| BCR-ABL triggers a glucose-dependent survival program during leukemogenesis through the suppression of TXNIP. | BCR-ABL triggers a glucose-dependent survival program during leukemogenesis through the suppression of TXNIP.
Feng L, Ding R, Qu X, Li Y, Shen T, Wang L, Li R, Zhang J, Ru Y, Bu X, Wang Y, Li M, Song W, Shen L, Zhang P., Free PMC Article | 04/26/2023 |
| The oncogene ABL1 regulates the inflammatory response of innate immunity via mediating TRAF6 ubiquitination. | The oncogene ABL1 regulates the inflammatory response of innate immunity via mediating TRAF6 ubiquitination.
Xu F, Yao W, Xue Y, Sun Q, Cao C. | 09/24/2022 |
| c-Abl kinase regulates neutrophil extracellular trap formation and lung injury in abdominal sepsis. | c-Abl kinase regulates neutrophil extracellular trap formation and lung injury in abdominal sepsis.
Hawez A, Ding Z, Taha D, Madhi R, Rahman M, Thorlacius H., Free PMC Article | 03/19/2022 |
| ABL1 and Cofilin1 promote T-cell acute lymphoblastic leukemia cell migration. | ABL1 and Cofilin1 promote T-cell acute lymphoblastic leukemia cell migration.
Luo J, Zheng H, Wang S, Li D, Ma W, Wang L, Crabbe MJC. | 02/12/2022 |
| c-Abl activates RIPK3 signaling in Gaucher disease. | c-Abl activates RIPK3 signaling in Gaucher disease.
Yañez MJ, Campos F, Marín T, Klein AD, Futerman AH, Alvarez AR, Zanlungo S. | 09/11/2021 |
| Abl1 deletion in gut stem cells suppresses p53 induction and promotes colitis-associated tumor formation. | Abl1 deletion in gut stem cells suppresses p53 induction and promotes colitis-associated tumor formation.
Yu G, Fu J, Romo A, Li B, Liu H., Free PMC Article | 08/28/2021 |
| Abl2:Cortactin Interactions Regulate Dendritic Spine Stability via Control of a Stable Filamentous Actin Pool. | Abl2:Cortactin Interactions Regulate Dendritic Spine Stability via Control of a Stable Filamentous Actin Pool.
Shaw JE, Kilander MBC, Lin YC, Koleske AJ., Free PMC Article | 08/21/2021 |
| Interaction of the mTERT telomerase catalytic subunit with the c-Abl tyrosine kinase in mouse granulosa cells. | Interaction of the mTERT telomerase catalytic subunit with the c-Abl tyrosine kinase in mouse granulosa cells.
Yaba A, Agus S, Yıldırım E, Erdogan CS, Yılmaz B. | 04/24/2021 |
| ABL1, Overexpressed in Hepatocellular Carcinomas, Regulates Expression of NOTCH1 and Promotes Development of Liver Tumors in Mice. | ABL1, Overexpressed in Hepatocellular Carcinomas, Regulates Expression of NOTCH1 and Promotes Development of Liver Tumors in Mice.
Wang F, Hou W, Chitsike L, Xu Y, Bettler C, Perera A, Bank T, Cotler SJ, Dhanarajan A, Denning MF, Ding X, Breslin P, Qiang W, Li J, Koleske AJ, Qiu W., Free PMC Article | 04/3/2021 |
| CRISPR/CAS9-mediated knockout of Abi1 inhibits p185(Bcr-Abl)-induced leukemogenesis and signal transduction to ERK and PI3K/Akt pathways. | CRISPR/CAS9-mediated knockout of Abi1 inhibits p185(Bcr-Abl)-induced leukemogenesis and signal transduction to ERK and PI3K/Akt pathways.
Faulkner J, Jiang P, Farris D, Walker R, Dai Z., Free PMC Article | 02/2/2021 |
| Timely Inhibitory Circuit Formation Controlled by Abl1 Regulates Innate Olfactory Behaviors in Mouse. | Timely Inhibitory Circuit Formation Controlled by Abl1 Regulates Innate Olfactory Behaviors in Mouse.
Kim JY, Cho B, Moon C. | 01/9/2021 |
| Role of c-Abl in Ang II-induced aortic dissection formation: Potential regulatory efficacy on phenotypic transformation and apoptosis of VSMCs. | Role of c-Abl in Ang II-induced aortic dissection formation: Potential regulatory efficacy on phenotypic transformation and apoptosis of VSMCs.
Zhou X, Cheng J, Chen Z, Li H, Chen S, Xu F, Fan R, Zhuang J, Sun T. | 09/5/2020 |
| These findings reveal a critical BCR signal-enhancing function of FcRL1 through its intrinsic recruitment to B cell immunological synapses and subsequent recruitment of c-Abl upon BCR cross-linking. | Fc receptor-like 1 intrinsically recruits c-Abl to enhance B cell activation and function.
Zhao X, Xie H, Zhao M, Ahsan A, Li X, Wang F, Yi J, Yang Z, Wu C, Raman I, Li QZ, Kim TJ, Liu W., Free PMC Article | 05/9/2020 |
| The c-Abl/YAPY357 pathway serves as a mechanism for the activation of integrin alpha5beta1 and the atherogenic phenotype of ECs in response to OSS, and provides a potential therapeutic strategy for atherogenesis. | c-Abl regulates YAPY357 phosphorylation to activate endothelial atherogenic responses to disturbed flow.
