| Enhanced TRPC3 transcription through AT1R/PKA/CREB signaling contributes to mitochondrial dysfunction in renal tubular epithelial cells in D-galactose-induced accelerated aging mice. | Enhanced TRPC3 transcription through AT1R/PKA/CREB signaling contributes to mitochondrial dysfunction in renal tubular epithelial cells in D-galactose-induced accelerated aging mice.
Wang B, Yu W, Zhang W, Zhang M, Niu Y, Jin X, Zhang J, Sun D, Li H, Zhang Z, Luo Q, Cheng X, Niu J, Cai G, Chen X, Chen Y., Free PMC Article | 06/15/2024 |
| Microglial AT1R Conditional Knockout Ameliorates Hypoperfusive Cognitive Impairment by Reducing Microglial Inflammatory Responses. | Microglial AT1R Conditional Knockout Ameliorates Hypoperfusive Cognitive Impairment by Reducing Microglial Inflammatory Responses.
Li D, Zhang Q, Yang X, Zhang G, Wang J, Zhang R, Liu Y. | 05/21/2024 |
| miR-125a-5p/miR-125b-5p contributes to pathological activation of angiotensin II-AT1R in mouse distal convoluted tubule cells by the suppression of Atrap. | miR-125a-5p/miR-125b-5p contributes to pathological activation of angiotensin II-AT1R in mouse distal convoluted tubule cells by the suppression of Atrap.
Hirota K, Yamashita A, Abe E, Yamaji T, Azushima K, Tanaka S, Taguchi S, Tsukamoto S, Wakui H, Tamura K., Free PMC Article | 01/3/2024 |
| Angiotensin II type 1 receptor-associated protein in immune cells: a possible key factor in the pathogenesis of visceral obesity. | Angiotensin II type 1 receptor-associated protein in immune cells: a possible key factor in the pathogenesis of visceral obesity.
Tsukamoto S, Suzuki T, Wakui H, Uehara T, Ichikawa J, Okuda H, Haruhara K, Azushima K, Abe E, Tanaka S, Taguchi S, Hirota K, Kinguchi S, Yamashita A, Tamura T, Tamura K. | 11/30/2023 |
| Increased Arterial Responsiveness to Angiotensin II in Mice Conceived by Assisted Reproductive Technologies. | Increased Arterial Responsiveness to Angiotensin II in Mice Conceived by Assisted Reproductive Technologies.
Meister TA, Soria R, Dogar A, Messerli FH, Paoloni-Giacobino A, Stenz L, Scherrer U, Sartori C, Rexhaj E., Free PMC Article | 11/26/2022 |
| Angiotensin II type-1 receptor-associated protein interacts with transferrin receptor-1 and promotes its internalization. | Angiotensin II type-1 receptor-associated protein interacts with transferrin receptor-1 and promotes its internalization.
Abe E, Yamashita A, Hirota K, Yamaji T, Azushima K, Urate S, Suzuki T, Tanaka S, Taguchi S, Tsukamoto S, Uehara T, Wakui H, Tamura K, Takahashi H., Free PMC Article | 10/22/2022 |
| Deficiency of the kidney tubular angiotensin II type1 receptor-associated protein ATRAP exacerbates streptozotocin-induced diabetic glomerular injury via reducing protective macrophage polarization. | Deficiency of the kidney tubular angiotensin II type1 receptor-associated protein ATRAP exacerbates streptozotocin-induced diabetic glomerular injury via reducing protective macrophage polarization.
Haruhara K, Suzuki T, Wakui H, Azushima K, Kurotaki D, Kawase W, Uneda K, Kobayashi R, Ohki K, Kinguchi S, Yamaji T, Kato I, Ohashi K, Yamashita A, Tamura T, Tsuboi N, Yokoo T, Tamura K. | 07/30/2022 |
| The Functional Interaction of EGFR with AT1R or TP in Primary Vascular Smooth Muscle Cells Triggers a Synergistic Regulation of Gene Expression. | The Functional Interaction of EGFR with AT1R or TP in Primary Vascular Smooth Muscle Cells Triggers a Synergistic Regulation of Gene Expression.
