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    Dlk1 delta like non-canonical Notch ligand 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114587, updated on 9-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The pituitary tumour-transforming gene 1/delta-like homologue 1 pathway plays a key role in liver fibrogenesis.

    The pituitary tumour-transforming gene 1/delta-like homologue 1 pathway plays a key role in liver fibrogenesis.
    Perramón M, Carvajal S, Reichenbach V, Fernández-Varo G, Boix L, Macias-Muñoz L, Melgar-Lesmes P, Bruix J, Melmed S, Lamas S, Jiménez W., Free PMC Article

    03/12/2022
    Functional characterization of DLK1/MEG3 locus on chromosome 14q32.2 reveals the differentiation of pituitary neuroendocrine tumors.

    Functional characterization of DLK1/MEG3 locus on chromosome 14q32.2 reveals the differentiation of pituitary neuroendocrine tumors.
    Chen Y, Gao H, Liu Q, Xie W, Li B, Cheng S, Guo J, Fang Q, Zhu H, Wang Z, Wang J, Li C, Zhang Y., Free PMC Article

    05/15/2021
    Decreased Dlk1 expression relates to visceral fat expansion and insulin resistance in a rat model of catch-up growth following prenatal growth restriction

    Dlk1 expression relates to visceral fat expansion and insulin resistance in male and female rats with postnatal catch-up growth.
    Carreras-Badosa G, Remesar X, Prats-Puig A, Xargay-Torrent S, Lizarraga-Mollinedo E, de Zegher F, Ibáñez L, Bassols J, López-Bermejo A.

    07/11/2020
    Adipocyte progenitor cells are involved in the rat mesenteric lymph node (MLN) development through differentiation into fibroblastic reticular cells or follicular dendritic cells; expression of the relevant chemokines during the development of MLNs is dynamic and may be related to the maintenance of lymph nodes self-balance state.

    Expression of Pref-1 and Related Chemokines during theDevelopment of Rat Mesenteric Lymph Nodes.
    Peng Y, Jia LM, Li BX, Xie LP, Xie ZJ, Zheng JH.

    11/10/2018
    Neither of the two doses of FLX has significantly affected the Pref-1 expression in any type of adipose tissue.

    Chronic fluoxetine treatment induces lipid accumulation but does not alter the expression of Pref-1 in rat adipose tissue.
    Bába LI, Gáll Z, Bíró IL, Mezei T, Kun IZ, Kolcsár M.

    08/25/2018
    Pref-1 induces insulin synthesis and secretion via two independent pathways

    Preadipocyte factor 1 induces pancreatic ductal cell differentiation into insulin-producing cells.
    Rhee M, Lee SH, Kim JW, Ham DS, Park HS, Yang HK, Shin JY, Cho JH, Kim YB, Youn BS, Sul HS, Yoon KH., Free PMC Article

    04/8/2017
    The differential expression of FA1/dlk1 in the SNc and the striatum of dopamine-depleted rats could indicate a potential involvement of FA1/dlk1 in the cellular response to the degenerative processes.

    Characterization of fetal antigen 1/delta-like 1 homologue expressing cells in the rat nigrostriatal system: effects of a unilateral 6-hydroxydopamine lesion.
    Liechti R, Ducray AD, Jensen P, Di Santo S, Seiler S, Jensen CH, Meyer M, Widmer HR., Free PMC Article

    11/21/2015
    The Dlk1-Dio3-imprinted domain on 6q32, is associated with the syntenic human locus in schizophrenia.

    Alteration of imprinted Dlk1-Dio3 miRNA cluster expression in the entorhinal cortex induced by maternal immune activation and adolescent cannabinoid exposure.
    Hollins SL, Zavitsanou K, Walker FR, Cairns MJ., Free PMC Article

    11/7/2015
    Study shows that the expression of hypothalamus-enriched DLK1 is regulated by nutritional challenge and that the DLK1 protein is present in many neurons of the arcuate nucleus, the ventromedial subdivision in particular

    Delta-like 1 homologue (DLK1) protein in neurons of the arcuate nucleus that control weight homeostasis and effect of fasting on hypothalamic DLK1 mRNA.
    Persson-Augner D, Lee YW, Tovar S, Dieguez C, Meister B.

    10/3/2015
    presence of DLK1 in a population of lateral hypothalamic neurones suggests a functional role for DLK1 in orexin/hypocretin/dynorphin neurones

    Delta-like 1 homologue is a hypothalamus-enriched protein that is present in orexin-containing neurones of the lateral hypothalamic area.
    Meister B, Perez-Manso M, Daraio T.

    02/1/2014
    new insights into the mechanism of Dlk1 regarding its regulation of pituitary hormone-secreting cells during development.

    The spatial and temporal expression of delta-like protein 1 in the rat pituitary gland during development.
    Nakakura T, Sato M, Suzuki M, Hatano O, Takemori H, Taniguchi Y, Minoshima Y, Tanaka S.

    01/28/2013
    novel roles of HSC-derived DLK1 in activating HSCs via epigenetic Ppargamma repression and participating in liver regeneration and development in a manner involving the mesenchymal-epithelial interaction.

    Hepatic stellate cell-derived delta-like homolog 1 (DLK1) protein in liver regeneration.
    Zhu NL, Asahina K, Wang J, Ueno A, Lazaro R, Miyaoka Y, Miyajima A, Tsukamoto H., Free PMC Article

    05/19/2012
    Results suggest that pleiotrophin regulates fetal type II cell proliferation and differentiation via integration of multiple signaling pathways including pleiotrophin, Dlk-1, beta-catenin, and Notch pathways.

    Pleiotrophin regulates lung epithelial cell proliferation and differentiation during fetal lung development via beta-catenin and Dlk1.
    Weng T, Gao L, Bhaskaran M, Guo Y, Gou D, Narayanaperumal J, Chintagari NR, Zhang K, Liu L., Free PMC Article

    01/21/2010
    Highly divergent expression of pref-1, upregulated expression of adiponectin, interleukin-6 and TNF-alpha mRNA was observed in adipose tissues of the diabetic Goto Kakizaki rat compared to the obese Zucker rat.

    Pref-1 and adipokine expression in adipose tissues of GK and Zucker rats.
    Barbu A, Hedlund GP, Lind J, Carlsson C.

    01/21/2010
    localisation in rat was in the medulla and the zona glomerulosa of the cortex of the adrenal glands, in the pars distalis of the adenohypophysis, and in the ovarian granulosa lutein cells but no staining was found in the pancreas

    Fetal antigen 1 (FA1) in the adult rat adrenal gland, ovary and pituitary gland.
    Hedlund GP, Carlsson HE, Shieck E, Nilsson I, Lundblad C, Arons S, Iversen AK, Looman C, Jensen HE, Hau J.

    01/21/2010
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