| The immunomodulatory role of paracrine signalling factor VSIG4 in peritoneal metastases. | The immunomodulatory role of paracrine signalling factor VSIG4 in peritoneal metastases.
Chong YY, Thiagarajan S, Tan QX, Lim HJ, Tan JW, Hendrikson J, Ng G, Liu Y, Chong CYL, Guo W, Ngo NT, Leow WQ, Loh T, Sam XX, Lim TKH, Cai M, Seo CJ, Wong JSM, Soo KC, Chia CS, Shannon NB, Ong CJ., Free PMC Article | 09/9/2024 |
| VSIG4 ameliorates intestinal inflammation through inhibiting macrophages NLRP3 inflammasome and pyroptosis. | VSIG4 ameliorates intestinal inflammation through inhibiting macrophages NLRP3 inflammasome and pyroptosis.
Liao Y, Deng C, Wang X. | 01/26/2024 |
| V-Set Immunoglobulin Domain-Containing Protein 4 as a Novel Serum Biomarker of Lupus Nephritis and Renal Pathology Activity. | V-Set Immunoglobulin Domain-Containing Protein 4 as a Novel Serum Biomarker of Lupus Nephritis and Renal Pathology Activity.
Tang C, Zhang S, Teymur A, Yang B, Nazir F, Cai Q, Saxena R, Olsen NJ, Mohan C, Wu T., Free PMC Article | 08/31/2023 |
| CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease. | CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease.
Duan Y, Chu H, Brandl K, Jiang L, Zeng S, Meshgin N, Papachristoforou E, Argemi J, Mendes BG, Wang Y, Su H, Sun W, Llorente C, Hendrikx T, Liu X, Hosseini M, Kisseleva T, Brenner DA, Bataller R, Ramachandran P, Karin M, Fu W, Schnabl B., Free PMC Article | 01/22/2022 |
| Rab18 interacted with V-set and immunoglobulin domain-containing 4 (VSIG4) to involve in the apoptosis of glioma and the sensitivity to temozolomide. | Rab18 interacted with V-set and immunoglobulin domain-containing 4 (VSIG4) to involve in the apoptosis of glioma and the sensitivity to temozolomide.
Yang K, Wang Z., Free PMC Article | 12/4/2021 |
| Impact of VSIG4 gene polymorphisms on susceptibility and functional status of rheumatoid arthritis. | Impact of VSIG4 gene polymorphisms on susceptibility and functional status of rheumatoid arthritis.
Antunes Andrade F, Goeldner Eibofner I, Pieczarka C, van Tong H, Sena L, Skare T, Ramos da Rosa Utiyama S, Jose de Messias-Reason I, P Velavan T. | 08/21/2021 |
| The results indicated that Vsig4 expression was markedly down-regulated in fatty livers of nonalcoholic fatty liver disease patients and obese mice. | Expression of Vsig4 attenuates macrophage-mediated hepatic inflammation and fibrosis in high fat diet (HFD)-induced mice.
Li Y, Sun JP, Wang J, Lu WH, Xie LY, Lv J, Li HX, Yang SF. | 07/11/2020 |
| this study shows that CRIg/FH ameliorates renal ischemia reperfusion injury via activation of PI3K/AKT signaling | Complement Inhibitor CRIg/FH Ameliorates Renal Ischemia Reperfusion Injury via Activation of PI3K/AKT Signaling.
Hu C, Li L, Ding P, Li L, Ge X, Zheng L, Wang X, Wang J, Zhang W, Wang N, Gu H, Zhong F, Xu M, Rong R, Zhu T, Hu W., Free PMC Article | 08/3/2019 |
| CRIg is a novel interacting partner of TRIM72 in the lung. | Inhibition of Macrophage Complement Receptor CRIg by TRIM72 Polarizes Innate Immunity of the Lung.
Nagre N, Cong X, Terrazas C, Pepper I, Schreiber JM, Fu H, Sill JM, Christman JW, Satoskar AR, Zhao X., Free PMC Article | 07/27/2019 |
| Soluble VSIG4 levels are associated with the progression and recurrence of ovarian cancer, indicating that soluble VSIG4 may be used as a potential biomarker for predicting tumor prognosis. | The Significance of VSIG4 Expression in Ovarian Cancer.
Byun JM, Jeong DH, Choi IH, Lee DS, Kang MS, Jung KO, Jeon YK, Kim YN, Jung EJ, Lee KB, Sung MS, Kim KT. | 02/3/2018 |
| VSIG4 signaling provides an anti-immune evasion mechanism that prevents the outgrowth of intracellular bacteria in macrophages | Extracellular stimulation of VSIG4/complement receptor Ig suppresses intracellular bacterial infection by inducing autophagy.
Kim KH, Choi BK, Kim YH, Han C, Oh HS, Lee DG, Kwon BS., Free PMC Article | 12/30/2017 |
| The VSIG4 upregulation by LMP1 was regulated at the transcriptional level via the NF-kB signaling axis. | Epstein-Barr virus-encoded latent membrane protein 1 induces epithelial to mesenchymal transition by inducing V-set Ig domain containing 4 (VSIG4) expression via NF-kB in renal tubular epithelial HK-2 cells.
Kim SM, Oh SW, Park SH, Hur DY, Hong SW, Han SY. | 10/28/2017 |
| VSIG4 expression is significantly upregulated in human masticatory mucosa during wound healing | Human gingiva transcriptome during wound healing.
