| Loss of OVOL2 in Triple-Negative Breast Cancer Promotes Fatty Acid Oxidation Fueling Stemness Characteristics. | Loss of OVOL2 in Triple-Negative Breast Cancer Promotes Fatty Acid Oxidation Fueling Stemness Characteristics.
Lu R, Hong J, Fu T, Zhu Y, Tong R, Ai D, Wang S, Huang Q, Chen C, Zhang Z, Zhang R, Guo H, Li B., Free PMC Article | 11/4/2024 |
| Expression Patterns of Grainyhead-Like 2 and Ovo-Like 2 in Mouse Mammary Gland Development During Pregnancy, Lactation, and Weaning. | Expression Patterns of Grainyhead-Like 2 and Ovo-Like 2 in Mouse Mammary Gland Development During Pregnancy, Lactation, and Weaning.
Elfeky M, Matsuoka S, Yamamoto I, Elewa YHA, Nakamura K, Suzuki H, Kamikawa A, Okamatu-Ogura Y, Kimura K. | 07/29/2024 |
| Ovol2 promoter mutations in mice and human illuminate species-specific phenotypic divergence. | Ovol2 promoter mutations in mice and human illuminate species-specific phenotypic divergence.
Sunny SS, Lachova J, Kasparek P, Palkova M, Spoutil F, Prochazka J, Sedlacek R, Liskova P, Kozmik Z. | 03/5/2024 |
| OVOL2 sustains postnatal thymic epithelial cell identity. | OVOL2 sustains postnatal thymic epithelial cell identity.
Zhong X, Peddada N, Wang J, Moresco JJ, Zhan X, Shelton JM, SoRelle JA, Keller K, Lazaro DR, Moresco EMY, Choi JH, Beutler B., Free PMC Article | 12/1/2023 |
| Dysregulation of the Pdx1/Ovol2/Zeb2 axis in dedifferentiated beta-cells triggers the induction of genes associated with epithelial-mesenchymal transition in diabetes. | Dysregulation of the Pdx1/Ovol2/Zeb2 axis in dedifferentiated β-cells triggers the induction of genes associated with epithelial-mesenchymal transition in diabetes.
de Jesus DS, Mak TCS, Wang YF, von Ohlen Y, Bai Y, Kane E, Chabosseau P, Chahrour CM, Distaso W, Salem V, Tomas A, Stoffel M, Rutter GA, Latreille M., Free PMC Article | 03/26/2022 |
| Dual role of Ovol2 on the germ cell lineage segregation during gastrulation in mouse embryogenesis. | Dual role of Ovol2 on the germ cell lineage segregation during gastrulation in mouse embryogenesis.
Naitou Y, Nagamatsu G, Hamazaki N, Shirane K, Hayashi M, Hayashi M, Kobayashi S, Hayashi K. | 03/12/2022 |
| The Transcription Factor OVOL2 Represses ID2 and Drives Differentiation of Trophoblast Stem Cells and Placental Development in Mice. | The Transcription Factor OVOL2 Represses ID2 and Drives Differentiation of Trophoblast Stem Cells and Placental Development in Mice.
Jeyarajah MJ, Jaju Bhattad G, Hillier DM, Renaud SJ., Free PMC Article | 02/27/2021 |
| Conditional zinc finger protein mOVO (ovol2) knockout mouse model show that loss of ovol2 in embryonic germ cells does not affect fecundity in mice. | Ovol2, a zinc finger transcription factor, is dispensable for spermatogenesis in mice.
Zhang J, Dong J, Qin W, Cao C, Wen Y, Tang Y, Yuan S., Free PMC Article | 04/25/2020 |
| TRPV1 is a potential therapeutic target in hepatocellular carcinoma and exerts effects on cellular plasticity with modulation of Ovol2, Zeb1 and Sox10. | Targeting TRPV1 on cellular plasticity regulated by Ovol 2 and Zeb 1 in hepatocellular carcinoma.
Xie C, Liu G, Li M, Fang Y, Qian K, Tang Y, Wu X, Lei X, Li X, Liu Q, Liu G, Liu J, Zhang Y, Huang Z, Hu Z, Cao Z, Hu J, Huang S, Zhong D, Huang J, Wu F, Wang J, Mori M, Yamamoto H, Wang J, Xu X. | 02/8/2020 |
| simultaneous deletion of Zeb1 encoding an EMT-promoting factor restores directional migration to Ovol2-deficient Bu-HFSCs. Taken together, our findings highlight the important function of an Ovol2-Zeb1 EMT-regulatory circuit in controlling the directional migration of epithelial stem and progenitor cells to facilitate adult skin epithelial regeneration and repair. | An Ovol2-Zeb1 transcriptional circuit regulates epithelial directional migration and proliferation.
