| The crucial relationship between miRNA-27 and CSE/H2S, and the mechanism of action of GLP-1 in myocardial hypertrophy. | The crucial relationship between miRNA-27 and CSE/H(2)S, and the mechanism of action of GLP-1 in myocardial hypertrophy.
Gao S, Li Y, Liu MM, Xiong X, Cui CP, Huo QJ, Li KX, Sun X, Zhang R, Wu D, Li BY., Free PMC Article | 04/18/2024 |
| Weakening of M1 macrophage and bone resorption in periodontitis cystathionine gamma-lyase-deficient mice. | Weakening of M1 macrophage and bone resorption in periodontitis cystathionine γ-lyase-deficient mice.
Li S, Hua Y, Liao C. | 03/1/2024 |
| Disrupted Binding of Cystathionine gamma-Lyase to p53 Promotes Endothelial Senescence. | Disrupted Binding of Cystathionine γ-Lyase to p53 Promotes Endothelial Senescence.
Hu J, Leisegang MS, Looso M, Drekolia MK, Wittig J, Mettner J, Karantanou C, Kyselova A, Dumbovic G, Li X, Li Y, Guenther S, John D, Siragusa M, Zukunft S, Oo JA, Wittig I, Hille S, Weigert A, Knapp S, Brandes RP, Müller OJ, Papapetropoulos A, Sigala F, Dobreva G, Kojonazarov B, Fleming I, Bibli SI. | 11/1/2023 |
| Hydrogen sulfide regulates the redox state of soluble guanylate cyclase in CSE[-/-] mice corpus cavernosum microcirculation. | Hydrogen sulfide regulates the redox state of soluble guanylate cyclase in CSE(-/-) mice corpus cavernosum microcirculation.
Olivencia MA, Esposito E, Brancaleone V, Castaldo S, Cirino G, Pérez-Vizcaino F, Sorrentino R, d'Emmanuele di Villa Bianca R, Mitidieri E. | 08/28/2023 |
| Cystathionine gamma-lyase (CTH) inhibition attenuates glioblastoma formation. | Cystathionine gamma-lyase (CTH) inhibition attenuates glioblastoma formation.
Peleli M, Antoniadou I, Rodrigues-Junior DM, Savvoulidou O, Caja L, Katsouda A, Ketelhuth DFJ, Stubbe J, Madsen K, Moustakas A, Papapetropoulos A., Free PMC Article | 07/13/2023 |
| Cystine/Glutamate Xc[-] Antiporter Induction Compensates for Transsulfuration Pathway Repression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) to Ensure Cysteine for Hepatic Glutathione Biosynthesis. | Cystine/Glutamate Xc(-) Antiporter Induction Compensates for Transsulfuration Pathway Repression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) to Ensure Cysteine for Hepatic Glutathione Biosynthesis.
Orlowska K, Fling RR, Nault R, Schilmiller AL, Zacharewski TR., Free PMC Article | 06/21/2023 |
| Cystathionine gamma-lyase (Cth) induces efferocytosis in macrophages via ERK1/2 to modulate intestinal barrier repair. | Cystathionine gamma-lyase (Cth) induces efferocytosis in macrophages via ERK1/2 to modulate intestinal barrier repair.
Zhao XH, Yang T, Zheng MY, Zhao P, An LY, Qi YX, Yi KQ, Zhang PC, Sun DL., Free PMC Article | 02/4/2023 |
| Hepatocellular cystathionine gamma lyase/hydrogen sulfide attenuates nonalcoholic fatty liver disease by activating farnesoid X receptor. | Hepatocellular cystathionine γ lyase/hydrogen sulfide attenuates nonalcoholic fatty liver disease by activating farnesoid X receptor.
Xu W, Cui C, Cui C, Chen Z, Zhang H, Cui Q, Xu G, Fan J, Han Y, Tang L, Targher G, Byrne CD, Zheng MH, Yang L, Cai J, Geng B., Free PMC Article | 11/19/2022 |
| The DR1CSE/H2S system inhibits renal fibrosis by downregulating the ERK1/2 signaling pathway in diabetic mice. | The DR1‑CSE/H(2)S system inhibits renal fibrosis by downregulating the ERK1/2 signaling pathway in diabetic mice.
