| Blocking CXC Motif Chemokine Ligand 2 Ameliorates Diabetic Peripheral Neuropathy via Inhibiting Apoptosis and NLRP3 Inflammasome Activation. | Blocking CXC Motif Chemokine Ligand 2 Ameliorates Diabetic Peripheral Neuropathy via Inhibiting Apoptosis and NLRP3 Inflammasome Activation.
Zhang Y, Li C, Wang Z, Wang T, Zhou Y, Zheng L. | 08/25/2023 |
| Rat peri-implant soft tissue specifically expressed CXCL2 on titanium implant during wound healing. | Rat peri-implant soft tissue specifically expressed CXCL2 on titanium implant during wound healing.
Asami Y, Sasaki H, Harada A, Hanazawa K, Kobayashi T, Mori G, Yajima Y. | 04/9/2022 |
| CXCL2 inhibits axon outgrowth of dorsal root ganglia neurons. | CXCL1 and CXCL2 Inhibit the Axon Outgrowth in a Time- and Cell-Type-Dependent Manner in Adult Rat Dorsal Root Ganglia Neurons.
Deftu AT, Ciorescu R, Gheorghe RO, Mihăilescu D, Ristoiu V. | 01/25/2020 |
| Although infarct volumes did not differ, septic embolic stroke caused higher mortality than sterile embolic stroke. Brain abscesses were observed only in the septic group. Approximately 400-500 fold increases were observed for Orm1 and Cxcl2 respectively in the septic group compared to the sterile group, and these were the most dramatically regulated genes in septic embolic stroke compared to sterile embolic stroke. | Staphylococcus aureus infected embolic stroke upregulates Orm1 and Cxcl2 in a rat model of septic stroke pathology.
Astrup LB, Skovgaard K, Rasmussen RS, Iburg TM, Agerholm JS, Aalbæk B, Jensen HE, Nielsen OL, Johansen FF, Heegaard PMH, Leifsson PS. | 04/20/2019 |
| The results showed that after short-term incubation both CXCL1 and CXCL2 can activate TRPV1+/IB4+ DRG neurons by significantly reducing TRPV1 desensitization, while at acute application both chemokines induced an increase in [Ca2+]i although of different amplitudes, in a subset of neurons partially also itch-sensitive in the case of CXCL1, or non-itch sensitive in the case of CXCL2. | Chemokine (C-X-C motif) ligand 1 (CXCL1) and chemokine (C-X-C motif) ligand 2 (CXCL2) modulate the activity of TRPV1+/IB4+ cultured rat dorsal root ganglia neurons upon short-term and acute application.
Deftu AF, Filippi A, Shibsaki K, Gheorghe RO, Chiritoiu M, Ristoiu V. | 05/12/2018 |
| this study shows elevated expression of CINC-3 at the site of inflammation as well as their significant reflection in the circulation, thereby suggesting their frontline role in carrageenan-induced acute inflammation | Local and Systemic Profiles of Inflammatory Cytokines in Carrageenan-induced Paw Inflammation in Rats.
Annamalai P, Thangam EB. | 04/8/2017 |
| Quercetin might protect against acute lung injury in rats with sepsis by suppressing ICAM-1 and MIP-2 expression. | Protective effect of quercetin on acute lung injury in rats with sepsis and its influence on ICAM-1 and MIP-2 expression.
Meng L, Lv Z, Yu ZZ, Xu D, Yan X. | 03/4/2017 |
| rutin is a potential protective agent in spinal cord injury enhancing the neurotrophic effect by inhibiting the expression of MIP-2 and activation of MMP-9, and downregulating the expression of p-Akt. | Effect of rutin on spinal cord injury through inhibition of the expression of MIP-2 and activation of MMP-9, and downregulation of Akt phosphorylation.
Zhang P, Ma X. | 09/3/2016 |
| IL-1beta-mediated regulation of the CXCL1 and CXCL2 genes in pancreatic beta-cells requires stimulus-induced changes in histone chemical modifications, recruitment of the NF-kappaB and STAT1 transcription factors to genomic regulatory sequences within the proximal gene promoters, and increases in phosphorylated forms of RNA polymerase II. | NF-κB and STAT1 control CXCL1 and CXCL2 gene transcription.
Burke SJ, Lu D, Sparer TE, Masi T, Goff MR, Karlstad MD, Collier JJ., Free PMC Article | 03/15/2014 |
| The rat spiral ligament fibrocytes were found to release CXCL2 in response to nontypeable H. influenzae via activation of c-Jun, leading to the recruitment of polymorphonuclear cells to the cochlea. | ERK2-dependent activation of c-Jun is required for nontypeable Haemophilus influenzae-induced CXCL2 upregulation in inner ear fibrocytes.
Oh S, Woo JI, Lim DJ, Moon SK., Free PMC Article | 06/9/2012 |
| CsA has no significant effect on serum levels of MCP-1 and MIP-2 following renal transplantation in rats. | [Dynamic changes of serum MCP-1 and MIP-2 chemokines after renal transplantation in rats].
Yao H, Yu JJ. | 04/2/2011 |
| Results identify FQHPSFI peptide may be used for the modulation of lipopolysaccharide-stimulated MIP-2 production in alveolar macrophagess. | A FQHPSFI peptide selectively binds to LPS-activated alveolar macrophages and inhibits LPS-induced MIP-2 production.
