| Early loss of Scribble affects cortical development, interhemispheric connectivity and psychomotor activity. | Early loss of Scribble affects cortical development, interhemispheric connectivity and psychomotor activity.
Ezan J, Moreau MM, Mamo TM, Shimbo M, Decroo M, Richter M, Peyroutou R, Rachel R, Tissir F, de Anda FC, Sans N, Montcouquiol M., Free PMC Article | 10/30/2021 |
| Scribble mutation disrupts convergent extension and apical constriction during mammalian neural tube closure. | Scribble mutation disrupts convergent extension and apical constriction during mammalian neural tube closure.
Lesko AC, Keller R, Chen P, Sutherland A., Free PMC Article | 10/16/2021 |
| Scribble promotes alveologenesis in the pregnant mammary gland for milk production. | Scribble promotes alveologenesis in the pregnant mammary gland for milk production.
Aikawa S, Yuan J, Dewar A, Sun X, Dey SK., Free PMC Article | 05/29/2021 |
| Low SCRIB expression in fibroblasts promotes invasion of lung cancer cells. | Low SCRIB expression in fibroblasts promotes invasion of lung cancer cells.
Wang Y, Liu H, Bian Y, An J, Duan X, Wan J, Yao X, Du C, Ni C, Zhu L, Lei N, Wang F, Zhang L, Wang M, Qin Z. | 09/5/2020 |
| By maintaining a quiescent endothelial phenotype, the polarity protein Scrib elicits anti-atherosclerotic functions. | The polarity protein Scrib limits atherosclerosis development in mice.
Schürmann C, Dienst FL, Pálfi K, Vasconez AE, Oo JA, Wang S, Buchmann GK, Offermanns S, van de Sluis B, Leisegang MS, Günther S, Humbert PO, Lee E, Zhu J, Weigert A, Mathoor P, Wittig I, Kruse C, Brandes RP. | 07/11/2020 |
| Uterine deletion of Scrib leads to defective primary decidual zone (PDZ) formation and implantation chamber (crypt) formation, compromising pregnancy success. Interestingly, epithelial-specific Scrib deletion does not adversely affect PDZ formation and pregnancy success. | Primary decidual zone formation requires Scribble for pregnancy success in mice.
Yuan J, Aikawa S, Deng W, Bartos A, Walz G, Grahammer F, Huber TB, Sun X, Dey SK., Free PMC Article | 03/7/2020 |
| Scribble deficiency reduces surface expression of Epo receptor but selectively retains survival signaling via Akt. | Iron modulation of erythropoiesis is associated with Scribble-mediated control of the erythropoietin receptor.
Khalil S, Delehanty L, Grado S, Holy M, White Z 3rd, Freeman K, Kurita R, Nakamura Y, Bullock G, Goldfarb A., Free PMC Article | 03/30/2019 |
| Scribdeficient hematopoietic stem cells reveal impaired migratory capacity. | Diverging impact of cell fate determinants Scrib and Llgl1 on adhesion and migration of hematopoietic stem cells.
Dash BP, Schnöder TM, Kathner C, Mohr J, Weinert S, Herzog C, Godavarthy PS, Zanetti C, Perner F, Braun-Dullaeus R, Hartleben B, Huber TB, Walz G, Naumann M, Ellis S, Vasioukhin V, Kähne T, Krause DS, Heidel FH. | 10/6/2018 |
| Results identify a key planar cell polarity (PCP) protein, Scrib, as one of the fundamental scaffold proteins that enable hippocampal glutamatergic synapses to mature and to express bidirectional plasticity required for memory formation. Study offers a unique insight into the mechanism by which the PCP protein Scrib can regulate memory formation at postnatal stages. | Activity-Dependent Neuroplasticity Induced by an Enriched Environment Reverses Cognitive Deficits in Scribble Deficient Mouse.
Hilal ML, Moreau MM, Racca C, Pinheiro VL, Piguel NH, Santoni MJ, Dos Santos Carvalho S, Blanc JM, Abada YK, Peyroutou R, Medina C, Doat H, Papouin T, Vuillard L, Borg JP, Rachel R, Panatier A, Montcouquiol M, Oliet SHR, Sans N., Free PMC Article | 07/7/2018 |
| In the Scrib mutant, despite severe neural tube defects, epF and preBotC neurons settled at their expected hindbrain positions. Furthermore, both networks remained capable of generating rhythmically organized, respiratory-related activities and exhibited normal sensitivity to pharmacological agents known to modify respiratory circuit function. | The embryonic development of hindbrain respiratory networks is unaffected by mutation of the planar polarity protein Scribble.
Chevalier M, Cardoit L, Moreau M, Sans N, Montcouquiol M, Simmers J, Thoby-Brisson M. | 05/26/2018 |
| SCRIB is a positive regulator of mammary epithelial cell proliferation during pregnancy. | Scribble is required for pregnancy-induced alveologenesis in the adult mammary gland.
Baker L, BeGora M, Au Yeung F, Feigin ME, Rosenberg AZ, Lowe SW, Kislinger T, Muthuswamy SK., Free PMC Article | 08/5/2017 |
| Suggest a role for Plexin-B1 as a ligand and Sema4A as a receptor and characterize a reverse signaling pathway downstream of Sema4A regulating cell migration via Scrib. | A reverse signaling pathway downstream of Sema4A controls cell migration via Scrib.
Sun T, Yang L, Kaur H, Pestel J, Looso M, Nolte H, Krasel C, Heil D, Krishnan RK, Santoni MJ, Borg JP, Bünemann M, Offermanns S, Swiercz JM, Worzfeld T., Free PMC Article | 06/3/2017 |
| SCRIB uncouples reactive oxygen species-dependent bacterial killing activity from M1 polarization and inflammatory functions of macrophages | An interaction between Scribble and the NADPH oxidase complex controls M1 macrophage polarization and function.
