| AKAP1 in Renal Patients with AHF to Reduce Ferroptosis of Cardiomyocyte. | AKAP1 in Renal Patients with AHF to Reduce Ferroptosis of Cardiomyocyte.
Fang Y, Xu J, Huang R. | 02/21/2024 |
| Akap1 deficiency exacerbates diabetic cardiomyopathy in mice by NDUFS1-mediated mitochondrial dysfunction and apoptosis. | Akap1 deficiency exacerbates diabetic cardiomyopathy in mice by NDUFS1-mediated mitochondrial dysfunction and apoptosis.
Qi B, He L, Zhao Y, Zhang L, He Y, Li J, Li C, Zhang B, Huang Q, Xing J, Li F, Li Y, Ji L. | 06/5/2021 |
| Loss of AKAP1 triggers Drp1 dephosphorylation-mediated mitochondrial fission and loss in retinal ganglion cells. | Loss of AKAP1 triggers Drp1 dephosphorylation-mediated mitochondrial fission and loss in retinal ganglion cells.
Edwards G, Perkins GA, Kim KY, Kong Y, Lee Y, Choi SH, Liu Y, Skowronska-Krawczyk D, Weinreb RN, Zangwill L, Strack S, Ju WK., Free PMC Article | 04/3/2021 |
| AKAP121/PKA confers neuroprotection in an in vitro model of oxidative stress induced by exposure to excess glutamate. | Neuroprotective Mitochondrial Remodeling by AKAP121/PKA Protects HT22 Cell from Glutamate-Induced Oxidative Stress.
Zhang J, Feng J, Ma D, Wang F, Wang Y, Li C, Wang X, Yin X, Zhang M, Dagda RK, Zhang Y., Free PMC Article | 12/21/2019 |
| genetic disinhibition of Drp1 via knock-out of the mitochondrial protein kinase A (PKA) scaffold AKAP1 exacerbates stroke injury in mice. Mechanistically, we show that electron transport deficiency, increased superoxide production, and Ca(2+) overload result from genetic disinhibition of Drp1. | AKAP1 Protects from Cerebral Ischemic Stroke by Inhibiting Drp1-Dependent Mitochondrial Fission.
Flippo KH, Gnanasekaran A, Perkins GA, Ajmal A, Merrill RA, Dickey AS, Taylor SS, McKnight GS, Chauhan AK, Usachev YM, Strack S., Free PMC Article | 10/19/2019 |
| Ring finger protein20 regulates hepatic lipid metabolism through protein kinase A-dependent sterol regulatory element binding protein1c degradation. | Ring finger protein20 regulates hepatic lipid metabolism through protein kinase A-dependent sterol regulatory element binding protein1c degradation.
Lee JH, Lee GY, Jang H, Choe SS, Koo SH, Kim JB., Free PMC Article | 04/22/2019 |
| Loss of AKAP1 expression is associated with acute lung injury. | Akap1 genetic deletion increases the severity of hyperoxia-induced acute lung injury in mice.
Narala VR, Fukumoto J, Hernández-Cuervo H, Patil SS, Krishnamurthy S, Breitzig M, Galam L, Soundararajan R, Lockey RF, Kolliputi N., Free PMC Article | 01/12/2019 |
| these results identify a novel AKAP-mediated biochemical mechanism that increases TRPA1 sensitivity in peripheral sensory neurons, and likely contributes to persistent mechanical hypersensitivity. | A-Kinase Anchoring Protein 79/150 Scaffolds Transient Receptor Potential A 1 Phosphorylation and Sensitization by Metabotropic Glutamate Receptor Activation.
Brackley AD, Gomez R, Guerrero KA, Akopian AN, Glucksman MJ, Du J, Carlton SM, Jeske NA., Free PMC Article | 12/22/2018 |
| AKAP1 is a transcriptional target of Myc, and it supports mTOR pathway and the growth of cancer cells. | Mitochondrial AKAP1 supports mTOR pathway and tumor growth.
