| Sleep-related hypermotor epilepsy associated mutations uncover important kinetic roles of alpha4beta2- nicotinic acetylcholine receptor intracellular structures. | Sleep-related hypermotor epilepsy associated mutations uncover important kinetic roles of α4β2- nicotinic acetylcholine receptor intracellular structures.
Weltzin MM, George AA, Lukas RJ, Whiteaker P., Free PMC Article | 10/16/2021 |
| Variants in CHRNB2 and CHRNA4 Identified in Patients with Insular Epilepsy. | Variants in CHRNB2 and CHRNA4 Identified in Patients with Insular Epilepsy.
Cadieux-Dion M, Meneghini S, Villa C, Toffa DH, Wickstrom R, Bouthillier A, Sandvik U, Gustavsson B, Mohamed I, Cossette P, Combi R, Becchetti A, Nguyen DK. | 10/9/2021 |
| The alpha7 and beta2 nicotinic acetylcholine receptor subunits regulate apoptosis in the infant hippocampus, and in sudden infant death syndrome (SIDS). | The α7 and β2 nicotinic acetylcholine receptor subunits regulate apoptosis in the infant hippocampus, and in sudden infant death syndrome (SIDS).
Luijerink LLM, Vivekanandarajah A, Waters KA, Machaalani R. | 06/5/2021 |
| Identification of the initial steps in signal transduction in the alpha4beta2 nicotinic receptor has been reported. | Identification of the Initial Steps in Signal Transduction in the α4β2 Nicotinic Receptor: Insights from Equilibrium and Nonequilibrium Simulations.
Oliveira ASF, Shoemark DK, Campello HR, Wonnacott S, Gallagher T, Sessions RB, Mulholland AJ. | 05/2/2020 |
| The fifth subunit in the (alpha4beta2)2 beta2 receptor isoform modulates maximal ACh responses. This effect appears to be driven by a modulatory, and asymmetric, association with the alpha4(+)/beta2(-) agonist sites. | The fifth subunit of the (α4β2)(2) β2 nicotinic ACh receptor modulates maximal ACh responses.
New K, Del Villar SG, Mazzaferro S, Alcaino C, Bermudez I., Free PMC Article | 08/10/2019 |
| cryoelectron microscopy and the structural principles of distinct assemblies of the human alpha4beta2 nicotinic receptor | Structural principles of distinct assemblies of the human α4β2 nicotinic receptor.
Walsh RM Jr, Roh SH, Gharpure A, Morales-Perez CL, Teng J, Hibbs RE., Free PMC Article | 10/20/2018 |
| the mechanism of interaction between [Upsilon4E]GID and the agonist binding pockets of the alpha4beta2 and the halpha7 receptors, and to estimate their relative binding affinities, was investigated. | Molecular simulation study of the unbinding of α-conotoxin [ϒ4E]GID at the α7 and α4β2 neuronal nicotinic acetylcholine receptors.
Suresh A, Hung A. | 02/3/2018 |
| Reactive oxygen species, generated by 6-hydroxydopamine (6-OHDA), could cause the current rundown in alpha4beta2 nAChRs, which may play a role in Parkinson disease. | Molecular basis of reactive oxygen species-induced inactivation of α4β2 nicotinic acetylcholine receptors.
Zhao J, Zheng Y, Xue F, Chang Y, Yang H, Zhang J. | 01/6/2018 |
| Data suggest that amino acid residues alpha4Gly-41, alpha4Lys-64, and alpha4Thr-66 are critical for (alpha4)3(beta2)2 neuronal AChR potentiation by positive allosteric modulator (PAM) CMPI, but not by PAM NS9283; amino acid substitution at alpha4His-116, a known determinant of NS9283 binding and of agonist binding at alpha4:alpha4 subunit interface, did not reduce CMPI potentiation. | Unraveling amino acid residues critical for allosteric potentiation of (α4)3(β2)2-type nicotinic acetylcholine receptor responses.
Wang ZJ, Deba F, Mohamed TS, Chiara DC, Ramos K, Hamouda AK., Free PMC Article | 07/8/2017 |
| This study shows that unorthodox acetylcholine binding sites can form at the alpha5/alpha4 and beta3/alpha4 interfaces in (alpha4beta2)2alpha5 and (alpha4beta2)2beta3 nicotinic acetylcholine receptors (nAChRs) and at the alpha4/alpha5 in (beta2alpha4)2alpha5 nAChRs. | Unorthodox Acetylcholine Binding Sites Formed by α5 and β3 Accessory Subunits in α4β2* Nicotinic Acetylcholine Receptors.
Jain A, Kuryatov A, Wang J, Kamenecka TM, Lindstrom J., Free PMC Article | 06/3/2017 |
| The form containing three copies of alpha4 and two of beta2 was potentiated at low concentrations of acetylcholine chloride (ACh) and physostigmine, whereas the form containing two copies of alpha4 and three of beta2 was inhibited. | The E Loop of the Transmitter Binding Site Is a Key Determinant of the Modulatory Effects of Physostigmine on Neuronal Nicotinic α4β2 Receptors.
Jin X, McCollum MM, Germann AL, Akk G, Steinbach JH., Free PMC Article | 05/13/2017 |
| X-ray crystallographic structure of the human alpha4beta2 nicotinic receptor, the most abundant nicotinic subtype in the brain; structure provides insights into the architectural principles governing ligand recognition, heteromer assembly, ion permeation and desensitization in this prototypical receptor class | X-ray structure of the human α4β2 nicotinic receptor.
