| VLA-1 Binding to Collagen IV Controls Effector T Cell Suppression by Myeloid-Derived Suppressor Cells in the Splenic Red Pulp. | VLA-1 Binding to Collagen IV Controls Effector T Cell Suppression by Myeloid-Derived Suppressor Cells in the Splenic Red Pulp.
Eckert IN, Ribechini E, Jarick KJ, Strozniak S, Potter SJ, Beilhack A, Lutz MB., Free PMC Article | 07/3/2021 |
| Influence of the integrin alpha-1 subunit and its relationship with high-fat diet upon extracellular matrix synthesis in skeletal muscle and tendon. | Influence of the integrin alpha-1 subunit and its relationship with high-fat diet upon extracellular matrix synthesis in skeletal muscle and tendon.
Bayer ML, Svensson RB, Schjerling P, Williams AS, Wasserman DH, Kjaer M. | 02/6/2021 |
| TRM integrins CD103 and CD49a differentially support adherence and motility after resolution of influenza virus infection. | T(RM) integrins CD103 and CD49a differentially support adherence and motility after resolution of influenza virus infection.
Reilly EC, Lambert Emo K, Buckley PM, Reilly NS, Smith I, Chaves FA, Yang H, Oakes PW, Topham DJ., Free PMC Article | 09/5/2020 |
| Sema7A, as an inflammation regulator in CVB3-induced Viral myocarditis, might interact with alpha1beta1-integrin in macrophages to enhance the inflammatory response and aggravate disease severity. | Semaphorin7A aggravates coxsackievirusB3-induced viral myocarditis by increasing α1β1-integrin macrophages and subsequent enhanced inflammatory response.
Wu X, Meng Y, Wang C, Yue Y, Dong C, Xiong S. | 06/29/2019 |
| the cross-talk between SFRP4, integrin alpha1beta1, and Notch1 suppresses the cardiac differentiation of P19CL6 cells. | Cross-talk of SFRP4, integrin α1β1, and Notch1 inhibits cardiac differentiation of P19CL6 cells.
Tian Y, Wang W, Lu Q, Chen P, Ma K, Jia Z, Zhou C. | 12/2/2017 |
| Data show that in the absence of Langerhans Cells, CD49a(+) liver NK cells display an inappropriately proinflammatory phenotype that results in increased local skin inflammation. | Langerhans Cells Suppress CD49a+ NK Cell-Mediated Skin Inflammation.
Scholz F, Naik S, Sutterwala FS, Kaplan DH., Free PMC Article | 12/19/2015 |
| The decrease in hepatic lipid accumulation in HF-fed itga1(-/-) mice was associated with altered free fatty acid metabolism. These studies establish a role for integrin signaling in facilitating hepatic insulin action | Integrin α1-null mice exhibit improved fatty liver when fed a high fat diet despite severe hepatic insulin resistance.
Williams AS, Kang L, Zheng J, Grueter C, Bracy DP, James FD, Pozzi A, Wasserman DH., Free PMC Article | 05/23/2015 |
| a crosstalk between integrin alpha1beta1 and TbetaRII is essential for TbetaRII-mediated SMAD activation and fibrotic signaling pathways | Integrin-mediated type II TGF-β receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling.
Chen X, Wang H, Liao HJ, Hu W, Gewin L, Mernaugh G, Zhang S, Zhang ZY, Vega-Montoto L, Vanacore RM, Fässler R, Zent R, Pozzi A., Free PMC Article | 02/21/2015 |
| Synthesis and modeling of linear and cyclic KTS-containing peptides is described that leads to their use as inhibitors of integrin alpha1beta1/alpha2beta1-mediated adhesion and other antiangiogenetic activity in human serum. | Vimocin and vidapin, cyclic KTS peptides, are dual antagonists of α1β1/α2β1 integrins with antiangiogenic activity.
Momic T, Katzehendler J, Benny O, Lahiani A, Cohen G, Noy E, Senderowitz H, Eble JA, Marcinkiewicz C, Lazarovici P. | 10/4/2014 |
| Data indicate that integrin alpha1beta1 is a key participant in chondrocyte transduction of a hypo-osmotic stress. | Integrin α1β1 participates in chondrocyte transduction of osmotic stress.
Jablonski CL, Ferguson S, Pozzi A, Clark AL., Free PMC Article | 05/3/2014 |
| These findings predict a role for biomechanical insult in the induction of integrin alpha1beta1-dependent Rac1-mediated mesangial cell process invasion of the glomerular capillary tuft as an initiation mechanism of Alport glomerular pathology. | α1β1 integrin/Rac1-dependent mesangial invasion of glomerular capillaries in Alport syndrome.
Zallocchi M, Johnson BM, Meehan DT, Delimont D, Cosgrove D., Free PMC Article | 04/26/2014 |
| Macrophages express the highest levels of alpha1 integrin in the inflamed footpad. | α1β1 integrin-mediated adhesion inhibits macrophage exit from a peripheral inflammatory lesion.
Becker HM, Rullo J, Chen M, Ghazarian M, Bak S, Xiao H, Hay JB, Cybulsky MI. | 06/8/2013 |
| overexpression of mesangial integrin alpha1 and podocyte vimentin and integrin alpha3 may be important features of glomerular Alport disease | Upregulated expression of integrin α1 in mesangial cells and integrin α3 and vimentin in podocytes of Col4a3-null (Alport) mice.
