| Nicotine promotes renal interstitial fibrosis via upregulation of XIAP in an alpha7-nAChR-dependent manner. | Nicotine promotes renal interstitial fibrosis via upregulation of XIAP in an alpha7-nAChR-dependent manner.
Guo L, Zhang Y, Lu J, Li X, Zhang C, Song W, Dong Y, Zhou X, Li R. | 09/8/2023 |
| Autosomal dominant sleep-related hypermotor epilepsy caused by a previously unreported CHRNA4 variant. | Autosomal dominant sleep-related hypermotor epilepsy caused by a previously unreported CHRNA4 variant.
Nielsen TØ, Herlin MK, Linnet KM, Beniczky S, Sommerlund M, Granild-Jensen JB, Gregersen PA. | 06/18/2022 |
| Sleep-related hypermotor epilepsy associated mutations uncover important kinetic roles of alpha4beta2- nicotinic acetylcholine receptor intracellular structures. | Sleep-related hypermotor epilepsy associated mutations uncover important kinetic roles of α4β2- nicotinic acetylcholine receptor intracellular structures.
Weltzin MM, George AA, Lukas RJ, Whiteaker P., Free PMC Article | 10/16/2021 |
| Variants in CHRNB2 and CHRNA4 Identified in Patients with Insular Epilepsy. | Variants in CHRNB2 and CHRNA4 Identified in Patients with Insular Epilepsy.
Cadieux-Dion M, Meneghini S, Villa C, Toffa DH, Wickstrom R, Bouthillier A, Sandvik U, Gustavsson B, Mohamed I, Cossette P, Combi R, Becchetti A, Nguyen DK. | 10/9/2021 |
| Novel variant in CHRNA4 with benign childhood epilepsy with centrotemporal spikes and contribution to precise medicine. | Novel variant in CHRNA4 with benign childhood epilepsy with centrotemporal spikes and contribution to precise medicine.
Neng X, Xiao M, Yuanlu C, Qinyan L, Li S, Zhanyi S., Free PMC Article | 05/1/2021 |
| Association Between Nicotine-dependent Gene Polymorphism and Smoking Cessation in Patients With Lung Cancer. | Association Between Nicotine-dependent Gene Polymorphism and Smoking Cessation in Patients With Lung Cancer.
Gu F, Zhao C, Jiang T, Li X, Mao Y, Zhou C. | 04/3/2021 |
| Concatemers to re-investigate the role of alpha5 in alpha4beta2 nicotinic receptors. | Concatemers to re-investigate the role of α5 in α4β2 nicotinic receptors.
Prevost MS, Bouchenaki H, Barilone N, Gielen M, Corringer PJ., Free PMC Article | 03/6/2021 |
| Depletion of miR-380 mitigates human bronchial epithelial cells injury to improve chronic obstructive pulmonary disease through targeting CHRNA4. | Depletion of miR-380 mitigates human bronchial epithelial cells injury to improve chronic obstructive pulmonary disease through targeting CHRNA4.
Wu X. | 01/2/2021 |
| Identification of the initial steps in signal transduction in the alpha4beta2 nicotinic receptor has been reported. | Identification of the Initial Steps in Signal Transduction in the α4β2 Nicotinic Receptor: Insights from Equilibrium and Nonequilibrium Simulations.
Oliveira ASF, Shoemark DK, Campello HR, Wonnacott S, Gallagher T, Sessions RB, Mulholland AJ. | 05/2/2020 |
| SNPs of the CHRNA4 gene may play an important role in the response to antidepressant drugs among ethnic Han Chinese with major depressive disorder. | [Association of CHRNA4 gene polymorphisms with response to antidepressant among ethnic Han Chinese].
Yu J, Dong Z, Yu T, Li X, Sun X. | 12/14/2019 |
| The fifth subunit in the (alpha4beta2)2 beta2 receptor isoform modulates maximal ACh responses. This effect appears to be driven by a modulatory, and asymmetric, association with the alpha4(+)/beta2(-) agonist sites. | The fifth subunit of the (α4β2)(2) β2 nicotinic ACh receptor modulates maximal ACh responses.
New K, Del Villar SG, Mazzaferro S, Alcaino C, Bermudez I., Free PMC Article | 08/10/2019 |
| cryoelectron microscopy and the structural principles of distinct assemblies of the human alpha4beta2 nicotinic receptor | Structural principles of distinct assemblies of the human α4β2 nicotinic receptor.
Walsh RM Jr, Roh SH, Gharpure A, Morales-Perez CL, Teng J, Hibbs RE., Free PMC Article | 10/20/2018 |
| Results are comparable to the impact of nicotine on withdrawal-related impaired plasticity in smokers and suggest that alpha4beta2 nicotinic receptors are relevantly involved in plasticity deficits and restitution in smokers. | Compromised neuroplasticity in cigarette smokers under nicotine withdrawal is restituted by the nicotinic α(4)β(2)-receptor partial agonist varenicline.
Batsikadze G, Paulus W, Hasan A, Grundey J, Kuo MF, Nitsche MA., Free PMC Article | 09/15/2018 |
| Results find that overexpression of hTau increases intracellular calcium, which in turn activates calpain-2 and induces degradation of alpha4 nAChR. | Accumulation of human full-length tau induces degradation of nicotinic acetylcholine receptor α4 via activating calpain-2.
Yin Y, Wang Y, Gao D, Ye J, Wang X, Fang L, Wu D, Pi G, Lu C, Zhou XW, Yang Y, Wang JZ., Free PMC Article | 04/28/2018 |
| Orienting attention predicted by CHRNA4 and maternal sensitivity interaction in 6-month-old infants. | The influence of CHRNA4, COMT, and maternal sensitivity on orienting and executive attention in 6-month-old infants.
