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    Asic1 acid-sensing ion channel 1 [ Mus musculus (house mouse) ]

    Gene ID: 11419, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    ASIC1/RIP1 accelerates atherosclerosis via disrupting lipophagy.

    ASIC1/RIP1 accelerates atherosclerosis via disrupting lipophagy.
    Wang YM, Tang H, Tang YJ, Liu J, Yin YF, Tang YL, Feng YG, Gu HF., Free PMC Article

    10/1/2024
    Glutamate acts on acid-sensing ion channels to worsen ischaemic brain injury.

    Glutamate acts on acid-sensing ion channels to worsen ischaemic brain injury.
    Lai K, Pritišanac I, Liu ZQ, Liu HW, Gong LN, Li MX, Lu JF, Qi X, Xu TL, Forman-Kay J, Shi HB, Wang LY, Yin SK., Free PMC Article

    07/31/2024
    Inhibition of ASIC1a Improves Behavioral Recovery after Stroke.

    Inhibition of ASIC1a Improves Behavioral Recovery after Stroke.
    Armstrong A, Yang T, Leng T, Xiong ZG., Free PMC Article

    02/20/2024
    ASIC1a affects hypothalamic signaling and regulates the daily rhythm of body temperature in mice.

    ASIC1a affects hypothalamic signaling and regulates the daily rhythm of body temperature in mice.
    Peng Z, Ziros PG, Martini T, Liao XH, Stoop R, Refetoff S, Albrecht U, Sykiotis GP, Kellenberger S., Free PMC Article

    08/22/2023
    Acid-sensing ion channel 1a exacerbates renal ischemia-reperfusion injury through the NF-kappaB/NLRP3 inflammasome pathway.

    Acid-sensing ion channel 1a exacerbates renal ischemia-reperfusion injury through the NF-κB/NLRP3 inflammasome pathway.
    Yang Y, Jin S, Zhang J, Chen W, Lu Y, Chen J, Yan Z, Shen B, Ning Y, Shi Y, Chen J, Wang J, Xu S, Jia P, Teng J, Fang Y, Song N, Ding X., Free PMC Article

    06/29/2023
    Acid-sensitive ion channel 1a regulates TNF-alpha expression in LPS-induced acute lung injury via ERS-CHOP-C/EBPalpha signaling pathway.

    Acid-sensitive ion channel 1a regulates TNF-α expression in LPS-induced acute lung injury via ERS-CHOP-C/EBPα signaling pathway.
    Liu Y, Zhu Y, Wang L, Li K, Du N, Pan X, Li Y, Cao R, Li B, Lin H, Song Y, Zhang Y, Wu X, Hu C, Wang Y, Liao S, Huang Y.

    01/28/2023
    Acid-sensing ion channel 1a activates IKCa/SKCa channels and contributes to endothelium-dependent dilation.

    Acid-sensing ion channel 1a activates IKCa/SKCa channels and contributes to endothelium-dependent dilation.
    Garcia SM, Naik JS, Resta TC, Jernigan NL., Free PMC Article

    12/31/2022
    Knockdown of Acid-sensing Ion Channel 1a in the PVN Promotes Metabolic Disturbances in Male Mice.

    Knockdown of Acid-sensing Ion Channel 1a in the PVN Promotes Metabolic Disturbances in Male Mice.
    Wang W, Xu M, Yue J, Zhang Q, Nie X, Jin Y, Zhang Z.

    08/27/2022
    Acid-sensing ion channel 1a regulates the specificity of reconsolidation of conditioned threat responses.

    Acid-sensing ion channel 1a regulates the specificity of reconsolidation of conditioned threat responses.
    Koffman EE, Kruse CM, Singh K, Naghavi FS, Curtis MA, Egbo J, Houdi M, Lin B, Lu H, Debiec J, Du J., Free PMC Article

    04/2/2022
    Activation of acid-sensing ion channels by carbon dioxide regulates amygdala synaptic protein degradation in memory reconsolidation.

    Activation of acid-sensing ion channels by carbon dioxide regulates amygdala synaptic protein degradation in memory reconsolidation.
    Lin B, Alganem K, O'Donovan SM, Jin Z, Naghavi F, Miller OA, Ortyl TC, Ruan YC, McCullumsmith RE, Du J., Free PMC Article

    01/22/2022
    C-Jun N-Terminal Kinase Post-Translational Regulation of Pain-Related Acid-Sensing Ion Channels 1b and 3.

    C-Jun N-Terminal Kinase Post-Translational Regulation of Pain-Related Acid-Sensing Ion Channels 1b and 3.
    Verkest C, Diochot S, Lingueglia E, Baron A., Free PMC Article

    11/27/2021
    Acid-sensing ion channel 1 contributes to pulmonary arterial smooth muscle cell depolarization following hypoxic pulmonary hypertension.

    Acid-sensing ion channel 1 contributes to pulmonary arterial smooth muscle cell depolarization following hypoxic pulmonary hypertension.
    Jernigan NL, Naik JS, Resta TC., Free PMC Article

    11/22/2021
    Upregulation of acid sensing ion channel 1a (ASIC1a) by hydrogen peroxide through the JNK pathway.

