| Biological functions of Circular RNA_LARP4/ Upstream frameshift 1 in development of gastric cancer. | Biological functions of Circular RNA_LARP4/ Upstream frameshift 1 in development of gastric cancer.
Zhang J, Yang Y, Song X, Xing K, Chen Y. | 05/22/2024 |
| LARP4 is an RNA-binding protein that binds nuclear-encoded mitochondrial mRNAs to promote mitochondrial function. | LARP4 is an RNA-binding protein that binds nuclear-encoded mitochondrial mRNAs to promote mitochondrial function.
Lewis BM, Cho CY, Her HL, Mizrahi O, Hunter T, Yeo GW., Free PMC Article | 02/22/2024 |
| CircBNC2 affects epithelial ovarian cancer progression through the miR-223-3p/ LARP4 axis. | CircBNC2 affects epithelial ovarian cancer progression through the miR-223-3p/ LARP4 axis.
Lu M, Gong B, Wang Y, Li J. | 02/13/2023 |
| Circular RNA La-related RNA-binding protein 4 correlates with reduced tumor stage, as well as better prognosis, and promotes chemosensitivity to doxorubicin in breast cancer. | Circular RNA La-related RNA-binding protein 4 correlates with reduced tumor stage, as well as better prognosis, and promotes chemosensitivity to doxorubicin in breast cancer.
Zhang X, Su X, Guo Z, Jiang X, Li X., Free PMC Article | 08/7/2021 |
| Circular RNA_LARP4 inhibits cell migration and invasion of prostate cancer by targeting FOXO3A. | Circular RNA_LARP4 inhibits cell migration and invasion of prostate cancer by targeting FOXO3A.
Weng XD, Yan T, Liu CL. | 04/3/2021 |
| Circular RNA_LARP4 inhibits the progression of non-small-cell lung cancer by regulating the expression of SMAD7. | Circular RNA_LARP4 inhibits the progression of non-small-cell lung cancer by regulating the expression of SMAD7.
Shi JQ, Wang B, Cao XQ, Wang YX, Cheng X, Jia CL, Wen T, Luo BJ, Liu ZD. | 03/20/2021 |
| Single molecule poly(A) tail-seq shows LARP4 opposes deadenylation throughout mRNA lifespan with most impact on short tails. | Single molecule poly(A) tail-seq shows LARP4 opposes deadenylation throughout mRNA lifespan with most impact on short tails.
Mattijssen S, Iben JR, Li T, Coon SL, Maraia RJ., Free PMC Article | 02/20/2021 |
| Circular RNA LARP4 correlates with decreased Enneking stage, better histological response, and prolonged survival profiles, and it elevates chemosensitivity to cisplatin and doxorubicin via sponging microRNA-424 in osteosarcoma. | Circular RNA LARP4 correlates with decreased Enneking stage, better histological response, and prolonged survival profiles, and it elevates chemosensitivity to cisplatin and doxorubicin via sponging microRNA-424 in osteosarcoma.
Hu Y, Gu J, Shen H, Shao T, Li S, Wang W, Yu Z., Free PMC Article | 12/19/2020 |
| Circular RNA_LARP4 Sponges miR-1323 and Hampers Progression of Esophageal Squamous Cell Carcinoma Through Modulating PTEN/PI3K/AKT Pathway. | Circular RNA_LARP4 Sponges miR-1323 and Hampers Progression of Esophageal Squamous Cell Carcinoma Through Modulating PTEN/PI3K/AKT Pathway.
Chen Z, Yao N, Gu H, Song Y, Ye Z, Li L, Lu P, Shao Q. | 11/21/2020 |
| LARP4A recognizes polyA RNA via a novel binding mechanism mediated by disordered regions and involving the PAM2w motif, revealing interplay between PABP, LARP4A and mRNA. | LARP4A recognizes polyA RNA via a novel binding mechanism mediated by disordered regions and involving the PAM2w motif, revealing interplay between PABP, LARP4A and mRNA.
Cruz-Gallardo I, Martino L, Kelly G, Atkinson RA, Trotta R, De Tito S, Coleman P, Ahdash Z, Gu Y, Bui TTT, Conte MR., Free PMC Article | 11/30/2019 |
| These results indicated that circLARP4 expression was lower and highlighted that circLARP4 was identified as a potential biomarker of ovarian cancer prognosis. | Circular RNA_LARP4 is lower expressed and serves as a potential biomarker of ovarian cancer prognosis.