Ding N, Xiao H, Wang F, Xu L, She S. | 11/27/2010 |
| MIP-2/CXCL2 and MCP-1/CCL2 are increased after injury, and neurons appear to be the source of this expression. Chemokine expression was selectively inhibited by dexamethasone. | The temporal expression, cellular localization, and inhibition of the chemokines MIP-2 and MCP-1 after traumatic brain injury in the rat.
Rhodes JK, Sharkey J, Andrews PJ. | 01/21/2010 |
| demonstrated a novel role of thrombin: it stimulates the production of MCP-1 and MIP-2 by glomerular epithelial cells | Thrombin enhances the production of monocyte chemoattractant protein-1 and macrophage inflammatory protein-2 in cultured rat glomerular epithelial cells.
Fujita T, Yamabe H, Shimada M, Murakami R, Kumasaka R, Nakamura N, Osawa H, Okumura K. | 01/21/2010 |
| In summary, hyperalgesia, local PGE2 production, and spinal c-Fos expression occur after CFA-induced inflammation but not after CXCL1- or CXCL2/3-induced, selective PMN recruitment. | Selective local PMN recruitment by CXCL1 or CXCL2/3 injection does not cause inflammatory pain.
Rittner HL, Mousa SA, Labuz D, Beschmann K, Schäfer M, Stein C, Brack A. | 01/21/2010 |
| The TLR4 protein expression in rat type II cells is likely to be mediated by a heat-sensitive C. pneumoniae protein that induces a fast Ca2+-mediated NF-kappaB activity, necessary for maintenance of TLR4 expression and TNF-alpha and MIP-2. | Chlamydophila pneumoniae induces expression of toll-like receptor 4 and release of TNF-alpha and MIP-2 via an NF-kappaB pathway in rat type II pneumocytes.
Wissel H, Schulz C, Koehne P, Richter E, Maass M, Rüdiger M., Free PMC Article | 01/21/2010 |
| demonstrated that the beta-glucan component of the Pneumocystis carinii cell wall is able to stimulate alveolar epithelial cells to produce MIP-2 | Pneumocystis carinii beta-glucan induces release of macrophage inflammatory protein-2 from primary rat alveolar epithelial cells via a receptor distinct from CD11b/CD18.
Hahn PY, Limper AH. | 01/21/2010 |
| junctional epithelium cells produced MIP-2 and CINC-2 in response to LPS stimulation, suggesting that MIP-2 and CINC-2 may be responsible for PMN migration toward the periodontal pathogen and may play an important role in the initiation of inflammation | Immunolocalization of CXC chemokine and recruitment of polymorphonuclear leukocytes in the rat molar periodontal tissue after topical application of lipopolysaccharide.
Miyauchi M, Kitagawa S, Hiraoka M, Saito A, Sato S, Kudo Y, Ogawa I, Takata T. | 01/21/2010 |
| no significant differences were detected for MIP-2 levels in diabetic rats when compared with non-diabetic rats after hypoxia | MCP-1 and MIP-2 expression and production in BB diabetic rat: effect of chronic hypoxia.
Marisa C, Lucci I, Di Giulio C, Bianchi G, Grilli A, Patruno A, Reale M. | 01/21/2010 |
| role for the nitric oxide pathway in the overproduction of pro-inflammatory mediators IL-6 and MIP-2 during GBS-induced lung inflammation. | Nitric oxide-dependent regulation of pro-inflammatory cytokines in group B streptococcal inflammation of rat lung.
Raykova VD, Glibetic M, Ofenstein JP, Aranda JV. | 01/21/2010 |
| chemokine production by rat alveolar macrophages is inhibited by taurine chloramine | Chemokine production by rat alveolar macrophages is inhibited by taurine chloramine.
Liu Y, Quinn MR. | 01/21/2010 |
| macrophage inflammatory protein 2 mediates platelet-activating factor-induced intestinal injury | Macrophage inflammatory protein-2 mediates the bowel injury induced by platelet-activating factor.
Han XB, Liu X, Hsueh W, De Plaen IG. | 01/21/2010 |
| CINC, in contrast to MIP-2, is selectively transported from the lung to the systemic circulation, where it promotes neutrophil migration into the lung in response to a chemotactic stimulus. | Selective transport of cytokine-induced neutrophil chemoattractant from the lung to the blood facilitates pulmonary neutrophil recruitment.
Quinton LJ, Nelson S, Zhang P, Boé DM, Happel KI, Pan W, Bagby GJ. | 01/21/2010 |
| Following cecal ligation and puncture Cxcl2 production increases in the lung, setting the stage for neutrophil accumulation in lung during sepsis. | Divergent signaling pathways in phagocytic cells during sepsis.
Guo RF, Riedemann NC, Sun L, Gao H, Shi KX, Reuben JS, Sarma VJ, Zetoune FS, Ward PA. | 01/21/2010 |
| Data show that TII alveolar epithelial cells produce three of the major proinflammatory CXC chemokines (GRO, CINC-2alpha, and MIP-2) and their cognate receptor CXCR2. | CXC chemokines and their receptors are expressed in type II cells and upregulated following lung injury.
Vanderbilt JN, Mager EM, Allen L, Sawa T, Wiener-Kronish J, Gonzalez R, Dobbs LG. | 01/21/2010 |