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    IGF2BP2 insulin like growth factor 2 mRNA binding protein 2 [ Homo sapiens (human) ]

    Gene ID: 10644, updated on 10-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    METTL3-mediated TIM1 promotes macrophage M1 polarization and inflammation through IGF2BP2-dependent manner.

    METTL3-mediated TIM1 promotes macrophage M1 polarization and inflammation through IGF2BP2-dependent manner.
    Du X, Guo Y, Zhao X, Zhang L, Fan R, Li Y.

    11/5/2024
    The m6A reader IGF2BP2 promotes ESCC progression by stabilizing HDGF mRNA.

    The m6A reader IGF2BP2 promotes ESCC progression by stabilizing HDGF mRNA.
    Jia Y, Liu S, Zhang M, Wu X, Chen X, Xing M, Hou X, Jiang W.

    09/11/2024
    CircRHBDD1 promotes immune escape via IGF2BP2/PD-L1 signaling and acts as a nanotherapeutic target in gastric cancer.

    CircRHBDD1 promotes immune escape via IGF2BP2/PD-L1 signaling and acts as a nanotherapeutic target in gastric cancer.
    Li Y, Wang Z, Gao P, Cao D, Dong R, Zhu M, Fei Y, Zuo X, Cai J., Free PMC Article

    09/9/2024
    IGF2BP2 inhibits invasion and migration of clear cell renal cell carcinoma via targeting Netrin-4 in an m[6]A-dependent manner.

    IGF2BP2 inhibits invasion and migration of clear cell renal cell carcinoma via targeting Netrin-4 in an m(6)A-dependent manner.
    Wang G, Zhuang T, Zhen F, Zhang C, Wang Q, Miao X, Qi N, Yao R.

    08/2/2024
    The associations of IGF2, IGF2R and IGF2BP2 gene polymorphisms with gestational diabetes mellitus: A case-control study.

    The associations of IGF2, IGF2R and IGF2BP2 gene polymorphisms with gestational diabetes mellitus: A case-control study.
    Li W, She L, Zhang M, Yang M, Zheng W, He H, Wang P, Dai Q, Gong Z., Free PMC Article

    07/6/2024
    The RNA binding protein IGF2BP2/IMP2 alters the cargo of cancer cell-derived extracellular vesicles supporting tumor-associated macrophages.

    The RNA binding protein IGF2BP2/IMP2 alters the cargo of cancer cell-derived extracellular vesicles supporting tumor-associated macrophages.
    Mashayekhi V, Schomisch A, Rasheed S, Aparicio-Puerta E, Risch T, Yildiz D, Koch M, Both S, Ludwig N, Legroux TM, Keller A, Müller R, Fuhrmann G, Hoppstädter J, Kiemer AK., Free PMC Article

    07/2/2024
    Long noncoding RNA BMPR1B-AS1 stability regulated by IGF2BP2 affects the decidualization in endometriosis patients through the SMAD1/5/9 pathway.

    Long noncoding RNA BMPR1B-AS1 stability regulated by IGF2BP2 affects the decidualization in endometriosis patients through the SMAD1/5/9 pathway.
    Que X, Ren L, Yang L, Wang L, Li J, Wu R, Chen Q.

    05/9/2024
    The GRHL3-regulated long non-coding RNA lnc-DC modulates keratinocytes differentiation by interacting with IGF2BP2 and up-regulating ZNF750.

    The GRHL3-regulated long non-coding RNA lnc-DC modulates keratinocytes differentiation by interacting with IGF2BP2 and up-regulating ZNF750.
    Hu XT, Wu XF, Sui LM, Ao LQ, Pu CX, Yuan M, Xing W, Xu X.

    04/18/2024
    m[6]A-dependent upregulation of DDX21 by super-enhancer-driven IGF2BP2 and IGF2BP3 facilitates progression of acute myeloid leukaemia.

    m(6)A-dependent upregulation of DDX21 by super-enhancer-driven IGF2BP2 and IGF2BP3 facilitates progression of acute myeloid leukaemia.
    Zhao Y, Zhou Y, Qian Y, Wei W, Lin X, Mao S, Sun J, Jin J., Free PMC Article

    04/8/2024
    The m6A reader IGF2BP2 promotes the progression of esophageal squamous cell carcinoma cells by increasing the stability of OCT4 mRNA.

    The m6A reader IGF2BP2 promotes the progression of esophageal squamous cell carcinoma cells by increasing the stability of OCT4 mRNA.
    Zhao R, Li T, Zhao X, Yang Z, Ma L, Wang X.

    04/4/2024
    IGF2BP2 and IGFBP3 Genotypes, Haplotypes, and Genetic Models Studies in Polycystic Ovary Syndrome.

    IGF2BP2 and IGFBP3 Genotypes, Haplotypes, and Genetic Models Studies in Polycystic Ovary Syndrome.
    Govahi Kakhki F, Sargazi S, Montazerifar F, Majidpour M, Karajibani A, Karajibani M, Ghasemi M., Free PMC Article

    03/27/2024
    METTL14-mediated m6A epitranscriptomic modification contributes to chemotherapy-induced neuropathic pain by stabilizing GluN2A expression via IGF2BP2.

    METTL14-mediated m6A epitranscriptomic modification contributes to chemotherapy-induced neuropathic pain by stabilizing GluN2A expression via IGF2BP2.
    Lu W, Yang X, Zhong W, Chen G, Guo X, Ye Q, Xu Y, Qi Z, Ye Y, Zhang J, Wang Y, Wang X, Wang S, Zhao Q, Zeng W, Huang J, Ma H, Xie J., Free PMC Article

    03/19/2024
    KLF7 regulates super-enhancer-driven IGF2BP2 overexpression to promote the progression of head and neck squamous cell carcinoma.

