| ADP Ribosylation Factor 6 Relieves Airway Inflammation and Remodeling by Inhibiting Ovalbumin Induced-Epithelial Mesenchymal Transition in Experimental Asthma, Possibly by Regulating of E2F Transcription Factor 8. | ADP Ribosylation Factor 6 Relieves Airway Inflammation and Remodeling by Inhibiting Ovalbumin Induced-Epithelial Mesenchymal Transition in Experimental Asthma, Possibly by Regulating of E2F Transcription Factor 8.
Dou D, Bi M, Li X, Zhang N, Xu M, Guo A, Li F, Zhu W. | 08/2/2023 |
| Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation. | Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation.
Park SA, Lim YJ, Ku WL, Zhang D, Cui K, Tang LY, Chia C, Zanvit P, Chen Z, Jin W, Wang D, Xu J, Liu O, Wang F, Cain A, Guo N, Nakatsukasa H, Wu C, Zhang YE, Zhao K, Chen W., Free PMC Article | 10/22/2022 |
| E2F7 Is a Potent Inhibitor of Liver Tumor Growth in Adult Mice. | E2F7 Is a Potent Inhibitor of Liver Tumor Growth in Adult Mice.
Moreno E, Toussaint MJM, van Essen SC, Bongiovanni L, van Liere EA, Koster MH, Yuan R, van Deursen JM, Westendorp B, de Bruin A., Free PMC Article | 06/19/2021 |
| findings indicated that E2F8 is involved in gluconeogenesis and insulin resistance and may represent a new therapeutic target in T2DM prevention | Identification of E2F8 as a Transcriptional Regulator of Gluconeogenesis in Primary Mouse Hepatocytes.
Chen Y, Yu D, Wang L, Du S. | 02/15/2020 |
| Loss of E2F8 expression is associated with tumorigenesis in liver. | The Polyploid State Plays a Tumor-Suppressive Role in the Liver.
Zhang S, Zhou K, Luo X, Li L, Tu HC, Sehgal A, Nguyen LH, Zhang Y, Gopal P, Tarlow BD, Siegwart DJ, Zhu H., Free PMC Article | 06/2/2018 |
| we identified atypical E2fs to be essential for polyploidization in the pancreas and discovered that postnatal induced loss of both atypical E2fs in many organs is compatible with life until old age | Atypical E2f functions are critical for pancreas polyploidization.
Matondo RB, Moreno E, Toussaint MJM, Tooten PCJ, van Essen SC, van Liere EA, Youssef SA, Bongiovanni L, de Bruin A., Free PMC Article | 02/17/2018 |
| E2F8-mediated transcriptional repression is a critical tumor suppressor mechanism during postnatal liver development | E2f8 mediates tumor suppression in postnatal liver development.
Kent LN, Rakijas JB, Pandit SK, Westendorp B, Chen HZ, Huntington JT, Tang X, Bae S, Srivastava A, Senapati S, Koivisto C, Martin CK, Cuitino MC, Perez M, Clouse JM, Chokshi V, Shinde N, Kladney R, Sun D, Perez-Castro A, Matondo RB, Nantasanti S, Mokry M, Huang K, Machiraju R, Fernandez S, Rosol TJ, Coppola V, Pohar KS, Pipas JM, Schmidt CR, de Bruin A, Leone G., Free PMC Article | 09/30/2017 |
| transcription factor E2F8 is involved in the polyploidization during mouse and human decidualization | Involvement of atypical transcription factor E2F8 in the polyploidization during mouse and human decidualization.
Qi QR, Zhao XY, Zuo RJ, Wang TS, Gu XW, Liu JL, Yang ZM., Free PMC Article | 04/23/2016 |
| Rb and E2F8 collaborate to promote DNA replication. | Inactivation of Rb and E2f8 synergizes to trigger stressed DNA replication during erythroid terminal differentiation.
Ghazaryan S, Sy C, Hu T, An X, Mohandas N, Fu H, Aladjem MI, Chang VT, Opavsky R, Wu L., Free PMC Article | 09/6/2014 |
| The results identify E2F8 as a repressor and E2F1 as an activator of a transcriptional network controlling polyploidization in mammalian cells. | E2F8 is essential for polyploidization in mammalian cells.
Pandit SK, Westendorp B, Nantasanti S, van Liere E, Tooten PC, Cornelissen PW, Toussaint MJ, Lamers WH, de Bruin A. | 01/26/2013 |
| The specificity of E2F8 in mediating Rb function in erythropoiesis suggests a critical and overlapping roles of Rb and E2f8 in maintaining normal erythropoiesis and in preventing hemolysis. | Concomitant inactivation of Rb and E2f8 in hematopoietic stem cells synergizes to induce severe anemia.
Hu T, Ghazaryan S, Sy C, Wiedmeyer C, Chang V, Wu L., Free PMC Article | 07/21/2012 |
| Results identify E2F7 and E2F8 as a unique repressive arm of the E2F transcriptional network that is critical for embryonic development. | Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development.
Li J, Ran C, Li E, Gordon F, Comstock G, Siddiqui H, Cleghorn W, Chen HZ, Kornacker K, Liu CG, Pandit SK, Khanizadeh M, Weinstein M, Leone G, de Bruin A., Free PMC Article | 01/21/2010 |
| Overexpression of E2F8 significantly slows down the proliferation of primary mouse embryonic fibroblasts. | Cloning and characterization of mouse E2F8, a novel mammalian E2F family member capable of blocking cellular proliferation.
Maiti B, Li J, de Bruin A, Gordon F, Timmers C, Opavsky R, Patil K, Tuttle J, Cleghorn W, Leone G. | 01/21/2010 |
| E2F8 may have an important role in repressing the expression of E2F-target genes in the S-phase of the cell cycle. | Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription.
Christensen J, Cloos P, Toftegaard U, Klinkenberg D, Bracken AP, Trinh E, Heeran M, Di Stefano L, Helin K., Free PMC Article | 01/21/2010 |