| EPAC Regulates Melanoma Growth by Stimulating mTORC1 Signaling and Loss of EPAC Signaling Dependence Correlates with Melanoma Progression. | EPAC Regulates Melanoma Growth by Stimulating mTORC1 Signaling and Loss of EPAC Signaling Dependence Correlates with Melanoma Progression.
Krishnan A, Bhasker AI, Singh MK, Rodriguez CI, Pérez EC, Altameemi S, Lares M, Khan H, Ndiaye M, Ahmad N, Schieke SM, Setaluri V., Free PMC Article | 10/15/2022 |
| Pancreatic cancer-derived exosomal microRNA-19a induces beta-cell dysfunction by targeting ADCY1 and EPAC2. | Pancreatic cancer-derived exosomal microRNA-19a induces β-cell dysfunction by targeting ADCY1 and EPAC2.
Pang W, Yao W, Dai X, Zhang A, Hou L, Wang L, Wang Y, Huang X, Meng X, Li L., Free PMC Article | 02/26/2022 |
| Origin and Isoform Specific Functions of Exchange Proteins Directly Activated by cAMP: A Phylogenetic Analysis. | Origin and Isoform Specific Functions of Exchange Proteins Directly Activated by cAMP: A Phylogenetic Analysis.
Ni Z, Cheng X., Free PMC Article | 12/4/2021 |
| Epac: new emerging cAMP-binding protein. | Epac: new emerging cAMP-binding protein.
Lee K., Free PMC Article | 10/16/2021 |
| Broad Impact of Exchange Protein Directly Activated by cAMP 2 (EPAC2) on Respiratory Viral Infections. | Broad Impact of Exchange Protein Directly Activated by cAMP 2 (EPAC2) on Respiratory Viral Infections.
Choi EJ, Wu W, Cong X, Zhang K, Luo J, Ye S, Wang P, Suresh A, Ullah UM, Zhou J, Bao X., Free PMC Article | 07/17/2021 |
| The Epac2 coding gene (RAPGEF4) rs3769219 polymorphism is associated with protection against major depressive disorder in the Chinese Han population. | The Epac2 coding gene (RAPGEF4) rs3769219 polymorphism is associated with protection against major depressive disorder in the Chinese Han population.
Peng Q, Kong Y, Shi L, Yan Y, Yao Y, Wen Y, Liang Y, Lai C, Deng Z, Yan H. | 05/22/2021 |
| The authors conclude that Epac2/cAMP controls fusion pore expansion and thus the balance of hormone and transmitter release during insulin granule exocytosis. | Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis.
Guček A, Gandasi NR, Omar-Hmeadi M, Bakke M, Døskeland SO, Tengholm A, Barg S., Free PMC Article | 02/22/2020 |
| Through isoform-specific gene knockdown, the authors found that EPAC2, but not EPAC1, plays a dominant role in controlling RSV replication and virus-induced host responses. | Exchange Proteins Directly Activated by cAMP and Their Roles in Respiratory Syncytial Virus Infection.
Choi EJ, Ren Y, Chen Y, Liu S, Wu W, Ren J, Wang P, Garofalo RP, Zhou J, Bao X., Free PMC Article | 03/30/2019 |
| Cyclic AMP (cAMP), a secondary messenger responsible for various physiological processes regulates cell metabolism by activating Protein kinase A (PKA) and by targeting exchange protein directly activated by cAMP (EPAC). EPAC is present in two isoforms EPAC1 and EPAC2, which exhibit different tissue distribution and is involved in GDP/GTP exchange along with activating Rap1- and Rap2-mediated signaling pathways. | Insights into exchange factor directly activated by cAMP (EPAC) as potential target for cancer treatment.
Kumar N, Prasad P, Jash E, Saini M, Husain A, Goldman A, Sehrawat S. | 11/3/2018 |
| Study identifies Epac2-Rap1 signaling as a novel feedback mechanism in the heart, which controls mitochondrial reactive oxygen species production. | Epac2-Rap1 Signaling Regulates Reactive Oxygen Species Production and Susceptibility to Cardiac Arrhythmias.
Yang Z, Kirton HM, Al-Owais M, Thireau J, Richard S, Peers C, Steele DS., Free PMC Article | 03/10/2018 |
| rs17746510, one of the three single-nucleotide polymorphisms (SNPs) in RAPGEF4 associated with cognitive decline in Chinese Alzheimer's disease (AD) patients, was significantly correlated with apathy and mood disturbance | Anxiety and depression with neurogenesis defects in exchange protein directly activated by cAMP 2-deficient mice are ameliorated by a selective serotonin reuptake inhibitor, Prozac.
Zhou L, Ma SL, Yeung PK, Wong YH, Tsim KW, So KF, Lam LC, Chung SK., Free PMC Article | 11/11/2017 |
| This review focus is on the function of Epac in the heart. Accumulating evidence has revealed that both Epac1 and Epac2 play important roles in the structure and function of the heart under physiological and pathological conditions. [review] | The role of Epac in the heart.
Fujita T, Umemura M, Yokoyama U, Okumura S, Ishikawa Y., Free PMC Article | 09/2/2017 |
| Data show that Epac2 is activated by cAMP and changes its structure. It is involved in cAMP-mediated signal transduction through activation of the Ras-like small GTPase and is expressed mainly in brain, neuroendocrine and endocrine tissues. [review] | Structure and functional roles of Epac2 (Rapgef4).
Sugawara K, Shibasaki T, Takahashi H, Seino S., Free PMC Article | 03/19/2016 |
| Identified a conserved nuclear pore localisation signal (NPLS; amino acids 764-838 of EPAC1) in the catalytic domains of the cAMP-sensors, EPAC1 and EPAC2A. EPAC1 and EPAC2, display distinct subcellular distributions. | The cAMP sensors, EPAC1 and EPAC2, display distinct subcellular distributions despite sharing a common nuclear pore localisation signal.
