| Nkx2-5 Regulates the Proliferation and Migration of H9c2 Cells. | Nkx2-5 Regulates the Proliferation and Migration of H9c2 Cells.
Wang H, Liu Y, Han S, Zi Y, Zhang Y, Kong R, Liu Z, Cai Z, Zhong C, Liu W, Li L, Jiang L., Free PMC Article | 05/29/2021 |
| Homocysteine downregulates cardiac homeobox transcription factor NKX2.5 via IGFBP5. | Homocysteine downregulates cardiac homeobox transcription factor NKX2.5 via IGFBP5.
Lai G, Wang L, Li Z, Zhao Y. | 01/2/2021 |
| The authors findings suggest that Nkx2.5, as a transcription factor, may be a regulatory element connecting different signaling pathways in response to oxidative stress and that reduced Nsd1 (Nuclear receptor-binding SET domain-containing protein 1) expression could lead to the alteration of global H3K36 and H4K20 methylation, influencing cardiac development. | Role of Nkx2.5 in H(2)O(2)-induced Nsd1 suppression.
Liang X, Chu G, Wang L, Lai G, Zhao Y., Free PMC Article | 06/13/2020 |
| The data indicated that inhibition of Smad4 diminished both AdBMP2 induced and basal histone acetylation levels in the promoter regions of GATA4 and Nkx2.5. | Smad4 mediated BMP2 signal is essential for the regulation of GATA4 and Nkx2.5 by affecting the histone H3 acetylation in H9c2 cells.
Si L, Shi J, Gao W, Zheng M, Liu L, Zhu J, Tian J. | 09/27/2014 |
| SIRT1 acts as a direct transcriptional target of Nkx2.5 that maintains cardiomyocyte homeostasis and survival. | SIRT1 mediates the protective function of Nkx2.5 during stress in cardiomyocytes.
Zheng W, Lu YB, Liang ST, Zhang QJ, Xu J, She ZG, Zhang ZQ, Yang RF, Mao BB, Xu Z, Li L, Hao DL, Lu J, Wei YS, Chen HZ, Liu DP. | 11/23/2013 |
| pacemaking cells originate from Nkx2.5 positive cardiac progenitor cells present in embryonic heart tubes | Endothelin-induced differentiation of Nkx2.5⁺ cardiac progenitor cells into pacemaking cells.
Zhang X, Guo JP, Chi YL, Liu YC, Zhang CS, Yang XQ, Lin HY, Jiang EP, Xiong SH, Zhang ZY, Liu BH. | 10/13/2012 |
| GATA-4 and Nkx2. 5 gene expression increased gradually in the course of mesenchymal stem cells differentiation into cardiomyocytes. | [The expression of GATA-4 and Nkx2.5 gene in the transformation of Rattus mesenchymal stem cells into cardiomyocytes].
Wu CX, Zhang EY, Yang SY, Ma JY, An Q, Shi YK. | 03/8/2010 |
| novel function for Nkx2.5 as a repressor of alpha-SMA gene transcription, which may be of homeostatic significance as a means of suppressing myofibroblast differentiation | Nkx2.5/Csx represses myofibroblast differentiation.
Hu B, Wu YM, Wu Z, Phan SH., Free PMC Article | 02/8/2010 |
| p300 acts as an Nkx2.5 cofactor and facilitates increased Nkx2.5 activity by relieving the conformational impediment of its inhibitory C-terminal domain. | Carboxyl terminus of Nkx2.5 impairs its interaction with p300.
Li T, Li YM, Jia ZQ, Chen P, Ma KT, Zhou CY. | 01/21/2010 |
| Nkx2.5 regulates expression of Ca2+ channels in neonatal heart. | Transcription factors Csx/Nkx2.5 and GATA4 distinctly regulate expression of Ca2+ channels in neonatal rat heart.
Wang Y, Morishima M, Zheng M, Uchino T, Mannen K, Takahashi A, Nakaya Y, Komuro I, Ono K. | 01/21/2010 |
| Endothelin-converting enzyme-1 is a downstream target of the homeobox transcription factor Nkx2-5. | Endothelin-converting enzyme-1 (ECE-1) is a downstream target of the homeobox transcription factor Nkx2-5.
Funke-Kaiser H, Lemmer J, Langsdorff CV, Thomas A, Kovacevic SD, Strasdat M, Behrouzi T, Zollmann FS, Paul M, Orzechowski HD. | 01/21/2010 |