Rinaldi L, Sepe M, Delle Donne R, Conte K, Arcella A, Borzacchiello D, Amente S, De Vita F, Porpora M, Garbi C, Oliva MA, Procaccini C, Faicchia D, Matarese G, Zito Marino F, Rocco G, Pignatiello S, Franco R, Insabato L, Majello B, Feliciello A., Free PMC Article | 03/10/2018 |
| Genetic ablation of AKAP7 specifically from dentate granule cells results in disruption of mossy fiber-CA3 pyramidal neuron long-term potentiation directly initiated by cAMP, and the AKAP7 mutant mice are selectively deficient in pattern separation behaviors. The results suggest that the AKAP7/PKA complex in the mossy fiber projections plays an essential role in synaptic plasticity and contextual memory formation. | Targeted deletion of AKAP7 in dentate granule cells impairs spatial discrimination.
Jones BW, Deem J, Younts TJ, Weisenhaus M, Sanford CA, Slack MC, Chin J, Nachmanson D, McKennon A, Castillo PE, McKnight GS., Free PMC Article | 11/4/2017 |
| The results demonstrate that Akap1 deficiency promotes cardiac mitochondrial aberrations and mitophagy, enhancing infarct size, pathological cardiac remodeling and mortality under ischemic conditions. | Akap1 Deficiency Promotes Mitochondrial Aberrations and Exacerbates Cardiac Injury Following Permanent Coronary Ligation via Enhanced Mitophagy and Apoptosis.
Schiattarella GG, Cattaneo F, Pironti G, Magliulo F, Carotenuto G, Pirozzi M, Polishchuk R, Borzacchiello D, Paolillo R, Oliveti M, Boccella N, Avvedimento M, Sepe M, Lombardi A, Busiello RA, Trimarco B, Esposito G, Feliciello A, Perrino C., Free PMC Article | 07/15/2017 |
| The tongue epithelium is differentiated into multiple epithelial cell layers via the PI3K and PKA pathways in tissue-specific manner during the epithelial-mesenchymal interactions. | Involvement of PI3K and PKA pathways in mouse tongue epithelial differentiation.
Jung JK, Jung HI, Neupane S, Kim KR, Kim JY, Yamamoto H, Cho SW, Lee Y, Shin HI, Sohn WJ, Kim JY. | 01/14/2017 |
| Data suggest that D-AKAP1 is a transmembrane protein in mitochondrial outer membrane; D-AKAP1 appears to participate in cAMP signaling; hydrophobicity of D-AKAP1 transmembrane domain regulates localization to either ER or mitochondria. | D-AKAP1a is a signal-anchored protein in the mitochondrial outer membrane.
Jun YW, Park H, Lee YK, Kaang BK, Lee JA, Jang DJ. | 09/3/2016 |
| NCX3 regulates mitochondrial calcium handling from the outer mitochondrial membrane through an AKAP121-anchored signaling complex. | NCX3 regulates mitochondrial Ca(2+) handling through the AKAP121-anchored signaling complex and prevents hypoxia-induced neuronal death.
Scorziello A, Savoia C, Sisalli MJ, Adornetto A, Secondo A, Boscia F, Esposito A, Polishchuk EV, Polishchuk RS, Molinaro P, Carlucci A, Lignitto L, Di Renzo G, Feliciello A, Annunziato L. | 08/9/2014 |
| PKC and PKA regulate AChR dynamics at the neuromuscular junction of living mice. | PKC and PKA regulate AChR dynamics at the neuromuscular junction of living mice.
Martinez-Pena y Valenzuela I, Pires-Oliveira M, Akaaboune M., Free PMC Article | 07/5/2014 |
| Activation of NOD1 induces lipolysis through NF-kappaB and the lipolytic PKA activation in 3T3-L1 adipocytes. | Activation of nucleotide oligomerization domain containing protein 1 induces lipolysis through NF-κB and the lipolytic PKA activation in 3T3-L1 adipocytes.
Purohit JS, Hu P, Chen G, Whelan J, Moustaid-Moussa N, Zhao L. | 06/7/2014 |
| hypoxia induces fission of mitochondrial membranes, dependent on availability of protein AKAP121 | Fine-tuning of Drp1/Fis1 availability by AKAP121/Siah2 regulates mitochondrial adaptation to hypoxia.
