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    CENPB centromere protein B [ Homo sapiens (human) ]

    Gene ID: 1059, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    LINC01123 potentially correlates with radioresistance in glioma through the miR-151a/CENPB axis.

    LINC01123 potentially correlates with radioresistance in glioma through the miR-151a/CENPB axis.
    Tian W, Zhang Y, Liu H, Jin H, Sun T.

    02/5/2022
    CENP-B promotes the centromeric localization of ZFAT to control transcription of noncoding RNA.

    CENP-B promotes the centromeric localization of ZFAT to control transcription of noncoding RNA.
    Ishikura S, Yoshida K, Hashimoto S, Nakabayashi K, Tsunoda T, Shirasawa S., Free PMC Article

    11/27/2021
    Centromeric transcription maintains centromeric cohesion in human cells.

    Centromeric transcription maintains centromeric cohesion in human cells.
    Chen Y, Zhang Q, Teng Z, Liu H., Free PMC Article

    10/9/2021
    Proteomics characterization of CENP-B epitope in Moroccan scleroderma patients with anti-centromere autoantibodies.

    Proteomics characterization of CENP-B epitope in Moroccan scleroderma patients with anti-centromere autoantibodies.
    Zian Z, Bennani Mechita M, Hamdouch K, Maamar M, Barakat A, Ghailani Nourouti N, El Aouad R, Valdivia MM, Arji N.

    05/22/2021
    The Elusive Structure of Centro-Chromatin: Molecular Order or Dynamic Heterogenetity?

    The Elusive Structure of Centro-Chromatin: Molecular Order or Dynamic Heterogenetity?
    Nagpal H, Fierz B.

    05/8/2021
    A genetic memory initiates the epigenetic loop necessary to preserve centromere position.

    A genetic memory initiates the epigenetic loop necessary to preserve centromere position.
    Hoffmann S, Izquierdo HM, Gamba R, Chardon F, Dumont M, Keizer V, Hervé S, McNulty SM, Sullivan BA, Manel N, Fachinetti D., Free PMC Article

    04/17/2021
    From evolution to function: Two sides of the same CENP-B coin?

    From evolution to function: Two sides of the same CENP-B coin?
    Gamba R, Fachinetti D.

    12/12/2020
    Given that CENP-B is the only centromere protein that binds centromere-specific DNA elements, our study provides a new link between centromere DNA and unique epigenetic landscape of centromere chromatin

    CENP-B protects centromere chromatin integrity by facilitating histone deposition via the H3.3-specific chaperone Daxx.
    Morozov VM, Giovinazzi S, Ishov AM., Free PMC Article

    08/4/2018
    Upon cross-linking, the entire CENPA/CENPB/CENPC/CENPT complex is nuclease-protected over an alpha-satellite dimer that comprises the fundamental unit of centromeric chromatin. We conclude that CENPA/CENPC and CENPT pathways for kinetochore assembly are physically integrated over young alpha-satellite dimers.

    CENPT bridges adjacent CENPA nucleosomes on young human α-satellite dimers.
    Thakur J, Henikoff S., Free PMC Article

    01/6/2018
    Findings indicate that expression of the scleroderma autoantigens IFI-16 and CENPs, which are associated with severe vascular disease, is increased in vascular progenitors and mature endothelial cells. High level, lineage-enriched expression of autoantigens may explain the striking association between clinical phenotypes and the immune targeting of specific autoantigens.

    Enrichment of Scleroderma Vascular Disease-Associated Autoantigens in Endothelial Lineage Cells.
    McMahan ZH, Cottrell TR, Wigley FM, Antiochos B, Zambidis ET, Park TS, Halushka MK, Gutierrez-Alamillo L, Cimbro R, Rosen A, Casciola-Rosen L., Free PMC Article

    07/8/2017
    The results indicated that CENPB boxes are highly conserved in Down syndrome (DS) patients and may not be responsible for Chr21 nondisjunction events. However, alphasatDNA in Chr21 is variable and deoxynucleotide deletions, mutations and polymorphisms may act as potential molecular diagnostic markers of DS.

    Mutational spectrum of CENP-B box and α-satellite DNA on chromosome 21 in Down syndrome children.
    Chen Q, Tan B, He JL, Liu XQ, Chen XM, Gao RF, Zhu J, Wang YX, Qi HB.

    06/24/2017
    CENP-B directly binds both CENP-A's amino-terminal tail and CENP-C, a key nucleator of kinetochore assembly

    DNA Sequence-Specific Binding of CENP-B Enhances the Fidelity of Human Centromere Function.
    Fachinetti D, Han JS, McMahon MA, Ly P, Abdullah A, Wong AJ, Cleveland DW., Free PMC Article

    09/26/2015
    The results revealed that CENP-B binding in the vicinity of the CENP-A nucleosome substantially stabilizes the CENP-A nucleosome on alphoid DNA in human cells.

