| Association analysis of SNPs in GRHL3, FAF1, and KCNJ2 with NSCPO sub-phenotypes in Han Chinese. | Association analysis of SNPs in GRHL3, FAF1, and KCNJ2 with NSCPO sub-phenotypes in Han Chinese.
Sun JL, Shi JY, Yin B, Lin YS, Shi B, Jia ZL. | 10/15/2022 |
| FAF1 downregulation by Toxoplasma gondii enables host IRF3 mobilization and promotes parasite growth. | FAF1 downregulation by Toxoplasma gondii enables host IRF3 mobilization and promotes parasite growth.
Gao FF, Quan JH, Choi IW, Lee YJ, Jang SG, Yuk JM, Lee YH, Cha GH., Free PMC Article | 02/19/2022 |
| USP7 and VCP(FAF1) define the SUMO/Ubiquitin landscape at the DNA replication fork. | USP7 and VCP(FAF1) define the SUMO/Ubiquitin landscape at the DNA replication fork.
Franz A, Valledor P, Ubieto-Capella P, Pilger D, Galarreta A, Lafarga V, Fernández-Llorente A, de la Vega-Barranco G, den Brave F, Hoppe T, Fernandez-Capetillo O, Lecona E., Free PMC Article | 02/19/2022 |
| A novel function of FAF1, which induces dopaminergic neuronal death through cell-to-cell transmission. | A novel function of FAF1, which induces dopaminergic neuronal death through cell-to-cell transmission.
Park G, Kim BS, Kim E., Free PMC Article | 08/14/2021 |
| Germline Mutations in FAF1 Are Associated With Hereditary Colorectal Cancer. | Germline Mutations in FAF1 Are Associated With Hereditary Colorectal Cancer.
Bonjoch L, Franch-Expósito S, Garre P, Belhadj S, Muñoz J, Arnau-Collell C, Díaz-Gay M, Gratacós-Mulleras A, Raimondi G, Esteban-Jurado C, Soares de Lima Y, Herrera-Pariente C, Cuatrecasas M, Ocaña T, Castells A, Fillat C, Capellá G, Balaguer F, Caldés T, Valle L, Castellví-Bel S. | 04/3/2021 |
| the mechanisms of FAF1/SIM-mediated MR transrepression involve inhibition of MR N/C interactions and promotion of MR polyubiquitination and degradation. | Identification of two independent SUMO-interacting motifs in Fas-associated factor 1 (FAF1): Implications for mineralocorticoid receptor (MR)-mediated transcriptional regulation.
Wang CH, Hung PW, Chiang CW, Lombès M, Chen CH, Lee KH, Lo YC, Wu MH, Chang WC, Lin DY. | 11/30/2019 |
| C18H17NO6 and Scutellarin in the study. In molecular level, the mRNA and protein expression of Fas-associated factor 1 (FAF1) expression in U251 and LN229 were upregulated by C18H17NO6 and its combination with Scutellarin, especially the protein expression. | C(18)H(17)NO(6) and Its Combination with Scutellarin Suppress the Proliferation and Induce the Apoptosis of Human Glioma Cells via Upregulation of Fas-Associated Factor 1 Expression.
He XY, Xiong LL, Xia QJ, Wang YY, Zhao XM, Du RL, Huang J, He XQ, Jia-Liu, Wang TH., Free PMC Article | 07/20/2019 |
| These findings establish FAF1 as a modulator of MAVS and uncover mechanisms that regulate FAF1 to insure timely activation of antiviral defense. | FAF1 Regulates Antiviral Immunity by Inhibiting MAVS but Is Antagonized by Phosphorylation upon Viral Infection.
Dai T, Wu L, Wang S, Wang J, Xie F, Zhang Z, Fang X, Li J, Fang P, Li F, Jin K, Dai J, Yang B, Zhou F, van Dam H, Cai D, Huang H, Zhang L. | 07/13/2019 |
| Data show that activated proto-oncogene protein Akt (AKT) directly phosphorylates Fas associated factor 1 (FAF1) reduces FAF1 at the plasma membrane and results in an increase in TGF-beta type II receptor (TbetaRII) at the cell surface. | FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis.
Xie F, Jin K, Shao L, Fan Y, Tu Y, Li Y, Yang B, van Dam H, Ten Dijke P, Weng H, Dooley S, Wang S, Jia J, Jin J, Zhou F, Zhang L., Free PMC Article | 12/1/2018 |
| FAF1 was vital in the proliferation of NP cells by modulating the Erk signaling pathway, which suggests that FAF1 may be a novel marker in the early diagnosis of Intervertebral disc degeneration. | Long non‑coding RNA FAF1 promotes intervertebral disc degeneration by targeting the Erk signaling pathway.
Mi D, Cai C, Zhou B, Liu X, Ma P, Shen S, Lu W, Huang W. | 07/21/2018 |
| Helicobacter pylori, a risk factor for gastric cancer, down-regulated FAF1 expression via NF-kappaB signaling in gastric carcinoma cells, promoting tumor growth. | Fas-associated factor 1 inhibits tumor growth by suppressing Helicobacter pylori-induced activation of NF-κB signaling in human gastric carcinoma.
Liu AQ, Xie Z, Chen XN, Feng J, Chen JW, Qin FJ, Ge LY., Free PMC Article | 03/3/2018 |
| Knockdown of FAF1 suppressed Sanguinarine (SNG)-induced inhibition of cell proliferation, invasion, and migration and induction of cell cycle arrest and apoptosis in NSCLC cells. SNG also inhibited implanted tumor growth and increased FAF1 expression in tumors in vivo. | Sanguinarine exhibits antitumor activity via up-regulation of Fas-associated factor 1 in non-small cell lung cancer.