Zheng W, Umitsu M, Jagan I, Tran CW, Ishiyama N, BeGora M, Araki K, Ohashi PS, Ikura M, Muthuswamy SK. | 05/27/2017 |
| we provide genetic evidence of a unique link between skin carcinogenesis and loss of the epithelial polarity regulator Scrib, emphasizing that Scrib exerts a wide-spread tumor suppressive function in epithelia. | The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis.
Pearson HB, McGlinn E, Phesse TJ, Schlüter H, Srikumar A, Gödde NJ, Woelwer CB, Ryan A, Phillips WA, Ernst M, Kaur P, Humbert P., Free PMC Article | 05/21/2016 |
| The polarity protein Scribble regulates myelination and remyelination in the central nervous system. | The polarity protein Scribble regulates myelination and remyelination in the central nervous system.
Jarjour AA, Boyd A, Dow LE, Holloway RK, Goebbels S, Humbert PO, Williams A, ffrench-Constant C., Free PMC Article | 01/23/2016 |
| Scrib is a regulator of tissue stem cells, controlling population expansion and self-renewal with Scrib expression dynamics directing satellite cell fate. | Muscle stem cell fate is controlled by the cell-polarity protein Scrib.
Ono Y, Urata Y, Goto S, Nakagawa S, Humbert PO, Li TS, Zammit PS. | 12/5/2015 |
| Scrib is a novel proinflammatory regulator in endothelial cells, which maintains the protein expression of GATA-like protein-1. | Polarity Protein Scrib Facilitates Endothelial Inflammatory Signaling.
Kruse C, Kurz AR, Pálfi K, Humbert PO, Sperandio M, Brandes RP, Fork C, Michaelis UR. | 11/21/2015 |
| The Scrib-Rac1 interaction plays a crucial role in the organization of developing cardiomyocytes and formation of the ventricular myocardium. | Scrib:Rac1 interactions are required for the morphogenesis of the ventricular myocardium.
Boczonadi V, Gillespie R, Keenan I, Ramsbottom SA, Donald-Wilson C, Al Nazer M, Humbert P, Schwarz RJ, Chaudhry B, Henderson DJ., Free PMC Article | 06/20/2015 |
| We show that loss of Scrib and activated oncogenic KRas cooperate in vivo, resulting in more aggressive lung tumors | Scrib heterozygosity predisposes to lung cancer and cooperates with KRas hyperactivation to accelerate lung cancer progression in vivo.
Elsum IA, Yates LL, Pearson HB, Phesse TJ, Long F, O'Donoghue R, Ernst M, Cullinane C, Humbert PO. | 01/24/2015 |
| findings, based on a definitive genetic mouse model provide fundamental insights into mammary duct maturation and homeostasis and reveal that Scrib loss activates a MAPK/Fra1 pathway that alters mammary progenitor activity | Scribble modulates the MAPK/Fra1 pathway to disrupt luminal and ductal integrity and suppress tumour formation in the mammary gland.
Godde NJ, Sheridan JM, Smith LK, Pearson HB, Britt KL, Galea RC, Yates LL, Visvader JE, Humbert PO., Free PMC Article | 11/29/2014 |
| The Scribble knockout fetus exhibits exomphalos (intact and ruptured), in contrast to the original published phenotype of gastroschisis. | Novel exomphalos genetic mouse model: the importance of accurate phenotypic classification.
Carnaghan H, Roberts T, Savery D, Norris FC, McCann CJ, Copp AJ, Scambler PJ, Lythgoe MF, Greene ND, Decoppi P, Burns AJ, Pierro A, Eaton S., Free PMC Article | 05/31/2014 |
| Scrib is required to maintain epithelial identity and that loss of Scrib can culminate in EMT, mediated, at least in part, through TGFbeta signaling. | Scrib is required for epithelial cell identity and prevents epithelial to mesenchymal transition in the mouse.
Yamben IF, Rachel RA, Shatadal S, Copeland NG, Jenkins NA, Warming S, Griep AE., Free PMC Article | 02/1/2014 |
| B cell differentiation does not require polarity proteins of the Scribble complex, and the findings do not support a role for asymmetric cell division in B cell activation and differentiation. | Regulation of asymmetric cell division and polarity by Scribble is not required for humoral immunity.
Hawkins ED, Oliaro J, Kallies A, Belz GT, Filby A, Hogan T, Haynes N, Ramsbottom KM, Van Ham V, Kinwell T, Seddon B, Davies D, Tarlinton D, Lew AM, Humbert PO, Russell SM. | 11/30/2013 |
| Scrib is required for normal lung epithelial organisation and lumen morphogenesis by maintaining cell-cell contacts. | Scribble is required for normal epithelial cell-cell contacts and lumen morphogenesis in the mammalian lung.
Yates LL, Schnatwinkel C, Hazelwood L, Chessum L, Paudyal A, Hilton H, Romero MR, Wilde J, Bogani D, Sanderson J, Formstone C, Murdoch JN, Niswander LA, Greenfield A, Dean CH., Free PMC Article | 02/23/2013 |
| while Scribble seems to be important for general epithelial cell and pronephros development, it appears to be dispensable for podocyte function and development | Role of the polarity protein Scribble for podocyte differentiation and maintenance.
Hartleben B, Widmeier E, Wanner N, Schmidts M, Kim ST, Schneider L, Mayer B, Kerjaschki D, Miner JH, Walz G, Huber TB., Free PMC Article | 09/29/2012 |