| Circulating apelin, IL22RA2 and VEGF in pre-capillary pulmonary hypertension. | Circulating apelin, IL22RA2 and VEGF in pre-capillary pulmonary hypertension.
Csósza G, Szűcs G, Rozgonyi Z, Csoma B, Losonczy G, Müller V, Karlócai K, Lázár Z. | 12/27/2023 |
| IL-22BP production is heterogeneously distributed in Crohn's disease. | IL-22BP production is heterogeneously distributed in Crohn's disease.
Fantou A, Lagrue E, Laurent T, Delbos L, Blandin S, Jarry A, Beriou G, Braudeau C, Salabert N, Marin E, Moreau A, Podevin J, Bourreille A, Josien R, Martin JC., Free PMC Article | 11/5/2022 |
| Down-regulating Interleukin-22/Interleukin-22 binding protein axis promotes inflammation and aggravates diet-induced metabolic disorders. | Down-regulating Interleukin-22/Interleukin-22 binding protein axis promotes inflammation and aggravates diet-induced metabolic disorders.
Gu J, Zhou P, Liu Y, Xu Q, Chen X, Chen M, Lu C, Qu C, Tong Y, Yu Q, Lu X, Yu C, Liu Z. | 10/15/2022 |
| Liver expression of IL-22, IL-22R1 and IL-22BP in patients with chronic hepatitis C with different fibrosis stages. | Liver expression of IL-22, IL-22R1 and IL-22BP in patients with chronic hepatitis C with different fibrosis stages.
de Brito RJVC, do Carmo RF, Silva BMS, Costa ACS, Rocha SWS, Vasconcelos LRS, Pereira LMMB, de Moura PMMF. | 04/16/2022 |
| The good and the bad about separation anxiety: roles of IL-22 and IL-22BP in liver pathologies. | The good and the bad about separation anxiety: roles of IL-22 and IL-22BP in liver pathologies.
Lücke J, Sabihi M, Zhang T, Bauditz LF, Shiri AM, Giannou AD, Huber S., Free PMC Article | 10/30/2021 |
| Elevated IL-22 in psoriasis plays an anti-apoptotic role in keratinocytes through mediating Bcl-xL/Bax. | Elevated IL-22 in psoriasis plays an anti-apoptotic role in keratinocytes through mediating Bcl-xL/Bax.
Wang B, Han D, Li F, Hou W, Wang L, Meng L, Mou K, Lu S, Zhu W, Zhou Y., Free PMC Article | 07/31/2021 |
| Low Interleukin-22 Binding Protein Is Associated With High Mortality in Alcoholic Hepatitis and Modulates Interleukin-22 Receptor Expression. | Low Interleukin-22 Binding Protein Is Associated With High Mortality in Alcoholic Hepatitis and Modulates Interleukin-22 Receptor Expression.
Støy S, Laursen TL, Glavind E, Eriksen PL, Terczynska-Dyla E, Magnusson NE, Hamilton-Dutoit S, Mortensen FV, Veidal SS, Rigbolt K, Riggio O, Deleuran B, Vilstrup H, Sandahl TD., Free PMC Article | 07/17/2021 |
| The Rare IL22RA2 Signal Peptide Coding Variant rs28385692 Decreases Secretion of IL-22BP Isoform-1, -2 and -3 and Is Associated with Risk for Multiple Sclerosis. | The Rare IL22RA2 Signal Peptide Coding Variant rs28385692 Decreases Secretion of IL-22BP Isoform-1, -2 and -3 and Is Associated with Risk for Multiple Sclerosis.
Gómez-Fernández P, Lopez de Lapuente Portilla A, Astobiza I, Mena J, Urtasun A, Altmann V, Matesanz F, Otaegui D, Urcelay E, Antigüedad A, Malhotra S, Montalban X, Castillo-Triviño T, Espino-Paisán L, Aktas O, Buttmann M, Chan A, Fontaine B, Gourraud PA, Hecker M, Hoffjan S, Kubisch C, Kümpfel T, Luessi F, Zettl UK, Zipp F, Alloza I, Comabella M, Lill CM, Vandenbroeck K., Free PMC Article | 01/16/2021 |
| Our results demonstrate a pathogenic role of IL-22BP in three species with a potential mechanism of action involving T cell polarization | IL-22 Binding Protein Promotes the Disease Process in Multiple Sclerosis.
Lindahl H, Guerreiro-Cacais AO, Bedri SK, Linnerbauer M, Lindén M, Abdelmagid N, Tandre K, Hollins C, Irving L, Glover C, Jones C, Alfredsson L, Rönnblom L, Kockum I, Khademi M, Jagodic M, Olsson T. | 04/11/2020 |
| Upon silencing of interleukin 22 receptor subunit alpha 2 (IL22RA2) expression in immature dendritic cells (moDC), molecular chaperone GRP78 (GRP78) levels were significantly reduced, suggesting that native IL22RA2 expression naturally contributes to upregulating GRP78 levels in these cells. | Long Interleukin-22 Binding Protein Isoform-1 Is an Intracellular Activator of the Unfolded Protein Response.
Gómez-Fernández P, Urtasun A, Paton AW, Paton JC, Borrego F, Dersh D, Argon Y, Alloza I, Vandenbroeck K., Free PMC Article | 10/26/2019 |
| IL-22BP expression was downregulated in skin biopsies of psoriasis patients compared to the skin of healthy donors. | Regulation of IL-22BP in psoriasis.