Steenhard BM, Vanacore R, Friedman D, Zelenchuk A, Stroganova L, Isom K, St John PL, Hudson BG, Abrahamson DR., Free PMC Article | 05/25/2013 |
| TSC2 controls cell migration, attachment, and spreading through the alpha1beta1-integrin receptor. | TSC2 modulates cell adhesion and migration via integrin-α1β1.
Moir LM, Black JL, Krymskaya VP., Free PMC Article | 12/29/2012 |
| Integrin alpha1KOAkitaKO Balb/c mouse represents a promising model presenting with most features of human diabetic nephropathy. | Integrin α1/Akita double-knockout mice on a Balb/c background develop advanced features of human diabetic nephropathy.
Yu L, Su Y, Paueksakon P, Cheng H, Chen X, Wang H, Harris RC, Zent R, Pozzi A., Free PMC Article | 09/15/2012 |
| Data show that the induction of collagen XIII in endothelial cells of Alport syndrome kidneys mediates the selective recruitment of alpha1beta1 integrin-positive monocytes. | Collagen XIII induced in vascular endothelium mediates alpha1beta1 integrin-dependent transmigration of monocytes in renal fibrosis.
Dennis J, Meehan DT, Delimont D, Zallocchi M, Perry GA, O'Brien S, Tu H, Pihlajaniemi T, Cosgrove D., Free PMC Article | 03/26/2011 |
| Collectively, our results suggest that vascular basement membrane components substantially impact gene expression in astrocytes during brain tissue repair. | Type IV collagen induces expression of thrombospondin-1 that is mediated by integrin alpha1beta1 in astrocytes.
Yonezawa T, Hattori S, Inagaki J, Kurosaki M, Takigawa T, Hirohata S, Miyoshi T, Ninomiya Y. | 07/5/2010 |
| The ERK/PPARgamma axis plays a key role in regulating integrin alpha1beta1-dependent Cav-1 expression and consequent EGFR-mediated reactive oxygen species production. | Integrin alpha1beta1 regulates epidermal growth factor receptor activation by controlling peroxisome proliferator-activated receptor gamma-dependent caveolin-1 expression.
Chen X, Whiting C, Borza C, Hu W, Mont S, Bulus N, Zhang MZ, Harris RC, Zent R, Pozzi A., Free PMC Article | 06/28/2010 |
| data suggest VLA-1 expression defines a population of tissue memory CD4(+) T cells that act as rapid effectors upon influenza reinfection | Identification of a unique population of tissue-memory CD4+ T cells in the airways after influenza infection that is dependent on the integrin VLA-1.
Chapman TJ, Topham DJ., Free PMC Article | 05/3/2010 |
| These data suggest that SPRR3 may play a role in vascular smooth muscle cells adaptation to local biomechanical stress within the plaque microenvironment. | Regulation of the atheroma-enriched protein, SPRR3, in vascular smooth muscle cells through cyclic strain is dependent on integrin alpha1beta1/collagen interaction.
Pyle AL, Atkinson JB, Pozzi A, Reese J, Eckes B, Davidson JM, Crimmins DL, Young PP., Free PMC Article | 01/21/2010 |
| results indicate that loss of integrin alpha1 subunit decreases incidence and growth of lung epithelial tumors initiated by oncogenic Kras, suggesting that both Kras and integrin alpha1beta1 cooperate to drive growth of non-small cell lung cancer in vivo | Loss of integrin alpha1beta1 ameliorates Kras-induced lung cancer.
Macias-Perez I, Borza C, Chen X, Yan X, Ibanez R, Mernaugh G, Matrisian LM, Zent R, Pozzi A., Free PMC Article | 01/21/2010 |
| Alpha(1)beta(1)-integrin has a key role in flow (shear stress)-dependent vasodilation in resistance arteries by transmitting the signal to eNOS through activation of PI3-kinase and Akt. | Key role of alpha(1)beta(1)-integrin in the activation of PI3-kinase-Akt by flow (shear stress) in resistance arteries.
Loufrani L, Retailleau K, Bocquet A, Dumont O, Danker K, Louis H, Lacolley P, Henrion D. | 01/21/2010 |
| Integrin alpha1beta1 regulates matrix metalloproteinases via P38 mitogen-activated protein kinase in mesangial cells. | Integrin alpha1beta1 regulates matrix metalloproteinases via P38 mitogen-activated protein kinase in mesangial cells: implications for Alport syndrome.
Cosgrove D, Meehan DT, Delimont D, Pozzi A, Chen X, Rodgers KD, Tempero RM, Zallocchi M, Rao VH., Free PMC Article | 01/21/2010 |
| Oxygen-glucose deprivation produced a further significant increase in subunit beta1 expression by both cell types, but a clear decrease in both alpha1 and alpha 6 subunits by murine astrocytes. | Responses of endothelial cell and astrocyte matrix-integrin receptors to ischemia mimic those observed in the neurovascular unit.
Milner R, Hung S, Wang X, Berg GI, Spatz M, del Zoppo GJ., Free PMC Article | 01/21/2010 |
| Emphasize the importance of alpha(1)beta(1)-integrin in p38 MAPK and FAK phosphorylation during vascular hypertrophy in response to ANG II. | Role of alpha1beta1-integrin in arterial stiffness and angiotensin-induced arterial wall hypertrophy in mice.
Louis H, Kakou A, Regnault V, Labat C, Bressenot A, Gao-Li J, Gardner H, Thornton SN, Challande P, Li Z, Lacolley P. | 01/21/2010 |