| SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation. | SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation.
Chen CW, Zhang L, Dutta R, Niroula A, Miller PG, Gibson CJ, Bick AG, Reyes JM, Lee YT, Tovy A, Gu T, Waldvogel S, Chen YH, Venters BJ, Estève PO, Pradhan S, Keogh MC, Natarajan P, Takahashi K, Sperling AS, Goodell MA., Free PMC Article | 11/10/2023 |
| LINC00665 sponges miR-641 to promote the progression of breast cancer by targeting the SNF2-related CREBBP activator protein (SRCAP). | LINC00665 sponges miR-641 to promote the progression of breast cancer by targeting the SNF2-related CREBBP activator protein (SRCAP).
Cao W, Liu X, Su W, Liang H, Tang H, Zhang W, Huang S, Dang N, Qiao A., Free PMC Article | 03/26/2022 |
| Cancer-related SRCAP and TPR mutations in colon cancers. | Cancer-related SRCAP and TPR mutations in colon cancers.
Moon SW, Mo HY, Choi EJ, Yoo NJ, Lee SH. | 10/16/2021 |
| Systematic analysis of exonic germline and postzygotic de novo mutations in bipolar disorder. | Systematic analysis of exonic germline and postzygotic de novo mutations in bipolar disorder.
Nishioka M, Kazuno AA, Nakamura T, Sakai N, Hayama T, Fujii K, Matsuo K, Komori A, Ishiwata M, Watanabe Y, Oka T, Matoba N, Kataoka M, Alkanaq AN, Hamanaka K, Tsuboi T, Sengoku T, Ogata K, Iwata N, Ikeda M, Matsumoto N, Kato T, Takata A., Free PMC Article | 07/10/2021 |
| Truncating SRCAP variants outside the Floating-Harbor syndrome locus cause a distinct neurodevelopmental disorder with a specific DNA methylation signature. | Truncating SRCAP variants outside the Floating-Harbor syndrome locus cause a distinct neurodevelopmental disorder with a specific DNA methylation signature.
Rots D, Chater-Diehl E, Dingemans AJM, Goodman SJ, Siu MT, Cytrynbaum C, Choufani S, Hoang N, Walker S, Awamleh Z, Charkow J, Meyn S, Pfundt R, Rinne T, Gardeitchik T, de Vries BBA, Deden AC, Leenders E, Kwint M, Stumpel CTRM, Stevens SJC, Vermeulen JR, van Harssel JVT, Bosch DGM, van Gassen KLI, van Binsbergen E, de Geus CM, Brackel H, Hempel M, Lessel D, Denecke J, Slavotinek A, Strober J, Crunk A, Folk L, Wentzensen IM, Yang H, Zou F, Millan F, Person R, Xie Y, Liu S, Ousager LB, Larsen M, Schultz-Rogers L, Morava E, Klee EW, Berry IR, Campbell J, Lindstrom K, Pruniski B, Neumeyer AM, Radley JA, Phornphutkul C, Schmidt B, Wilson WG, Õunap K, Reinson K, Pajusalu S, van Haeringen A, Ruivenkamp C, Cuperus R, Santos-Simarro F, Palomares-Bralo M, Pacio-Míguez M, Ritter A, Bhoj E, Tønne E, Tveten K, Cappuccio G, Brunetti-Pierri N, Rowe L, Bunn J, Saenz M, Platzer K, Mertens M, Caluseriu O, Nowaczyk MJM, Cohn RD, Kannu P, Alkhunaizi E, Chitayat D, Scherer SW, Brunner HG, Vissers LELM, Kleefstra T, Koolen DA, Weksberg R., Free PMC Article | 07/3/2021 |
| cryo-EM structure of human SRCAP complex | Cryo-EM structure of human SRCAP complex.
Feng Y, Tian Y, Wu Z, Xu Y., Free PMC Article | 10/5/2019 |
| Data show that PCI domain-containing protein 2 (Pcid2) controls lymphoid lineage commitment through the regulation of Snf2-related CREBBP activator protein (SRCAP) remodelling activity. | Suppression of SRCAP chromatin remodelling complex and restriction of lymphoid lineage commitment by Pcid2.
Ye B, Liu B, Yang L, Huang G, Hao L, Xia P, Wang S, Du Y, Qin X, Zhu P, Wu J, Sakaguchi N, Zhang J, Fan Z., Free PMC Article | 10/6/2018 |
| Alterative hypotheses to explain how the Srcap truncating mutations lead to the onset of Floating-Harbor syndrome are presented. | When chromatin organisation floats astray: the Srcap gene and Floating-Harbor syndrome.
Messina G, Atterrato MT, Dimitri P. | 08/26/2017 |
| Data confirm a mutational hot spot in the final exon of SRCAP in the majority of Floating-Harbor syndrome patients but also show that exon 33 of this gene can be affected. | Expanded spectrum of exon 33 and 34 mutations in SRCAP and follow-up in patients with Floating-Harbor syndrome.
Seifert W, Meinecke P, Krüger G, Rossier E, Heinritz W, Wüsthof A, Horn D., Free PMC Article | 07/4/2015 |
| This study implicates the human SRCAP chromatin remodeling complex as a novel regulator of DNA damage responses that orchestrates proper signaling and repair of DSBs in the context of chromatin. | The human SRCAP chromatin remodeling complex promotes DNA-end resection.