Li H, Sun F, Bai S, Chang G, Wu R, Wei Y, Wen X, Xi Y, Hao J, Zaid A., Free PMC Article | 03/12/2022 |
| High protein diet-induced metabolic changes are transcriptionally regulated via KLF15-dependent and independent pathways. | High protein diet-induced metabolic changes are transcriptionally regulated via KLF15-dependent and independent pathways.
Mehrazad Saber Z, Takeuchi Y, Sawada Y, Aita Y, Ho MH, Karkoutly S, Tao D, Katabami K, Ye C, Murayama Y, Shikama A, Masuda Y, Izumida Y, Miyamoto T, Matsuzaka T, Sugasawa T, Takekoshi K, Kawakami Y, Shimano H, Yahagi N. | 01/1/2022 |
| DR1 activation promotes vascular smooth muscle cell apoptosis via up-regulation of CSE/H2 S pathway in diabetic mice. | DR1 activation promotes vascular smooth muscle cell apoptosis via up-regulation of CSE/H(2) S pathway in diabetic mice.
Wen X, Xi Y, Zhang Y, Jiao L, Shi S, Bai S, Sun F, Chang G, Wu R, Hao J, Li H. | 12/25/2021 |
| CD4(+) T-Cell Endogenous Cystathionine gamma Lyase-Hydrogen Sulfide Attenuates Hypertension by Sulfhydrating Liver Kinase B1 to Promote T Regulatory Cell Differentiation and Proliferation. | CD4(+) T-Cell Endogenous Cystathionine γ Lyase-Hydrogen Sulfide Attenuates Hypertension by Sulfhydrating Liver Kinase B1 to Promote T Regulatory Cell Differentiation and Proliferation.
Cui C, Fan J, Zeng Q, Cai J, Chen Y, Chen Z, Wang W, Li SY, Cui Q, Yang J, Tang C, Xu G, Cai J, Geng B. | 10/2/2021 |
| CSE/H2S system alleviates uremic accelerated atherosclerosis by regulating TGF-beta/Smad3 pathway in 5/6 nephrectomy ApoE(-/-) mice. | CSE/H(2)S system alleviates uremic accelerated atherosclerosis by regulating TGF-β/Smad3 pathway in 5/6 nephrectomy ApoE(-/-) mice.
Lu X, Wang S, Feng S, Li H., Free PMC Article | 09/4/2021 |
| Cystathionine-gamma-lyase ameliorates the histone demethylase JMJD3-mediated autoimmune response in rheumatoid arthritis. | Cystathionine-γ-lyase ameliorates the histone demethylase JMJD3-mediated autoimmune response in rheumatoid arthritis.
Wu W, Qin M, Jia W, Huang Z, Li Z, Yang D, Huang M, Xiao C, Long F, Mao J, Moore PK, Liu X, Zhu YZ., Free PMC Article | 08/22/2020 |
| Cystathionine gamma lyase is major key enzyme of hydrogen sulfide generation controlling perilipin 1 sulfhydration. | Sulfhydration of perilipin 1 is involved in the inhibitory effects of cystathionine gamma lyase/hydrogen sulfide on adipocyte lipolysis.
Ding Y, Wang H, Geng B, Xu G. | 08/1/2020 |
| Cystathionine gamma-lyase in mice may have a role in reducing airway reactivity and viral-induced disease in experimental exposure to side-stream tobacco smoke with respiratory syncytial virus infection | Cystathionine γ-lyase deficiency enhances airway reactivity and viral-induced disease in mice exposed to side-stream tobacco smoke.
Ivanciuc T, Sbrana E, Casola A, Garofalo RP., Free PMC Article | 07/11/2020 |
| The cystathionine-gamma-lyase system regulates the expression of coproporphyrinogen oxidase and consequent heme synthesis. | Cystathionine-γ-lyase (CSE) deficiency increases erythropoiesis and promotes mitochondrial electron transport via the upregulation of coproporphyrinogen III oxidase and consequent stimulation of heme biosynthesis.
