| Transcriptomic Changes Following Partial Depletion of CENP-E in Normal Human Fibroblasts. | Transcriptomic Changes Following Partial Depletion of CENP-E in Normal Human Fibroblasts.
Cilluffo D, Chiavetta RF, Bivona S, Contino F, Coronnello C, Feo S, Di Leonardo A, Barra V., Free PMC Article | 08/26/2024 |
| CKAP5 stabilizes CENP-E at kinetochores by regulating microtubule-chromosome attachments. | CKAP5 stabilizes CENP-E at kinetochores by regulating microtubule-chromosome attachments.
Lakshmi RB, Nayak P, Raz L, Sarkar A, Saroha A, Kumari P, Nair VM, Kombarakkaran DP, Sajana S, M G S, Agasti SS, Paul R, Ben-David U, Manna TK., Free PMC Article | 05/20/2024 |
| A farnesyl-dependent structural role for CENP-E in expansion of the fibrous corona. | A farnesyl-dependent structural role for CENP-E in expansion of the fibrous corona.
Wu J, Raas MWD, Alcaraz PS, Vos HR, Tromer EC, Snel B, Kops GJPL., Free PMC Article | 11/8/2023 |
| CENP-E activation by Aurora A and B controls kinetochore fibrous corona disassembly. | CENP-E activation by Aurora A and B controls kinetochore fibrous corona disassembly.
Eibes S, Rajendraprasad G, Guasch-Boldu C, Kubat M, Steblyanko Y, Barisic M., Free PMC Article | 09/7/2023 |
| Poly-SUMO-2/3 chain modification of Nuf2 facilitates CENP-E kinetochore localization and chromosome congression during mitosis. | Poly-SUMO-2/3 chain modification of Nuf2 facilitates CENP-E kinetochore localization and chromosome congression during mitosis.
Subramonian D, Chen TA, Paolini N, Zhang XD., Free PMC Article | 02/19/2022 |
| Centromere protein E as a novel biomarker and potential therapeutic target for retinoblastoma. | Centromere protein E as a novel biomarker and potential therapeutic target for retinoblastoma.
Shi K, Zhu X, Wu J, Chen Y, Zhang J, Sun X., Free PMC Article | 01/1/2022 |
| CENPE, PRC1, TTK, and PLK4 May Play Crucial Roles in the Osteosarcoma Progression. | CENPE, PRC1, TTK, and PLK4 May Play Crucial Roles in the Osteosarcoma Progression.
Wang F, Zhao Q, Liu W, Kong D., Free PMC Article | 11/27/2021 |
| Structure and comparison of the motor domain of centromere-associated protein E. | Structure and comparison of the motor domain of centromere-associated protein E.
Shibuya A, Ogo N, Sawada JI, Asai A, Yokoyama H., Free PMC Article | 09/25/2021 |
| Mitotic motor CENP-E cooperates with PRC1 in temporal control of central spindle assembly. | Mitotic motor CENP-E cooperates with PRC1 in temporal control of central spindle assembly.
Liu X, Xu L, Li J, Yao PY, Wang W, Ismail H, Wang H, Liao B, Yang Z, Ward T, Ruan K, Zhang J, Wu Q, He P, Ding X, Wang D, Fu C, Dou Z, Yan F, Wang W, Liu X, Yao X., Free PMC Article | 08/28/2021 |
| A non-canonical function for Centromere-associated protein-E controls centrosome integrity and orientation of cell division. | A non-canonical function for Centromere-associated protein-E controls centrosome integrity and orientation of cell division.
Owa M, Dynlacht B., Free PMC Article | 08/14/2021 |
| Kinesin Family Member C1 (KIFC1) Regulated by Centrosome Protein E (CENPE) Promotes Proliferation, Migration, and Epithelial-Mesenchymal Transition of Ovarian Cancer. | Kinesin Family Member C1 (KIFC1) Regulated by Centrosome Protein E (CENPE) Promotes Proliferation, Migration, and Epithelial-Mesenchymal Transition of Ovarian Cancer.
Li J, Diao H, Guan X, Tian X., Free PMC Article | 05/22/2021 |
| Reduced expression of CENP-E contributes to the development of hepatocellular carcinoma and is associated with adverse clinical features. | Reduced expression of CENP-E contributes to the development of hepatocellular carcinoma and is associated with adverse clinical features.
He P, Hu P, Yang C, He X, Shao M, Lin Y. | 11/21/2020 |
| These results collectively suggest a tension-independent mechanism to reduce Aurora B-mediated phosphorylation of outer kinetochore components in response to microtubule capture by CENP-E. | A tension-independent mechanism reduces Aurora B-mediated phosphorylation upon microtubule capture by CENP-E at the kinetochore.
Taveras C, Liu C, Mao Y., Free PMC Article | 07/4/2020 |
| Study revealed that CENPE is highly expressed in lung adenocarcinoma (LUAD) tissues. In addition, FOXM1 is correlated with the expression of CENE and is associated with the proliferation of lung cancer cells. FOXM1 binds directly to the promoter region of CENPE. Therefore, the current data indicate that CENPE can promote the proliferation of LUAD cells and is directly regulated by FOXM1. | CENPE promotes lung adenocarcinoma proliferation and is directly regulated by FOXM1.