Dubourg V, Schreier B, Schwerdt G, Rabe S, Benndorf RA, Gekle M., Free PMC Article | 07/2/2022 |
| Lay A TRAP for myeloid cell response in diabetic kidney disease. | Lay A TRAP for myeloid cell response in diabetic kidney disease.
Nishi H. | 05/14/2022 |
| Myogenic Vasoconstriction Requires Canonical Gq/11 Signaling of the Angiotensin II Type 1 Receptor. | Myogenic Vasoconstriction Requires Canonical G(q/11) Signaling of the Angiotensin II Type 1 Receptor.
Cui Y, Kassmann M, Nickel S, Zhang C, Alenina N, Anistan YM, Schleifenbaum J, Bader M, Welsh DG, Huang Y, Gollasch M., Free PMC Article | 04/16/2022 |
| Impaired angiotensin II type 1 receptor signaling contributes to sepsis-induced acute kidney injury. | Impaired angiotensin II type 1 receptor signaling contributes to sepsis-induced acute kidney injury.
Leisman DE, Fernandes TD, Bijol V, Abraham MN, Lehman JR, Taylor MD, Capone C, Yaipan O, Bellomo R, Deutschman CS., Free PMC Article | 08/14/2021 |
| The pathophysiological role of angiotensin receptor-binding protein in hypertension and kidney diseases: Oshima Award Address 2019. | The pathophysiological role of angiotensin receptor-binding protein in hypertension and kidney diseases: Oshima Award Address 2019.
Wakui H., Free PMC Article | 01/16/2021 |
| Angiotensin-Receptor-Associated Protein Modulates Ca(2+) Signals in Photoreceptor and Mossy Fiber cells. | Angiotensin-Receptor-Associated Protein Modulates Ca(2+) Signals in Photoreceptor and Mossy Fiber cells.
Barro-Soria R, Caicedo A, Jägle H, Merkel L, Zhao N, Knop G, Gierke K, Dannullis A, Castrop H, Brandstätter JH, Kirchhoff F, Feigenspan A, Strauß O., Free PMC Article | 11/21/2020 |
| AT1/2R affects the proliferation and apoptosis of chondrocytes induced by oxygen-glucose deprivation. | AT1/2R affects the proliferation and apoptosis of chondrocytes induced by oxygen-glucose deprivation.
Cai HQ, Miao MY, Zhang WL. | 09/19/2020 |
| ATRAP deficiency in proximal tubules did not exacerbate angiotensin-dependent hypertension in vivo. The results indicate that renal proximal tubule ATRAP has a minor role in angiotensin-dependent hypertension in vivo. | Effects of ATRAP in Renal Proximal Tubules on Angiotensin-Dependent Hypertension.
Kinguchi S, Wakui H, Azushima K, Haruhara K, Koguchi T, Ohki K, Uneda K, Matsuda M, Haku S, Yamaji T, Yamada T, Kobayashi R, Minegishi S, Ishigami T, Yamashita A, Fujikawa T, Tamura K., Free PMC Article | 07/25/2020 |
| This work demonstrates that acute blockade of AT1R has the potential for robust injury prevention in a model of Iso-induced dystrophic heart injury. In addition to selectively limiting dystrophic cardiac damage, blocking AT1R may serve to limit the inflammatory nature of the immune response to injury in all hearts. | Acute AT(1)R blockade prevents isoproterenol-induced injury in mdx hearts.
Meyers TA, Heitzman JA, Krebsbach AM, Aufdembrink LM, Hughes R, Bartolomucci A, Townsend D., Free PMC Article | 06/20/2020 |
| sympathetic vasomotor control by spinal AT1 and V1a receptors in the acute phase of hemorrhagic shock | Differential sympathetic vasomotor control by spinal AT(1) and V1a receptors in the acute phase of hemorrhagic shock.
Milanez MIO, Martins GR, Nishi EE, Bergamaschi CT, Campos RR. | 06/6/2020 |
| When AT1R signaling is blocked, AT2R activation is a key modulator to prevent aortic dilation that occurs with transverse aortic constriction. | Reversal of Aortic Enlargement Induced by Increased Biomechanical Forces Requires AT1R Inhibition in Conjunction With AT2R Activation.
