| Muscarinic Receptors Expression in the Peripheral Blood Cells Differentiate Dementia with Lewy Bodies from Alzheimer's Disease. | Muscarinic Receptors Expression in the Peripheral Blood Cells Differentiate Dementia with Lewy Bodies from Alzheimer's Disease.
Reale M, Carrarini C, Russo M, Dono F, Ferri L, Di Pietro M, Costantini E, Porreca A, Di Nicola M, Onofrj M, Bonanni L. | 02/19/2022 |
| Group II muscarinic acetylcholine receptors attenuate hepatic injury via Nrf2/ARE pathway. | Group II muscarinic acetylcholine receptors attenuate hepatic injury via Nrf2/ARE pathway.
Luo L, Zhang G, Mao L, Wang P, Xi C, Shi G, Leavenworth JW. | 08/22/2020 |
| Authors discuss how M4 activity regulates DA release and signaling, the potential sources of ACh that can regulate M4 activity, and the implications of targeting M4 activity for the treatment of the motor symptoms in movement disorders. [Review] | Roles of the M(4) acetylcholine receptor in the basal ganglia and the treatment of movement disorders.
Moehle MS, Conn PJ., Free PMC Article | 06/27/2020 |
| the association of the African-specific CHRM4 SNP with cocaine dependence survived correction for multiple testing | African-specific variability in the acetylcholine muscarinic receptor M4: association with cocaine and heroin addiction.
Levran O, Randesi M, Peles E, Correa da Rosa J, Ott J, Rotrosen J, Adelson M, Kreek MJ., Free PMC Article | 08/12/2017 |
| crystal structures of the M1 and M4 muscarinic receptors bound to the inverse agonist, tiotropium | Crystal structures of the M1 and M4 muscarinic acetylcholine receptors.
Thal DM, Sun B, Feng D, Nawaratne V, Leach K, Felder CC, Bures MG, Evans DA, Weis WI, Bachhawat P, Kobilka TS, Sexton PM, Kobilka BK, Christopoulos A., Free PMC Article | 04/16/2016 |
| This study demonstrated that CD4+ and CD8+ T cells expressed M2 and M4 muscarinic receptors which density were significantly increased in asthmatic children in comparison with controls. | Modified expression of peripheral blood lymphocyte muscarinic cholinergic receptors in asthmatic children.
Cherubini E, Tabbì L, Scozzi D, Mariotta S, Galli E, Carello R, Avitabile S, Tayebati SK, Amenta F, De Vitis C, Mancini R, Ricci A. | 08/22/2015 |
| This study identify suppression of the PVHSIM1-->PAGvl/DR circuit connection as sufficient to induce overeating behavior. | Chemogenetic synaptic silencing of neural circuits localizes a hypothalamus→midbrain pathway for feeding behavior.
Stachniak TJ, Ghosh A, Sternson SM., Free PMC Article | 07/19/2014 |
| [(3)H]LY2119620 to probe specifically the human M2 and M4 muscarinic receptor allosteric binding sites. | Development of a radioligand, [(3)H]LY2119620, to probe the human M(2) and M(4) muscarinic receptor allosteric binding sites.
Schober DA, Croy CH, Xiao H, Christopoulos A, Felder CC. | 07/5/2014 |
| Data indicate that compounds derived from VU0152100 showed M4 muscarinic receptor (M4 mAChR) direct agoinst properties. | Probing structural requirements of positive allosteric modulators of the M4 muscarinic receptor.
Huynh T, Valant C, Crosby IT, Sexton PM, Christopoulos A, Capuano B. | 03/15/2014 |
| The data of this study suggested that the rs2067482 polymorphism may help to predict susceptibility to schizophrenia and/or therapeutic responsiveness. | Cholinergic muscarinic M4 receptor gene polymorphisms: a potential risk factor and pharmacogenomic marker for schizophrenia.
Scarr E, Um JY, Cowie TF, Dean B. | 10/26/2013 |
| Use of HM4- and green fluorescent protein-expressing trangenic mice as tissue donors in cell-based therapy validates a rodent model of Huntington disease. | Validating the use of M4-BAC-GFP mice as tissue donors in cell replacement therapies in a rodent model of Huntington's disease.
Döbrössy M, Klein A, Janghra N, Nikkhah G, Dunnett SB. | 03/10/2012 |
| analysis of allosteric agonism and modulation at the M4 muscarinic acetylcholine receptor | Structural determinants of allosteric agonism and modulation at the M4 muscarinic acetylcholine receptor: identification of ligand-specific and global activation mechanisms.
Nawaratne V, Leach K, Felder CC, Sexton PM, Christopoulos A., Free PMC Article | 07/26/2010 |
| Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.
Need AC, Keefe RS, Ge D, Grossman I, Dickson S, McEvoy JP, Goldstein DB., Free PMC Article | 02/11/2009 |
| In progressive supranuclear palsy: there were no changes in M4 muscarinic receptor density | Intact coupling of M1 receptors and preserved M2 and M4 receptors in the cortex in progressive supranuclear palsy: contrast with other dementias.
Warren NM, Piggott MA, Lees AJ, Perry EK, Burn DJ. | 01/21/2010 |
| Regions in i3 including Leu272-Arg338 and Val373-Ala393 are involved in internalization of the M4 receptor; the region including Val373-Ala393 is indispensable for its recycling, whereas the other regions are dispensable for internalization and recycling. | Muscarinic M4 receptor recycling requires a motif in the third intracellular loop.
Hashimoto Y, Morisawa K, Saito H, Jojima E, Yoshida N, Haga T. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesGenetical genomic determinants of alcohol consumption in rats and humans.
Tabakoff B, Saba L, Printz M, Flodman P, Hodgkinson C, Goldman D, Koob G, Richardson HN, Kechris K, Bell RL, Hübner N, Heinig M, Pravenec M, Mangion J, Legault L, Dongier M, Conigrave KM, Whitfield JB, Saunders J, Grant B, Hoffman PL, WHO/ISBRA Study on State and Trait Markers of Alcoholism. No evidence for association between 19 cholinergic genes and bipolar disorder.
Shi J, Hattori E, Zou H, Badner JA, Christian SL, Gershon ES, Liu C. | 03/13/2008 |
| relative to other muscarinic receptor subtypes, the M(4) receptor could be the subtype which is selectively compromised in Alzeheimer's disease | Loss of muscarinic M4 receptors in hippocampus of Alzheimer patients.
Mulugeta E, Karlsson E, Islam A, Kalaria R, Mangat H, Winblad B, Adem A. | 01/21/2010 |
| M4 increases expression of "migratory" integrins; M4 effects resulted from inhibition of the inhibitory pathway involving the adenylyl cyclase-cyclic AMP-protein kinase A pathway | Novel signaling pathways mediating reciprocal control of keratinocyte migration and wound epithelialization through M3 and M4 muscarinic receptors.
Chernyavsky AI, Arredondo J, Wess J, Karlsson E, Grando SA., Free PMC Article | 01/21/2010 |