Kim H, Scimia MC, Wilkinson D, Trelles RD, Wood MR, Bowtell D, Dillin A, Mercola M, Ronai ZA., Free PMC Article | 01/21/2012 |
| Six putative caspase substrates, including five novel proteins (ABCF1, AKAP1, CPE, DOPEY1 and GOPC1) that may be targeted specifically by the initiator caspases 8 and 10 during the early stages of apoptosis, were identified.[caspase 10] | Genome-wide screening and identification of novel proteolytic cleavage targets of caspase-8 and -10 in vitro.
Bae S, Ha TS, Yoon Y, Lee J, Cha HJ, Yoo H, Choe TB, Li S, Sohn I, Kim JY, Kim CS, Jin HO, Lee HC, Park IC, Kim CS, Jin YW, Ahn SK. | 03/8/2011 |
| AKAP121 regulates the response to stress in cardiomyocytes, and therefore AKAP121 downregulation might represent an important event contributing to the development of cardiac dysfunction. | AKAP121 downregulation impairs protective cAMP signals, promotes mitochondrial dysfunction, and increases oxidative stress.
Perrino C, Feliciello A, Schiattarella GG, Esposito G, Guerriero R, Zaccaro L, Del Gatto A, Saviano M, Garbi C, Carangi R, Di Lorenzo E, Donato G, Indolfi C, Avvedimento VE, Chiariello M. | 01/15/2011 |
| LPL translational inhibition occurs through an RNA-binding complex involving PKA subunits and AKAP121, and this complex can be activated either through traditional PKA activation methods or through the depletion of PKCalpha | Translational regulation of lipoprotein lipase in adipocytes: depletion of cellular protein kinase Calpha activates binding of the C subunit of protein kinase A to the 3'-untranslated region of the lipoprotein lipase mRNA.
Unal R, Pokrovskaya I, Tripathi P, Monia BP, Kern PA, Ranganathan G., Free PMC Article | 01/21/2010 |
| dAKAP1 possesses a single targeting element capable of targeting to both mitochondria and ER, with the ER signal overlapping the mitochondria signal | A molecular switch for targeting between endoplasmic reticulum (ER) and mitochondria: conversion of a mitochondria-targeting element into an ER-targeting signal in DAKAP1.
Ma Y, Taylor SS., Free PMC Article | 01/21/2010 |
| AKAP121 levels are regulated post-translationally by the ubiquitin/proteasome pathway. | Proteolysis of AKAP121 regulates mitochondrial activity during cellular hypoxia and brain ischaemia.
Carlucci A, Adornetto A, Scorziello A, Viggiano D, Foca M, Cuomo O, Annunziato L, Gottesman M, Feliciello A., Free PMC Article | 01/21/2010 |
| AKAP121 and PKAR2A serve to enhance steroidogenesis by directing the synthesis and activation of STAR at the mitochondria in response to cAMP. | Mitochondrial A-kinase anchoring protein 121 binds type II protein kinase A and enhances steroidogenic acute regulatory protein-mediated steroidogenesis in MA-10 mouse leydig tumor cells.
Dyson MT, Jones JK, Kowalewski MP, Manna PR, Alonso M, Gottesman ME, Stocco DM. | 01/21/2010 |
| AKAP1 is a bifunctional helical element that is required for both ER and mitochondrion targeting. | A 15-residue bifunctional element in D-AKAP1 is required for both endoplasmic reticulum and mitochondrial targeting.
Ma Y, Taylor S. | 01/21/2010 |
| AKAP121, through its role in enhancing cAMP and tyrosine kinase signaling to distal organelles, is an important regulator in mitochondrial metabolism | Mitochondrial AKAP121 links cAMP and src signaling to oxidative metabolism.
Livigni A, Scorziello A, Agnese S, Adornetto A, Carlucci A, Garbi C, Castaldo I, Annunziato L, Avvedimento EV, Feliciello A., Free PMC Article | 01/21/2010 |