Quan J, Ong ML, Bureau JF, Sim LW, Sanmugam S, Abdul Malik AB, Wong E, Wong J, Chong YS, Saw SM, Kwek K, Qiu A, Holbrook JD, Rifkin-Graboi A, GUSTO Study Group. | 02/24/2018 |
| This study demonstrated that rs1044396 of CHRNA4 was significantly associated with Internet gaming disorder | The association between the nicotinic acetylcholine receptor α4 subunit gene (CHRNA4) rs1044396 and Internet gaming disorder in Korean male adults.
Jeong JE, Rhee JK, Kim TM, Kwak SM, Bang SH, Cho H, Cheon YH, Min JA, Yoo GS, Kim K, Choi JS, Choi SW, Kim DJ., Free PMC Article | 02/24/2018 |
| the mechanism of interaction between [Upsilon4E]GID and the agonist binding pockets of the alpha4beta2 and the halpha7 receptors, and to estimate their relative binding affinities, was investigated. | Molecular simulation study of the unbinding of α-conotoxin [ϒ4E]GID at the α7 and α4β2 neuronal nicotinic acetylcholine receptors.
Suresh A, Hung A. | 02/3/2018 |
| Reactive oxygen species, generated by 6-hydroxydopamine (6-OHDA), could cause the current rundown in alpha4beta2 nAChRs, which may play a role in Parkinson disease. | Molecular basis of reactive oxygen species-induced inactivation of α4β2 nicotinic acetylcholine receptors.
Zhao J, Zheng Y, Xue F, Chang Y, Yang H, Zhang J. | 01/6/2018 |
| As well as basal forebrain and brainstem cholinergic system dysfunction, cholinergic deficits mediated through nicotinic acetylcholine receptors could be evident within key networks in AD. | A spatial covariance (123)I-5IA-85380 SPECT study of α4β2 nicotinic receptors in Alzheimer's disease.
Colloby SJ, Field RH, Wyper DJ, O'Brien JT, Taylor JP., Free PMC Article | 10/21/2017 |
| A polymorphism in CHRNA4 leads to an overdominant effect at this locus, with higher activity in the cingulo-opercular network underlying alertness. | Overdominant Effect of a CHRNA4 Polymorphism on Cingulo-Opercular Network Activity and Cognitive Control.
Sadaghiani S, Ng B, Altmann A, Poline JB, Banaschewski T, Bokde ALW, Bromberg U, Büchel C, Burke Quinlan E, Conrod P, Desrivières S, Flor H, Frouin V, Garavan H, Gowland P, Gallinat J, Heinz A, Ittermann B, Martinot JL, Paillère Martinot ML, Lemaitre H, Nees F, Papadopoulos Orfanos D, Paus T, Poustka L, Millenet S, Fröhner JH, Smolka MN, Walter H, Whelan R, Schumann G, Napolioni V, Greicius M., Free PMC Article | 10/14/2017 |
| Ability to navigate in the wilderness benefits from heightened ability to focus attention (CHRNA4). | A role for attention during wilderness navigation: Comparing effects of BDNF, KIBRA, and CHRNA4.
Rovira E, Mackie RS, Clark N, Squire PN, Hendricks MD, Pulido AM, Greenwood PM. | 08/12/2017 |
| Data suggest that amino acid residues alpha4Gly-41, alpha4Lys-64, and alpha4Thr-66 are critical for (alpha4)3(beta2)2 neuronal AChR potentiation by positive allosteric modulator (PAM) CMPI, but not by PAM NS9283; amino acid substitution at alpha4His-116, a known determinant of NS9283 binding and of agonist binding at alpha4:alpha4 subunit interface, did not reduce CMPI potentiation. | Unraveling amino acid residues critical for allosteric potentiation of (α4)3(β2)2-type nicotinic acetylcholine receptor responses.
Wang ZJ, Deba F, Mohamed TS, Chiara DC, Ramos K, Hamouda AK., Free PMC Article | 07/8/2017 |
| This study shows that unorthodox acetylcholine binding sites can form at the alpha5/alpha4 and beta3/alpha4 interfaces in (alpha4beta2)2alpha5 and (alpha4beta2)2beta3 nicotinic acetylcholine receptors (nAChRs) and at the alpha4/alpha5 in (beta2alpha4)2alpha5 nAChRs. | Unorthodox Acetylcholine Binding Sites Formed by α5 and β3 Accessory Subunits in α4β2* Nicotinic Acetylcholine Receptors.
Jain A, Kuryatov A, Wang J, Kamenecka TM, Lindstrom J., Free PMC Article | 06/3/2017 |
| the role of CHRNA4 and CHRNA7 genetic polymorphisms in moderating auditory target and novelty attentional processing in healthy subjects exposed to the auditory "oddball" P300 paradigm. | Cholinergic modulation of auditory P3 event-related potentials as indexed by CHRNA4 and CHRNA7 genotype variation in healthy volunteers.
Hyde M, Choueiry J, Smith D, de la Salle S, Nelson R, Impey D, Baddeley A, Aidelbaum R, Millar A, Knott V. | 05/27/2017 |
| The form containing three copies of alpha4 and two of beta2 was potentiated at low concentrations of acetylcholine chloride (ACh) and physostigmine, whereas the form containing two copies of alpha4 and three of beta2 was inhibited. | The E Loop of the Transmitter Binding Site Is a Key Determinant of the Modulatory Effects of Physostigmine on Neuronal Nicotinic α4β2 Receptors.
Jin X, McCollum MM, Germann AL, Akk G, Steinbach JH., Free PMC Article | 05/13/2017 |