| SOX7 inhibits the malignant progression of bladder cancer via the DNMT3B/CYGB axis. | SOX7 inhibits the malignant progression of bladder cancer via the DNMT3B/CYGB axis.
Zhang J, Zhang W, Liu J, Liu Y, Jiang Y, Ainiwaer A, Chen H, Gu Z, Chen H, Mao S, Guo Y, Xu T, Xu Y, Wu Y, Yao X, Yan Y., Free PMC Article | 10/11/2024 |
| The cytoglobin-dependent transcriptome in melanoma indicates a protective function associated with oxidative stress, inflammation and cancer-associated pathways. | The cytoglobin-dependent transcriptome in melanoma indicates a protective function associated with oxidative stress, inflammation and cancer-associated pathways.
De Backer J, Hoogewijs D., Free PMC Article | 09/13/2024 |
| Cytoglobin as a Prognostic Factor for Pancreatic Ductal Adenocarcinoma: A Retrospective Analysis of 75 Patients. | Cytoglobin as a Prognostic Factor for Pancreatic Ductal Adenocarcinoma: A Retrospective Analysis of 75 Patients.
Kono H, Hosomura N, Amemiya H, Kawaida H, Furuya S, Akaike H, Kawaguchi Y, Sudo M, Ichikawa D. | 03/26/2022 |
| Cytoglobin has potent superoxide dismutase function. | Cytoglobin has potent superoxide dismutase function.
Zweier JL, Hemann C, Kundu T, Ewees MG, Khaleel SA, Samouilov A, Ilangovan G, El-Mahdy MA., Free PMC Article | 02/12/2022 |
| TGF-beta1-driven reduction of cytoglobin leads to oxidative DNA damage in stellate cells during non-alcoholic steatohepatitis. | TGF-β1-driven reduction of cytoglobin leads to oxidative DNA damage in stellate cells during non-alcoholic steatohepatitis.
Okina Y, Sato-Matsubara M, Matsubara T, Daikoku A, Longato L, Rombouts K, Thanh Thuy LT, Ichikawa H, Minamiyama Y, Kadota M, Fujii H, Enomoto M, Ikeda K, Yoshizato K, Pinzani M, Kawada N. | 11/22/2021 |
| A reliable set of reference genes to normalize oxygen-dependent cytoglobin gene expression levels in melanoma. | A reliable set of reference genes to normalize oxygen-dependent cytoglobin gene expression levels in melanoma.
De Backer J, Maric D, Bosman M, Dewilde S, Hoogewijs D., Free PMC Article | 11/6/2021 |
| Cytoglobin-expressing cells in the splenic cords contribute to splenic fibrosis in cirrhotic patients. | Cytoglobin-expressing cells in the splenic cords contribute to splenic fibrosis in cirrhotic patients.
Iimuro Y, Yada A, Okada T, Nakamura I, Suzumura K, Xu J, Sudo M, Nishiguchi S, Kawada N, Hatano E, Fujimoto J. | 10/16/2021 |
| Cytoglobin promotes sensitivity to ferroptosis by regulating p53-YAP1 axis in colon cancer cells. | Cytoglobin promotes sensitivity to ferroptosis by regulating p53-YAP1 axis in colon cancer cells.
Ye S, Xu M, Zhu T, Chen J, Shi S, Jiang H, Zheng Q, Liao Q, Ding X, Xi Y., Free PMC Article | 09/18/2021 |
| The Antioxidative Role of Cytoglobin in Podocytes: Implications for a Role in Chronic Kidney Disease. | The Antioxidative Role of Cytoglobin in Podocytes: Implications for a Role in Chronic Kidney Disease.
Randi EB, Vervaet B, Tsachaki M, Porto E, Vermeylen S, Lindenmeyer MT, Thuy LTT, Cohen CD, Devuyst O, Kistler AD, Szabo C, Kawada N, Hankeln T, Odermatt A, Dewilde S, Wenger RH, Hoogewijs D. | 07/17/2021 |
| Regulation of Nitric Oxide Metabolism and Vascular Tone by Cytoglobin. | Regulation of Nitric Oxide Metabolism and Vascular Tone by Cytoglobin.
Zweier JL, Ilangovan G., Free PMC Article | 07/17/2021 |
| This study suggests CYGB aids in promoting triple negative breast cancer cell death and migration once AhR signaling activation occurs. | Putative tumor suppressor cytoglobin promotes aryl hydrocarbon receptor ligand-mediated triple negative breast cancer cell death.
Rowland LK, Campbell PS, Mavingire N, Wooten JV, McLean L, Zylstra D, Thorne G, Daly D, Boyle K, Whang S, Unternaehrer J, Brantley EJ., Free PMC Article | 07/25/2020 |
| HIF-1alpha regulates cytoglobin expression and fibroblast proliferation in keloids. | Role of Hypoxia Inducible Factor-1 Alpha (HIF-1α) in Cytoglobin Expression and Fibroblast Proliferation of Keloids.
Jusman SWA, Sari DH, Ningsih SS, Hardiany NS, Sadikin M., Free PMC Article | 02/1/2020 |
| Nitric oxide generation by cytoglobin nitrite reductase activity is modulated by the oxidation state of surface-exposed cysteines C38 and C83.Cysteine oxidation has no discernible effect on the rate of nitric oxide dioxygenase activity but does influence the rate of penta-to hexa-heme iron coordination following nitrate dissociation. | Strong modulation of nitrite reductase activity of cytoglobin by disulfide bond oxidation: Implications for nitric oxide homeostasis.
