| The molecular characteristics and functional roles of microspherule protein 1 (MCRS1) in gene expression, cell proliferation, and organismic development. | The molecular characteristics and functional roles of microspherule protein 1 (MCRS1) in gene expression, cell proliferation, and organismic development.
Huang CJ, Lyu X, Kang J., Free PMC Article | 03/3/2023 |
| MCRS1 modulates the heterogeneity of microtubule minus-end morphologies in mitotic spindles. | MCRS1 modulates the heterogeneity of microtubule minus-end morphologies in mitotic spindles.
Laguillo-Diego A, Kiewisz R, Martí-Gómez C, Baum D, Müller-Reichert T, Vernos I., Free PMC Article | 12/24/2022 |
| This study confirmed the specific tumor suppressive activity of MCRS1 in gastric cancer proliferation, invasion and migration and suggested that it might inhibit the progression of gastric cancer through its interaction with Pkmyt1. | Effects of MCRS1 on proliferation, migration, invasion, and epithelial mesenchymal transition of gastric cancer cells by interacting with Pkmyt1 protein kinase.
Wang XM, Li QY, Ren LL, Liu YM, Wang TS, Mu TC, Fu S, Liu C, Xiao JY. | 08/12/2020 |
| Our data suggest that decreased expression of miR-186 in hepatocellular carcinoma is responsible for the high expression of MCRS1 | miR-186 modulates hepatocellular carcinoma cell proliferation and mobility via targeting MCRS1-mediated Wnt/β-catenin signaling.
Wang H, Ou J, Jian Z, Ou Y. | 06/13/2020 |
| Authors show that Mps1 regulates chromosome alignment through MCRS1, a spindle assembly factor that controls the dynamics of the minus end of kinetochore microtubules. Mps1 binds and phosphorylates MCRS1. | Mps1 regulates spindle morphology through MCRS1 to promote chromosome alignment.
Yang H, Zhang F, Huang CJ, Liao J, Han Y, Hao P, Chu Y, Lu X, Li W, Yu H, Kang J., Free PMC Article | 09/14/2019 |
| Study shows that MCRS1 binds to cytoplasmic dynein and contributes to the establishment of centriolar satellites and ciliogenesis. | MCRS1 associates with cytoplasmic dynein and mediates pericentrosomal material recruitment.
Lee SH, Lee MS, Choi TI, Hong H, Seo JY, Kim CH, Kim J., Free PMC Article | 04/28/2018 |
| MSP58 downregulation suppressed the proliferation and invasion of renal cell carcinoma cells. | Knockdown of MSP58 inhibits the proliferation and metastasis in human renal cell carcinoma cells.
Zhai X, Wu Y, Zhang D, Chong T, Zhao J. | 03/31/2018 |
| MCRS1 is phosphorylated by the Aurora-A kinase in mitosis on Ser35/36. | Aurora-A regulates MCRS1 function during mitosis.
Meunier S, Timón K, Vernos I., Free PMC Article | 06/10/2017 |
| RINT-1 interacts with MSP58 and UBF within nucleoli and plays a role in ribosomal gene transcription. | RINT-1 interacts with MSP58 within nucleoli and plays a role in ribosomal gene transcription.
Yang CP, Kuo YL, Lee YC, Lee KH, Chiang CW, Wang JM, Hsu CC, Chang WC, Lin DY. | 05/20/2017 |
| The immunoreactivity score (IRS) of MSP58 increased with tumor grade with grade IV gliomas exhibiting the highest expression and showed a highly significant positive correlation with the Ki-67 index (r = 0.65, P < 0.001). | Expression of 58-kD Microspherule Protein (MSP58) is Highly Correlated with PET Imaging of Tumor Malignancy and Cell Proliferation in Glioma Patients.
Lin W, Dai SH, Chen T, Kawai N, Miyake K, Okada M, Haba R, Yamamoto Y, Tamiya T, Fei Z. | 11/12/2016 |
| Suggest that MSP58 plays an important role in tumorigenesis and progression and may help predict the prognosis of gastric cancer patients. | Increased Expression of 58-kDa Microspherule Protein (MSP58) in Human Gastric Cancer Promotes Cell Proliferation and Correlates with Poor Patient Survival.
Cui J, Xi H, Cai A, Ma L, Bian S, Zhang K, Wei B, Chen L. | 09/10/2016 |
| MCRS1 overexpression induced non-small cell lung cancer proliferation through the miR-155-Rb1 pathway and DNA copy-number amplification is one of the mechanisms underlying MCRS1 overexpression in non-small cell lung cancer. | The candidate oncogene (MCRS1) promotes the growth of human lung cancer cells via the miR-155-Rb1 pathway.
