| Positive and negative regulators of RAD51/DMC1 in homologous recombination and DNA replication. | Positive and negative regulators of RAD51/DMC1 in homologous recombination and DNA replication.
Ito M, Fujita Y, Shinohara A. | 01/31/2024 |
| FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in pre-meiotic DNA replication and meiotic recombination. | FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in pre-meiotic DNA replication and meiotic recombination.
Ito M, Furukohri A, Matsuzaki K, Fujita Y, Toyoda A, Shinohara A., Free PMC Article | 11/1/2023 |
| Can PCNA and LIM15 gene expression levels predict sperm retrieval success in men with non-obstructive azoospermia? | Can PCNA and LIM15 gene expression levels predict sperm retrieval success in men with non-obstructive azoospermia?
Ibis MA, Aydos K, Baltaci V, Aktuna S, Yaman O. | 10/22/2022 |
| MiR-4284 inhibits sensitivity to paclitaxel in human ovarian carcinoma SKOV3ip1 and HeyA8 cells by targeting DMC1. | MiR-4284 inhibits sensitivity to paclitaxel in human ovarian carcinoma SKOV3ip1 and HeyA8 cells by targeting DMC1.
Sun D, Shang D, Miao P, Jiang Z, Chen Y, Gao J. | 08/27/2022 |
| Recent advances in functional conservation and divergence of recombinase RAD51 and DMC1. | Recent advances in functional conservation and divergence of recombinase RAD51 and DMC1.
Guo YX, Yan SP, Wang YX. | 07/2/2022 |
| A pathogenic DMC1 frameshift mutation causes nonobstructive azoospermia but not primary ovarian insufficiency in humans. | A pathogenic DMC1 frameshift mutation causes nonobstructive azoospermia but not primary ovarian insufficiency in humans.
Cao D, Shi F, Guo C, Liu Y, Lin Z, Zhang J, Li RHW, Yao Y, Liu K, Ng EHY, Yeung WSB, Wang T. | 01/29/2022 |
| Mechanisms of distinctive mismatch tolerance between Rad51 and Dmc1 in homologous recombination. | Mechanisms of distinctive mismatch tolerance between Rad51 and Dmc1 in homologous recombination.
Xu J, Zhao L, Peng S, Chu H, Liang R, Tian M, Connell PP, Li G, Chen C, Wang HW., Free PMC Article | 01/15/2022 |
| Identification of fidelity-governing factors in human recombinases DMC1 and RAD51 from cryo-EM structures. | Identification of fidelity-governing factors in human recombinases DMC1 and RAD51 from cryo-EM structures.
Luo SC, Yeh HY, Lan WH, Wu YM, Yang CH, Chang HY, Su GC, Lee CY, Wu WJ, Li HW, Ho MC, Chi P, Tsai MD., Free PMC Article | 02/13/2021 |
| To the best of our knowledge, this is the first report identifying DMC1 as the causative gene for human non-obstructive azoospermia and premature ovarian insufficiency. | DMC1 mutation that causes human non-obstructive azoospermia and premature ovarian insufficiency identified by whole-exome sequencing.
He WB, Tu CF, Liu Q, Meng LL, Yuan SM, Luo AX, He FS, Shen J, Li W, Du J, Zhong CG, Lu GX, Lin G, Fan LQ, Tan YQ. | 09/21/2019 |
| In this study, we created a mouse model of a putative infertility allele, DMC1M200V. DMC1 encodes a RecA homolog essential for meiotic recombination and fertility in mice..we found that Dmc1M200V/M200V male and female mice are fully fertile and do not exhibit any gonadal abnormalities | A putative human infertility allele of the meiotic recombinase DMC1 does not affect fertility in mice.
Tran TN, Schimenti JC., Free PMC Article | 05/11/2019 |
| Data indicate that ahomologous pairing by DMC1 protein or RAD51 recombinase in chromatin containing nucleosome-depleted double-stranded DNA (dsDNA) regions. | Chromatin architecture may dictate the target site for DMC1, but not for RAD51, during homologous pairing.
Kobayashi W, Takaku M, Machida S, Tachiwana H, Maehara K, Ohkawa Y, Kurumizaka H., Free PMC Article | 03/11/2017 |
| BRCA2 protein stimulates DMC1-mediated DNA strand exchange between RPA-ssDNA complexes and duplex DNA, thus identifying BRCA2 as a mediator of DMC1 recombination function. | BRCA2 regulates DMC1-mediated recombination through the BRC repeats.
