| N-glycosylation by Mgat5 imposes a targetable constraint on immune-mediated tumor clearance. | N-glycosylation by Mgat5 imposes a targetable constraint on immune-mediated tumor clearance.
Hollander EE, Flock RE, McDevitt JC, Vostrejs WP, Campbell SL, Orlen MI, Kemp SB, Kahn BM, Wellen KE, Kim IK, Stanger BZ., Free PMC Article | 07/11/2024 |
| Loss of N-acetylglucosaminyl transferase V is involved in the impaired osteogenic differentiation of bone marrow mesenchymal stem cells. | Loss of N-acetylglucosaminyl transferase V is involved in the impaired osteogenic differentiation of bone marrow mesenchymal stem cells.
Liu XP, Li JQ, Li RY, Cao GL, Feng YB, Zhang W., Free PMC Article | 08/9/2023 |
| Regulation of neural stem cell differentiation and brain development by MGAT5-mediated N-glycosylation. | Regulation of neural stem cell differentiation and brain development by MGAT5-mediated N-glycosylation.
Yale AR, Kim E, Gutierrez B, Hanamoto JN, Lav NS, Nourse JL, Salvatus M, Hunt RF, Monuki ES, Flanagan LA., Free PMC Article | 07/6/2023 |
| Deficiency in Branched Glycosylation in MGAT5 Null or Heterozygous Mice Is Associated with Early-Onset Disease and Increased Severity of Colitis> | Metabolic control of T cell immune response through glycans in inflammatory bowel disease.
Dias AM, Correia A, Pereira MS, Almeida CR, Alves I, Pinto V, Catarino TA, Mendes N, Leander M, Oliva-Teles MT, Maia L, Delerue-Matos C, Taniguchi N, Lima M, Pedroto I, Marcos-Pinto R, Lago P, Reis CA, Vilanova M, Pinho SS., Free PMC Article | 09/1/2018 |
| Study indicates that Mgat5 genotype affects both behaviour and physical outcomes in response to early life stress, suggesting some shared pathways for both in a mouse model. These results provide a starting point for studying the mechanisms by which protein N-glycosylation mediates the effects of early life adversity. | Mgat5 modulates the effect of early life stress on adult behavior and physical health in mice.
Feldcamp L, Doucet JS, Pawling J, Fadel MP, Fletcher PJ, Maunder R, Dennis JW, Wong AH. | 12/16/2017 |
| Overexpression of GnT-V exacerbated murine experimental colitis by inducing macrophage dysfunction, thereby enhancing colorectal tumorigenesis | N-Acetylglucosaminyltransferase V exacerbates murine colitis with macrophage dysfunction and enhances colitic tumorigenesis.
Shinzaki S, Ishii M, Fujii H, Iijima H, Wakamatsu K, Kawai S, Shiraishi E, Hiyama S, Inoue T, Hayashi Y, Kuwahara R, Takamatsu S, Kamada Y, Morii E, Tsujii M, Takehara T, Miyoshi E. | 01/14/2017 |
| Expression of GnT-V was also elevated in bleomycin (BLM)-injected sclerotic skin, and MGAT5(-/-) mice were resistant to BLM-induced skin sclerosis with reduced collagen type 1 alpha1 content. | Oligosaccharide modification by N-acetylglucosaminyltransferase-V in macrophages are involved in pathogenesis of bleomycin-induced scleroderma.
Kato A, Yutani M, Terao M, Kimura A, Itoi S, Murota H, Miyoshi E, Katayama I. | 05/21/2016 |
| GnT-V regulates the canonical Wnt/beta-catenin signaling pathway by modulating N-glycosylation of Wnt receptors, which changes cancer stem cells in colorectal tumors, causing altered colon tumorigenesis and adenoma progression in Apc(min/+) mice | Post-translational glycoprotein modifications regulate colon cancer stem cells and colon adenoma progression in Apc(min/+) mice through altered Wnt receptor signaling.
Guo H, Nagy T, Pierce M., Free PMC Article | 01/24/2015 |
| this study suggests that the GnT-V expression is inversely correlated with radiation sensitivity in prostate cancer(PCa)cells | Inhibition of N-acetylglucosaminyltransferase V enhances sensitivity of radiotherapy in human prostate cancer.
Huang H, Chen W, Liu Q, Wei T, Zhu W, Meng H, Guo L, Zhang J. | 11/8/2014 |
| The GnT-V prevented steatohepatitis progression through modulating lymphocyte and HSC functions. | N-Acetylglucosaminyltransferase V regulates TGF-β response in hepatic stellate cells and the progression of steatohepatitis.
Kamada Y, Mori K, Matsumoto H, Kiso S, Yoshida Y, Shinzaki S, Hiramatsu N, Ishii M, Moriwaki K, Kawada N, Takehara T, Miyoshi E. | 01/12/2013 |
| GnT-V overexpression promotes EMT and keratinocyte migration in part through enhanced EGF receptor signaling. | Enhanced epithelial-mesenchymal transition-like phenotype in N-acetylglucosaminyltransferase V transgenic mouse skin promotes wound healing.