Zou T, Wang PL, Gao Y, Liang WT. | 11/23/2019 |
| The role of circLARP4/miR-761/RUNX3/p53/p21 signaling in HCC progression, providing a potential survival predictor and therapeutic candidate for HCC. | circLARP4 induces cellular senescence through regulating miR-761/RUNX3/p53/p21 signaling in hepatocellular carcinoma.
Chen Z, Zuo X, Pu L, Zhang Y, Han G, Zhang L, Wu J, Wang X., Free PMC Article | 02/16/2019 |
| LARP4 could suppress motility and metastatic potential of ovarian cancer cells. | La-Related Protein 4 as a Suppressor for Motility of Ovarian Cancer Cells.
Egiz M, Usui T, Ishibashi M, Zhang X, Shigeta S, Toyoshima M, Kitatani K, Yaegashi N. | 02/9/2019 |
| The expression of circLARP4 was downregulated in GC tissues and represented an independent prognostic factor for overall survival of GC patients. | Circular RNA_LARP4 inhibits cell proliferation and invasion of gastric cancer by sponging miR-424-5p and regulating LATS1 expression.
Zhang J, Liu H, Hou L, Wang G, Zhang R, Huang Y, Chen X, Zhu J., Free PMC Article | 05/26/2018 |
| The results indicate that LARP4 is a posttranscriptional regulator of ribosomal protein production in mammalian cells and suggest that this activity can be controlled by tRNA levels. | LARP4 mRNA codon-tRNA match contributes to LARP4 activity for ribosomal protein mRNA poly(A) tail length protection.
Mattijssen S, Arimbasseri AG, Iben JR, Gaidamakov S, Lee J, Hafner M, Maraia RJ., Free PMC Article | 05/26/2018 |
| A cytoplasmic isoform of La protein as well as LARPs 6, 4, and 1 function in mRNA metabolism and translation in distinct but similar ways, sometimes with the poly(A)-binding protein, and in some cases by direct binding to poly(A)-RNA. | The La and related RNA-binding proteins (LARPs): structures, functions, and evolving perspectives.
Maraia RJ, Mattijssen S, Cruz-Gallardo I, Conte MR., Free PMC Article | 02/17/2018 |
| LARP4 inhibits migration and invasion of cancer cells, and that some cancer-associated mutations stimulate these effects of LARP4. | The RNA-binding protein LARP4 regulates cancer cell migration and invasion.
Seetharaman S, Flemyng E, Shen J, Conte MR, Ridley AJ., Free PMC Article | 11/25/2017 |
| Involvement of LARP4 as a target of TNF-alpha-TTP regulation provides a clue as to how its functional activity may be used in a physiologic pathway. | LARP4 Is Regulated by Tumor Necrosis Factor Alpha in a Tristetraprolin-Dependent Manner.
Mattijssen S, Maraia RJ., Free PMC Article | 06/28/2016 |
| The results demonstrate that the La modules of the human LARP4 is also active in tRNA-mediated suppression, even in the absence of stable UUU-3'OH trailer protection. | Conservation of RNA chaperone activity of the human La-related proteins 4, 6 and 7.
Hussain RH, Zawawi M, Bayfield MA., Free PMC Article | 12/7/2013 |
| LARP4 activity is integrated with other PAM2 protein activities by PABP as part of mRNA homeostasis. | La-related protein 4 binds poly(A), interacts with the poly(A)-binding protein MLLE domain via a variant PAM2w motif, and can promote mRNA stability.
Yang R, Gaidamakov SA, Xie J, Lee J, Martino L, Kozlov G, Crawford AK, Russo AN, Conte MR, Gehring K, Maraia RJ., Free PMC Article | 02/26/2011 |
| The c-MPL protein altered expression provide an opportunity to diagnose and identify subpopulations of MPD patients. | Molecular pathogenesis of Philadelphia chromosome negative myeloproliferative disorders.
Kralovics R, Skoda RC. | 01/21/2010 |
| FISH study showed no cytogenetic abnormalities in any of the analyzed cases. | Detection of abnormalities of PRV-1, TPO, and c-MPL genes detected by fluorescence in situ hybridization in essential thrombocythemia.
Puigdecanet E, Espinet B, Villa O, Florensa L, Besses C, Serrano S, Solé F. | 01/21/2010 |