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    OLFM4 olfactomedin 4 [ Homo sapiens (human) ]

    Gene ID: 10562, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Comprehensive single-cell analysis deciphered microenvironmental dynamics and immune regulator olfactomedin 4 in pathogenesis of gallbladder cancer.

    Comprehensive single-cell analysis deciphered microenvironmental dynamics and immune regulator olfactomedin 4 in pathogenesis of gallbladder cancer.
    He H, Chen S, Yu Y, Fan Z, Qian Y, Dong Y, Song Y, Zhong C, Sun X, Cao Q, Li S, Huang W, Li W, Zhuang M, Yang J, Wang X, Wang J, Wu D, Wang H, Wen W., Free PMC Article

    09/17/2024
    OLFM4 modulates intestinal inflammation by promoting IL-22[+]ILC3 in the gut.

    OLFM4 modulates intestinal inflammation by promoting IL-22(+)ILC3 in the gut.
    Xing Z, Li X, He J, Chen Y, Zhu L, Zhang X, Huang Z, Tang J, Guo Y, He Y., Free PMC Article

    09/6/2024
    Blocking OLFM4/galectin-3 axis in placental polymorphonuclear myeloid-derived suppressor cells triggers intestinal inflammation in newborns.

    Blocking OLFM4/galectin-3 axis in placental polymorphonuclear myeloid-derived suppressor cells triggers intestinal inflammation in newborns.
    Lv S, Chen M, Li Z, Huang Z, Wan S, Kuang S, Peng L, Ye J, Yang M, Li J, He Y.

    06/17/2024
    LRFN5 and OLFM4 as novel potential biomarkers for major depressive disorder: a pilot study.

    LRFN5 and OLFM4 as novel potential biomarkers for major depressive disorder: a pilot study.
    Xu K, Zheng P, Zhao S, Wang J, Feng J, Ren Y, Zhong Q, Zhang H, Chen X, Chen J, Xie P., Free PMC Article

    06/9/2023
    Olfactomedin 4 produces dysplasia but suppresses metastasis of colon cancer.

    Olfactomedin 4 produces dysplasia but suppresses metastasis of colon cancer.
    Ma HW, Kim JM, Kim DH, Park IS, Kim JH, Park KC, Seo DH, Kim JH, Che X, Kim TI, Cheon JH, Kim SW.

    05/19/2023
    Olfactomedin 4 associates with expression of differentiation markers but not with properties of cancer stemness, EMT nor metastatic spread in colorectal cancer.

    Olfactomedin 4 associates with expression of differentiation markers but not with properties of cancer stemness, EMT nor metastatic spread in colorectal cancer.
    Jaitner S, Pretzsch E, Neumann J, Schäffauer A, Schiemann M, Angele M, Kumbrink J, Schwitalla S, Greten FR, Brandl L, Klauschen F, Horst D, Kirchner T, Jung A., Free PMC Article

    03/8/2023
    Olfactomedin-4-Positive Neutrophils in Neonates: Link to Systemic Inflammation and Bronchopulmonary Dysplasia.

    Olfactomedin-4-Positive Neutrophils in Neonates: Link to Systemic Inflammation and Bronchopulmonary Dysplasia.
    Al Gharaibeh FN, Kempton KM, Alder MN., Free PMC Article

    03/7/2023
    New Insights of OLFM2 and OLFM4 in Gut-Liver Axis and Their Potential Involvement in Nonalcoholic Fatty Liver Disease.

    New Insights of OLFM2 and OLFM4 in Gut-Liver Axis and Their Potential Involvement in Nonalcoholic Fatty Liver Disease.
    Bertran L, Jorba-Martin R, Barrientos-Riosalido A, Portillo-Carrasquer M, Aguilar C, Riesco D, Martínez S, Vives M, Sabench F, Castillo DD, Richart C, Auguet T., Free PMC Article

    07/23/2022
    OLFM4 deficiency delays the progression of colitis to colorectal cancer by abrogating PMN-MDSCs recruitment.

