| Aspartoacylase suppresses prostate cancer progression by blocking LYN activation. | Aspartoacylase suppresses prostate cancer progression by blocking LYN activation.
Weng H, Xiong KP, Wang W, Qian KY, Yuan S, Wang G, Yu F, Luo J, Lu MX, Yang ZH, Liu T, Huang X, Zheng H, Wang XH., Free PMC Article | 06/7/2023 |
| This study demonstrated that N-acetylaspartate supports the energetic demands of developmental myelination via oligodendroglial aspartoacylase. | N-acetylaspartate supports the energetic demands of developmental myelination via oligodendroglial aspartoacylase.
Francis JS, Wojtas I, Markov V, Gray SJ, McCown TJ, Samulski RJ, Bilaniuk LT, Wang DJ, De Vivo DC, Janson CG, Leone P., Free PMC Article | 02/10/2018 |
| Gata6 regulates differentiation, metabolism, and survival of resident peritoneal macrophages through aspartoacylase. | Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival.
Gautier EL, Ivanov S, Williams JW, Huang SC, Marcelin G, Fairfax K, Wang PL, Francis JS, Leone P, Wilson DB, Artyomov MN, Pearce EJ, Randolph GJ., Free PMC Article | 09/27/2014 |
| aspartoacylase is proposed here to support lipid synthesis and energy metabolism via the provision of substrate for both cellular processes during early postnatal development | Aspartoacylase supports oxidative energy metabolism during myelination.
Francis JS, Strande L, Markov V, Leone P., Free PMC Article | 11/24/2012 |
| Intracellular vacuolisation in astrocytes coincides with axonal swellings in cerebellum and brain stem of aspa(lacZ/lacZ) mutants indicating that astroglia may act as an osmolyte buffer in the aspa-deficient CNS | Aspartoacylase-lacZ knockin mice: an engineered model of Canavan disease.
Mersmann N, Tkachev D, Jelinek R, Röth PT, Möbius W, Ruhwedel T, Rühle S, Weber-Fahr W, Sartorius A, Klugmann M., Free PMC Article | 10/22/2011 |
| Aspa defects were associated with increased levels of acetylated histone H3, decreased chromatin compaction and increased GFAP protein, a marker for astrogliosis. Early in postnatal development ASPA defic affects oligodendrocyte maturation and myelination | Aspartoacylase deficiency affects early postnatal development of oligodendrocytes and myelination.
Mattan NS, Ghiani CA, Lloyd M, Matalon R, Bok D, Casaccia P, de Vellis J., Free PMC Article | 01/15/2011 |
| Death of OLs, neurons, and astrocytes was identified in every region of the aspartoacylase KO brain. These findings support involvement of ASPA in CNS development and function. | Lack of aspartoacylase activity disrupts survival and differentiation of neural progenitors and oligodendrocytes in a mouse model of Canavan disease.
Kumar S, Biancotti JC, Matalon R, de Vellis J. | 02/8/2010 |
| Nur7( Q193X) is a nonsense mutation in the mouse aspartoacylase gene that causes spongy degeneration of the CNS. | Nur7 is a nonsense mutation in the mouse aspartoacylase gene that causes spongy degeneration of the CNS.
Traka M, Wollmann RL, Cerda SR, Dugas J, Barres BA, Popko B., Free PMC Article | 01/21/2010 |
| we now present immunoblot, proteomic, and biochemical evidence that the membrane-bound form of ASPA is intrinsic to purified myelin membranes. | Bimodal occurrence of aspartoacylase in myelin and cytosol of brain.
Wang J, Matalon R, Bhatia G, Wu G, Li H, Liu T, Lu ZH, Ledeen RW. | 01/21/2010 |
| ASPA gene defect in the mouse leads to spinal cord pathology; these changes may be involved in the cause of the physiological/behavioral abnormalities seen in the knockout mouse. | Aspartoacylase gene knockout results in severe vacuolation in the white matter and gray matter of the spinal cord in the mouse.
Surendran S, Campbell GA, Tyring SK, Matalon R. | 01/21/2010 |
| normal hydrolysis of N-acetylaspartic acid is affected by aspartoacylase activity seen in the type 2 diabetes model mouse | Upregulation of aspartoacylase activity in the duodenum of obesity induced diabetes mouse: implications on diabetic neuropathy.
Surendran S, Matalon R, Tyring SK. | 01/21/2010 |