| Serine-Threonine Kinase Receptor Associate Protein (STRAP) confers an aggressive phenotype in neuroblastoma via regulation of Focal Adhesion Kinase (FAK). | Serine-Threonine Kinase Receptor Associate Protein (STRAP) confers an aggressive phenotype in neuroblastoma via regulation of Focal Adhesion Kinase (FAK).
Bownes LV, Marayati R, Quinn CH, Hutchins SC, Stewart JE, Anderson JC, Willey CD, Datta PK, Beierle EA., Free PMC Article | 05/28/2022 |
| Serine-threonine Kinase Receptor-Associated Protein is a Critical Mediator of APC Mutation-Induced Intestinal Tumorigenesis Through a Feed-Forward Mechanism. | Serine-threonine Kinase Receptor-Associated Protein is a Critical Mediator of APC Mutation-Induced Intestinal Tumorigenesis Through a Feed-Forward Mechanism.
Vu T, Datta A, Banister C, Jin L, Yuan G, Samuel T, Bae S, Eltoum IE, Manne U, Zhang B, Welner RS, Mitra K, Buckhaults P, Datta PK., Free PMC Article | 01/22/2022 |
| SIRT7 Deacetylates STRAP to Regulate p53 Activity and Stability. | SIRT7 Deacetylates STRAP to Regulate p53 Activity and Stability.
Yu M, Shi X, Ren M, Liu L, Qi H, Zhang C, Zou J, Qiu X, Zhu WG, Zhang YE, Wang W, Luo J., Free PMC Article | 03/27/2021 |
| Results show that the increased STRAP protein levels observed in HCC provide growth advantage among others by enhancing Wnt/beta-catenin signaling. | Oncogenic STRAP Supports Hepatocellular Carcinoma Growth by Enhancing Wnt/β-Catenin Signaling.
Wang W, Li S, Liu P, Sideras K, van de Werken HJG, van der Heide M, Cao W, Lavrijsen M, Peppelenbosch MP, Bruno M, Pan Q, Smits R. | 02/1/2020 |
| Strap associates with Csde1 and affects expression of select Csde1-bound transcripts | Strap associates with Csde1 and affects expression of select Csde1-bound transcripts.
Moore KS, Yagci N, van Alphen F, Meijer AB, 't Hoen PAC, von Lindern M., Free PMC Article | 02/9/2019 |
| Study found that STRAP and MELK were overexpressed and highly phosphorylated in samples form colorectal adenocarcinoma patients and their expression were significantly correlated with tumor stages. | Sanguinarine triggers intrinsic apoptosis to suppress colorectal cancer growth through disassociation between STRAP and MELK.
Gong X, Chen Z, Han Q, Chen C, Jing L, Liu Y, Zhao L, Yao X, Sun X., Free PMC Article | 01/19/2019 |
| STRAP plays an inhibitory role in hepatocellular carcinoma via regulating PTEN expression.STRAP is down-regulated in the hepatocellular carcinoma tissues. | Downregulation of STRAP promotes tumor growth and metastasis in hepatocellular carcinoma via reducing PTEN level.
Wu Q, Yu S, Chen J, Li Y, Gao Y. | 01/12/2019 |
| these results suggest that STRAP increases invasion and metastasis of colorectal cancer partly through inhibiting ubiquitin-dependent degradation of beta-catenin and promoting Wnt/beta-catenin signaling | Novel role of STRAP in progression and metastasis of colorectal cancer through Wnt/β-catenin signaling.
Yuan G, Zhang B, Yang S, Jin L, Datta A, Bae S, Chen X, Datta PK., Free PMC Article | 12/9/2017 |
| Findings illuminated a novel STRAP-NOTCH1-HES1 molecular axis as a CSC regulator in colorectal cancer. | STRAP Promotes Stemness of Human Colorectal Cancer via Epigenetic Regulation of the NOTCH Pathway.
Jin L, Vu T, Yuan G, Datta PK., Free PMC Article | 11/11/2017 |
| MAWD and MAWBP were downregulated and associated with the differentiation grade in GC tissues. | Mitogen-activated protein kinase activator with WD40 repeats (MAWD) and MAWD-binding protein induce cell differentiation in gastric cancer.
Li D, Zhang J, Xi Y, Zhang L, Li W, Cui J, Xing R, Pan Y, Pan Z, Li F, Lu Y., Free PMC Article | 06/28/2016 |
| STRAP inhibits the transactivation function of Sp1 either by directly blocking its DNA binding domain or destabilizing Sp1 protein through ubiquitin-proteasome pathway in cell cycle G1 phase. | Oncogenic STRAP functions as a novel negative regulator of E-cadherin and p21(Cip1) by modulating the transcription factor Sp1.
Jin L, Datta PK., Free PMC Article | 09/5/2015 |
| Strap augments the apoptotic effects of mitochondrial p53. | Cofactor Strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase.
