| C5a-C5AR1 axis as a potential trigger of the rupture of intracranial aneurysms. | C5a-C5AR1 axis as a potential trigger of the rupture of intracranial aneurysms.
Okada A, Shimizu K, Kawashima A, Kayahara T, Itani M, Kurita H, Miyamoto S, Kataoka H, Aoki T., Free PMC Article | 02/14/2024 |
| Silenced-C5ar1 improved multiple organ injury in sepsis rats via inhibiting neutrophil extracellular trap. | Silenced-C5ar1 improved multiple organ injury in sepsis rats via inhibiting neutrophil extracellular trap.
Shen B, Shen Q, Zeng Q, Zhang L, Li X., Free PMC Article | 02/9/2024 |
| C5aR1 Mediates the Progression of Inflammatory Responses in the Brain of Rats in the Early Stage after Ischemia and Reperfusion. | C5aR1 Mediates the Progression of Inflammatory Responses in the Brain of Rats in the Early Stage after Ischemia and Reperfusion.
Shi Y, Jin Y, Li X, Chen C, Zhang Z, Liu X, Deng Y, Fan X, Wang C. | 11/27/2021 |
| Study concludes, Toll-like receptor 4 (TLR4) and C5aR1 played a vital role during ischemia and reperfusion brain injury in rats, and schisantherin A exhibited neuroprotective effects by TLR4 and C5aR1 signaling pathways. | Schisantherin A attenuates ischemia/reperfusion-induced neuronal injury in rats via regulation of TLR4 and C5aR1 signaling pathways.
Shi YW, Zhang XC, Chen C, Tang M, Wang ZW, Liang XM, Ding F, Wang CP. | 06/9/2018 |
| The C5aR expression was upregulated and localized to neurons and microglia in spinal cord ischemia reperfusion injury in the rat. | Expression of C5a and its receptor following spinal cord ischemia reperfusion injury in the rat.
Dong Q, Sun L, Peng L, Yan B, Lv J, Wang G, Gong S. | 04/30/2016 |
| C5aR and C5L2, but not C3aR, are expressed on CD11b-positive leukocytes in islet preparations | Expression of receptors for anaphylatoxins C3a and C5a on rat islet preparations.
Tokodai K, Goto M, Inagaki A, Imura T, Nakanishi W, Satomi S. | 10/4/2014 |
| C5aR is critically involved in ventricular remodeling by regulating inflammatory responses in the hypertensive heart. | Inhibition of inflammation and fibrosis by a complement C5a receptor antagonist in DOCA-salt hypertensive rats.
Iyer A, Woodruff TM, Wu MC, Stylianou C, Reid RC, Fairlie DP, Taylor SM, Brown L. | 03/17/2012 |
| present in bone forming osteoblasts and bone resorbing osteoclasts, suggesting role in fracture healing | The anaphylatoxin receptor C5aR is present during fracture healing in rats and mediates osteoblast migration in vitro.
Ignatius A, Ehrnthaller C, Brenner RE, Kreja L, Schoengraf P, Lisson P, Blakytny R, Recknagel S, Claes L, Gebhard F, Lambris JD, Huber-Lang M., Free PMC Article | 12/3/2011 |
| These results demonstrate that CD88 is expressed on presynaptic terminals of mossy fibres within the CA3 region of the hippocampus. | The C5a anaphylatoxin receptor CD88 is expressed in presynaptic terminals of hippocampal mossy fibres.
Crane JW, Baiquni GP, Sullivan RK, Lee JD, Sah P, Taylor SM, Noakes PG, Woodruff TM., Free PMC Article | 02/8/2010 |
| C5a receptors and C5L2 were demonstrated in the rat anterior pituitary gland and they may play a role in dampening down inflammation by inhibiting the release of MIF and stimulating the release of ACTH. | Complement C5a receptors in the pituitary gland: expression and function.
Francis K, Lewis BM, Monk PN, Ham J. | 01/21/2010 |
| Role of C5ar1 in the development of the rat cerebellum is reported. | Role of complement anaphylatoxin receptors (C3aR, C5aR) in the development of the rat cerebellum.
Bénard M, Raoult E, Vaudry D, Leprince J, Falluel-Morel A, Gonzalez BJ, Galas L, Vaudry H, Fontaine M. | 01/21/2010 |
| Our findings demonstrate that C5a may have a role in the activation of the HPA axis in response to systemic LPS. | Systemic blockade of complement C5a receptors reduces lipopolysacharride-induced responses in the paraventricular nucleus and the central amygdala.
Crane JW, Buller KM. | 01/21/2010 |
| results provide the first evidence that C3aR and C5aR are both expressed in cerebellar granule cells during development and that C5a, but not C3a, is a potent inhibitor of apoptotic cell death in cultured granule neurons | Characterization of C3a and C5a receptors in rat cerebellar granule neurons during maturation. Neuroprotective effect of C5a against apoptotic cell death.
Bénard M, Gonzalez BJ, Schouft MT, Falluel-Morel A, Vaudry D, Chan P, Vaudry H, Fontaine M. | 01/21/2010 |