Reeder BJ, Ukeri J. | 02/16/2019 |
| CYGB is a potential tumor suppressor in breast cancer that is epigenetically suppressed. The results for the first time suggest that CYGB suppresses breast cancer through inhibiting glucose metabolism. | The epigenetically downregulated factor CYGB suppresses breast cancer through inhibition of glucose metabolism.
Feng Y, Wu M, Li S, He X, Tang J, Peng W, Zeng B, Deng C, Ren G, Xiang T., Free PMC Article | 02/16/2019 |
| The results obtained in this study (1) show that plasma-produced reactive oxygen and nitrogen species can extensively oxidize proteins and (2) that the oxidation status of two redox-active cysteines lead to different conformations of CYGB. | The effect of reactive oxygen and nitrogen species on the structure of cytoglobin: A potential tumor suppressor.
De Backer J, Razzokov J, Hammerschmid D, Mensch C, Hafideddine Z, Kumar N, van Raemdonck G, Yusupov M, Van Doorslaer S, Johannessen C, Sobott F, Bogaerts A, Dewilde S., Free PMC Article | 12/22/2018 |
| Endothelial cells facilitate the ability of smooth muscle cells to metabolize nitric oxide through upregulation of cytoglobin. | Endothelial cell-induced cytoglobin expression in vascular smooth muscle cells contributes to modulation of nitric oxide.
Lilly B, Dammeyer K, Marosis S, McCallinhart PE, Trask AJ, Lowe M, Sawant D., Free PMC Article | 11/10/2018 |
| FGF2 initiates CYGB transcription via the JNK pathway. | Fibroblast growth factor 2 (FGF2) regulates cytoglobin expression and activation of human hepatic stellate cells via JNK signaling.
Sato-Matsubara M, Matsubara T, Daikoku A, Okina Y, Longato L, Rombouts K, Thuy LTT, Adachi J, Tomonaga T, Ikeda K, Yoshizato K, Pinzani M, Kawada N., Free PMC Article | 11/3/2018 |
| the study reveals a novel mechanism for the regulated expression of Cygb and also assigns a new role to Cygb in cell cycle control. | Cell cycle-dependent regulation of cytoglobin by Skp2.
John R, Atri Y, Chand V, Jaiswal N, Raj K, Nag A. | 11/25/2017 |
| Data suggest that cytochrome b5 (CYB5) and cytochrome b5 reductase 3 (CYB5R3) can reduce human cytoglobin (CYGB) and zebrafish cytoglobins at rates up to 250-fold higher than those reported for the known physiological substrates, hemoglobin and myoglobin; the three proteins (CYB5+CYB5R3+CYGB) appear to constitute a metabolon involved in generation of nitric oxide. | Efficient Reduction of Vertebrate Cytoglobins by the Cytochrome b(5)/Cytochrome b(5) Reductase/NADH System.
Amdahl MB, Sparacino-Watkins CE, Corti P, Gladwin MT, Tejero J., Free PMC Article | 08/12/2017 |
| DeltaNp63-CYGB axis is also present in lung and breast cancer cell lines, indicating that CYGB-mediated ROS-scavenging activity may also have a role in epithelial tumours | ΔNp63 targets cytoglobin to inhibit oxidative stress-induced apoptosis in keratinocytes and lung cancer.
Latina A, Viticchiè G, Lena AM, Piro MC, Annicchiarico-Petruzzelli M, Melino G, Candi E. | 08/13/2016 |
| Propose a bipartite lipid binding model that rationalizes the modes of interactions of cytoglobin with phospholipids, the effects on structural re-arrangements and the peroxidase activity of the hemoprotein. | Peroxidase activation of cytoglobin by anionic phospholipids: Mechanisms and consequences.
Tejero J, Kapralov AA, Baumgartner MP, Sparacino-Watkins CE, Anthonymutu TS, Vlasova II, Camacho CJ, Gladwin MT, Bayir H, Kagan VE., Free PMC Article | 07/2/2016 |
| This review provides an overview of the proposed role of cytoglobin and explores its potential functional role as a biomarker for cancer and other diseases | Cytoglobin as a Biomarker in Cancer: Potential Perspective for Diagnosis and Management.
Bholah TC, Neergheen-Bhujun VS, Hodges NJ, Dyall SD, Bahorun T., Free PMC Article | 05/21/2016 |
| Cygb, expressed in hepatic stellate cells during liver fibrosis, plays role in cancer development with nonalcoholic steatohepatitis. | Cytoglobin deficiency promotes liver cancer development from hepatosteatosis through activation of the oxidative stress pathway.
Thuy le TT, Matsumoto Y, Thuy TT, Hai H, Suoh M, Urahara Y, Motoyama H, Fujii H, Tamori A, Kubo S, Takemura S, Morita T, Yoshizato K, Kawada N. | 12/12/2015 |
| Cygb stabilizes p53 by inhibiting its ubiquitination and elicit cell cycle arrest in DNA damaged cells. | DNA damage induced activation of Cygb stabilizes p53 and mediates G1 arrest.
John R, Chand V, Chakraborty S, Jaiswal N, Nag A. | 10/24/2015 |
| The cysteine redox state of the monomer controls histidine dissociation rate constants and hence extrinsic ligand binding in human cytoglobin. | Coupling of disulfide bond and distal histidine dissociation in human ferrous cytoglobin regulates ligand binding.
Beckerson P, Reeder BJ, Wilson MT. | 04/18/2015 |