Wang Y, Tatakis DN. | 03/22/2017 |
| we concluded that let-7g-5p inhibits epithelial-mesenchymal transition (EMT) consistent with reduction of glioma stem cell (GSC) phenotypes by targeting VSIG4 in glioblastoma. | Let-7g-5p inhibits epithelial-mesenchymal transition consistent with reduction of glioma stem cell phenotypes by targeting VSIG4 in glioblastoma.
Zhang XH, Qian Y, Li Z, Zhang NN, Xie YJ. | 03/11/2017 |
| Data indicate that rotein kinase calpha (PKCalpha) plays a role in downregulating complement receptor Ig (CRIg coded by V-set and Ig domain-containing protein 4 VSIG4) expression. | Protein kinase cα regulates the expression of complement receptor Ig in human monocyte-derived macrophages.
Ma Y, Usuwanthim K, Munawara U, Quach A, Gorgani NN, Abbott CA, Hii CS, Ferrante A. | 06/20/2015 |
| complement receptor of the immunoglobulin superfamily-L-factor H protects glomerular mesangial cells from complement-mediated injury and proliferative lesions | A novel CRIg-targeted complement inhibitor protects cells from complement damage.
Qiao Q, Teng X, Wang N, Lu R, Guo L, Zhang X, Du Y, Wang W, Chen S, Wu Q, He G, Wang Y, Hu W. | 01/31/2015 |
| we identified VSIG4 as a potential diagnostic marker of severe preeclampsia. The determination of this gene may improve the prognostic assessment of severe preeclampsia. | Evaluation of current and new biomarkers in severe preeclampsia: a microarray approach reveals the VSIG4 gene as a potential blood biomarker.
Textoris J, Ivorra D, Ben Amara A, Sabatier F, Ménard JP, Heckenroth H, Bretelle F, Mege JL., Free PMC Article | 10/11/2014 |
| Data indicate that massive V-set and Ig domain-containing 4 VSIG4(+) cell infiltration throughout the non-small-cell lung cancer samples. | VSIG4 expression on macrophages facilitates lung cancer development.
Liao Y, Guo S, Chen Y, Cao D, Xu H, Yang C, Fei L, Ni B, Ruan Z. | 09/6/2014 |
| we showed that a complement receptor of the Ig superfamily (CRIg, also known as Z39Ig), a receptor for complement fragments (C3b and iC3b), was expressed on a subset of intestinal macrophages in murine and human large intestine | Phenotypic and functional profiles of CRIg (Z39Ig)-expressing macrophages in the large intestine.
Tanaka M, Nagai T, Usami M, Hasui K, Takao S, Matsuyama T. | 07/21/2012 |
| These results suggest that T cells can opposite T cell hyporesponsiveness through dampening Z39Ig inhibitory signals from macrophages and thus maintain their anti-viral function in chronic hepatitis B. | Down-regulation of Z39Ig on macrophages by IFN-gamma in patients with chronic HBV infection.
Guo S, Yang C, Mei F, Wu S, Luo N, Fei L, Chen Y, Wu Y. | 08/9/2010 |
| hVSIG4 recombinant adenovirus-transfected DCs suppress T cell proliferation, cytokine production and activation marker expression with | Induction of T cells suppression by dendritic cells transfected with VSIG4 recombinant adenovirus.
Xu S, Sun Z, Li L, Liu J, He J, Song D, Shan G, Liu H, Wu X. | 06/14/2010 |
| These data indicate that the macrophage Z39Ig is involved in the pathogenesis of inflammatory diseases through chemokine induction, which will promote the migration of inflammatory cells into the lesion area, and MMP-9 induction. | Z39Ig is expressed on macrophages and may mediate inflammatory reactions in arthritis and atherosclerosis.
Lee MY, Kim WJ, Kang YJ, Jung YM, Kang YM, Suk K, Park JE, Choi EM, Choi BK, Kwon BS, Lee WH. | 01/21/2010 |
| The specific expression of VSIG4 on resting macrophages suggests that VSIG4 may be important for the maintenance of T cell unresponsiveness in healthy tissues. | VSIG4, a B7 family-related protein, is a negative regulator of T cell activation.
Vogt L, Schmitz N, Kurrer MO, Bauer M, Hinton HI, Behnke S, Gatto D, Sebbel P, Beerli RR, Sonderegger I, Kopf M, Saudan P, Bachmann MF., Free PMC Article | 01/21/2010 |
| CRIg is not only a phagocytic receptor, but also a potent inhibitor of the alternative pathway convertases | Structure of C3b in complex with CRIg gives insights into regulation of complement activation.
Wiesmann C, Katschke KJ, Yin J, Helmy KY, Steffek M, Fairbrother WJ, McCallum SA, Embuscado L, DeForge L, Hass PE, van Lookeren Campagne M. | 01/21/2010 |
| Results report the identification and characterization of a Complement Receptor of the Immunoglobulin superfamily, CRIg, that binds complement fragments C3b and iC3b. | CRIg: a macrophage complement receptor required for phagocytosis of circulating pathogens.
Helmy KY, Katschke KJ Jr, Gorgani NN, Kljavin NM, Elliott JM, Diehl L, Scales SJ, Ghilardi N, van Lookeren Campagne M. | 01/21/2010 |