| Mitochondrial metallopeptidase OMA1 in cancer. | Mitochondrial metallopeptidase OMA1 in cancer.
Purohit G, Ghosh P, Khalimonchuk O. | 09/6/2024 |
| Melatonin Rescues Influenza A Virus-Induced Cellular Energy Exhaustion via OMA1-OPA1-S in Acute Exacerbation of COPD. | Melatonin Rescues Influenza A Virus-Induced Cellular Energy Exhaustion via OMA1-OPA1-S in Acute Exacerbation of COPD.
Wei YY, Ye JJ, Zhang DW, Hu L, Wu HM, Fei GH. | 07/23/2024 |
| OMA1 competitively binds to HSPA9 to promote mitophagy and activate the cGAS-STING pathway to mediate GBM immune escape. | OMA1 competitively binds to HSPA9 to promote mitophagy and activate the cGAS-STING pathway to mediate GBM immune escape.
Zhu W, Rao J, Zhang LH, Xue KM, Li L, Li JJ, Chen QZ, Fu R., Free PMC Article | 04/30/2024 |
| OMA1 protease eliminates arrested protein import intermediates upon mitochondrial depolarization. | OMA1 protease eliminates arrested protein import intermediates upon mitochondrial depolarization.
Krakowczyk M, Lenkiewicz AM, Sitarz T, Malinska D, Borrero M, Mussulini BHM, Linke V, Szczepankiewicz AA, Biazik JM, Wydrych A, Nieznanska H, Serwa RA, Chacinska A, Bragoszewski P., Free PMC Article | 03/29/2024 |
| The mitochondrial protease OMA1 acts as a metabolic safeguard upon nuclear DNA damage. | The mitochondrial protease OMA1 acts as a metabolic safeguard upon nuclear DNA damage.
Rivera-Mejías P, Narbona-Pérez ÁJ, Hasberg L, Kroczek L, Bahat A, Lawo S, Folz-Donahue K, Schumacher AL, Ahola S, Mayer FC, Giavalisco P, Nolte H, Lavandero S, Langer T. | 10/6/2023 |
| Long Noncoding RNA PCGEM1 Facilitates Tumor Growth and Metastasis of Osteosarcoma by Sponging miR-433-3p and Targeting OMA1. | Long Noncoding RNA PCGEM1 Facilitates Tumor Growth and Metastasis of Osteosarcoma by Sponging miR-433-3p and Targeting OMA1.
Li J, Zhang Y, Sun F, Zhang G, Pan XA, Zhou Q., Free PMC Article | 04/19/2023 |
| The Mitochondrial PHB2/OMA1/DELE1 Pathway Cooperates with Endoplasmic Reticulum Stress to Facilitate the Response to Chemotherapeutics in Ovarian Cancer. | The Mitochondrial PHB2/OMA1/DELE1 Pathway Cooperates with Endoplasmic Reticulum Stress to Facilitate the Response to Chemotherapeutics in Ovarian Cancer.
Cheng M, Yu H, Kong Q, Wang B, Shen L, Dong D, Sun L., Free PMC Article | 03/12/2022 |
| Circular RNA OMA1 regulates the progression of breast cancer via modulation of the miR1276/SIRT4 axis. | Circular RNA OMA1 regulates the progression of breast cancer via modulation of the miR‑1276/SIRT4 axis.
Xu L, Xu K, Xiang L, Yan J., Free PMC Article | 01/15/2022 |
| Tau phosphorylation and OPA1 proteolysis are unrelated events: Implications for Alzheimer's Disease. | Tau phosphorylation and OPA1 proteolysis are unrelated events: Implications for Alzheimer's Disease.
Alavi MV., Free PMC Article | 01/1/2022 |
| Mitochondrial Safeguard: a stress response that offsets extreme fusion and protects respiratory function via flickering-induced Oma1 activation. | Mitochondrial Safeguard: a stress response that offsets extreme fusion and protects respiratory function via flickering-induced Oma1 activation.
Murata D, Yamada T, Tokuyama T, Arai K, Quirós PM, López-Otín C, Iijima M, Sesaki H., Free PMC Article | 04/17/2021 |
| OMA1-An integral membrane protease? | OMA1-An integral membrane protease?
Alavi MV., Free PMC Article | 04/17/2021 |
| Overexpression of ROMO1 and OMA1 are Potentially Biomarkers and Predict Unfavorable Prognosis in Gastric Cancer. | Overexpression of ROMO1 and OMA1 are Potentially Biomarkers and Predict Unfavorable Prognosis in Gastric Cancer.
Amini MA, Karimi J, Khodadadi I, Tavilani H, Talebi SS, Afshar B. | 03/27/2021 |
| Depletion of mitochondrial protease OMA1 alters proliferative properties and promotes metastatic growth of breast cancer cells. | Depletion of mitochondrial protease OMA1 alters proliferative properties and promotes metastatic growth of breast cancer cells.