    KLF7 regulates super-enhancer-driven IGF2BP2 overexpression to promote the progression of head and neck squamous cell carcinoma.
    Cai H, Liang J, Jiang Y, Wang Z, Li H, Wang W, Wang C, Hou J., Free PMC Article

    03/7/2024
    Gene Editing and Small Molecule Inhibitors of the RNA Binding Protein IGF2BP2/IMP2 Show its Potential as an Anti-Cancer Drug Target.

    Gene Editing and Small Molecule Inhibitors of the RNA Binding Protein IGF2BP2/IMP2 Show its Potential as an Anti-Cancer Drug Target.
    Chanda S, Lepikhov K, Dahlem C, Schymik HS, Hoppstädter J, Geber AK, Wagner K, Kessler SM, Empting M, Kiemer AK.

    03/1/2024
    Pancancer analysis uncovers an immunological role and prognostic value of the m6A reader IGF2BP2 in pancreatic cancer.

    Pancancer analysis uncovers an immunological role and prognostic value of the m6A reader IGF2BP2 in pancreatic cancer.
    Deng H, Yao H, Zhou S, He C, Huang Y, Li Y, Chen H, Shu J.

    02/28/2024
    m6A reader IGF2BP2 promotes lymphatic metastasis by stabilizing DPP4 in papillary thyroid carcinoma.

    m6A reader IGF2BP2 promotes lymphatic metastasis by stabilizing DPP4 in papillary thyroid carcinoma.
    Wang W, Ding Y, Zhao Y, Li X.

    02/22/2024
    CircEXOC5 Aggravates Sepsis-Induced Acute Lung Injury by Promoting Ferroptosis Through the IGF2BP2/ATF3 Axis.

    CircEXOC5 Aggravates Sepsis-Induced Acute Lung Injury by Promoting Ferroptosis Through the IGF2BP2/ATF3 Axis.
    Wang W, Xu R, He P, Xiong Y, Zhao H, Fu X, Lin J, Ye L.

    02/20/2024
    IGF2BP2 promotes cell invasion and epithelial-mesenchymal transition through Src-mediated upregulation of EREG in oral cancer.

    IGF2BP2 promotes cell invasion and epithelial-mesenchymal transition through Src-mediated upregulation of EREG in oral cancer.
    Lin CW, Yang WE, Su CW, Lu HJ, Su SC, Yang SF., Free PMC Article

    02/16/2024
    Insulin-like growth factor 2 mRNA-binding protein 2 is a therapeutic target in ovarian cancer.

    Insulin-like growth factor 2 mRNA-binding protein 2 is a therapeutic target in ovarian cancer.
    Yuan J, Li X, Wang F, Liu H, Guan W, Xu G., Free PMC Article

    02/2/2024
    IGF2BP2 promotes glycolysis and hepatocellular carcinoma stemness by stabilizing CDC45 mRNA via m6A modification.

    IGF2BP2 promotes glycolysis and hepatocellular carcinoma stemness by stabilizing CDC45 mRNA via m6A modification.
    Wu T, Liao L, Wu T, Chen S, Yi Q, Xu M.,

    12/21/2023
    IGF2BP2 promotes the progression of ovarian endometriosis by regulating m6A-modified MEIS2 and GATA6.

    IGF2BP2 promotes the progression of ovarian endometriosis by regulating m6A-modified MEIS2 and GATA6.
    Zhao S, Zhang B, Yuan H, Yin Y, Qi S, Li W, Wu X, Yaling F.

    11/13/2023
    METTL3/IGF2BP2 axis affects the progression of colorectal cancer by regulating m6A modification of STAG3.

    METTL3/IGF2BP2 axis affects the progression of colorectal cancer by regulating m6A modification of STAG3.
    Yi J, Peng F, Zhao J, Gong X., Free PMC Article

    11/7/2023
    ALKBH5 controls the meiosis-coupled mRNA clearance in oocytes by removing the N [6]-methyladenosine methylation.

    ALKBH5 controls the meiosis-coupled mRNA clearance in oocytes by removing the N (6)-methyladenosine methylation.
    Bai L, Xiang Y, Tang M, Liu S, Chen Q, Chen Q, Zhang M, Wan S, Sang Y, Li Q, Wang S, Li Z, Song Y, Hu X, Mao L, Feng G, Cui L, Ye Y, Zhu Y., Free PMC Article

    11/1/2023
    ALKBH5 enhances lipid metabolism reprogramming by increasing stability of FABP5 to promote pancreatic neuroendocrine neoplasms progression in an m6A-IGF2BP2-dependent manner.

    ALKBH5 enhances lipid metabolism reprogramming by increasing stability of FABP5 to promote pancreatic neuroendocrine neoplasms progression in an m6A-IGF2BP2-dependent manner.
    Chen J, Ye M, Bai J, Gong Z, Yan L, Gu D, Hu C, Lu F, Yu P, Xu L, Wang Y, Tian Y, Tang Q., Free PMC Article

    10/30/2023
    m6A-modified circABCC4 promotes stemness and metastasis of prostate cancer by recruiting IGF2BP2 to increase stability of CCAR1.

    m6A-modified circABCC4 promotes stemness and metastasis of prostate cancer by recruiting IGF2BP2 to increase stability of CCAR1.
    Huang C, Xu R, Zhu X, Jiang H.

    10/28/2023
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