| BIN1 regulates actin-membrane interactions during IRSp53-dependent filopodia formation. | BIN1 regulates actin-membrane interactions during IRSp53-dependent filopodia formation.
Picas L, André-Arpin C, Comunale F, Bousquet H, Tsai FC, Rico F, Maiuri P, Pernier J, Bodin S, Nicot AS, Laporte J, Bassereau P, Goud B, Gauthier-Rouvière C, Miserey S., Free PMC Article | 07/2/2024 |
| Actin Filaments Couple the Protrusive Tips to the Nucleus through the I-BAR Domain Protein IRSp53 during the Migration of Cells on 1D Fibers. | Actin Filaments Couple the Protrusive Tips to the Nucleus through the I-BAR Domain Protein IRSp53 during the Migration of Cells on 1D Fibers.
Mukherjee A, Ron JE, Hu HT, Nishimura T, Hanawa-Suetsugu K, Behkam B, Mimori-Kiyosue Y, Gov NS, Suetsugu S, Nain AS., Free PMC Article | 03/28/2023 |
| Genetic variation in genes regulating skeletal muscle regeneration and tissue remodelling associated with weight loss in chronic obstructive pulmonary disease. | Genetic variation in genes regulating skeletal muscle regeneration and tissue remodelling associated with weight loss in chronic obstructive pulmonary disease.
Lakshman Kumar P, Wilson AC, Rocco A, Cho MH, Wan E, Hobbs BD, Washko GR, Ortega VE, Christenson SA, Li X, Wells JM, Bhatt SP, DeMeo DL, Lutz SM, Rossiter H, Casaburi R, Rennard SI, Lomas DA, Labaki WW, Tal-Singer R, Bowler RP, Hersh CP, Tiwari HK, Dransfield M, Thalacker-Mercer A, Meyers DA, Silverman EK, McDonald MN, COPDGene, ECLIPSE and SPIROMICS investigators., Free PMC Article | 02/5/2022 |
| Impaired prepulse inhibition in mice with IRSp53 deletion in modulatory neurotransmitter neurons including dopamine, acetylcholine, oxytocin, and serotonin. | Impaired prepulse inhibition in mice with IRSp53 deletion in modulatory neurotransmitter neurons including dopamine, acetylcholine, oxytocin, and serotonin.
Kim Y, Yang E, Kim H. | 01/15/2022 |
| IRSp53 is a novel interactor of SHIP2: A role of the actin binding protein Mena in their cellular localization in breast cancer cells. | IRSp53 is a novel interactor of SHIP2: A role of the actin binding protein Mena in their cellular localization in breast cancer cells.
Antoine M, Vandenbroere I, Ghosh S, Erneux C, Pirson I. | 10/30/2021 |
| BAIAP2 rs8079781, postnatal smoking exposure, and emotional problems in Japanese children aged 5 years: the Kyushu Okinawa Maternal and Child Health Study. | BAIAP2 rs8079781, postnatal smoking exposure, and emotional problems in Japanese children aged 5 years: the Kyushu Okinawa Maternal and Child Health Study.
Miyake Y, Tanaka K, Arakawa M. | 10/23/2021 |
| Insulin Receptor Substrate p53 Ameliorates High-Glucose-Induced Activation of NF-kappaB and Impaired Mobility of HUVECs. | Insulin Receptor Substrate p53 Ameliorates High-Glucose-Induced Activation of NF-κB and Impaired Mobility of HUVECs.
Liu F, Chen Y, Zhao S, Li M, Luo F, Tang CE., Free PMC Article | 06/19/2021 |
| Phosphorylation-dependent inhibition of IRSp53 by 14-3-3 counters activation by Cdc42 and cytoskeletal effectors, resulting in down-regulation of filopodia dynamics and cancer cell migration. In serum-starved cells, increased IRSp53 phosphorylation triggers 14-3-3 binding, which inhibits filopodia formation and dynamics, irrespective of whether IRSp53 is activated by Cdc42 or downstream effectors (Eps8, Ena/VASP). | IRSp53 coordinates AMPK and 14-3-3 signaling to regulate filopodia dynamics and directed cell migration.
Kast DJ, Dominguez R., Free PMC Article | 12/14/2019 |
| IRSp53 heterodimer with only one subunit is phosphorylated, and each subunit of IRSp53 independently binds one 14-3-3 dimer. | Mechanism of IRSp53 inhibition by 14-3-3.
Kast DJ, Dominguez R., Free PMC Article | 04/20/2019 |
| Coincident with the loss of PICK1 by GBF1-activated ARF1, CDC42 recruitment leads to the activation of IRSp53 and the ARP2/3 complex, resulting in a burst of F-actin polymerisation potentially powering scission. | Small GTPases and BAR domain proteins regulate branched actin polymerisation for clathrin and dynamin-independent endocytosis.
Sathe M, Muthukrishnan G, Rae J, Disanza A, Thattai M, Scita G, Parton RG, Mayor S., Free PMC Article | 12/22/2018 |
| A BAIAP2 polymorphism, rs8079626, affects medial frontal gyrus and inferior parietal lobe connectivity in attention deficit hyperactivity order adults. | Inter-hemispherical asymmetry in default-mode functional connectivity and BAIAP2 gene are associated with anger expression in ADHD adults.
Hasler R, Preti MG, Meskaldji DE, Prados J, Adouan W, Rodriguez C, Toma S, Hiller N, Ismaili T, Hofmeister J, Sinanaj I, Baud P, Haller S, Giannakopoulos P, Schwartz S, Perroud N, Van De Ville D. | 05/5/2018 |
| BAIAP2 is a candidate gene for mediating dendritic spine density abnormalities in schizophrenia. Data suggest that altered DNA methylation in schizophrenia may be a mechanism for schizophrenia-related dendritic spine density reductions. | DNA methylation as a putative mechanism for reduced dendritic spine density in the superior temporal gyrus of subjects with schizophrenia.
