| Mice lacking alpha4 nicotinic acetylcholine receptors are protected against alcohol-associated liver injury. | Mice lacking α4 nicotinic acetylcholine receptors are protected against alcohol-associated liver injury.
Watson WH, Ritzenthaler JD, Torres-Gonzalez E, Arteel GE, Roman J., Free PMC Article | 09/3/2022 |
| alpha4beta2 nicotinic acetylcholine receptors intrinsically influence body weight in mice. | α4β2 nicotinic acetylcholine receptors intrinsically influence body weight in mice.
Dezfuli G, Olson TT, Martin LM, Keum Y, Siegars BA, Desai A, Uitz M, Sahibzada N, Gillis RA, Kellar KJ. | 04/3/2021 |
| Following alpha4beta2 nAChR stimulation, activated PKCbetaII translocated to the plasma membrane to induce clathrin-mediated endocytosis of D3R, resulting in downregulation and signal inhibition. | α4β2 nicotinic acetylcholine receptor downregulates D(3) dopamine receptor expression through protein kinase C activation.
Acharya S, Kim KM. | 06/20/2020 |
| Serine residues S336, S470 and S530 in Chrna4 protein have a brain region dependent modulatory role on surface alpha4beta2 nicotinic receptor expression. | Serine residues in the α4 nicotinic acetylcholine receptor subunit regulate surface α4β2(*) receptor expression and clustering.
Zambrano CA, Escobar D, Ramos-Santiago T, Bollinger I, Stitzel J., Free PMC Article | 09/7/2019 |
| The numbers of nAChR alpha4 immuno-positive cells and western blot levels were significally increased by 15-Hz auricular electrical stimulation in the hippocampal CA2 output cortex. The numbers of choline acetyltransferase (ChAT) - a key enzyme for biosynthesis of ACh - immuno-positive cells and western blot levels had no significant differences. | Short-term auricular electrical stimulation rapidly elevated cortical blood flow and promoted the expression of nicotinic acetylcholine receptor α4 in the 2 vessel occlusion rats model.
Huang TH, Lin YW, Huang CP, Chen JM, Hsieh CL., Free PMC Article | 08/3/2019 |
| Acetylcholine tone fine-tunes the firing properties of Dopamine (DA) neurons of the ventral tegmental area through beta2-containing (beta2*) nicotinic Acetylcholine receptors. | Manipulating midbrain dopamine neurons and reward-related behaviors with light-controllable nicotinic acetylcholine receptors.
Durand-de Cuttoli R, Mondoloni S, Marti F, Lemoine D, Nguyen C, Naudé J, d'Izarny-Gargas T, Pons S, Maskos U, Trauner D, Kramer RH, Faure P, Mourot A., Free PMC Article | 01/12/2019 |
| Data suggest that receptor complex assembly from Chrna4 and Chrnb2 on neuronal cell surface is up-regulated by nicotine; combined effects of increased assembly stoichiometry and preferential trafficking likely drive up-regulation of this receptor complex on neuronal cell surface upon nicotine exposure. (Chrna4 = a4 nicotinic receptor; Chrnb2 = b2 nicotinic receptor) | Organelle-specific single-molecule imaging of α4β2 nicotinic receptors reveals the effect of nicotine on receptor assembly and cell-surface trafficking.
Fox-Loe AM, Moonschi FH, Richards CI., Free PMC Article | 11/17/2018 |
| Results suggest that alpha4beta2( *) nAChRs can produce sustained regulation of inhibitory post-synaptic GABA currents, in fast-spiking layer V neurons of the mouse frontal area 2. | α4β2(∗) nicotinic receptors stimulate GABA release onto fast-spiking cells in layer V of mouse prefrontal (Fr2) cortex.
Aracri P, Meneghini S, Coatti A, Amadeo A, Becchetti A., Free PMC Article | 11/11/2017 |
| Mice lacking alpha4 subunits in ventral midbrain consumed significantly more nicotine at the highest offered nicotine concentration compared to control mice. | Altered nicotine reward-associated behavior following α4 nAChR subunit deletion in ventral midbrain.
Peng C, Engle SE, Yan Y, Weera MM, Berry JN, Arvin MC, Zhao G, McIntosh JM, Chester JA, Drenan RM., Free PMC Article | 09/30/2017 |
| Varenicline treatment may prevent scopolamine-induced memory disturbance by a molecular mechanism that may involve increased alpha4beta2 nAChR availability. Varenicline dose-dependently increased protein expression of both the alpha4 and beta2 subunit in cell cultures and brain tissues, respectively, but had no effect on mRNA expression; lack of change in mRNA expression suggests a still unknown post-transcriptional me... | Effects of varenicline on alpha4-containing nicotinic acetylcholine receptor expression and cognitive performance in mice.
Lange-Asschenfeldt C, Schäble S, Suvorava T, Fahimi EG, Bisha M, Stermann T, Henning U, Kojda G. | 06/24/2017 |
| Results demonstrate that high-affinity alpha4beta2 nicotinic acetylcholine receptors are necessary for the effects of acute nicotine on contextual fear extinction. | High-affinity α4β2 nicotinic receptors mediate the impairing effects of acute nicotine on contextual fear extinction.
Kutlu MG, Holliday E, Gould TJ., Free PMC Article | 10/29/2016 |
| Data show alpha4 subunit role in conferring potentiation by 17beta-estradiol (BEST) and indicate that the C-terminal region is involved in both binding of betaEST and potentiation, while the N-terminal domain seems involved in enhancing its efficacy. | Potentiation of Neuronal Nicotinic Receptors by 17β-Estradiol: Roles of the Carboxy-Terminal and the Amino-Terminal Extracellular Domains.