    OLFM4 deficiency delays the progression of colitis to colorectal cancer by abrogating PMN-MDSCs recruitment.
    Chen Z, Zhang X, Xing Z, Lv S, Huang L, Liu J, Ye S, Li X, Chen M, Zuo S, Tao Y, He Y.

    06/11/2022
    Olfactomedin 4 Is Not a Precise Marker for Human Intestinal Stem Cells, But Is Involved in Intestinal Carcinogenesis.

    Olfactomedin 4 Is Not a Precise Marker for Human Intestinal Stem Cells, But Is Involved in Intestinal Carcinogenesis.
    Liu W, Rodgers GP.

    05/14/2022
    Increased expression of OLFM4 and lysozyme during necrotizing enterocolitis in neonates: an observational research study.

    Increased expression of OLFM4 and lysozyme during necrotizing enterocolitis in neonates: an observational research study.
    Diez S, Renner M, Bahlinger V, Hartmann A, Besendörfer M, Müller H., Free PMC Article

    04/23/2022
    Olfactomedin 4 regulates migration and proliferation of immortalized non-transformed keratinocytes through modulation of the cell cycle machinery and actin cytoskeleton remodelling.

    Olfactomedin 4 regulates migration and proliferation of immortalized non-transformed keratinocytes through modulation of the cell cycle machinery and actin cytoskeleton remodelling.
    Cárdenas-León CG, Klaas M, Mäemets-Allas K, Arak T, Eller M, Jaks V.

    04/23/2022
    Comparative Analysis of Patient-Matched PDOs Revealed a Reduction in OLFM4-Associated Clusters in Metastatic Lesions in Colorectal Cancer.

    Comparative Analysis of Patient-Matched PDOs Revealed a Reduction in OLFM4-Associated Clusters in Metastatic Lesions in Colorectal Cancer.
    Okamoto T, duVerle D, Yaginuma K, Natsume Y, Yamanaka H, Kusama D, Fukuda M, Yamamoto M, Perraudeau F, Srivastava U, Kashima Y, Suzuki A, Kuze Y, Takahashi Y, Ueno M, Sakai Y, Noda T, Tsuda K, Suzuki Y, Nagayama S, Yao R., Free PMC Article

    03/5/2022
    Overexpression of Cancer-Associated Stem Cell Gene OLFM4 in the Colonic Epithelium of Patients With Primary Sclerosing Cholangitis.

    Overexpression of Cancer-Associated Stem Cell Gene OLFM4 in the Colonic Epithelium of Patients With Primary Sclerosing Cholangitis.
    Neyazi M, Bharadwaj SS, Bullers S, Varenyiova Z, Oxford IBD Cohort Study Investigators, Travis S, Arancibia-Cárcamo CV, Powrie F, Geremia A., Free PMC Article

    02/12/2022
    Olfm4 Is Highly Expressed in HCC Patients and as a Biomarker and Therapeutic Target for HCC.

    Olfm4 Is Highly Expressed in HCC Patients and as a Biomarker and Therapeutic Target for HCC.
    Wei Y, Song Q, Zhang F, Yuan T., Free PMC Article

    01/29/2022
    Quantitative Proteomic Analysis of Synovial Tissue Reveals That Upregulated OLFM4 Aggravates Inflammation in Rheumatoid Arthritis.

    Quantitative Proteomic Analysis of Synovial Tissue Reveals That Upregulated OLFM4 Aggravates Inflammation in Rheumatoid Arthritis.
    Ren X, Geng M, Xu K, Lu C, Cheng Y, Kong L, Cai Y, Hou W, Lu Y, Aihaiti Y, Xu P.

    11/22/2021
    A neutrophil subset defined by intracellular olfactomedin 4 is associated with mortality in sepsis.