McKinney B, Ding Y, Lewis DA, Sweet RA., Free PMC Article | 11/18/2017 |
| Overexpression of LIN7 or IRSp53 did not prevent the formation of hyperfused mitochondria in cells coexpressing the Drp1 K38A mutant, thus suggesting that LIN7-IRSp53 complex requires functional Drp1 to regulate mitochondrial morphology. | Novel localisation and possible function of LIN7 and IRSp53 in mitochondria of HeLa cells.
Ferrari I, Crespi A, Fornasari D, Pietrini G. | 02/18/2017 |
| Results suggest the hypothesis that defective actin/membrane modulation in IRSp53-deficient dendritic spines may lead to social and cognitive deficits through N-methyl-d-aspartate receptor dysfunction. | IRSp53/BAIAP2 in dendritic spine development, NMDA receptor regulation, and psychiatric disorders.
Kang J, Park H, Kim E. | 07/16/2016 |
| dimers sense negative membrane curvature, display a non-monotonic sorting with curvature, and expand the membrane tube at high imposed tension while constricting it at low tension | IRSp53 senses negative membrane curvature and phase separates along membrane tubules.
Prévost C, Zhao H, Manzi J, Lemichez E, Lappalainen P, Callan-Jones A, Bassereau P., Free PMC Article | 05/28/2016 |
| determined the alpha-synuclein-binding domain of beta-III tubulin and demonstrated that a short fragment containing this domain can suppress alpha-synuclein accumulation in the primary cultured cells | Dynamin1 is a novel target for IRSp53 protein and works with mammalian enabled (Mena) protein and Eps8 to regulate filopodial dynamics.
Chou AM, Sem KP, Wright GD, Sudhaharan T, Ahmed S., Free PMC Article | 01/24/2015 |
| BAIAP2 is related to emotional modulation of human memory strength. | BAIAP2 is related to emotional modulation of human memory strength.
Luksys G, Ackermann S, Coynel D, Fastenrath M, Gschwind L, Heck A, Rasch B, Spalek K, Vogler C, Papassotiropoulos A, de Quervain D., Free PMC Article | 11/22/2014 |
| These above results indicated the possible involvement of BAIAP2 in the etiology of attention deficit disorder with hyperactivity, especially ADHD-I. | BAIAP2 exhibits association to childhood ADHD especially predominantly inattentive subtype in Chinese Han subjects.
Liu L, Sun L, Li ZH, Li HM, Wei LP, Wang YF, Qian QJ., Free PMC Article | 08/23/2014 |
| IRSp53 adopts a closed inactive conformation that opens synergistically with the binding of human Cdc42 to the CRIB-PR and effector proteins, such as the tumor-promoting factor Eps8, to the SH3 domain. | Mechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectors.
Kast DJ, Yang C, Disanza A, Boczkowska M, Madasu Y, Scita G, Svitkina T, Dominguez R., Free PMC Article | 06/21/2014 |
| LIN7 is a novel regulator of IRSp53. | LIN7 regulates the filopodium- and neurite-promoting activity of IRSp53.
Crespi A, Ferrari I, Lonati P, Disanza A, Fornasari D, Scita G, Padovano V, Pietrini G. | 04/27/2013 |
| mDia1 and WAVE2 are important Src homology 3 domain partners of IRSp53 in forming filopodia. | mDia1 and WAVE2 proteins interact directly with IRSp53 in filopodia and are involved in filopodium formation.
Goh WI, Lim KB, Sudhaharan T, Sem KP, Bu W, Chou AM, Ahmed S., Free PMC Article | 04/21/2012 |
| Structural basis for complex formation between human IRSp53 and the translocated intimin receptor Tir of enterohemorrhagic E. coli | Structural basis for complex formation between human IRSp53 and the translocated intimin receptor Tir of enterohemorrhagic E. coli.
de Groot JC, Schlüter K, Carius Y, Quedenau C, Vingadassalom D, Faix J, Weiss SM, Reichelt J, Standfuss-Gabisch C, Lesser CF, Leong JM, Heinz DW, Büssow K, Stradal TE., Free PMC Article | 12/31/2011 |
| Studied generation of filopodia with regards to the dynamic interaction established by Eps8, IRSp53 and VASP with actin filaments. | The Eps8/IRSp53/VASP network differentially controls actin capping and bundling in filopodia formation.
Vaggi F, Disanza A, Milanesi F, Di Fiore PP, Menna E, Matteoli M, Gov NS, Scita G, Ciliberto A., Free PMC Article | 12/17/2011 |
| A molecular dynamics study of the interaction between domain I-BAR of the IRSp53 protein and negatively charged membranes | [A molecular dynamics study of the interaction between domain I-BAR of the IRSp53 protein and negatively charged membranes].
Levtsova OV, Davletov ID, Sokolova OS, Shaĭtan KV. | 06/18/2011 |
| The results of this study and the supporting evidence highlighted previously suggest that the BAIAP2 gene may be involved in autism susceptibility. | Association study of six candidate genes asymmetrically expressed in the two cerebral hemispheres suggests the involvement of BAIAP2 in autism.
Toma C, Hervás A, Balmaña N, Vilella E, Aguilera F, Cuscó I, del Campo M, Caballero R, De Diego-Otero Y, Ribasés M, Cormand B, Bayés M. | 04/30/2011 |