Martinez JS, von Nicolai C, Kim T, Ehlén Å, Mazin AV, Kowalczykowski SC, Carreira A., Free PMC Article | 09/3/2016 |
| Dmc1 can reject divergent DNA sequences while bypassing a few mismatches in the DNA sequence. | Tolerance of DNA Mismatches in Dmc1 Recombinase-mediated DNA Strand Exchange.
Borgogno MV, Monti MR, Zhao W, Sung P, Argaraña CE, Pezza RJ., Free PMC Article | 08/6/2016 |
| In contrast to RAD51, stabilization of the presynaptic filament via ATP hydrolysis attenuation is insufficient for enhancement of the DMC1-catalyzed recombination reaction. | Functional Relationship of ATP Hydrolysis, Presynaptic Filament Stability, and Homologous DNA Pairing Activity of the Human Meiotic Recombinase DMC1.
Chang HY, Liao CY, Su GC, Lin SW, Wang HW, Chi P., Free PMC Article | 11/7/2015 |
| truncated DMC1 octamers further stack with alternate polarity into a filament | Structure of a filament of stacked octamers of human DMC1 recombinase.
Du L, Luo Y., Free PMC Article | 12/21/2013 |
| results suggested mutations in the coding sequence of DMC1 are not associated with premature ovarian failure in Chinese women | Mutations in DMC1 are not responsible for premature ovarian failure in Chinese women.
Wang H, Sun M, Qin Y, Xia T, Ma J, Chen ZJ. | 09/7/2013 |
| conserved lysine in the Walker A motif of hDMC1 is critical for ATP binding. | Role of the conserved lysine within the Walker A motif of human DMC1.
Sharma D, Say AF, Ledford LL, Hughes AJ, Sehorn HA, Dwyer DS, Sehorn MG., Free PMC Article | 06/22/2013 |
| The results suggested that PSF may function as an activator for the meiosis-specific recombinase DMC1. | Human PSF concentrates DNA and stimulates duplex capture in DMC1-mediated homologous pairing.
Morozumi Y, Ino R, Takaku M, Hosokawa M, Chuma S, Kurumizaka H., Free PMC Article | 06/16/2012 |
| RAD51-associated protein 1 (RAD51AP1) interacts with the meiotic recombinase DMC1 through a conserved motif. | RAD51-associated protein 1 (RAD51AP1) interacts with the meiotic recombinase DMC1 through a conserved motif.
Dunlop MH, Dray E, Zhao W, Tsai MS, Wiese C, Schild D, Sung P., Free PMC Article | 12/17/2011 |
| RAD51AP1 foci colocalize with a subset of DMC1 foci in spermatocytes. | Molecular basis for enhancement of the meiotic DMC1 recombinase by RAD51 associated protein 1 (RAD51AP1).
Dray E, Dunlop MH, Kauppi L, San Filippo J, Wiese C, Tsai MS, Begovic S, Schild D, Jasin M, Keeney S, Sung P., Free PMC Article | 05/14/2011 |
| D-loops in a human DMC1-driven reaction are substantially more resistant to dissociation by branch-migration proteins such as RAD54 than those formed by RAD51. | The resistance of DMC1 D-loops to dissociation may account for the DMC1 requirement in meiosis.
Bugreev DV, Pezza RJ, Mazina OM, Voloshin ON, Camerini-Otero RD, Mazin AV., Free PMC Article | 02/26/2011 |
| the Dmc1 filament formed on single-stranded DNA has a mass per unit length expected from approximately 6.5 subunits per turn | Helical filaments of human Dmc1 protein on single-stranded DNA: a cautionary tale.
Yu X, Egelman EH., Free PMC Article | 09/27/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population.
Loizidou MA, Cariolou MA, Neuhausen SL, Newbold RF, Bashiardes E, Marcou Y, Michael T, Daniel M, Kakouri E, Papadopoulos P, Malas S, Hadjisavvas A, Kyriacou K. | 09/15/2010 |
| Reversibility, equilibration, and fidelity of strand exchange reaction between short oligonucleotides promoted by RecA protein from escherichia coli and human Rad51 and Dmc1 proteins. | Reversibility, equilibration, and fidelity of strand exchange reaction between short oligonucleotides promoted by RecA protein from escherichia coli and human Rad51 and Dmc1 proteins.
Volodin AA, Bocharova TN, Smirnova EA, Camerini-Otero RD., Free PMC Article | 01/21/2010 |
| DMC1-I37N polymorphism may be a source of improper meiotic recombination, causing meiotic defects in humans | Biochemical analysis of the human DMC1-I37N polymorphism.
Hikiba J, Takizawa Y, Ikawa S, Shibata T, Kurumizaka H. | 01/21/2010 |