Dong S, Han J, Chen H, Liu T, Huen MSY, Yang Y, Guo C, Huang J. | 05/30/2015 |
| Functional studies and reports of patients with additional SRCAP mutations will eventually lead to a better understanding of biological mechanisms underlying this disorder. | Floating-Harbor syndrome: SRCAP mutations are not restricted to exon 34.
Kehrer M, Beckmann A, Wyduba J, Finckh U, Dufke A, Gaiser U, Tzschach A. | 11/22/2014 |
| These results indicate that perturbed skeletal maturation from infancy through adolescence is a characteristic feature in patients with SRCAP mutations. | Long-term follow-up study for a patient with Floating-Harbor syndrome due to a hotspot SRCAP mutation.
Nagasaki K, Asami T, Sato H, Ogawa Y, Kikuchi T, Saitoh A, Ogata T, Fukami M. | 11/8/2014 |
| Sequencing of the SRCAP gene demonstrated a de novo mutation matching one of the known FHS-associated mutations. | Floating-Harbor syndrome and polycystic kidneys associated with SRCAP mutation.
Reschen M, Kini U, Hood RL, Boycott KM, Hurst J, O'Callaghan CA. | 08/10/2013 |
| Data indicate that the absence of SRCAP mutations in 3/9 cases suggesting genetic heterogeneity of floating-harbor syndrome (FH syndrome). | Not all floating-harbor syndrome cases are due to mutations in exon 34 of SRCAP.
Le Goff C, Mahaut C, Bottani A, Doray B, Goldenberg A, Moncla A, Odent S, Nitschke P, Munnich A, Faivre L, Cormier-Daire V. | 07/6/2013 |
| Our genome-wide expression results demonstrate that SRCAP-mediated H2A.Z deposition at promoter regions is necessary for complete gene reactivation induced by DNA demethylation. | Gene reactivation by 5-aza-2'-deoxycytidine-induced demethylation requires SRCAP-mediated H2A.Z insertion to establish nucleosome depleted regions.
Yang X, Noushmehr H, Han H, Andreu-Vieyra C, Liang G, Jones PA., Free PMC Article | 09/8/2012 |
| Sanger sequencing identified mutations in SRCAP in eight more affected persons. | Mutations in SRCAP, encoding SNF2-related CREBBP activator protein, cause Floating-Harbor syndrome.
Hood RL, Lines MA, Nikkel SM, Schwartzentruber J, Beaulieu C, Nowaczyk MJ, Allanson J, Kim CA, Wieczorek D, Moilanen JS, Lacombe D, Gillessen-Kaesbach G, Whiteford ML, Quaio CR, Gomy I, Bertola DR, Albrecht B, Platzer K, McGillivray G, Zou R, McLeod DR, Chudley AE, Chodirker BN, Marcadier J, FORGE Canada Consortium, Majewski J, Bulman DE, White SM, Boycott KM., Free PMC Article | 06/23/2012 |
| HCV NS3 protein is involved in the activation of the Notch-signaling pathway through the targeting to both SRCAP and p400 | Hepatitis C virus NS3 protein can activate the Notch-signaling pathway through binding to a transcription factor, SRCAP.
Iwai A, Takegami T, Shiozaki T, Miyazaki T., Free PMC Article | 10/1/2011 |
| These data identify SRCAP as a physiologically relevant mediator of PSA expression, and demonstrate that SRCAP plays a role in prostate cancer cell proliferation. | The chromatin remodeling factor SRCAP modulates expression of prostate specific antigen and cellular proliferation in prostate cancer cells.
Slupianek A, Yerrum S, Safadi FF, Monroy MA. | 06/28/2010 |
| SRCAP is recruited to promoters and is critical for the deposition of H2A.Z. | The chromatin remodeling protein, SRCAP, is critical for deposition of the histone variant H2A.Z at promoters.
Wong MM, Cox LK, Chrivia JC. | 01/21/2010 |
| SRCAP-containing complex supports ATP-dependent exchange of histone dimers containing H2B and H2A.Z into mononucleosomes reconstituted with recombinant H2A, H2B, H3, and H4. | Purification of a human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomes.
Ruhl DD, Jin J, Cai Y, Swanson S, Florens L, Washburn MP, Conaway RC, Conaway JW, Chrivia JC. | 01/21/2010 |
| SRCAP is implicated in developmental gene activation | Human SRCAP and Drosophila melanogaster DOM are homologs that function in the notch signaling pathway.
Eissenberg JC, Wong M, Chrivia JC., Free PMC Article | 01/21/2010 |
| Methods for purification and assay of the SRCAP chromatin remodeling complexes are described. | Purification and assay of the human INO80 and SRCAP chromatin remodeling complexes.
Cai Y, Jin J, Gottschalk AJ, Yao T, Conaway JW, Conaway RC., Free PMC Article | 01/21/2010 |
| Results identify YL1 as a subunit of the TRRAP/TIP60 HAT complex, and also as a component of a novel mammalian multiprotein complex that includes the SNF2-related helicase SRCAP. | The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes.
Cai Y, Jin J, Florens L, Swanson SK, Kusch T, Li B, Workman JL, Washburn MP, Conaway RC, Conaway JW. | 01/21/2010 |
| SRCAP functions as a coactivator to regulate transcription initiated by several signaling pathways. | SNF2-related CBP activator protein (SRCAP) functions as a coactivator of steroid receptor-mediated transcription through synergistic interactions with CARM-1 and GRIP-1.
Monroy MA, Schott NM, Cox L, Chen JD, Ruh M, Chrivia JC. | 01/21/2010 |