| Regulation of a Novel CircTRRAP/miR-761/MAP3K2 CeRNA Cascade in Inflammation, Apoptosis, and Oxidative Stress in Human AC16 Cardiomyocytes under Hypoxia Conditions. | Regulation of a Novel CircTRRAP/miR-761/MAP3K2 CeRNA Cascade in Inflammation, Apoptosis, and Oxidative Stress in Human AC16 Cardiomyocytes under Hypoxia Conditions.
Xu W, Qian L, Yuan X, Lu Y. | 06/3/2023 |
| CircHSPG2 knockdown attenuates hypoxia-induced apoptosis, inflammation, and oxidative stress in human AC16 cardiomyocytes by regulating the miR-1184/MAP3K2 axis. | CircHSPG2 knockdown attenuates hypoxia-induced apoptosis, inflammation, and oxidative stress in human AC16 cardiomyocytes by regulating the miR-1184/MAP3K2 axis.
Huang L, Guo B, Yan J, Wei H, Liu S, Li Y., Free PMC Article | 03/30/2023 |
| CircRNA circBACH1 facilitates hepatitis B virus replication and hepatoma development by regulating the miR-200a-3p/MAP3K2 axis. | CircRNA circBACH1 facilitates hepatitis B virus replication and hepatoma development by regulating the miR-200a-3p/MAP3K2 axis.
Du N, Li K, Wang Y, Song B, Zhou X, Duan S. | 10/29/2022 |
| miRNA-338-3p inhibits the migration, invasion and proliferation of human lung adenocarcinoma cells by targeting MAP3K2. | miRNA-338-3p inhibits the migration, invasion and proliferation of human lung adenocarcinoma cells by targeting MAP3K2.
Zhang B, Wang D, Wang Y, Chen G., Free PMC Article | 08/27/2022 |
| miR36133p/MAP3K2/p38/caspase3 pathway regulates the heatstressinduced apoptosis of endothelial cells. | miR‑3613‑3p/MAP3K2/p38/caspase‑3 pathway regulates the heat‑stress‑induced apoptosis of endothelial cells.
Liu J, Xu S, Liu S, Chen B., Free PMC Article | 12/18/2021 |
| Mass-spectrometry-based proteomic correlates of grade and stage reveal pathways and kinases associated with aggressive human cancers. | Mass-spectrometry-based proteomic correlates of grade and stage reveal pathways and kinases associated with aggressive human cancers.
Monsivais D, Vasquez YM, Chen F, Zhang Y, Chandrashekar DS, Faver JC, Masand RP, Scheurer ME, Varambally S, Matzuk MM, Creighton CJ., Free PMC Article | 10/16/2021 |
| Structural basis for antigen recognition by methylated lysine-specific antibodies. | Structural basis for antigen recognition by methylated lysine-specific antibodies.
Ishii M, Nakakido M, Caaveiro JMM, Kuroda D, Okumura CJ, Maruyama T, Entzminger K, Tsumoto K., Free PMC Article | 08/28/2021 |
| MIR205HG acts as a ceRNA to expedite cell proliferation and progression in lung squamous cell carcinoma via targeting miR-299-3p/MAP3K2 axis. | MIR205HG acts as a ceRNA to expedite cell proliferation and progression in lung squamous cell carcinoma via targeting miR-299-3p/MAP3K2 axis.
Liu L, Li Y, Zhang R, Li C, Xiong J, Wei Y., Free PMC Article | 03/13/2021 |
| MEKK2 mediates aberrant ERK activation in neurofibromatosis type I. | MEKK2 mediates aberrant ERK activation in neurofibromatosis type I.
Bok S, Shin DY, Yallowitz AR, Eiseman M, Cung M, Xu R, Li N, Sun J, Williams AL, Scott JE, Su B, Shim JH, Greenblatt MB., Free PMC Article | 12/5/2020 |
| circ-PITX1 exerted as a competing endogenous RNA (ceRNA) in glioblastoma by sponging miR-379-5p to elevate MAP3K2 expression | Circular RNA circ-PITX1 promotes the progression of glioblastoma by acting as a competing endogenous RNA to regulate miR-379-5p/MAP3K2 axis.
Lv X, Wang M, Qiang J, Guo S. | 03/28/2020 |
| these results indicated that miR36133p may have complicated roles in endothelial cells (ECs) under heat stress. miR36133p may serve an important role in the apoptosis of heattreated ECs, and this effect may be partly achieved by targeting MAP3K2. | Analysis of potential functional significance of microRNA‑3613‑3p in human umbilical vein endothelial cells affected by heat stress.
Liu J, Han X, Zhu G, Liu S, Lu Q, Tang Z., Free PMC Article | 12/28/2019 |
| Degradation of mitogen-activated protein kinase kinase kinase 2 (MEKK2). | Kir2.1 Interaction with Stk38 Promotes Invasion and Metastasis of Human Gastric Cancer by Enhancing MEKK2-MEK1/2-ERK1/2 Signaling.
Ji CD, Wang YX, Xiang DF, Liu Q, Zhou ZH, Qian F, Yang L, Ren Y, Cui W, Xu SL, Zhao XL, Zhang X, Wang Y, Zhang P, Wang JM, Cui YH, Bian XW., Free PMC Article | 06/15/2019 |
| These results suggest that NDR2 may play important roles in IL-17-associated inflammation by promoting Smurf1-mediated MEKK2 ubiquitination and degradation. | Hippo kinase NDR2 inhibits IL-17 signaling by promoting Smurf1-mediated MEKK2 ubiquitination and degradation.