Zhou Z, Peters AM, Wang S, Janda A, Chen J, Zhou P, Arthur E, Kwartler CS, Milewicz DM., Free PMC Article | 01/18/2020 |
| These data suggest that AT1 and AT2 receptors have opposite effects in modulating airway hyperresponsiveness and inflammation in asthma. | Role of angiotensin II type 1 (AT1) and type 2 (AT2) receptors in airway reactivity and inflammation in an allergic mouse model of asthma.
Patel M, Kurade M, Rajalingam S, Bhavsar R, Mustafa SJ, Ponnoth DS., Free PMC Article | 12/14/2019 |
| Leukocyte ATRAP is an emerging marker capable of reflecting the systemic and leukocyte inflammatory profile, and plays a role as an anti-inflammatory factor in the pathophysiology of non-communicable diseases. | Angiotensin receptor-binding molecule in leukocytes in association with the systemic and leukocyte inflammatory profile.
Haruhara K, Wakui H, Azushima K, Kurotaki D, Kawase W, Uneda K, Haku S, Kobayashi R, Ohki K, Kinguchi S, Ohsawa M, Minegishi S, Ishigami T, Matsuda M, Yamashita A, Nakajima H, Tamura T, Tsuboi N, Yokoo T, Tamura K. | 06/1/2019 |
| high glucose-induced podocytes damage by activating miR-370 signaling targeted to inhibit the expression of AGTRAP. | miR-370 promotes high glucose-induced podocyte injuries by inhibiting angiotensin II type 1 receptor-associated protein.
Xian Y, Dong L, Jia Y, Lin Y, Jiao W, Wang Y. | 12/22/2018 |
| verexpression of ATRAP induced adiponectin expression both in adipose tissue and primary adipocyte. Our data revealed that adipose ATRAP plays an important role in preventing metabolic disorders and adiponectin possibly mediates the effects of adipose ATRAP. | Adipose angiotensin II type 1 receptor-associated protein ameliorates metabolic disorders via promoting adipose tissue adipogenesis and browning.
Luo C, Lv N, Chang Z, Qu Q, Huang J. | 06/9/2018 |
| ATRAP plays an important role in inhibiting kidney aging, possibly through sirtuin1-mediated mechanism independent of blocking AT1R signaling, and further protecting normal life span. | Angiotensin II Type 1 Receptor-Associated Protein Regulates Kidney Aging and Lifespan Independent of Angiotensin.
Uneda K, Wakui H, Maeda A, Azushima K, Kobayashi R, Haku S, Ohki K, Haruhara K, Kinguchi S, Matsuda M, Ohsawa M, Minegishi S, Ishigami T, Toya Y, Atobe Y, Yamashita A, Umemura S, Tamura K., Free PMC Article | 05/5/2018 |
| Results presented in this study suggested that the enhancement in adipose ATRAP plays a protective role against the development of diet-induced visceral obesity and insulin resistance through improvement of adipose inflammation and function via the suppression of overactivation of adipose AT1R signaling. | Adipocyte-Specific Enhancement of Angiotensin II Type 1 Receptor-Associated Protein Ameliorates Diet-Induced Visceral Obesity and Insulin Resistance.
Azushima K, Ohki K, Wakui H, Uneda K, Haku S, Kobayashi R, Haruhara K, Kinguchi S, Matsuda M, Maeda A, Toya Y, Yamashita A, Umemura S, Tamura K., Free PMC Article | 02/17/2018 |
| Renal ATRAP downregulation is involved in the onset and progression of blood pressure elevation caused by renal mass reduction, and implicates ATRAP as a therapeutic target for hypertension in chronic kidney disease. | An angiotensin II type 1 receptor binding molecule has a critical role in hypertension in a chronic kidney disease model.
Kobayashi R, Wakui H, Azushima K, Uneda K, Haku S, Ohki K, Haruhara K, Kinguchi S, Matsuda M, Ohsawa M, Toya Y, Nishiyama A, Yamashita A, Tanabe K, Maeshima Y, Umemura S, Tamura K. | 09/30/2017 |