| The role of placental kisspeptin in trophoblast invasion and migration: an assessment in Kiss1r knockout mice, BeWo cell lines and human term placenta. | The role of placental kisspeptin in trophoblast invasion and migration: an assessment in Kiss1r knockout mice, BeWo cell lines and human term placenta.
Panting EN, Weight JH, Sartori JA, Coall DA, Smith JT. | 08/1/2024 |
| Uterine kisspeptin receptor critically regulates epithelial estrogen receptor alpha transcriptional activity at the time of embryo implantation in a mouse model. | Uterine kisspeptin receptor critically regulates epithelial estrogen receptor α transcriptional activity at the time of embryo implantation in a mouse model.
Schaefer J, Vilos AG, Vilos GA, Bhattacharya M, Babwah AV., Free PMC Article | 03/19/2022 |
| KISS1/KISS1R mediates Sertoli cell apoptosis via the PI3K/AKT signalling pathway in a highglucose environment. | KISS1/KISS1R mediates Sertoli cell apoptosis via the PI3K/AKT signalling pathway in a high‑glucose environment.
Gan DM, Zhang PP, Zhang JP, Ding SX, Fang J, Liu Y. | 05/15/2021 |
| These findings suggest that the previously observed obesity and decreased metabolism in global Kiss1r KOs reflect impaired kisspeptin signaling in non-BAT tissues. | Conditional knockout of kisspeptin signaling in brown adipose tissue increases metabolic rate and body temperature and lowers body weight.
Tolson KP, Marooki N, De Bond JP, Walenta E, Stephens SBZ, Liaw RB, Savur R, Wolfe A, Oh DY, Smith JT, Kauffman AS., Free PMC Article | 07/18/2020 |
| Loss of Kiss1r expression is associated with hypogonadal, obese, and metabolically-impaired phenotype. | Cre/lox generation of a novel whole-body Kiss1r KO mouse line recapitulates a hypogonadal, obese, and metabolically-impaired phenotype.
Tolson KP, Marooki N, Wolfe A, Smith JT, Kauffman AS., Free PMC Article | 06/27/2020 |
| deletion from all cells but GnRH neurons abolishes the effect of kisspeptin on prolactin secretion | Kisspeptin Stimulation of Prolactin Secretion Requires Kiss1 Receptor but Not in Tuberoinfundibular Dopaminergic Neurons.
Aquino NSS, Kokay IC, Perez CT, Ladyman SR, Henriques PC, Silva JF, Broberger C, Grattan DR, Szawka RE. | 12/14/2019 |
| we demonstrate that in the presence of E2, NKB signaling induces LH release in a kisspeptin-independent manner through the activation of NK3R (NKB receptor) neurons in the posterodorsal medial amygdala (MePD). Importantly, we show that chemogenetic activation of MePD Kiss1 neurons induces LH release, however, the stimulatory action of NKB in this area is Kiss1 neuron-independent. | NKB signaling in the posterodorsal medial amygdala stimulates gonadotropin release in a kisspeptin-independent manner in female mice.
Fergani C, Leon S, Padilla SL, Verstegen AM, Palmiter RD, Navarro VM., Free PMC Article | 03/30/2019 |
| These lines of evidence suggest that downregulation of Ob-R and kisspeptin/GPR54 in the murine hypothalamus may contribute to male hypogonadism caused by high-fat diet-induced obesity. | Downregulation of leptin receptor and kisspeptin/GPR54 in the murine hypothalamus contributes to male hypogonadism caused by high-fat diet-induced obesity.
Zhai L, Zhao J, Zhu Y, Liu Q, Niu W, Liu C, Wang Y. | 02/16/2019 |
| G-protein coupled receptor 54 (GPR54) deficiency leads to elevated experimental autoimmune encephalomyelitis (EAE) disease severity independent of the reproductive axis. GPR54 deficiency leads to impaired immunotolerance in association with reduced number of Regulatory T-Lymphocytes, increased T-cell activation, and altered thymocyte subsets. | GPR54 deficiency reduces the Treg population and aggravates experimental autoimmune encephalomyelitis in mice.