    A neutrophil subset defined by intracellular olfactomedin 4 is associated with mortality in sepsis.
    Kangelaris KN, Clemens R, Fang X, Jauregui A, Liu T, Vessel K, Deiss T, Sinha P, Leligdowicz A, Liu KD, Zhuo H, Alder MN, Wong HR, Calfee CS, Lowell C, Matthay MA., Free PMC Article

    07/31/2021
    Super-enhancer-associated long noncoding RNA AC005592.2 promotes tumor progression by regulating OLFM4 in colorectal cancer.

    Super-enhancer-associated long noncoding RNA AC005592.2 promotes tumor progression by regulating OLFM4 in colorectal cancer.
    Yan L, Chen H, Tang L, Jiang P, Yan F., Free PMC Article

    05/15/2021
    Olfactomedin 4 mediation of prostate stem/progenitor-like cell proliferation and differentiation via MYC.

    Olfactomedin 4 mediation of prostate stem/progenitor-like cell proliferation and differentiation via MYC.
    Li H, Chaitankar V, Zhu J, Chin K, Liu W, Pirooznia M, Rodgers GP., Free PMC Article

    05/1/2021
    Clinicopathological significance of olfactomedin-4 in extrahepatic bile duct carcinoma.

    Clinicopathological significance of olfactomedin-4 in extrahepatic bile duct carcinoma.
    Jun SY, An S, Huh T, Chung JY, Hong SM.

    02/27/2021
    Olfactomedin 4-Positive Neutrophils Are Upregulated after Hemorrhagic Shock.

    Olfactomedin 4-Positive Neutrophils Are Upregulated after Hemorrhagic Shock.
    Kassam AF, Levinsky NC, Mallela JP, Angel K, Opoka A, Lahni P, Sahay RD, Fei L, Nomellini V, Wong HR, Alder MN., Free PMC Article

    02/27/2021
    Prognostic Significance and Functional Relevance of Olfactomedin 4 in Early-Stage Hepatocellular Carcinoma.

    Prognostic Significance and Functional Relevance of Olfactomedin 4 in Early-Stage Hepatocellular Carcinoma.
    Ye L, Kriegl L, Reiter FP, Munker SM, Itzel T, Teufel A, Ziesch A, Török HP, Kirchner T, Gerbes AL, Guba M, Mayerle J, De Toni EN., Free PMC Article

    11/21/2020
    circulating OLFM4 could be an interesting biomarker of early breast cancer.

    OLFM4 Expression in Ductal Carcinoma In Situ and in Invasive Breast Cancer Cohorts by a SWATH-Based Proteomic Approach.
    Valo I, Raro P, Boissard A, Maarouf A, Jézéquel P, Verriele V, Campone M, Coqueret O, Guette C.

    06/27/2020
    high expression of OLFM4 was involved in chemoresistance and was an independent prognostic factor in pancreatic cancer

    High expression of olfactomedin-4 is correlated with chemoresistance and poor prognosis in pancreatic cancer.
    Ohkuma R, Yada E, Ishikawa S, Komura D, Ishizaki H, Tamada K, Kubota Y, Hamada K, Ishida H, Hirasawa Y, Ariizumi H, Satoh E, Shida M, Watanabe M, Onoue R, Ando K, Tsurutani J, Yoshimura K, Yokobori T, Sasada T, Aoki T, Murakami M, Norose T, Ohike N, Takimoto M, Izumizaki M, Kobayashi S, Tsunoda T, Wada S., Free PMC Article

    04/11/2020
    Results confirm OLFM4 as a tumor suppressor that inhibits cervical cancer metastasis by regulating mTOR signal pathway.

    OLFM4 Inhibits Epithelial-Mesenchymal Transition and Metastatic Potential of Cervical Cancer Cells.
    Li J, Liu C, Li D, Wan M, Zhang H, Zheng X, Jie X, Zhang P, Li J, Hou H, Sun Q., Free PMC Article

    02/22/2020
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