Haensel D, Sun P, MacLean AL, Ma X, Zhou Y, Stemmler MP, Brabletz S, Berx G, Plikus MV, Nie Q, Brabletz T, Dai X., Free PMC Article | 08/17/2019 |
| Association of a chromosomal rearrangement event with mouse posterior polymorphous corneal dystrophy and alterations in Csrp2bp, Dzank1, and Ovol2 gene expression have been reported. | Association of a Chromosomal Rearrangement Event with Mouse Posterior Polymorphous Corneal Dystrophy and Alterations in Csrp2bp, Dzank1, and Ovol2 Gene Expression.
Shen AL, Moran SA, Glover EA, Drinkwater NR, Swearingen RE, Teixeira LB, Bradfield CA., Free PMC Article | 07/29/2017 |
| OVOL2 is a colorectal tumor suppressor that blocks WNT signaling by facilitating the recruitment of histone deacetylase 1 to the TCF4-beta-catenin complex. | OVOL2, an Inhibitor of WNT Signaling, Reduces Invasive Activities of Human and Mouse Cancer Cells and Is Down-regulated in Human Colorectal Tumors.
Ye GD, Sun GB, Jiao P, Chen C, Liu QF, Huang XL, Zhang R, Cai WY, Li SN, Wu JF, Liu YJ, Wu RS, Xie YY, Chan EC, Liou YC, Li BA. | 07/16/2016 |
| a Grhl2/Ovol2 network controls Cldn4 and Rab25 expression that facilitates lumen expansion and barrier formation in subtypes of renal epithelia | A Grainyhead-Like 2/Ovo-Like 2 Pathway Regulates Renal Epithelial Barrier Function and Lumen Expansion.
Aue A, Hinze C, Walentin K, Ruffert J, Yurtdas Y, Werth M, Chen W, Rabien A, Kilic E, Schulzke JD, Schumann M, Schmidt-Ott KM., Free PMC Article | 02/27/2016 |
| We show that ER71 directly interacts with OVOL2 and that such interaction is critical for FLK1(+) cell generation and their differentiation into downstream cell lineages. | OVOL2 is a critical regulator of ER71/ETV2 in generating FLK1+, hematopoietic, and endothelial cells from embryonic stem cells.
Kim JY, Lee RH, Kim TM, Kim DW, Jeon YJ, Huh SH, Oh SY, Kyba M, Kataoka H, Choi K, Ornitz DM, Chae JI, Park C., Free PMC Article | 01/10/2015 |
| Deletion of Ovol2 blocks mammary ductal morphogenesis, depletes stem and progenitor cell reservoirs, and leads epithelial cells to undergo EMT . | Mammary morphogenesis and regeneration require the inhibition of EMT at terminal end buds by Ovol2 transcriptional repressor.
Watanabe K, Villarreal-Ponce A, Sun P, Salmans ML, Fallahi M, Andersen B, Dai X., Free PMC Article | 06/21/2014 |
| Ovol2 acts downstream of the BMP pathway in the cell fate decision between neuroectoderm and mesendoderm to ensure proper germ layer development. | The zinc finger transcription factor Ovol2 acts downstream of the bone morphogenetic protein pathway to regulate the cell fate decision between neuroectoderm and mesendoderm.
Zhang T, Zhu Q, Xie Z, Chen Y, Qiao Y, Li L, Jing N., Free PMC Article | 05/11/2013 |
| Ovol2/MOVO may play an important role in the XY body during spermatogenesis, possibly in the processes of XY body formation and meiotic sex chromosome inactivation. | Restricted expression of Ovol2/MOVO in XY body of mouse spermatocytes at the pachytene stage.
Chizaki R, Yao I, Katano T, Matsuda T, Ito S. | 06/2/2012 |
| Ovol2 may play a critical role in vascular angiogenesis during early embryogenesis | Ovol2/Movo, a homologue of Drosophila ovo, is required for angiogenesis, heart formation and placental development in mice.
Unezaki S, Horai R, Sudo K, Iwakura Y, Ito S. | 01/21/2010 |
| Expression of Ovol2 was up-regulated in Ovol1-deficient epidermis; Ovol1 represses the activity of Ovol2 promoter in a DNA binding-dependent manner identifying Ovol2 as a downstream target of Ovol1. | Strain-dependent perinatal lethality of Ovol1-deficient mice and identification of Ovol2 as a downstream target of Ovol1 in skin epidermis.
Teng A, Nair M, Wells J, Segre JA, Dai X., Free PMC Article | 01/21/2010 |
| Ovol2 is a key regulator of neural development and reveal a previously unexplored role for Ovo genes in mammalian embryogenesis. | The mouse Ovol2 gene is required for cranial neural tube development.
Mackay DR, Hu M, Li B, Rhéaume C, Dai X., Free PMC Article | 01/21/2010 |
| Ovol2 transcription was dramatically reduced in testes from blind-sterile mice, suggesting that Ovol2 is expressed in male germ cells | Ovol2, a mammalian homolog of Drosophila ovo: gene structure, chromosomal mapping, and aberrant expression in blind-sterile mice.
Li B, Dai Q, Li L, Nair M, Mackay DR, Dai X., Free PMC Article | 01/21/2010 |