| Keratin 5 basal cells are temporally regulated developmental and tissue repair progenitors in bladder urothelium. | Keratin 5 basal cells are temporally regulated developmental and tissue repair progenitors in bladder urothelium.
Becknell B, El-Harakeh M, Rodriguez-Tirado F, Grounds KM, Li B, Kercsmar M, Wang X, Jackson AR., Free PMC Article | 06/7/2024 |
| Inhibition of Notch activity promotes pancreatic cytokeratin 5-positive cell differentiation to beta cells and improves glucose homeostasis following acute pancreatitis. | Inhibition of Notch activity promotes pancreatic cytokeratin 5-positive cell differentiation to beta cells and improves glucose homeostasis following acute pancreatitis.
Zhang X, Tao J, Yu J, Hu N, Zhang X, Wang G, Feng J, Xiong X, Li M, Chai D, Li H, Rong Y, Tang Z, Wang W, Peng Z, Shi Q., Free PMC Article | 02/5/2022 |
| Keratin 5-Cre-driven deletion of Ncstn in an acne inversa-like mouse model leads to a markedly increased IL-36a and Sprr2 expression. | Keratin 5-Cre-driven deletion of Ncstn in an acne inversa-like mouse model leads to a markedly increased IL-36a and Sprr2 expression.
Yang J, Wang L, Huang Y, Liu K, Lu C, Si N, Wang R, Liu Y, Zhang X. | 03/13/2021 |
| Krt5(+) renal urothelial cells drive renal urothelial formation during normal ontogeny and after urinary tract obstruction by differentiating into Upk(+) RUCs in a temporally restricted manner. | Krt5(+) urothelial cells are developmental and tissue repair progenitors in the kidney.
Jackson AR, Hoff ML, Li B, Ching CB, McHugh KM, Becknell B., Free PMC Article | 03/28/2020 |
| We demonstrate using lineage-tracing systems that urothelial regeneration following augmentation cystoplasty with acellular grafts exclusively depends on host keratin 5-expressing basal cells to repopulate all lineages of the de novo urothelium at implant sites | Mode of Surgical Injury Influences the Source of Urothelial Progenitors during Bladder Defect Repair.
Schäfer FM, Algarrahi K, Savarino A, Yang X, Seager C, Franck D, Costa K, Liu S, Logvinenko T, Adam R, Mauney JR., Free PMC Article | 07/21/2018 |
| CDK1, Aurora-B, and Rho-kinase phosphorylate keratin 5/14. | Regulation of keratin 5/14 intermediate filaments by CDK1, Aurora-B, and Rho-kinase.
Inaba H, Yamakawa D, Tomono Y, Enomoto A, Mii S, Kasahara K, Goto H, Inagaki M. | 05/5/2018 |
| Taken together, our data demonstrated that Krt5-expressing cells could be involved in the natural pancreas self-healing process and the renewal of beta cells after AP in adult mice. It is promising that promoting conversion of Krt5-expressing cells into functional beta cells may be a novel method to mitigate the development of diabetes mellitus after AP in vivo. | β cells can be generated from cytokeratin 5-positive cells after cerulein-induced pancreatitis in adult mice.
Shi Q, Hong YP, Zhang XY, Tao J, Wang CY, Zhao L, Mei FC, You YD, Xia H, Xiong XC, Wang GR, Wang WX. | 02/17/2018 |
| RA regulates Krt5 and Krt14 expression independently of stem cell character in developing salivary epithelium. The stem cell gene Kit is regulated inversely from Krt5/Krt14 by RA signaling. | Retinoic acid signaling regulates Krt5 and Krt14 independently of stem cell markers in submandibular salivary gland epithelium.
Abashev TM, Metzler MA, Wright DM, Sandell LL., Free PMC Article | 01/13/2018 |
| widespread destruction of airway and alveolar epithelial cells following severe influenza infection triggers a wound-healing response that initiates in the airways with the proliferation of rare airway-resident SOX2+ Lin- progenitor cells. These cells then give rise to nascent KRT5+ cells in remodeled airways and populate the damaged alveolar parenchyma. | Rare SOX2(+) Airway Progenitor Cells Generate KRT5(+) Cells that Repopulate Damaged Alveolar Parenchyma following Influenza Virus Infection.
