| KRAB-Zinc Finger Protein ZNF268a Deficiency Attenuates the Virus-Induced Pro-Inflammatory Response by Preventing IKK Complex Assembly. | KRAB-Zinc Finger Protein ZNF268a Deficiency Attenuates the Virus-Induced Pro-Inflammatory Response by Preventing IKK Complex Assembly.
Liu Y, Yin W, Wang J, Lei Y, Sun G, Li W, Huang Z, Guo M., Free PMC Article | 09/5/2020 |
| The nuclear localization activity of KRAB domain is a conserved feature of ZNF268. | Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1.
Wang W, Cai J, Wu Y, Hu L, Chen Z, Hu J, Chen Z, Li W, Guo M, Huang Z., Free PMC Article | 11/16/2013 |
| These results reveal a novel role of ZNF268b2 that contributes to cervical carcinogenesis in part through enhancing NF-kappaB signaling. | The zinc finger protein ZNF268 is overexpressed in human cervical cancer and contributes to tumorigenesis via enhancing NF-κB signaling.
Wang W, Guo M, Hu L, Cai J, Zeng Y, Luo J, Shu Z, Li W, Huang Z., Free PMC Article | 02/16/2013 |
| ZNF268 is a crucial downstream target and effector of GATA-1 | Knockdown of ZNF268, which is transcriptionally downregulated by GATA-1, promotes proliferation of K562 cells.
Zeng Y, Wang W, Ma J, Wang X, Guo M, Li W., Free PMC Article | 05/19/2012 |
| 4 alternative transcripts of ZNF268 were detected in the human blood cells. | [Cloning and characterization of two novel alternatively spliced transcripts of ZNF268].
Sun C, Zhao ZZ, Gao L, Sun Y, Shao HJ, Li WX. | 01/21/2010 |
| aberrant alternative splicing of ZNF268 is a potential prognostic factor of and may contribute to human hematological malignancies. | Aberrant alternative splicing of human zinc finger gene ZNF268 in human hematological malignancy.
Zhao Z, Wang D, Zhu C, Shao H, Sun C, Qiu H, Xue L, Xu J, Guo M, Li W. | 01/21/2010 |
| results indicate that a spliced form of ZNF268 lacking the KRAB domain is located in the cytosol, where it seems to play a role in TNF-alpha-induced NF-kappaB activation by interacting with the IKK complex. | A splice variant of the C(2)H(2)-type zinc finger protein, ZNF268s, regulates NF-kappaB activation by TNF-alpha.
Chun JN, Song IS, Kang DH, Song HJ, Kim HI, Seo J, Lee KJ, Kim J, Kang SW. | 01/21/2010 |
| Results demonstrate that the mammalian gene ZNF268 is regulated by hUpf1 via its promoter. | The mammalian gene ZNF268 is regulated by hUpf1.
Zhu C, Zhao Z, Guo M, Shao H, Qiu H, Wang D, Xu J, Xue L, Li W. | 01/21/2010 |
| HTLV-1 oncoprotein tax represses ZNF268 expression through the cAMP-responsive element-binding | Human T-cell leukemia virus type 1 oncoprotein tax represses ZNF268 expression through the cAMP-responsive element-binding protein/activating transcription factor pathway.
Wang D, Guo MX, Hu HM, Zhao ZZ, Qiu HL, Shao HJ, Zhu CG, Xue L, Shi YB, Li WX., Free PMC Article | 01/21/2010 |
| This protein has a conserved KRAB domain which localizes to the nucleus and has transcriptional repressor activity. | The KRAB domain of zinc finger gene ZNF268: a potential transcriptional repressor.
Sun Y, Gou DM, Liu H, Peng X, Li WX. | 01/21/2010 |
| ZNF268 plays a role in early human liver development most likely by functioning through a cytoplasmic mechanism | ZNF268, a novel kruppel-like zinc finger protein, is implicated in early human liver development.
Sun Y, Shao H, Li Z, Liu J, Gao L, Peng X, Meng Y, Li W. | 01/21/2010 |
| ZNF268 gene promoter is atypical and requires an intragenic element located within the first exon that mediates the effect of CREB for its activity | Transcription of human zinc finger ZNF268 gene requires an intragenic promoter element.
Guo MX, Wang D, Shao HJ, Qiu HL, Xue L, Zhao ZZ, Zhu CG, Shi YB, Li WX. | 01/21/2010 |
| ZNF268 gene may function as a transcriptional activator in the growth and differentiation of cells in development and/or pathogenesis. | KRAB-containing zinc finger gene ZNF268 encodes multiple alternatively spliced isoforms that contain transcription regulatory domains.
Shao H, Zhu C, Zhao Z, Guo M, Qiu H, Liu H, Wang D, Xue L, Gao L, Sun C, Li W. | 01/21/2010 |