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    ZWINT ZW10 interacting kinetochore protein [ Homo sapiens (human) ]

    Gene ID: 11130, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    ZWINT promotes the proliferation, migration, and invasion of cervical cancer cells by regulating the p53/p21 signaling pathway.

    ZWINT promotes the proliferation, migration, and invasion of cervical cancer cells by regulating the p53/p21 signaling pathway.
    Ma Z, Cai Y, Tian C.

    11/25/2023
    Genome-wide association analysis of cognitive function in Danish long-lived individuals.

    Genome-wide association analysis of cognitive function in Danish long-lived individuals.
    Nygaard M, Dowsett J, McGue M, Christensen K, Christiansen L, Tan Q, Mengel-From J., Free PMC Article

    11/22/2021
    Anaphase-promoting complex/cyclosome-Cdc-20 promotes Zwint-1 degradation.

    Anaphase-promoting complex/cyclosome-Cdc-20 promotes Zwint-1 degradation.
    He Y, Li R, Gu L, Deng H, Zhao Y, Guo Y, Yu S, Wang G.

    01/9/2021
    ZWINT: A potential therapeutic biomarker in patients with glioblastoma correlates with cell proliferation and invasion.

    ZWINT: A potential therapeutic biomarker in patients with glioblastoma correlates with cell proliferation and invasion.
    Yang L, Han N, Zhang X, Zhou Y, Chen R, Zhang M., Free PMC Article

    11/21/2020
    upregulated in prostate cancer tissues

    Identification of hub genes in prostate cancer using robust rank aggregation and weighted gene co-expression network analysis.
    Song ZY, Chao F, Zhuo Z, Ma Z, Li W, Chen G., Free PMC Article

    07/25/2020
    results suggested ZWINT as a potential gene associated with lung cancer cell proliferation

    ZWINT is the next potential target for lung cancer therapy.
    Peng F, Li Q, Niu SQ, Shen GP, Luo Y, Chen M, Bao Y.

    03/9/2019
    ZW10 interactor was frequently decreased in hepatocellular carcinoma.

    Decreased Expression of ZWINT is Associated With Poor Prognosis in Patients With HCC After Surgery.
    Yang XY, Wu B, Ma SL, Yin L, Wu MC, Li AJ., Free PMC Article

    12/22/2018
    Our results provide the first evidence that Zwint-1 is required to correct erroneous kinetochore-microtubule attachment and regulate spindle checkpoint function during meiosis.

    Zwint-1 is required for spindle assembly checkpoint function and kinetochore-microtubule attachment during oocyte meiosis.
    Woo Seo D, Yeop You S, Chung WJ, Cho DH, Kim JS, Su Oh J., Free PMC Article

    09/17/2016
    the E3 ubiquitin ligase terf causes protein degradation of ZWINT and negatively regulates cell proliferation

    Terf/TRIM17 stimulates degradation of kinetochore protein ZWINT and regulates cell proliferation.
    Endo H, Ikeda K, Urano T, Horie-Inoue K, Inoue S.

    06/9/2012
    These studies identify zwint-1 as a novel AurB substrate required for kinetochore assembly and for proper spindle assembly checkpoint silencing at metaphase

    Zwint-1 is a novel Aurora B substrate required for the assembly of a dynein-binding platform on kinetochores.
    Kasuboski JM, Bader JR, Vaughan PS, Tauhata SB, Winding M, Morrissey MA, Joyce MV, Boggess W, Vos L, Chan GK, Hinchcliffe EH, Vaughan KT., Free PMC Article

    01/14/2012
    hZwint-1 bridges the inner and outer kinetochore: identification of the kinetochore localization domain and the hZw10-interaction domain

    hZwint-1 bridges the inner and outer kinetochore: identification of the kinetochore localization domain and the hZw10-interaction domain.
    Vos LJ, Famulski JK, Chan GK.

    11/26/2011
    Stable hZW10 kinetochore residency at prometaphase kinetochores is dependent on its interaction with hZwint-1, and is essential for mitotic checkpoint arrest.

    Stable hZW10 kinetochore residency, mediated by hZwint-1 interaction, is essential for the mitotic checkpoint.
    Famulski JK, Vos L, Sun X, Chan G., Free PMC Article

    01/21/2010
    Observational study of gene-disease association. (HuGE Navigator)See all PubMed (2) articles

    Single nucleotide polymorphisms in chromosomal instability genes and risk and clinical outcome of breast cancer: a Swedish prospective case-control study.
    Brendle A, Brandt A, Johansson R, Enquist K, Hallmans G, Hemminki K, Lenner P, Försti A.

    Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease.
    Morgan AR, Turic D, Jehu L, Hamilton G, Hollingworth P, Moskvina V, Jones L, Lovestone S, Brayne C, Rubinsztein DC, Lawlor B, Gill M, O'Donovan MC, Owen MJ, Williams J.

    03/13/2008
    show that ZW10 interacting protein-1(Zwint-1) is required and is sufficient for kinetochore localization of Zeste White 10 (ZW10) in HeLa cells

    Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling.
    Wang H, Hu X, Ding X, Dou Z, Yang Z, Shaw AW, Teng M, Cleveland DW, Goldberg ML, Niu L, Yao X.

    01/21/2010
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