Jin X, Steinbach JH., Free PMC Article | 07/2/2016 |
| The alpha4 nAChR subunit is regulated by protein kinase C epsilon phosphorylation. | PKCε phosphorylates α4β2 nicotinic ACh receptors and promotes recovery from desensitization.
Lee AM, Wu DF, Dadgar J, Wang D, McMahon T, Messing RO., Free PMC Article | 05/14/2016 |
| neuroinflammation is sufficient to provoke the decrease of a7 and a4b2 nAChRs, Ab42 accumulation and memory impairment in mice and a7(1-208) nAChR-specific antibodies can cause inflammation of the brain with symptoms typical for Alzheimer disease. | α7 Nicotinic acetylcholine receptor-specific antibody induces inflammation and amyloid β42 accumulation in the mouse brain to impair memory.
Lykhmus O, Voytenko L, Koval L, Mykhalskiy S, Kholin V, Peschana K, Zouridakis M, Tzartos S, Komisarenko S, Skok M., Free PMC Article | 02/27/2016 |
| Lynx2 and Ly6g6e have roles in intracellular trafficking and allosteric potentiation of alpha4beta2 nAChRs, respectively | Mechanisms of inhibition and potentiation of α4β2 nicotinic acetylcholine receptors by members of the Ly6 protein family.
Wu M, Puddifoot CA, Taylor P, Joiner WJ., Free PMC Article | 01/16/2016 |
| cotinine alters the assembly and trafficking of alpha4beta2 nicotinic acetylcholine receptors | The nicotine metabolite, cotinine, alters the assembly and trafficking of a subset of nicotinic acetylcholine receptors.
Fox AM, Moonschi FH, Richards CI., Free PMC Article | 01/16/2016 |
| The study shows that nAChR alpha4 beta2 sensitizes a MAPK-linked toxicity pathway on prolonged exposure to ABETA (1-42). | Nicotinic Acetylcholine Receptors Sensitize a MAPK-linked Toxicity Pathway on Prolonged Exposure to β-Amyloid.
Arora K, Cheng J, Nichols RA., Free PMC Article | 12/12/2015 |
| This study has revealed complex effects of Chrna4 deficiency and prenatal nicotine exposure on ventilatory and metabolic interactions and responses to stress. | Prenatal nicotine exposure increases hyperventilation in α4-knock-out mice during mild asphyxia.
Avraam J, Cohen G, Drago J, Frappell PB. | 11/14/2015 |
| It indicated that Correlation between nAChalpha4-, 5-HT1A- and 5-HT7-containing receptors and latencies on day 16 may point to a probable link in extinction mechanisms. | A hippocampal nicotinic acetylcholine alpha 7-containing receptor complex is linked to memory retrieval in the multiple-T-maze in C57BL/6j mice.
Subramaniyan S, Heo S, Patil S, Li L, Hoger H, Pollak A, Lubec G. | 08/8/2015 |
| These results question the conclusion that a dominant-negative mechanism would explain the dominance of the mutant L501fsX533 Fz4 allele in the transmission of a form of Familial exudative vitreoretinopathy. | ER reorganization is remarkably induced in COS-7 cells accumulating transmembrane protein receptors not competent for export from the endoplasmic reticulum.
D'Agostino M, Crespi A, Polishchuk E, Generoso S, Martire G, Colombo SF, Bonatti S. | 06/27/2015 |
| Study demonstrates that chronic pre-exposure to nicotine at a dosing regimen that results in maximal alpha4 nAChR upregulation results in significantly elevated oral nicotine self-administration in a two-bottle choice paradigm in mice | Chronic nicotine pretreatment is sufficient to upregulate α4* nicotinic receptors and increase oral nicotine self-administration in mice.
Renda A, Nashmi R., Free PMC Article | 03/21/2015 |
| Lynx1 has a role in shifting alpha4beta2 nicotinic receptor subunit stoichiometry by affecting assembly in the endoplasmic reticulum | Lynx1 shifts α4β2 nicotinic receptor subunit stoichiometry by affecting assembly in the endoplasmic reticulum.
Nichols WA, Henderson BJ, Yu C, Parker RL, Richards CI, Lester HA, Miwa JM., Free PMC Article | 01/24/2015 |
| these data indicate that a4-nAChR have an impact on motor output. | A role for α4(non-α6)* nicotinic acetylcholine receptors in motor behavior.
Soll LG, Grady SR, Salminen O, Marks MJ, Tapper AR., Free PMC Article | 08/16/2014 |
| Cerebral cortex alpha4 nAChR subunits increased in rats given nicotine or varenicline, but subunits from rats given saline or saz-A during the phase 2 treatment were not significantly different from all-phase saline controls. | Chronic sazetidine-A maintains anxiolytic effects and slower weight gain following chronic nicotine without maintaining increased density of nicotinic receptors in rodent brain.
Hussmann GP, DeDominicis KE, Turner JR, Yasuda RP, Klehm J, Forcelli PA, Xiao Y, Richardson JR, Sahibzada N, Wolfe BB, Lindstrom J, Blendy JA, Kellar KJ., Free PMC Article | 06/21/2014 |
| a new mechanism of alpha4 nAChR signaling and immune regulation in T cells, possibly accounting for the effect of smoking on the immune system. | The α4 nicotinic receptor promotes CD4+ T-cell proliferation and a helper T-cell immune response.
Nordman JC, Muldoon P, Clark S, Damaj MI, Kabbani N., Free PMC Article | 03/8/2014 |