Módis K, Ramanujam VS, Govar AA, Lopez E, Anderson KE, Wang R, Szabo C., Free PMC Article | 07/11/2020 |
| CSE-/- mice were more susceptive to dextran sulfate sodium -induced colitis | Hydrogen sulfide protects against DSS-induced colitis by inhibiting NLRP3 inflammasome.
Qin M, Long F, Wu W, Yang D, Huang M, Xiao C, Chen X, Liu X, Zhu YZ. | 06/13/2020 |
| In adipose tissues of diabetic mice, the mRNA and protein expression of MMP14 increased while the mRNA and protein expression of CSE decreased. In CSE knockout mice, the mRNA and protein expression of MMP14 in adipose tissues increased. High glucose increased the expression of MMP14 in adipocytes and visceral adipose tissues through inhibiting the expression of CSE. | Reduced cystathionine-γ-lyase (CSE) expression is involved in high glucose induced MMP14 expression in adipocytes and adipose tissues.
Hu TX, Si YL, Ruan Y, Wang XJ, Yao JQ, Wang HL, Xu Y, Ni X, Tan QY, Wang J. | 04/25/2020 |
| results suggest that elevated homocysteine or other unknown factors in preeclampsia-like Cth(-/-) dams interfere with oxytocin that regulates milk ejection reflex. | Preeclampsia-Like Features and Partial Lactation Failure in Mice Lacking Cystathionine γ-Lyase-An Animal Model of Cystathioninuria.
Akahoshi N, Handa H, Takemoto R, Kamata S, Yoshida M, Onaka T, Ishii I., Free PMC Article | 12/21/2019 |
| Constitutive S-sulfhydration of human antigen R (on Cys13) by cystathionine gamma lyase -derived H2S prevents its homodimerization and activity, which attenuates the expression of target proteins such as CD62E and cathepsin S, preserving endothelial function and delaying atherogenesis. | Cystathionine γ Lyase Sulfhydrates the RNA Binding Protein Human Antigen R to Preserve Endothelial Cell Function and Delay Atherogenesis.
Bibli SI, Hu J, Sigala F, Wittig I, Heidler J, Zukunft S, Tsilimigras DI, Randriamboavonjy V, Wittig J, Kojonazarov B, Schürmann C, Siragusa M, Siuda D, Luck B, Abdel Malik R, Filis KA, Zografos G, Chen C, Wang DW, Pfeilschifter J, Brandes RP, Szabo C, Papapetropoulos A, Fleming I. | 10/26/2019 |
| role of NF-kappaB in the upregulation of cystathionine-gamma-lyase in bladder pain accompanying cystitis | Involvement of NF-κB in the upregulation of cystathionine-γ-lyase, a hydrogen sulfide-forming enzyme, and bladder pain accompanying cystitis in mice.
Ozaki T, Tsubota M, Sekiguchi F, Kawabata A. | 08/3/2019 |
| Cystathionine gamma lyase-H2S was a dominant H2S generating system in osteoclasts, while cystathionine beta-synthase did not generate H2S. | Cystathionine gamma lyase-H(2)S contributes to osteoclastogenesis during bone remodeling induced by mechanical loading.
Mo S, Hua Y. | 10/27/2018 |
| ZYZ-803 stimulated the expression of cystathionine gamma-lyase (CSE) for H2S generation and the activity of endothelial NO synthase (eNOS) for NO production.Blocking CSE and/or eNOS suppressed ZYZ-803-induced H2S and NO production and cardioprotection. | Novel H(2)S-NO hybrid molecule (ZYZ-803) promoted synergistic effects against heart failure.
Wu D, Hu Q, Xiong Y, Zhu D, Mao Y, Zhu YZ., Free PMC Article | 10/13/2018 |
| Golgi stress response elicited by monensin stimulates CSE by acting via ATF4 with characteristics distinguishable from the endoplasmic reticulum stress response | Golgi stress response reprograms cysteine metabolism to confer cytoprotection in Huntington's disease.
Sbodio JI, Snyder SH, Paul BD., Free PMC Article | 07/21/2018 |