Xing R, Liu F, Yang Y, Cui X, Wang T, Xie L, Zhao Y, Fang L, Yi T, Zheng B, Liu M, Chen H. | 12/22/2018 |
| while uterine growth was fully rescued by E2 treatment of Kiss1(-/-) mice and by genetic restoration of kisspeptin signaling in GnRH neurons in Kiss1r(-/-) mice, functional adenogenesis was only marginally restored. Thus, while uterine growth is largely dependent on ovarian E2-output via central kisspeptin signaling, peripheral kisspeptin signaling is indispensable for endometrial adenogenesis and function | Beyond the brain-Peripheral kisspeptin signaling is essential for promoting endometrial gland development and function.
León S, Fernandois D, Sull A, Sull J, Calder M, Hayashi K, Bhattacharya M, Power S, Vilos GA, Vilos AG, Tena-Sempere M, Babwah AV., Free PMC Article | 05/19/2018 |
| Study found unaltered hypothalamic metabolic gene expression in Kiss1 receptor knockout mice despite obesity and reduced energy expenditure. | Unaltered Hypothalamic Metabolic Gene Expression in Kiss1r Knockout Mice Despite Obesity and Reduced Energy Expenditure.
De Bond JP, Tolson KP, Nasamran C, Kauffman AS, Smith JT., Free PMC Article | 01/13/2018 |
| Nesfatin-1 increased Kiss1R expression in hypothalamic cells. | Gonadotropin-releasing hormone, kisspeptin, and gonadal steroids directly modulate nucleobindin-2/nesfatin-1 in murine hypothalamic gonadotropin-releasing hormone neurons and gonadotropes.
Hatef A, Unniappan S. | 11/26/2017 |
| Kisspeptin-10 may contribute to accelerate the progression and instability of atheromatous plaques, leading to plaque rupture. The GPR54 antagonist may be useful for prevention and treatment of atherosclerosis. | Potent Vasoconstrictor Kisspeptin-10 Induces Atherosclerotic Plaque Progression and Instability: Reversal by its Receptor GPR54 Antagonist.
Sato K, Shirai R, Hontani M, Shinooka R, Hasegawa A, Kichise T, Yamashita T, Yoshizawa H, Watanabe R, Matsuyama TA, Ishibashi-Ueda H, Koba S, Kobayashi Y, Hirano T, Watanabe T., Free PMC Article | 10/28/2017 |
| data suggest the utility of the KISS1R as a novel biomarker for multiple myeloma, capable of targeting both tumor cells and host cells of the tumor microenvironment | The KISS1 Receptor as an In Vivo Microenvironment Imaging Biomarker of Multiple Myeloma Bone Disease.
Dotterweich J, Tower RJ, Brandl A, Müller M, Hofbauer LC, Beilhack A, Ebert R, Glüer CC, Tiwari S, Schütze N, Jakob F., Free PMC Article | 07/29/2017 |
| kiss1 and kiss1r mRNA levels were significantly higher in old compared to reproductive-aged mice, and diet-induced obesity did not alter kiss1 or kiss1r mRNA levels. Compared to young control mice, young MCP-1 knockout mice had significantly lower ovarian kiss1 mRNA | Ovarian kisspeptin expression is related to age and to monocyte chemoattractant protein-1.
Merhi Z, Thornton K, Bonney E, Cipolla MJ, Charron MJ, Buyuk E., Free PMC Article | 12/17/2016 |
| On D4 of pregnancy, the mouse uterus expresses a functional kisspeptin/KISS1R signaling system. | The pregnant mouse uterus exhibits a functional kisspeptin/KISS1R signaling system on the day of embryo implantation.