Ma X, Wang D, Li N, Gao P, Zhang M, Zhang Y. | 05/4/2019 |
| Expression of MEKK2 and MEKK3 inhibits medulloblastoma cell proliferation. | MEKK2 and MEKK3 suppress Hedgehog pathway-dependent medulloblastoma by inhibiting GLI1 function.
Lu J, Liu L, Zheng M, Li X, Wu A, Wu Q, Liao C, Zou J, Song H., Free PMC Article | 03/2/2019 |
| Compound 1s displayed activity in cell-based assays in which it inhibited ERK5 pathway activation in cells and inhibited cell migration in a scratch assay. Thus, we have identified a scaffold that has promising potential to be developed into a highly selective and potent inhibitor of MEKK2. Information from these SAR studies provides specific guidance for the future design of MEKK2 inhibitor probes. | Discovery and characterization of an iminocoumarin scaffold as an inhibitor of MEKK2 (MAP3K2).
Ahmad S, St Hilaire VR, Dandepally SR, Johnson GL, Williams AL, Scott JE., Free PMC Article | 02/17/2018 |
| miR-34c-3p may regulate triple-negative breast cancer progression by directly targeting the 3'-untranslated region of mitogen-activated protein kinase kinase kinase 2 (MAP3K2). | Regulation of cancerous progression and epithelial-mesenchymal transition by miR-34c-3p via modulation of MAP3K2 signaling in triple-negative breast cancer cells.
Wu J, Li WZ, Huang ML, Wei HL, Wang T, Fan J, Li NL, Ling R. | 06/10/2017 |
| Study found miR-186 expression significantly decreased in lung cancer tissues and cells and MAP3K2 expression increased in the same cancer tissues. Also, results confirmed that MAP3K2 is a target gene of miR-186 and both expression correlated with prognosis. | MicroRNA-186 suppresses cell proliferation and metastasis through targeting MAP3K2 in non-small cell lung cancer.
Huang T, She K, Peng G, Wang W, Huang J, Li J, Wang Z, He J. | 04/8/2017 |
| SMYD3-mediated methylation of MAP3K2 increases mutant K-Ras-induced activation of ERK1/2. (Review) | Lysine methylation in cancer: SMYD3-MAP3K2 teaches us new lessons in the Ras-ERK pathway.
Colón-Bolea P, Crespo P. | 08/29/2015 |
| Restoration of miR17/20a in solid tumor cells enhances the natural killer cell antitumor activity by targeting Mekk2 | Restoration of miR17/20a in solid tumor cells enhances the natural killer cell antitumor activity by targeting Mekk2.
Jiang H, Wang P, Li X, Wang Q, Deng ZB, Zhuang X, Mu J, Zhang L, Wang B, Yan J, Miller D, Zhang HG., Free PMC Article | 04/4/2015 |
| HBXIP activated ERK1/2 through up-regulating MEKK2. | The oncoprotein HBXIP enhances migration of breast cancer cells through increasing filopodia formation involving MEKK2/ERK1/2/Capn4 signaling.
Li Y, Zhang Z, Zhou X, Li L, Liu Q, Wang Z, Bai X, Zhao Y, Shi H, Zhang X, Ye L. | 03/7/2015 |
| MEKK2 has a novel function as a regulator of ubiquitylation-dependent paxillin redistribution in breast tumour cells. | MEKK2 regulates paxillin ubiquitylation and localization in MDA-MB 231 breast cancer cells.
Ameka M, Kahle MP, Perez-Neut M, Gentile S, Mirza AA, Cuevas BD., Free PMC Article | 01/24/2015 |
| EBV microRNA BART 18-5p targets MAP3K2 to facilitate persistence in vivo by inhibiting viral replication in B cells. | EBV microRNA BART 18-5p targets MAP3K2 to facilitate persistence in vivo by inhibiting viral replication in B cells.
Qiu J, Thorley-Lawson DA., Free PMC Article | 11/8/2014 |
| Inhibitors of apoptosis proteins regulate myogenic differentiation by directly suppressing MEKK2/3-MEK5-ERK5 signaling. | Ubiquitin-dependent regulation of MEKK2/3-MEK5-ERK5 signaling module by XIAP and cIAP1.
Takeda AN, Oberoi-Khanuja TK, Glatz G, Schulenburg K, Scholz RP, Carpy A, Macek B, Remenyi A, Rajalingam K., Free PMC Article | 10/25/2014 |
| methylation of MAP3K2 by SMYD3 increases MAP kinase signalling and promotes the formation of Ras-driven carcinomas | SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer.
Mazur PK, Reynoird N, Khatri P, Jansen PW, Wilkinson AW, Liu S, Barbash O, Van Aller GS, Huddleston M, Dhanak D, Tummino PJ, Kruger RG, Garcia BA, Butte AJ, Vermeulen M, Sage J, Gozani O., Free PMC Article | 07/19/2014 |
| results strongly support a role for MEKK2 as a regulator of signaling that modulates breast tumor cell spread area and migration through control of focal adhesion stability | MEKK2 regulates focal adhesion stability and motility in invasive breast cancer cells.
Mirza AA, Kahle MP, Ameka M, Campbell EM, Cuevas BD., Free PMC Article | 05/10/2014 |