Shan L, Zhao M, Lu Y, Ning H, Yang S, Song Y, Chai W, Shi X. | 12/21/2019 |
| The methylation status of cg27443373 and cg24651824 might play a critical role in modulating CENPE expression. | CENPE expression is associated with its DNA methylation status in esophageal adenocarcinoma and independently predicts unfavorable overall survival.
Zhu X, Luo X, Feng G, Huang H, He Y, Ma W, Zhang C, Zeng M, Liu H., Free PMC Article | 11/2/2019 |
| Study demonstrates that KNL1 acts as a receptor of linear ubiquitin chains to anchor CENP-E at attached kinetochores. Thus, linear ubiquitin chains constitute a critical mechanism for chromosome congression and alignment by coupling the dynamic kinetochore microtubule motor CENP-E to the static one, the KMN network. | LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores.
Wu M, Chang Y, Hu H, Mu R, Zhang Y, Qin X, Duan X, Li W, Tu H, Zhang W, Wang G, Han Q, Li A, Zhou T, Iwai K, Zhang X, Li H., Free PMC Article | 02/23/2019 |
| Results found that CENPE partial depletion induces aneuploidy in IMR90 human primary fibroblasts and in HCT116 cells. | Proliferation of aneuploid cells induced by CENP-E depletion is counteracted by the p14(ARF) tumor suppressor.
Veneziano L, Barra V, Cilluffo D, Di Leonardo A. | 02/16/2019 |
| CENP-E and CENP-F directly and specifically interact with distinct BUB mitotic checkpoint Ser/Thr kinases | The kinetochore proteins CENP-E and CENP-F directly and specifically interact with distinct BUB mitotic checkpoint Ser/Thr kinases.
Ciossani G, Overlack K, Petrovic A, Huis In 't Veld PJ, Koerner C, Wohlgemuth S, Maffini S, Musacchio A., Free PMC Article | 01/19/2019 |
| SUMOylated NKAP is essential for chromosome alignment by anchoring CENP-E to kinetochores | SUMOylated NKAP is essential for chromosome alignment by anchoring CENP-E to kinetochores.
Li T, Chen L, Cheng J, Dai J, Huang Y, Zhang J, Liu Z, Li A, Li N, Wang H, Yin X, He K, Yu M, Zhou T, Zhang X, Xia Q., Free PMC Article | 09/29/2018 |
| CENP-E motor activity appears to play important roles in the organization of midbody proteins to complete cytokinetic abscission. | Motor activity of centromere-associated protein-E contributes to its localization at the center of the midbody to regulate cytokinetic abscission.
Ohashi A, Ohori M, Iwai K., Free PMC Article | 02/17/2018 |
| Data indicate that three genes, KIF14, NCAPG and CENPE that were upregulated in Pediatric high-grade gliomas (pHGGs) and were direct miR-137 or miR-6500-3p targets. | Downregulation of miR-137 and miR-6500-3p promotes cell proliferation in pediatric high-grade gliomas.
Liang ML, Hsieh TH, Ng KH, Tsai YN, Tsai CF, Chao ME, Liu DJ, Chu SS, Chen W, Liu YR, Liu RS, Lin SC, Ho DM, Wong TT, Yang MH, Wang HW., Free PMC Article | 12/2/2017 |
| CENPE was regulated by the co-binding of LSD1 and AR to its promoter, which was associated with loss of RB1 in CRPC. | LSD1-Mediated Epigenetic Reprogramming Drives CENPE Expression and Prostate Cancer Progression.
Liang Y, Ahmed M, Guo H, Soares F, Hua JT, Gao S, Lu C, Poon C, Han W, Langstein J, Ekram MB, Li B, Davicioni E, Takhar M, Erho N, Karnes RJ, Chadwick D, van der Kwast T, Boutros PC, Arrowsmith CH, Feng FY, Joshua AM, Zoubeidi A, Cai C, He HH. | 11/11/2017 |
| these results support a novel function of XAB2 in mitotic cell cycle regulation, which is partially mediated by transcription regulation on CENPE. | XAB2 functions in mitotic cell cycle progression via transcriptional regulation of CENPE.
Hou S, Li N, Zhang Q, Li H, Wei X, Hao T, Li Y, Azam S, Liu C, Cheng W, Jin B, Liu Q, Li M, Lei H., Free PMC Article | 08/5/2017 |
| CTCF helps recruit CENP-E to the centromere during mitosis and that it may do so through a structure stabilized by the CTCF/CENP-E complex. | CTCF Recruits Centromeric Protein CENP-E to the Pericentromeric/Centromeric Regions of Chromosomes through Unusual CTCF-Binding Sites.
Xiao T, Wongtrakoongate P, Trainor C, Felsenfeld G., Free PMC Article | 07/2/2016 |
| Chromokinesin Kid and kinetochore kinesin CENP-E differentially support chromosome congression without end-on attachment to microtubules. | Chromokinesin Kid and kinetochore kinesin CENP-E differentially support chromosome congression without end-on attachment to microtubules.
Iemura K, Tanaka K. | 02/20/2016 |