substrate-2 (irs-2) is required for maintaining glucokinase and glucokinase regulatory protein expression in mouse liver.
Roncero I, Alvarez E, Acosta C, Sanz C, Barrio P, Hurtado-Carneiro V, Burks D, Blázquez E., Free PMC Article | 09/21/2013 |