Parnell E, Smith BO, Yarwood SJ., Free PMC Article | 12/19/2015 |
| CALR regulated by EPAC2 in endometrial glandular epithelial cells is critical for the expression of LIF and PTGS2-mediated production of PGE2 through cAMP signaling. | EPAC2-mediated calreticulin regulates LIF and COX2 expression in human endometrial glandular cells.
Kusama K, Yoshie M, Tamura K, Imakawa K, Tachikawa E. | 09/12/2015 |
| Follow-up replication analyses in up to an additional 21,345 participants identified three new fasting plasma glucose loci reaching genome-wide significance in or near PDK1-RAPGEF4, KANK1, and IGF1R. | Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.
Hwang JY, Sim X, Wu Y, Liang J, Tabara Y, Hu C, Hara K, Tam CH, Cai Q, Zhao Q, Jee S, Takeuchi F, Go MJ, Ong RT, Ohkubo T, Kim YJ, Zhang R, Yamauchi T, So WY, Long J, Gu D, Lee NR, Kim S, Katsuya T, Oh JH, Liu J, Umemura S, Kim YJ, Jiang F, Maeda S, Chan JC, Lu W, Hixson JE, Adair LS, Jung KJ, Nabika T, Bae JB, Lee MH, Seielstad M, Young TL, Teo YY, Kita Y, Takashima N, Osawa H, Lee SH, Shin MH, Shin DH, Choi BY, Shi J, Gao YT, Xiang YB, Zheng W, Kato N, Yoon M, He J, Shu XO, Ma RC, Kadowaki T, Jia W, Miki T, Qi L, Tai ES, Mohlke KL, Han BG, Cho YS, Kim BJ., Free PMC Article | 03/21/2015 |
| EPAC1 and EPAC2 are critical signaling intermediates in osteoclast differentiation that permit RANKL-stimulated NFkB nuclear translocation and actin rearrangements | Activation of EPAC1/2 is essential for osteoclast formation by modulating NFκB nuclear translocation and actin cytoskeleton rearrangements.
Mediero A, Perez-Aso M, Cronstein BN., Free PMC Article | 01/31/2015 |
| data show the expression of EPAC is blunted in HPRT-deficient neuron-like cell lines and fibroblast cells from Lesch-Nyhan syndrome (LNS) patients; propose that the alterations in EPAC/RAP1 signaling and cell migration in HPRT deficiency are crucial for neuro-developmental events that may contribute to neurological dysfunctions in LNS | Deficiency of the purine metabolic gene HPRT dysregulates microRNA-17 family cluster and guanine-based cellular functions: a role for EPAC in Lesch-Nyhan syndrome.
Guibinga GH, Murray F, Barron N, Pandori W, Hrustanovic G., Free PMC Article | 06/7/2014 |
| EPAC2-mediated CRT expression is essential for the functional and morphological differentiation of endometrial stromal cells into decidual cells | The role of exchange protein directly activated by cyclic AMP 2-mediated calreticulin expression in the decidualization of human endometrial stromal cells.
Kusama K, Yoshie M, Tamura K, Nakayama T, Nishi H, Isaka K, Tachikawa E. | 03/1/2014 |
| Cigarette smoke extract decreased Epac1 expression, but did not affect Epac2 and PKA expression. | Anti-inflammatory role of the cAMP effectors Epac and PKA: implications in chronic obstructive pulmonary disease.
Oldenburger A, Roscioni SS, Jansen E, Menzen MH, Halayko AJ, Timens W, Meurs H, Maarsingh H, Schmidt M., Free PMC Article | 06/30/2012 |
| Mechanism of intracellular cAMP sensor Epac2 activation: cAMP-induced conformational changes identified by amide hydrogen/deuterium exchange mass spectrometry | Mechanism of intracellular cAMP sensor Epac2 activation: cAMP-induced conformational changes identified by amide hydrogen/deuterium exchange mass spectrometry (DXMS).
Li S, Tsalkova T, White MA, Mei FC, Liu T, Wang D, Woods VL Jr, Cheng X., Free PMC Article | 07/30/2011 |
| An important time-limited role is identified for hippocampal Epac2 signaling in cognition, opening new avenues to investigate the molecular mechanisms underlying memory retrieval. | Exchange protein activated by cyclic AMP 2 (Epac2) plays a specific and time-limited role in memory retrieval.
Ostroveanu A, van der Zee EA, Eisel UL, Schmidt M, Nijholt IM. | 06/4/2011 |
| Epac2 & Epac1 signaling pathways may be associated with cAMP-mediated functional differentiation and syncytialization of trophoblasts. Expression of Epac2 & Epac 1 in placenta at different stages was investigated. | Possible role of the exchange protein directly activated by cyclic AMP (Epac) in the cyclic AMP-dependent functional differentiation and syncytialization of human placental BeWo cells.
Yoshie M, Kaneyama K, Kusama K, Higuma C, Nishi H, Isaka K, Tamura K. | 01/1/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Studies demonstrate the occurrence of the EPAC2 splicing variant EPAC2B in adrenocortical cancer cells and reveal the involvement of EPAC2B in cAMP-induced effects on cytoskeleton integrity and cell migration. | Functional roles of protein kinase A (PKA) and exchange protein directly activated by 3',5'-cyclic adenosine 5'-monophosphate (cAMP) 2 (EPAC2) in cAMP-mediated actions in adrenocortical cells.
Aumo L, Rusten M, Mellgren G, Bakke M, Lewis AE. | 06/14/2010 |