Fayazi M, Calder M, Bhattacharya M, Vilos GA, Power S, Babwah AV., Free PMC Article | 05/28/2016 |
| Gnaq was selectively inactivated in GnRH neurons of global Gna11--null mice, but they still responded to kisspeptin, confirming that KISS1R signals via non-Galphaq/11-coupled pathways. | GnRH Neuron-Specific Ablation of Gαq/11 Results in Only Partial Inactivation of the Neuroendocrine-Reproductive Axis in Both Male and Female Mice: In Vivo Evidence for Kiss1r-Coupled Gαq/11-Independent GnRH Secretion.
Babwah AV, Navarro VM, Ahow M, Pampillo M, Nash C, Fayazi M, Calder M, Elbert A, Urbanski HF, Wettschureck N, Offermanns S, Carroll RS, Bhattacharya M, Tobet SA, Kaiser UB., Free PMC Article | 01/16/2016 |
| orchestrated onset of kisspeptin and GPR54 expression in the male embryonic brain at embryonic day 13.5 | In Utero Development of Kisspeptin/GnRH Neural Circuitry in Male Mice.
Kumar D, Periasamy V, Freese M, Voigt A, Boehm U. | 11/21/2015 |
| Results demonstrate defective negative feedback in global Gpr54-null mice that cannot be attributed to a lack of prior exposure of the gonadotropin-releasing hormone neuronal network to cyclical estradiol | Kisspeptin-gpr54 signaling at the GnRH neuron is necessary for negative feedback regulation of luteinizing hormone secretion in female mice.
Yeo SH, Clarkson J, Herbison AE. | 10/3/2015 |
| Expression of Kiss1 and Gpr54 was confirmed in mouse placenta but no differences in birth weight were found in mice that had been supported by a mutant placenta during fetal development. | Kiss1 mutant placentas show normal structure and function in the mouse.
Herreboudt AM, Kyle VR, Lawrence J, Doran J, Colledge WH., Free PMC Article | 08/22/2015 |
| Kiss1/GPR54 system is involved in promoting uterine decidualization during early pregnancy in mice | Expression and function of kisspeptin during mouse decidualization.
Zhang P, Tang M, Zhong T, Lin Y, Zong T, Zhong C, Zhang B, Ren M, Kuang H., Free PMC Article | 01/31/2015 |
| Kiss1r in GnRH neurons is critical for reproductive development and fertility. | Disrupted kisspeptin signaling in GnRH neurons leads to hypogonadotrophic hypogonadism.
Novaira HJ, Sonko ML, Hoffman G, Koo Y, Ko C, Wolfe A, Radovick S., Free PMC Article | 01/10/2015 |
| kisspeptin-1 and Kiss1r signaling influences BW, energy expenditure, and glucose homeostasis in a sexually dimorphic and partially sex steroid-independent manner | Impaired kisspeptin signaling decreases metabolism and promotes glucose intolerance and obesity.
Tolson KP, Garcia C, Yen S, Simonds S, Stefanidis A, Lawrence A, Smith JT, Kauffman AS., Free PMC Article | 10/11/2014 |
| kisspeptin receptor (Kiss1r), a GPCR that is activated by kisspeptin to regulate the onset of puberty and adult reproductive function, is enriched in cilia projecting from mouse | Primary cilia enhance kisspeptin receptor signaling on gonadotropin-releasing hormone neurons.
Koemeter-Cox AI, Sherwood TW, Green JA, Steiner RA, Berbari NF, Yoder BK, Kauffman AS, Monsma PC, Brown A, Askwith CC, Mykytyn K., Free PMC Article | 09/20/2014 |
| Oocytes fail to respond to gonadotropins with increased trk-B tyrosine kinase (Ntrk)2 expression in the absence of KISS1R | Loss of Ntrk2/Kiss1r signaling in oocytes causes premature ovarian failure.
Dorfman MD, Garcia-Rudaz C, Alderman Z, Kerr B, Lomniczi A, Dissen GA, Castellano JM, Garcia-Galiano D, Gaytan F, Xu B, Tena-Sempere M, Ojeda SR., Free PMC Article | 09/20/2014 |