Ray S, Chiba N, Yao C, Guan X, McConnell AM, Brockway B, Que L, McQualter JL, Stripp BR., Free PMC Article | 11/26/2017 |
| Loss of activating transcription factor 3 (ATF3) in knockout mice promotes the emergence of keratins CK5+CK8+ epithelial cells. | Loss of ATF3 promotes hormone-induced prostate carcinogenesis and the emergence of CK5(+)CK8(+) epithelial cells.
Wang Z, Kim J, Teng Y, Ding HF, Zhang J, Hai T, Cowell JK, Yan C., Free PMC Article | 09/16/2017 |
| B-1 B cells transiently and partially express K5 in bone marrow and are potent for both natural antibody production and antigen presentation. | B-1 B cell progenitors transiently and partially express keratin 5 during differentiation in bone marrow.
Hanafusa T, Kato K, Azukizawa H, Miyazaki J, Takeda J, Katayama I. | 12/17/2016 |
| Directed expression of a chimeric type II keratin partially rescues keratin 5-null mice. | Directed expression of a chimeric type II keratin partially rescues keratin 5-null mice.
Alvarado DM, Coulombe PA., Free PMC Article | 10/4/2014 |
| NMHC IIA may play critical roles in the early trophoblast-derived ectoplacental cone and extraembryonic ectoderm in Keratin 5-Cre transgenic mice. | Keratin 5-Cre-driven excision of nonmuscle myosin IIA in early embryo trophectoderm leads to placenta defects and embryonic lethality.
Crish J, Conti MA, Sakai T, Adelstein RS, Egelhoff TT., Free PMC Article | 11/30/2013 |
| Mice lacking the prostate epithelial AR have increased apoptosis in epithelial CK8-positive luminal cells and increased proliferation in epithelial CK5-positive basal cells. | Increased CK5/CK8-positive intermediate cells with stromal smooth muscle cell atrophy in the mice lacking prostate epithelial androgen receptor.
Niu Y, Wang J, Shang Z, Huang SP, Shyr CR, Yeh S, Chang C., Free PMC Article | 11/12/2011 |
| The involvement of Hsc70 and Hsp70 in mutant keratin degradation was demonstrated using CHIP-p.Met1_Ala142del (DeltaTPR-CHIP). | The ubiquitin ligase CHIP/STUB1 targets mutant keratins for degradation.
Löffek S, Wöll S, Höhfeld J, Leube RE, Has C, Bruckner-Tuderman L, Magin TM. | 08/2/2010 |
| Cytokines involved in the recruitment, maturation, and migration of Langerhans cells in the epidermis, are upregulated in the skin of K5(-/-) and epidermolysis bullosa simplex patients. | Cytokines as genetic modifiers in K5-/- mice and in human epidermolysis bullosa simplex.
Roth W, Reuter U, Wohlenberg C, Bruckner-Tuderman L, Magin TM. | 01/21/2010 |
| DeltaNp63 alone can restore the expression of the basal keratins and reinitiate the failed epidermal differentiation program in the skin of p63 null animals. | An active role of the DeltaN isoform of p63 in regulating basal keratin genes K5 and K14 and directing epidermal cell fate.
Romano RA, Ortt K, Birkaya B, Smalley K, Sinha S., Free PMC Article | 01/21/2010 |
| keratin 5 mutations contribute to epidermolysis bullosa simplex in a mouse model by inducing local inflammation that mediates a stress response | Induction of inflammatory cytokines by a keratin mutation and their repression by a small molecule in a mouse model for EBS.
Lu H, Chen J, Planko L, Zigrino P, Klein-Hitpass L, Magin TM. | 01/21/2010 |
| p63 protein is essential for the embryonic development of vibrissae and teeth; while it localizes with K5 in vibrissae, it is not fully colocalized with nuclear Ki67 expression | p63 protein is essential for the embryonic development of vibrissae and teeth.
Rufini A, Weil M, McKeon F, Barlattani A, Melino G, Candi E. | 01/21/2010 |