Liu M, Zhou K, Huang Y, Cao Y., Free PMC Article | 07/2/2016 |
| MSP58 subnuclear localization is regulated by two nuclear import signals, and proper subcellular localization of MSP58 is critical for its role in transcriptional regulation. A molecular mechanism controls nuclear and nucleolar localization of MSP58. | Identification and characterization of nuclear and nucleolar localization signals in 58-kDa microspherule protein (MSP58).
Yang CP, Chiang CW, Chen CH, Lee YC, Wu MH, Tsou YH, Yang YS, Chang WC, Lin DY., Free PMC Article | 03/12/2016 |
| BAP1 loss and MCRS1 down-regulation in renal cell carcinoma are associated with adverse clinicopathological features. | Stabilization of MCRS1 by BAP1 prevents chromosome instability in renal cell carcinoma.
Peng J, Ma J, Li W, Mo R, Zhang P, Gao K, Jin X, Xiao J, Wang C, Fan J. | 02/6/2016 |
| MiR-129* down-regulation induced MCRS1 overexpression. | MCRS1 overexpression, which is specifically inhibited by miR-129*, promotes the epithelial-mesenchymal transition and metastasis in non-small cell lung cancer.
Liu MX, Zhou KC, Cao Y., Free PMC Article | 07/25/2015 |
| High expression of MSP58 was also an independent unfavorable prognostic factor. | Increased expression of the 58-kD microspherule protein (MSP58) is correlated with poor prognosis in glioma patients.
Lin W, Li XM, Zhang J, Huang Y, Wang J, Zhang J, Jiang XF, Fei Z. | 09/6/2014 |
| MSP58 could suppress the transcription of hTERT promoter. | The 58-kda microspherule protein (MSP58) represses human telomerase reverse transcriptase (hTERT) gene expression and cell proliferation by interacting with telomerase transcriptional element-interacting factor (TEIF).
Hsu CC, Chen CH, Hsu TI, Hung JJ, Ko JL, Zhang B, Lee YC, Chen HK, Chang WC, Lin DY. | 05/24/2014 |
| MSP58 expression in hepatocellular carcinoma is closely related to the prognosis. | Expression of MSP58 in hepatocellular carcinoma.
Zhong M, Zhang X, Li B, Chen CS, Ji GL, Li SX, Bi DQ, Zhao QC, Shi H. | 10/26/2013 |
| Our results demonstrated MSP58 might serve as a novel prognostic marker for colorectal cancer | Expression of MSP58 in human colorectal cancer and its correlation with prognosis.
Shi H, Li SJ, Zhang B, Liu HL, Chen CS., Free PMC Article | 07/20/2013 |
| MSP58 contributes to the tumorigenesis of neuroblastoma by promoting cell proliferation. | Downregulation of MSP58 suppresses cell proliferation in neuroblastoma cell lines.
Wu L, Zhang ZG, Qin HZ, Zhang J, Gao GD, Lin W, Wang J, Zhang J. | 07/20/2013 |
| RACGAP1 and MCRS1 overexpression in nonsmall-cell lung cancer.RACGAP1 and MCRS1 may be cancer-related genes in NSCLC. | Analysis of 20 genes at chromosome band 12q13: RACGAP1 and MCRS1 overexpression in nonsmall-cell lung cancer.
Liang Y, Liu M, Wang P, Ding X, Cao Y. | 06/15/2013 |
| MSP58 depletion induced cell cycle arrest. | MSP58 knockdown inhibits the proliferation of esophageal squamous cell carcinoma in vitro and in vivo.
Xu CS, Zheng JY, Zhang HL, Zhao HD, Zhang J, Wu GQ, Wu L, Wang Q, Wang WZ, Zhang J. | 06/8/2013 |
| Interaction between microspherule protein Msp58 and ubiquitin E3 ligase EDD regulates cell cycle progression. | The novel interaction between microspherule protein Msp58 and ubiquitin E3 ligase EDD regulates cell cycle progression.
Benavides M, Chow-Tsang LF, Zhang J, Zhong H., Free PMC Article | 03/9/2013 |
| Our findings highlight new aspects of MSP58 in modulating cellular senescence and suggest that MSP58 has both oncogenic and tumor-suppressive properties. | 58-kDa microspherule protein (MSP58) is novel Brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway.
Hsu CC, Lee YC, Yeh SH, Chen CH, Wu CC, Wang TY, Chen YN, Hung LY, Liu YW, Chen HK, Hsiao YT, Wang WS, Tsou JH, Tsou YH, Wu MH, Chang WC, Lin DY., Free PMC Article | 09/15/2012 |
| MCRS2 plays a negative role in stress-induced ASK1 activation. | Microspherule protein 2 associates with ASK1 and acts as a negative regulator of stress-induced ASK1 activation.
Xu M, Zhang F, Da L, Li T, Zhao M. | 08/11/2012 |