Morales-Perez CL, Noviello CM, Hibbs RE., Free PMC Article | 03/11/2017 |
| findings indicate that alterations in expression of the alpha4beta2 subtype of nAChR may be involved in the molecular mechanism(s) underlying the cognitive deficit associated with vascular dementia | Inhibited Expression of α(4)β(2) Nicotinic Acetylcholine Receptor in Blood Leukocytes of Chinese Patients with Vascular Dementia and in Blood Leukocytes as Well as the Hippocampus of Brain from Ischemic Rats.
Xiao Y, Zhao L, Kuang SX, Guan ZZ. | 02/25/2017 |
| MAFA controls autonomic nervous system-mediated insulin secretion by activating the transcription of nicotinic (ChrnB2 and ChrnB4) receptor genes, which is impaired in patients with type 2 diabetes. | MafA-Controlled Nicotinic Receptor Expression Is Essential for Insulin Secretion and Is Impaired in Patients with Type 2 Diabetes.
Ganic E, Singh T, Luan C, Fadista J, Johansson JK, Cyphert HA, Bennet H, Storm P, Prost G, Ahlenius H, Renström E, Stein R, Groop L, Fex M, Artner I., Free PMC Article | 12/17/2016 |
| the identity of subunits neighboring the otherwise equivalent alpha4(+)/(-)beta2 agonist sites modifies their contributions to nAChR activation and E-loop residues are an important contributor to this neighbor effect | Differential α4(+)/(-)β2 Agonist-binding Site Contributions to α4β2 Nicotinic Acetylcholine Receptor Function within and between Isoforms.
Lucero LM, Weltzin MM, Eaton JB, Cooper JF, Lindstrom JM, Lukas RJ, Whiteaker P., Free PMC Article | 06/28/2016 |
| Data show efficient expression of (alpha6beta2)2beta3 nicotinic acetylcholine receptors (AChRs) in Xenopus oocytes using free subunits with only small changes in alpha6 subunits, while not altering AChR pharmacology or channel structure. | Efficient expression of functional (α6β2)2β3 AChRs in Xenopus oocytes from free subunits using slightly modified α6 subunits.
Ley CK, Kuryatov A, Wang J, Lindstrom JM., Free PMC Article | 12/5/2015 |
| The results of this study suggested that rs2072660 had a significant effect on the nicotine dependence There was no direct association between depressive phenotype (with neither ZSDS total scores and nor its subscales) and CHRNB2 variants. | The possible role of maternal bonding style and CHRNB2 gene polymorphisms in nicotine dependence and related depressive phenotype.
Csala I, Egervari L, Dome P, Faludi G, Dome B, Lazary J. | 11/21/2015 |
| analysis of how an agonist to the binding site promotes activation of alpha4beta2* nicotinic acetylcholine receptors | An Accessory Agonist Binding Site Promotes Activation of α4β2* Nicotinic Acetylcholine Receptors.
Wang J, Kuryatov A, Sriram A, Jin Z, Kamenecka TM, Kenny PJ, Lindstrom J., Free PMC Article | 08/22/2015 |
| Data indicate the binding mode and modulatory mechanism of NS9283 at alpha4beta2 nicotinic acetylcholine receptors. | Structural and functional studies of the modulator NS9283 reveal agonist-like mechanism of action at α4β2 nicotinic acetylcholine receptors.
Olsen JA, Ahring PK, Kastrup JS, Gajhede M, Balle T., Free PMC Article | 01/31/2015 |
| Smokers with less upregulation of available alpha4beta2* nAChRs have a greater likelihood of quitting with treatment than smokers with more upregulation. | Brain nicotinic acetylcholine receptor availability and response to smoking cessation treatment: a randomized trial.
Brody AL, Mukhin AG, Mamoun MS, Luu T, Neary M, Liang L, Shieh J, Sugar CA, Rose JE, Mandelkern MA., Free PMC Article | 08/30/2014 |
| findings suggest that CHRNB2 rs4845652 T-allele carriers may be associated with lower levels of nicotine dependence (ND), and that certain allelic combinations of CHRNA4 and CHRNB2 might be correlated with higher ND levels. | Possible association of nicotinic acetylcholine receptor gene (CHRNA4 and CHRNB2) polymorphisms with nicotine dependence in Japanese males: an exploratory study.
Chen HI, Shinkai T, Utsunomiya K, Yamada K, Sakata S, Fukunaka Y, Hwang R, De Luca V, Ohmori O, Kennedy JL, Chuang HY, Nakamura J. | 05/24/2014 |
| Data indicate that compounds showed favorable subtype selectivity for beta2*-nAChRs over beta4*-nAChRs. | Chemistry, pharmacology, and behavioral studies identify chiral cyclopropanes as selective α4β2-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profile. Part II.
Zhang HK, Yu LF, Eaton JB, Whiteaker P, Onajole OK, Hanania T, Brunner D, Lukas RJ, Kozikowski AP., Free PMC Article | 03/15/2014 |
| Following smoking reduction and cessation alpha4beta2* nAChR densities were decreased across brain regions. | Treatment for tobacco dependence: effect on brain nicotinic acetylcholine receptor density.
Brody AL, Mukhin AG, Stephanie Shulenberger, Mamoun MS, Kozman M, Phuong J, Neary M, Luu T, Mandelkern MA., Free PMC Article | 02/15/2014 |
| alpha4beta2-nAChR is a sensitive target to mediate oligomeric alpha-synuclein-induced modulation of cholinergic signaling. | Human α4β2 nicotinic acetylcholine receptor as a novel target of oligomeric α-synuclein.
Liu Q, Emadi S, Shen JX, Sierks MR, Wu J., Free PMC Article | 08/31/2013 |
| NMR resolved multiple anesthetic binding sites in the TM domains of the alpha4beta2 nAChR | NMR resolved multiple anesthetic binding sites in the TM domains of the α4β2 nAChR.
Bondarenko V, Mowrey D, Liu LT, Xu Y, Tang P., Free PMC Article | 04/6/2013 |