| Cilia defects upon loss of WDR4 are linked to proteasomal hyperactivity and ubiquitin shortage. | Cilia defects upon loss of WDR4 are linked to proteasomal hyperactivity and ubiquitin shortage.
Burkhalter MD, Stiff T, Maerz LD, Casar Tena T, Wiese H, Gerhards J, Sailer SA, Vu LAT, Duong Phu M, Donow C, Alupei M, Iben S, Groth M, Wiese S, Church JA, Jeggo PA, Philipp M., Free PMC Article | 10/30/2024 |
| WDR4 promotes HCC pathogenesis through N[7]-methylguanosine by regulating and interacting with METTL1. | WDR4 promotes HCC pathogenesis through N(7)-methylguanosine by regulating and interacting with METTL1.
Dong R, Wang C, Tang B, Cheng Y, Peng X, Yang X, Ni B, Li J. | 04/12/2024 |
| PTPN23 ubiquitination by WDR4 suppresses EGFR and c-MET degradation to define a lung cancer therapeutic target. | PTPN23 ubiquitination by WDR4 suppresses EGFR and c-MET degradation to define a lung cancer therapeutic target.
Singh S, Yeat NY, Wang YT, Lin SY, Kuo IY, Wu KP, Wang WJ, Wang WC, Su WC, Wang YC, Chen RH., Free PMC Article | 11/2/2023 |
| WDR4/TRIM28 is a novel molecular target linked to lenvatinib resistance that helps retain the stem characteristics in hepatocellular carcinomas. | WDR4/TRIM28 is a novel molecular target linked to lenvatinib resistance that helps retain the stem characteristics in hepatocellular carcinomas.
Han WY, Wang J, Zhao J, Zheng YM, Chai XQ, Gao C, Cai JB, Ke AW, Fan J, Gao PT, Sun HX. | 07/23/2023 |
| METTL1/WDR4-mediated tRNA m[7]G modification and mRNA translation control promote oncogenesis and doxorubicin resistance. | METTL1/WDR4-mediated tRNA m(7)G modification and mRNA translation control promote oncogenesis and doxorubicin resistance.
Wang Z, Yu P, Zou Y, Ma J, Han H, Wei W, Yang C, Zheng S, Guo S, Wang J, Liu L, Lin S. | 06/9/2023 |
| Wdr4 promotes cerebellar development and locomotion through Arhgap17-mediated Rac1 activation. | Wdr4 promotes cerebellar development and locomotion through Arhgap17-mediated Rac1 activation.
Wu PR, Chiang SY, Midence R, Kao WC, Lai CL, Cheng IC, Chou SJ, Chen CC, Huang CY, Chen RH., Free PMC Article | 03/10/2023 |
| Association of RNA m[7]G Modification Gene Polymorphisms with Pediatric Glioma Risk. | Association of RNA m(7)G Modification Gene Polymorphisms with Pediatric Glioma Risk.
Zhu J, Liu X, Chen W, Liao Y, Liu J, Yuan L, Ruan J, He J., Free PMC Article | 02/10/2023 |
| Structural basis of regulated m[7]G tRNA modification by METTL1-WDR4. | Structural basis of regulated m(7)G tRNA modification by METTL1-WDR4.
Li J, Wang L, Hahn Q, Nowak RP, Viennet T, Orellana EA, Roy Burman SS, Yue H, Hunkeler M, Fontana P, Wu H, Arthanari H, Fischer ES, Gregory RI., Free PMC Article | 01/21/2023 |
| Structures and mechanisms of tRNA methylation by METTL1-WDR4. | Structures and mechanisms of tRNA methylation by METTL1-WDR4.
Ruiz-Arroyo VM, Raj R, Babu K, Onolbaatar O, Roberts PH, Nam Y., Free PMC Article | 01/21/2023 |
| METTL1/WDR4-mediated m(7)G tRNA modifications and m(7)G codon usage promote mRNA translation and lung cancer progression. | METTL1/WDR4-mediated m(7)G tRNA modifications and m(7)G codon usage promote mRNA translation and lung cancer progression.
Ma J, Han H, Huang Y, Yang C, Zheng S, Cai T, Bi J, Huang X, Liu R, Huang L, Luo Y, Li W, Lin S., Free PMC Article | 04/16/2022 |
| Aberrant expression of WDR4 affects the clinical significance of cancer immunity in pan-cancer. | Aberrant expression of WDR4 affects the clinical significance of cancer immunity in pan-cancer.
Zeng H, Xu S, Xia E, Hirachan S, Bhandari A, Shen Y., Free PMC Article | 12/11/2021 |
| N(7)-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression. | N(7)-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression.
Dai Z, Liu H, Liao J, Huang C, Ren X, Zhu W, Zhu S, Peng B, Li S, Lai J, Liang L, Xu L, Peng S, Lin S, Kuang M. | 09/4/2021 |
| WDR4 is an additional example of a gene that encodes a tRNA modifying enzyme and gives rise to Galloway-Mowat syndrome, if mutated | Mutations in WDR4 as a new cause of Galloway-Mowat syndrome.
Braun DA, Shril S, Sinha A, Schneider R, Tan W, Ashraf S, Hermle T, Jobst-Schwan T, Widmeier E, Majmundar AJ, Daga A, Warejko JK, Nakayama M, Schapiro D, Chen J, Airik M, Rao J, Schmidt JM, Hoogstraten CA, Hugo H, Meena J, Lek M, Laricchia KM, Bagga A, Hildebrandt F., Free PMC Article | 11/2/2019 |
| We report here 2 sisters harboring compound heterozygous variants of WDR4. Their phenotype differs from that of the first 2 described patients: they both have a severe microcephaly but only one of the 2 sisters had a head circumference at birth below -2 SD, their intellectual deficiency is less severe, and they have a growth hormone deficiency and a partial hypogonadotropic hypogonadotropism | Further delineation of the phenotype caused by biallelic variants in the WDR4 gene.
Trimouille A, Lasseaux E, Barat P, Deiller C, Drunat S, Rooryck C, Arveiler B, Lacombe D. | 08/3/2019 |
| WDR4 is an oncoprotein that negatively regulates PML via ubiquitination to promote lung cancer progression by fostering an immunosuppressive and prometastatic tumor microenvironment | Ubiquitination of tumor suppressor PML regulates prometastatic and immunosuppressive tumor microenvironment.
Wang YT, Chen J, Chang CW, Jen J, Huang TY, Chen CM, Shen R, Liang SY, Cheng IC, Yang SC, Lai WW, Cheng KH, Hsieh TS, Lai MZ, Cheng HC, Wang YC, Chen RH., Free PMC Article | 10/14/2017 |
| Combined autozygome/exome analysis revealed a novel missense mutation in WDR4 as the likely causal variant of Primordial dwarfism | Mutation in WDR4 impairs tRNA m(7)G46 methylation and causes a distinct form of microcephalic primordial dwarfism.
Shaheen R, Abdel-Salam GM, Guy MP, Alomar R, Abdel-Hamid MS, Afifi HH, Ismail SI, Emam BA, Phizicky EM, Alkuraya FS., Free PMC Article | 07/16/2016 |
| regulates FEN1's potential DNA cleavage threat near the site of replication | Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1.
Cheng IC, Chen BC, Shuai HH, Chien FC, Chen P, Hsieh TS., Free PMC Article | 06/11/2016 |