    Upregulation of acid sensing ion channel 1a (ASIC1a) by hydrogen peroxide through the JNK pathway.
    Wu BM, Bargaineer J, Zhang L, Yang T, Xiong ZG, Leng TD., Free PMC Article

    11/6/2021
    ASIC1a is required for neuronal activation via low-intensity ultrasound stimulation in mouse brain.

    ASIC1a is required for neuronal activation via low-intensity ultrasound stimulation in mouse brain.
    Lim J, Tai HH, Liao WH, Chu YC, Hao CM, Huang YC, Lee CH, Lin SS, Hsu S, Chien YC, Lai DM, Chen WS, Chen CC, Wang JL., Free PMC Article

    10/30/2021
    Upregulation of ASIC1a channels in an in vitro model of Fabry disease.

    Upregulation of ASIC1a channels in an in vitro model of Fabry disease.
    Castellanos LCS, Rozenfeld P, Gatto RG, Reisin RC, Uchitel OD, Weissmann C.

    09/4/2021
    Protein Kinase C Regulates ASIC1a Protein Expression and Channel Function via NF-kB Signaling Pathway.

    Protein Kinase C Regulates ASIC1a Protein Expression and Channel Function via NF-kB Signaling Pathway.
    Zhang L, Leng TD, Yang T, Li J, Xiong ZG.

    07/3/2021
    Determinants of ion selectivity in ASIC1a- and ASIC2a-containing acid-sensing ion channels.

    Determinants of ion selectivity in ASIC1a- and ASIC2a-containing acid-sensing ion channels.
    Lynagh T, Flood E, Boiteux C, Sheikh ZP, Allen TW, Pless SA., Free PMC Article

    06/12/2021
    The interaction of ASIC1a and ERS mediates nerve cell apoptosis induced by insulin deficiency.

    The interaction of ASIC1a and ERS mediates nerve cell apoptosis induced by insulin deficiency.
    Pan X, Zhu Y, Wu X, Liu L, Ying R, Wang L, Du N, Zhang J, Jin J, Meng X, Dai F, Huang Y.

    05/22/2021
    ASIC1a regulates miR-350/SPRY2 by N(6) -methyladenosine to promote liver fibrosis.

    ASIC1a regulates miR-350/SPRY2 by N(6) -methyladenosine to promote liver fibrosis.
    Zhu Y, Pan X, Du N, Li K, Hu Y, Wang L, Zhang J, Liu Y, Zuo L, Meng X, Hu C, Wu X, Jin J, Wu W, Chen X, Wu F, Huang Y.

    05/1/2021
    Failed Neuroprotection of Combined Inhibition of L-Type and ASIC1a Calcium Channels with Nimodipine and Amiloride.

    Failed Neuroprotection of Combined Inhibition of L-Type and ASIC1a Calcium Channels with Nimodipine and Amiloride.
    Ort J, Kremer B, Grüßer L, Blaumeiser-Debarry R, Clusmann H, Coburn M, Höllig A, Lindauer U., Free PMC Article

    03/6/2021
    ASIC1a channels regulate mitochondrial ion signaling and energy homeostasis in neurons.

    ASIC1a channels regulate mitochondrial ion signaling and energy homeostasis in neurons.
    Savic Azoulay I, Liu F, Hu Q, Rozenfeld M, Ben Kasus Nissim T, Zhu MX, Sekler I, Xu TL., Free PMC Article

    09/5/2020
    Mechanism and site of action of big dynorphin on ASIC1a.

    Mechanism and site of action of big dynorphin on ASIC1a.
    Borg CB, Braun N, Heusser SA, Bay Y, Weis D, Galleano I, Lund C, Tian W, Haugaard-Kedström LM, Bennett EP, Lynagh T, Strømgaard K, Andersen J, Pless SA., Free PMC Article

    08/15/2020
    ASIC1a localized in the proximal tubular and contributed to ischemia/reperfusion induced kidney injury.

    Acid-sensing ion channel 1a is involved in ischaemia/reperfusion induced kidney injury by increasing renal epithelia cell apoptosis.
    Song N, Lu Z, Zhang J, Shi Y, Ning Y, Chen J, Jin S, Shen B, Fang Y, Zou J, Teng J, Chu XP, Shen L, Ding X., Free PMC Article

    07/18/2020
    Activation of ASIC1A, particularly in neurons, is critical for CO2-induced nitric oxide production and vasodilation.

    Acid-Sensing Ion Channels: Novel Mediators of Cerebral Vascular Responses.
    Faraci FM, Taugher RJ, Lynch C, Fan R, Gupta S, Wemmie JA., Free PMC Article

    06/27/2020
    A role was found for anterior cingulate cortex located ASIC1a in pain hypersensitivity through promoting long-term synaptic potentiation.

    Protein Kinase C Lambda Mediates Acid-Sensing Ion Channel 1a-Dependent Cortical Synaptic Plasticity and Pain Hypersensitivity.
    Li HS, Su XY, Song XL, Qi X, Li Y, Wang RQ, Maximyuk O, Krishtal O, Wang T, Fang H, Liao L, Cao H, Zhang YQ, Zhu MX, Liu MG, Xu TL., Free PMC Article

    06/20/2020
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