    Stable complex formation of CENP-B with the CENP-A nucleosome.
    Fujita R, Otake K, Arimura Y, Horikoshi N, Miya Y, Shiga T, Osakabe A, Tachiwana H, Ohzeki J, Larionov V, Masumoto H, Kurumizaka H., Free PMC Article

    08/22/2015
    Centromere protein B (CENP-B) as a novel interacting partner of HBZ.

    HTLV-1 bZIP factor suppresses the centromere protein B (CENP-B)-mediated trimethylation of histone H3K9 through the abrogation of DNA-binding ability of CENP-B.
    Mukai R, Ohshima T.

    04/4/2015
    INMAP as a model regulator of CENP-B

    A regulatory effect of INMAP on centromere proteins: antisense INMAP induces CENP-B variation and centromeric halo.
    Tan T, Chen Z, Lei Y, Zhu Y, Liang Q., Free PMC Article

    11/22/2014
    N-terminal methylation is required for CENP-B's binding to the CENP-B box.

    Identification of novel α-n-methylation of CENP-B that regulates its binding to the centromeric DNA.
    Dai X, Otake K, You C, Cai Q, Wang Z, Masumoto H, Wang Y., Free PMC Article

    04/12/2014
    Human Nap1, an acidic histone chaperone, inhibited the non-specific binding of CENP-B to nucleosomes and apparently stimulated CENP-B binding to its cognate CENP-B box DNA.

    Nap1 regulates proper CENP-B binding to nucleosomes.
    Tachiwana H, Miya Y, Shono N, Ohzeki J, Osakabe A, Otake K, Larionov V, Earnshaw WC, Kimura H, Masumoto H, Kurumizaka H., Free PMC Article

    05/4/2013
    CENP-A and/or B status is predictive of the extent of skin involvement over time in systemic sclerosis.

    Clinical correlates of CENP-A and CENP-B antibodies in a large cohort of patients with systemic sclerosis.
    Hudson M, Mahler M, Pope J, You D, Tatibouet S, Steele R, Baron M, Investigators of the Canadian Scleroderma Research Group, Fritzler M.

    01/26/2013
    Anti-CENP-B autoantibodies in breast cancer patients prolong disease-free and overall survival.

    Anti-CENP-B antibodies are associated with prolonged survival in breast cancer.
    Atalay C, Dogan L, Atalay G.

    06/28/2010
    CENP-B binding stimulated the cross-talk between CCR3 and epidermal growth factor receptor (EGFR) in human pulmonary artery smooth muscle cells.

    Nuclear autoantigen CENP-B transactivation of the epidermal growth factor receptor via chemokine receptor 3 in vascular smooth muscle cells.
    Robitaille G, Christin MS, Clément I, Senécal JL, Raymond Y.

    01/21/2010
    Study analyzed the distribution of PARP-1 and its interaction with CENP-B, -E, and -F during mitosis and apoptosis.

    Distribution of centromeric proteins and PARP-1 during mitosis and apoptosis.
    Perdoni F, Bottone MG, Soldani C, Veneroni P, Alpini C, Pellicciari C, Scovassi AI.

    01/21/2010
    Acceptor-bleaching FRET indicates that CENP-T directly associates with CENP-A and CENP-B.

    Live-cell imaging reveals sustained centromere binding of CENP-T via CENP-A and CENP-B.
    Hellwig D, Münch S, Orthaus S, Hoischen C, Hemmerich P, Diekmann S.

    01/21/2010
    observation of FRET between CENP-A and CENP-B at centromere locations; this indicates that these proteins are in the molecular vicinity (<10 nm) of each other

    Assembly of the inner kinetochore proteins CENP-A and CENP-B in living human cells.
    Orthaus S, Biskup C, Hoffmann B, Hoischen C, Ohndorf S, Benndorf K, Diekmann S.

    01/21/2010
    CENP-B was found to bind specifically to the surface of human pulmonary artery smooth muscle cells and not to fibroblasts or endothelial cells

    The nuclear autoantigen CENP-B displays cytokine-like activities toward vascular smooth muscle cells.
    Robitaille G, Hénault J, Christin MS, Senécal JL, Raymond Y.

    01/21/2010
    crystal structure of its dimerization domain (CENP-B-(540-599)), another functional domain of CENP-B, at 1.65-A resolution

    Crystal structure of the human centromere protein B (CENP-B) dimerization domain at 1.65-A resolution.
    Tawaramoto MS, Park SY, Tanaka Y, Nureki O, Kurumizaka H, Yokoyama S.

    01/21/2010
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