Terao M, Ishikawa A, Nakahara S, Kimura A, Kato A, Moriwaki K, Kamada Y, Murota H, Taniguchi N, Katayama I, Miyoshi E., Free PMC Article | 05/12/2012 |
| Mgat5-dependent glycosylation of proteins can modulate acquired immune responses, but it is not essential for the development of OVA-induced eosinophilic airway inflammation. | Alteration of immune responses by N-acetylglucosaminyltransferase V during allergic airway inflammation.
Shibui A, Nambu A, Shimura E, Yamaguchi S, Shiraishi C, Sato Y, Okumura K, Sugano S, Hozumi N, Nakae S. | 01/28/2012 |
| GnT-V expression and its branched glycan products effectively modulate her-2-mediated signaling pathways that, in turn, regulate the relative proportion of tumor initiating cells and the latency of her-2-driven tumor onset | Specific posttranslational modification regulates early events in mammary carcinoma formation.
Guo HB, Johnson H, Randolph M, Nagy T, Blalock R, Pierce M., Free PMC Article | 02/5/2011 |
| tyrosinase as a beta1,6 branch containing glycoprotein: substrate of GnT-V | Evidence for tyrosinase as a beta1,6 branch containing glycoprotein: substrate of GnT-V.
Chakraborty D, Chakraborty AK. | 01/21/2010 |
| Mgat5 modification of complex-type N-glycans on CNS glycoproteins is involved in the regulation of depression-like behavior. as seen in knockout mice. | Beta N-acetylglucosaminyltransferase V (Mgat5) deficiency reduces the depression-like phenotype in mice.
Soleimani L, Roder JC, Dennis JW, Lipina T. | 01/21/2010 |
| Blocking expression of Mgat5-modified complex N-glycans in mammary cancer cells using Mgat5 short hairpin RNA suppresses tumor progression both in vivo and in vitro and activates CD4-positive T cells and macrophages. | Knockdown of Mgat5 inhibits breast cancer cell growth with activation of CD4+ T cells and macrophages.
Li D, Li Y, Wu X, Li Q, Yu J, Gen J, Zhang XL. | 01/21/2010 |
| GnT-V and beta1, 6GlcNAc branching mediate the cell migration and invasion in Rac1-positive and RhoA-negative regulatory manners. | N-acetylglucosaminyltransferase V mediates cell migration and invasion of mouse mammary tumor cells 4TO7 via RhoA and Rac1 signaling pathway.
Zhao Y, Li J, Xing Y, Wang J, Lu C, Xin X, Geng M. | 01/21/2010 |
| Mgat5 and Pten interact in an opposing manner to regulate cellular sensitivities to extracelluar growth cues | Mgat5 and Pten interact to regulate cell growth and polarity.
Cheung P, Dennis JW. | 01/21/2010 |
| A secreted type of beta 1,6-N-acetylglucosaminyltransferase V (GnT-V) induces tumor angiogenesis without mediation of glycosylation: a novel function of GnT-V distinct from the original glycosyltransferase activity. | A secreted type of beta 1,6-N-acetylglucosaminyltransferase V (GnT-V) induces tumor angiogenesis without mediation of glycosylation: a novel function of GnT-V distinct from the original glycosyltransferase activity.
Saito T, Miyoshi E, Sasai K, Nakano N, Eguchi H, Honke K, Taniguchi N. | 01/21/2010 |
| fibroblast N-acetylglucosaminyltransferase V regulates alpha5beta1 integrin expression mediated by the protein kinase C signaling pathway | Deletion of mouse embryo fibroblast N-acetylglucosaminyltransferase V stimulates alpha5beta1 integrin expression mediated by the protein kinase C signaling pathway.
Guo HB, Lee I, Bryan BT, Pierce M. | 01/21/2010 |
| reporting of the sequence of mRNA | Sequences of the mouse N-acetylglucosaminyltransferase V (Mgat5) mRNA and an mRNA expressed by an Mgat5-deficient cell line.
Alverez K, Haswell C, St Clair M, Perng GS, Shorebah M, Pierce M, Fregien N. | 01/21/2010 |
| expression of Mgat5 sensitized cells to multiple cytokines;Galectin-3 cross-linked Mgat5-modified N-glycans on epidermal growth factor and transforming growth factor-beta receptors at the cell surface and delayed their removal by constitutive endocytosis | Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis.
Partridge EA, Le Roy C, Di Guglielmo GM, Pawling J, Cheung P, Granovsky M, Nabi IR, Wrana JL, Dennis JW. | 01/21/2010 |
| N-linked beta(1,6) branching has a role in cell-cell adhesion, cellular motility and neoplasm invasiveness | N-acetylglucosaminyltransferase V expression levels regulate cadherin-associated homotypic cell-cell adhesion and intracellular signaling pathways.
Guo HB, Lee I, Kamar M, Pierce M. | 01/21/2010 |