Wei G, Xu Y, Peng T, Yan J, Wang Z, Sun Z. | 12/23/2017 |
| These data demonstrate the presence of an FAF1-PARP1 axis that is involved in oxidative stress-induced necrosis and in the pathology of Parkinson's disease. | FAF1 mediates regulated necrosis through PARP1 activation upon oxidative stress leading to dopaminergic neurodegeneration.
Yu C, Kim BS, Kim E., Free PMC Article | 12/16/2017 |
| FAF1 physically interacts with XIAP. FAF1 attenuates XIAP-mediated NF-kappaB activation. | XIAP Interacts with and Regulates the Activity of FAF1.
Caballero-López MJ, Nieto-Díaz M, Yunta M, Reigada D, Muñoz-Galdeano T, Del Águila Á, Navarro-Ruíz R, Pita-Thomas W, Lindholm D, Maza RM. | 10/28/2017 |
| confirmation of the association between rs17106184 (FAF1) and Type 2 Diabetes in a northern Han Chinese population | Validation of Type 2 Diabetes Risk Variants Identified by Genome-Wide Association Studies in Northern Han Chinese.
Rao P, Zhou Y, Ge SQ, Wang AX, Yu XW, Alzain MA, Veronica AK, Qiu J, Song MS, Zhang J, Wang H, Fang HH, Gao Q, Wang YX, Wang W., Free PMC Article | 08/12/2017 |
| FAF1 plays a novel role in negatively regulating virus-induced IFN-beta production and the antiviral response by inhibiting the translocation of active, phosphorylated IRF3 from the cytosol to the nucleus | Fas-Associated Factor 1 Negatively Regulates the Antiviral Immune Response by Inhibiting Translocation of Interferon Regulatory Factor 3 to the Nucleus.
Song S, Lee JJ, Kim HJ, Lee JY, Chang J, Lee KJ., Free PMC Article | 08/13/2016 |
| Progression of the DNA replication fork is coordinated by FAF1. FAF1 binds to the licensing factor CDT-1 and additional ubiquitylated proteins, thus promoting CDC48-dependent turnover and disassembly of DNA replication factor complexes. | Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression.
Franz A, Pirson PA, Pilger D, Halder S, Achuthankutty D, Kashkar H, Ramadan K, Hoppe T., Free PMC Article | 07/2/2016 |
| Report a novel role for FAF1 in regulating CD40-induced NFkappaB activation via a negative feedback loop. | Fas-associated factor (Faf1) is a novel CD40 interactor that regulates CD40-induced NF-κB activation via a negative feedback loop.
Elmetwali T, Young LS, Palmer DH., Free PMC Article | 10/25/2014 |
| The repertoire of VAPB interactors is more diverse than previously anticipated and link VAPB to the function of ATPase complexes such as p97/FAF1 and ASNA1/transmembrane-domain recognition complex. | VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase.
Baron Y, Pedrioli PG, Tyagi K, Johnson C, Wood NT, Fountaine D, Wightman M, Alexandru G., Free PMC Article | 10/4/2014 |
| long-chain unsaturated fatty acids also induced polymerization of Fas-associated factor 1 (FAF1), the only other mammalian protein that contains a UAS domain homologous to that of Ubxd8 | UAS domain of Ubxd8 and FAF1 polymerizes upon interaction with long-chain unsaturated fatty acids.
Kim H, Zhang H, Meng D, Russell G, Lee JN, Ye J., Free PMC Article | 03/1/2014 |
| Data indicate that Npl4-Ufd1 heterodimer is required for VCP-FAF1 interaction. | Complex of Fas-associated factor 1 (FAF1) with valosin-containing protein (VCP)-Npl4-Ufd1 and polyubiquitinated proteins promotes endoplasmic reticulum-associated degradation (ERAD).
Lee JJ, Park JK, Jeong J, Jeon H, Yoon JB, Kim EE, Lee KJ., Free PMC Article | 05/4/2013 |
| hFAF1 inhibits tumor formation by increasing the degradation of Hsp70 mediated via its UBA domain. | Ubiquitin-associated (UBA) domain in human Fas associated factor 1 inhibits tumor formation by promoting Hsp70 degradation.
Lee JJ, Kim YM, Jeong J, Bae DS, Lee KJ., Free PMC Article | 01/26/2013 |
| Fas-associated factor 1 is a scaffold protein that promotes beta-transducin repeat-containing protein (beta-TrCP)-mediated beta-catenin ubiquitination and degradation. | Fas-associated factor 1 is a scaffold protein that promotes β-transducin repeat-containing protein (β-TrCP)-mediated β-catenin ubiquitination and degradation.
Zhang L, Zhou F, Li Y, Drabsch Y, Zhang J, van Dam H, ten Dijke P., Free PMC Article | 11/24/2012 |
| Wild-type p97/VCP ND1 in complex with FAF1 UBX crystallized into very thin sheet-shaped crystals which turned out to be of poor diffraction quality | Crystallization and preliminary X-ray crystallographic analysis of the hexameric human p97/VCP ND1 fragment in complex with the UBX domain of human FAF1.
Kang W, Yang JK., Free PMC Article | 02/4/2012 |
| The authors report the first in vitro confirmed non-homotypic interaction between NLRP12 pyrin domain and the pro-apoptotic protein Fas-associated factor 1 (FAF-1), which links the innate immune system to apoptotic signaling. | The NLRP12 pyrin domain: structure, dynamics, and functional insights.
Pinheiro AS, Eibl C, Ekman-Vural Z, Schwarzenbacher R, Peti W., Free PMC Article | 12/17/2011 |