Daverey A, Levytskyy RM, Stanke KM, Viana MP, Swenson S, Hayward SL, Narasimhan M, Khalimonchuk O, Kidambi S., Free PMC Article | 10/31/2020 |
| A Common Missense Variant in OMA1 Associated with the Prognosis of Heart Failure. | A Common Missense Variant in OMA1 Associated with the Prognosis of Heart Failure.
Hu D, Li S, Hu S, Sun Y, Xiao L, Li C, Wang J, Wang Y, Ni L, Zhao C, Wang DW. | 10/3/2020 |
| mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway; the OMA1-DELE1-HRI pathway represents a potential therapeutic target that could enable fine-tuning of the integrated stress response for beneficial outcomes in diseases that involve mitochondrial dysfunction | Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway.
Guo X, Aviles G, Liu Y, Tian R, Unger BA, Lin YT, Wiita AP, Xu K, Correia MA, Kampmann M., Free PMC Article | 05/30/2020 |
| Studies present evidence that OMA1 activation promotes cell death and its inhibition is protective against it. OMA1 activation on gene expression and protein levels is regulated by many tumor proteins. [review] | Targeted OMA1 therapies for cancer.
Alavi MV. | 01/25/2020 |
| leptin targeting the GSK3/OMA1/OPA1 signaling pathway can optimize hMSCs therapy for cardiovascular diseases such | Leptin increases mitochondrial OPA1 via GSK3-mediated OMA1 ubiquitination to enhance therapeutic effects of mesenchymal stem cell transplantation.
Yang F, Wu R, Jiang Z, Chen J, Nan J, Su S, Zhang N, Wang C, Zhao J, Ni C, Wang Y, Hu W, Zeng Z, Zhu K, Liu X, Hu X, Zhu W, Yu H, Huang J, Wang J., Free PMC Article | 11/9/2019 |
| we identify AFG3L2 [matrix (m)-AAA complex] as the major protease mediating this event, which acts by maturing the 60 kDa pre-pro-OMA1 to the 40 kDa pro-OMA1 form by severing the N-terminal portion without recognizing a specific consensus sequence. | m-AAA and i-AAA complexes coordinate to regulate OMA1, the stress-activated supervisor of mitochondrial dynamics.
Consolato F, Maltecca F, Tulli S, Sambri I, Casari G. | 10/19/2019 |
| Mitochondrial membrane potential loss-dependent PINK1 import arrest does not result solely from Tim23 inactivation but also through an actively regulated "tug of war" between Tom7 and OMA1. | Reciprocal Roles of Tom7 and OMA1 during Mitochondrial Import and Activation of PINK1.
Sekine S, Wang C, Sideris DP, Bunker E, Zhang Z, Youle RJ. | 06/29/2019 |
| differential stress-induced degradation of YME1L and OMA1 as a mechanism for sensitively adapting mitochondrial inner membrane protease activity and function in response to distinct types of cellular insults. | Reciprocal Degradation of YME1L and OMA1 Adapts Mitochondrial Proteolytic Activity during Stress.
Rainbolt TK, Lebeau J, Puchades C, Wiseman RL., Free PMC Article | 01/14/2017 |
| The mitochondrial metalloprotease OMA1 was activated in a Bax- and Bak-dependent fashion. | Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis.
Jiang X, Jiang H, Shen Z, Wang X., Free PMC Article | 05/2/2015 |
| Cleavage of the inner membrane fusion factor L-OPA1 is prevented due to the failure to activate the inner membrane protease OMA1 in mitochondria that have a collapsed membrane potential. | Impaired OMA1-dependent cleavage of OPA1 and reduced DRP1 fission activity combine to prevent mitophagy in cells that are dependent on oxidative phosphorylation.
MacVicar TD, Lane JD., Free PMC Article | 04/18/2015 |
| OMA1 is cleaved to a short form (S-OMA1) by itself upon mitochondrial membrane depolarization; S-OMA1 is degraded quickly but could be stabilized by CCCP treatment or Prohibitin knockdown in cells. | Membrane depolarization activates the mitochondrial protease OMA1 by stimulating self-cleavage.
Zhang K, Li H, Song Z., Free PMC Article | 01/17/2015 |
| These findings demonstrate that (a) p53 and Oma1 mediate L-Opa1 processing, (b) mitochondrial fragmentation is involved in CDDP-induced apoptosis in OVCA and CECA cells, and (c) dysregulated mitochondrial dynamics | p53 is required for cisplatin-induced processing of the mitochondrial fusion protein L-Opa1 that is mediated by the mitochondrial metallopeptidase Oma1 in gynecologic cancers.
Kong B, Wang Q, Fung E, Xue K, Tsang BK., Free PMC Article | 12/20/2014 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ., Free PMC Article | 12/5/2010 |