Li B, He J, Lv H, Liu Y, Lv X, Zhang C, Zhu Y, Ai D., Free PMC Article | 02/29/2020 |
| Nonreceptor Tyrosine Kinase c-Abl- and Arg-Mediated IRF3 Phosphorylation Regulates Innate Immune Responses by Promoting Type I IFN Production. | Nonreceptor Tyrosine Kinase c-Abl- and Arg-Mediated IRF3 Phosphorylation Regulates Innate Immune Responses by Promoting Type I IFN Production.
Luo F, Liu H, Yang S, Fang Y, Zhao Z, Hu Y, Jin Y, Li P, Gao T, Cao C, Liu X. | 12/28/2019 |
| IL-4 amplifies IgE- and histamine-induced vascular endothelium (VE) dysfunction, fluid extravasation, and the severity of anaphylaxis through a VE IL-4Ralpha/ABL1-dependent mechanism. | The vascular endothelial specific IL-4 receptor alpha-ABL1 kinase signaling axis regulates the severity of IgE-mediated anaphylactic reactions.
Yamani A, Wu D, Waggoner L, Noah T, Koleske AJ, Finkelman F, Hogan SP., Free PMC Article | 09/21/2019 |
| These results reveal a role for c-Abl-regulated smooth muscle proliferation in the pathogenesis of rectal prolapse, and imply that long-term use of imatinib mesylate may cause gastrointestinal problems in patients while ERK inhibitor may be effective in treating rectal prolapse. | c-Abl regulates gastrointestinal muscularis propria homeostasis via ERKs.
Xiang J, Zhang Y, Bao D, Cao N, Zhang X, Li P, Qiu S, Guo J, He D, Li B, Yao L, Liu H., Free PMC Article | 06/8/2019 |
| Radotinib HCl protects the alpha-synuclein preformed fibrils (PFF)-induced neuronal toxicity, reduces the alpha-synuclein PFF-induced Lewy bodies (LB)/Lewy neurites (LN)-like pathology and inhibits the alpha-synuclein PFF-induced c-Abl activation in primary cortical neurons. | The c-Abl inhibitor, Radotinib HCl, is neuroprotective in a preclinical Parkinson's disease mouse model.
Lee S, Kim S, Park YJ, Yun SP, Kwon SH, Kim D, Kim DY, Shin JS, Cho DJ, Lee GY, Ju HS, Yun HJ, Park JH, Kim WR, Jung EA, Lee S, Ko HS., Free PMC Article | 02/23/2019 |
| WAVE2/c-Abl survival signal required at the hematopoietic stem cell (HSC) fetal liver to marrow transition that confers fitness to the HSC for marrow hematopoiesis | The Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow.
Shao L, Chang J, Feng W, Wang X, Williamson EA, Li Y, Schajnovitz A, Scadden D, Mortensen LJ, Lin CP, Li L, Paulson A, Downing J, Zhou D, Hromas RA., Free PMC Article | 12/22/2018 |
| Results indicate that c-Abl may play roles in preimplantation embryo development, especially in TE formation and differentiation. | The Abelson tyrosine kinase (c-Abl) localization in preimplantation mouse development.
Mutluay D, Oner H. | 09/8/2018 |
| c-Abl phosphorylated Drp1 at tyrosine 266, 368 and 449 in vitro and in vivo, which augmented the GTPase activity of Drp1 and promoted Drp1-mediated mitochondrial fragmentation. | c-Abl-mediated Drp1 phosphorylation promotes oxidative stress-induced mitochondrial fragmentation and neuronal cell death.
Zhou L, Zhang Q, Zhang P, Sun L, Peng C, Yuan Z, Cheng J., Free PMC Article | 06/9/2018 |
| c-Abl phosphorylation of Mdm2 has a role in regulation of p53 tumor suppression and bone marrow failure | Phosphorylation of the Mdm2 oncoprotein by the c-Abl tyrosine kinase regulates p53 tumor suppression and the radiosensitivity of mice.
Carr MI, Roderick JE, Zhang H, Woda BA, Kelliher MA, Jones SN., Free PMC Article | 04/14/2018 |
| BOC interacts with ABL and activates JNK thereby promoting neuronal differentiation and neurite outgrowth. | A Sonic hedgehog coreceptor, BOC regulates neuronal differentiation and neurite outgrowth via interaction with ABL and JNK activation.
Vuong TA, Leem YE, Kim BG, Cho H, Lee SJ, Bae GU, Kang JS. | 12/2/2017 |
| These results uncover a murine hepatic steatosis regulatory axis consisting of ABL1-PPARgamma2-MLL4, which may serve as a target of anti-steatosis drug development. | Critical Roles of the Histone Methyltransferase MLL4/KMT2D in Murine Hepatic Steatosis Directed by ABL1 and PPARγ2.
Kim DH, Kim J, Kwon JS, Sandhu J, Tontonoz P, Lee SK, Lee S, Lee JW. | 11/26/2017 |
| this study shows that signaling downstream of murine inhibitory receptors does not involve c-Abl and that c-Abl plays no major role in NK cell education in the mouse | The Abl-1 Kinase is Dispensable for NK Cell Inhibitory Signalling and is not Involved in Murine NK Cell Education.
Ganesan S, Luu TT, Chambers BJ, Meinke S, Brodin P, Vivier E, Wetzel DM, Koleske AJ, Kadri N, Höglund P., Free PMC Article | 09/23/2017 |