Maniam S, Coutts AS, Stratford MR, McGouran J, Kessler B, La Thangue NB., Free PMC Article | 08/1/2015 |
| Coexpression of MAWBP and MAWD inhibited epithelial mesenchymal transformation, and EMT-aided malignant cell progression was suppressed in gastric cancer. | MAWBP and MAWD inhibit proliferation and invasion in gastric cancer.
Li DM, Zhang J, Li WM, Cui JT, Pan YM, Liu SQ, Xing R, Lu YY., Free PMC Article | 12/14/2013 |
| Data indicate serine-threonine kinase receptor-associated protein (STRAP) as a novel regulator of the coordinated translation of collagen alpha1(I) and alpha2(I) mRNAs. | Serine-threonine kinase receptor-associated protein (STRAP) regulates translation of type I collagen mRNAs.
Vukmirovic M, Manojlovic Z, Stefanovic B., Free PMC Article | 11/30/2013 |
| both of the TPR and OB-fold domains localize to the chromatin of p53 target genes and exhibit intrinsic regulatory activity necessary for the Strap-dependent p53 response | The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure.
Adams CJ, Pike AC, Maniam S, Sharpe TD, Coutts AS, Knapp S, La Thangue NB, Bullock AN., Free PMC Article | 05/5/2012 |
| STRAP protein decreases ubiquitination of intracellular domain of Notch3 and may help to stabilize it. | Role of STRAP in regulating GSK3β function and Notch3 stabilization.
Kashikar ND, Zhang W, Massion PP, Gonzalez AL, Datta PK., Free PMC Article | 10/1/2011 |
| B-MYB acts as a positive regulator of STRAP | B-MYB positively regulates serine-threonine kinase receptor-associated protein (STRAP) activity through direct interaction.
Seong HA, Manoharan R, Ha H., Free PMC Article | 05/7/2011 |
| gonucleotide pulldown identified STRAP (serine/threonine kinase receptor-associated protein) as a further protein recruited to the MMP28 promoter and acting functionally with Sp1. | MMP28 gene expression is regulated by Sp1 transcription factor acetylation.
Swingler TE, Kevorkian L, Culley KL, Illman SA, Young DA, Parker AE, Lohi J, Clark IM. | 05/3/2010 |
| STRAP can act as a negative regulator of ASK1. | Serine-threonine kinase receptor-associated protein inhibits apoptosis signal-regulating kinase 1 function through direct interaction.
Jung H, Seong HA, Manoharan R, Ha H., Free PMC Article | 02/1/2010 |
| Strap regulation reflects the coordinated interplay between different DNA damage-activated protein kinases, ATM and Chk2 (Checkpoint kinase 2), where phosphorylation by each kinase provides a distinct functional consequence on the activity of Strap. | ATM and Chk2 kinase target the p53 cofactor Strap.
Adams CJ, Graham AL, Jansson M, Coutts AS, Edelmann M, Smith L, Kessler B, La Thangue NB., Free PMC Article | 01/21/2010 |
| an interplay between PPM1G and unrip determine compartment-specific phosphorylation patterns, localization, and function of the SMN complex | Dephosphorylation of survival motor neurons (SMN) by PPM1G/PP2Cgamma governs Cajal body localization and stability of the SMN complex.
Petri S, Grimmler M, Over S, Fischer U, Gruss OJ., Free PMC Article | 01/21/2010 |
| unrip functions in the pathway of small nuclear ribonucleoproteins biogenesis | Unrip is a component of SMN complexes active in snRNP assembly.
Carissimi C, Baccon J, Straccia M, Chiarella P, Maiolica A, Sawyer A, Rappsilber J, Pellizzoni L. | 01/21/2010 |
| biochemical evidence for the existence of another, yet atypical, SMN complex component, termed unr-interacting protein (unrip) | Unrip, a factor implicated in cap-independent translation, associates with the cytosolic SMN complex and influences its intracellular localization.
Grimmler M, Otter S, Peter C, Müller F, Chari A, Fischer U. | 01/21/2010 |
| STRAP acts as an intermediate signaling molecule linking between the phosphatidylinositol 3-kinase/PDK1 and the TGF-beta signaling pathways | Regulation of transforming growth factor-beta signaling and PDK1 kinase activity by physical interaction between PDK1 and serine-threonine kinase receptor-associated protein.
Seong HA, Jung H, Choi HS, Kim KT, Ha H. | 01/21/2010 |
| Gemin8 has an essential role in the proper structural organization of the SMN complex and the involvement of the heteromeric subunit containing Gemin6, Gemin7, Gemin8, and Unrip in the recruitment of Sm proteins to the snRNP assembly pathway | Gemin8 is required for the architecture and function of the survival motor neuron complex.
Carissimi C, Saieva L, Gabanella F, Pellizzoni L. | 01/21/2010 |