Voglis S, Moos S, Kloos L, Wanke F, Zayoud M, Pelczar P, Giannou AD, Pezer S, Albers M, Luessi F, Huber S, Schäkel K, Kurschus FC., Free PMC Article | 09/28/2019 |
| expression higher in the epidermal compartment of the skin in comparison with dermis in both healthy skin and psoriasis skin | IL-22 binding protein regulates murine skin inflammation.
Lindahl H, Martini E, Brauner S, Nikamo P, Gallais Serezal I, Guerreiro-Cacais AO, Jagodic M, Eidsmo L, Ståhle M, Olsson T. | 09/29/2018 |
| suggest that the human IL-22BP isoforms have distinct spatial and temporal roles and coordinately fine-tune IL-22-dependent STAT3 responses in tissues as a type of rheostat. | Human IL-22 binding protein isoforms act as a rheostat for IL-22 signaling.
Lim C, Hong M, Savan R. | 11/25/2017 |
| thia study shows shows that nonaffected skin of psoriasis patients displays lower expression of IL-22BP than skin of healthy controls, and that the strong IL-22 increase in lesional psoriatic skin is accompanied by a moderate induction of IL-22BP | Limited Presence of IL-22 Binding Protein, a Natural IL-22 Inhibitor, Strengthens Psoriatic Skin Inflammation.
Martin JC, Wolk K, Bériou G, Abidi A, Witte-Händel E, Louvet C, Kokolakis G, Drujont L, Dumoutier L, Renauld JC, Sabat R, Josien R. | 05/6/2017 |
| The deletion of IFNGR1 causes complete IFN-gammaR1 deficiency. Despite the deletion ending very close to the IL22RA2 gene, it does not appear to affect IL22RA2 transcription. | Deletion of the entire interferon-γ receptor 1 gene causing complete deficiency in three related patients.
de Vor IC, van der Meulen PM, Bekker V, Verhard EM, Breuning MH, Harnisch E, van Tol MJ, Wieringa JW, van de Vosse E, Bredius RG., Free PMC Article | 12/17/2016 |
| IL-22BP is produced by eosinophils in the gut and blocks IL-22 protective actions in colitis. | IL-22BP is produced by eosinophils in human gut and blocks IL-22 protective actions during colitis.
Martin JC, Bériou G, Heslan M, Bossard C, Jarry A, Abidi A, Hulin P, Ménoret S, Thinard R, Anegon I, Jacqueline C, Lardeux B, Halary F, Renauld JC, Bourreille A, Josien R. | 12/17/2016 |
| Through a combined approach including genetic and immunological investigation in an animal model and large-scale association studies of patients with multiple sclerosis (MS), IL-22RA2 is established as an MS risk gene. | IL-22RA2 associates with multiple sclerosis and macrophage effector mechanisms in experimental neuroinflammation.
Beyeen AD, Adzemovic MZ, Ockinger J, Stridh P, Becanovic K, Laaksonen H, Lassmann H, Harris RA, Hillert J, Alfredsson L, Celius EG, Harbo HF, Kockum I, Jagodic M, Olsson T. | 01/15/2011 |
| Crystallization and preliminary X-ray diffraction results of the IL-22-IL-22 binding protein (IL-22BP) complex are described. | Crystallization and preliminary X-ray diffraction analysis of human IL-22 bound to its soluble decoy receptor IL-22BP.
Watanabe L, de Moura PR, Nascimento AS, Colau D, Dumoutier L, Renauld JC, Polikarpov I., Free PMC Article | 01/21/2010 |
| Polymorphisms in IL22RA1 are associated with severe CRS. | Polymorphisms in the interleukin-22 receptor alpha-1 gene are associated with severe chronic rhinosinusitis.
Endam LM, Bossé Y, Filali-Mouhim A, Cormier C, Boisvert P, Boulet LP, Hudson TJ, Desrosiers M. | 01/21/2010 |
| Comparison of IL-22/IL-22BP and IL-22/IL-22R1 crystal structures shows that both receptors display an overlapping IL-22 binding surface, which is consistent with the inhibitory role played by IL-22 binding protein. | Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22.
de Moura PR, Watanabe L, Bleicher L, Colau D, Dumoutier L, Lemaire MM, Renauld JC, Polikarpov I. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesNew genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M. Further association analysis of chr 6q22-24 suggests a role of IL-20RA polymorphisms in psoriasis.
Kingo K, Mössner R, Traks T, Rätsep R, Raud K, Reimann E, Krüger U, Silm H, Vasar E, Reich K, Kõks S. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA, Platteel M, Ryan AW, de Kovel C, Holmes GK, Howdle PD, Walters JR, Sanders DS, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, Kelleher D, Barisani D, Bardella MT, McManus R, van Heel DA, Wijmenga C. | 04/1/2009 |
| The IL-22R and IL-10R2 binding sites are juxtaposed on adjacent IL-22 surfaces contributed mostly by helices A, D, and F and loop AB. | IL-22R, IL-10R2, and IL-22BP binding sites are topologically juxtaposed on adjacent and overlapping surfaces of IL-22.
Wu PW, Li J, Kodangattil SR, Luxenberg DP, Bennett F, Martino M, Collins M, Dunussi-Joannopoulos K, Gill DS, Wolfman NM, Fouser LA. | 01/21/2010 |