| GnT-V-mediated aberrant N-glycosylation of TIMP-1 promotes diabetic retinopathy progression. | GnT-V-mediated aberrant N-glycosylation of TIMP-1 promotes diabetic retinopathy progression.
Xi X, Yang Y, Chen Q, Ma J, Wang X, Deng Y, Wang X, Li Y., Free PMC Article | 03/20/2024 |
| TIMP-1 Protects Tight Junctions of Brain Endothelial Cells From MMP-Mediated Degradation. | TIMP-1 Protects Tight Junctions of Brain Endothelial Cells From MMP-Mediated Degradation.
Ahmadighadykolaei H, Lambert JA, Raeeszadeh-Sarmazdeh M., Free PMC Article | 02/22/2024 |
| Coexpression of tissue kallikrein 1 and tissue inhibitor of matrix metalloproteinase 1 improves myocardial ischemiareperfusion injury by promoting angiogenesis and inhibiting oxidative stress. | Co‑expression of tissue kallikrein 1 and tissue inhibitor of matrix metalloproteinase 1 improves myocardial ischemia‑reperfusion injury by promoting angiogenesis and inhibiting oxidative stress.
Huang S, Chen M, Yu H, Lin K, Guo Y, Zhu P., Free PMC Article | 05/8/2021 |
| TIMP-1: A key cytokine released from activated astrocytes protects neurons and ameliorates cognitive behaviours in a rodent model of Alzheimer's disease. | TIMP-1: A key cytokine released from activated astrocytes protects neurons and ameliorates cognitive behaviours in a rodent model of Alzheimer's disease.
Saha P, Sarkar S, Paidi RK, Biswas SC. | 05/8/2021 |
| Inhibition of histone demethylase JMJD1C attenuates cardiac hypertrophy and fibrosis induced by angiotensin II. | Inhibition of histone demethylase JMJD1C attenuates cardiac hypertrophy and fibrosis induced by angiotensin II.
Zhang S, Lu Y, Jiang C. | 04/24/2021 |
| Secretome Analysis of Mesenchymal Stem Cell Factors Fostering Oligodendroglial Differentiation of Neural Stem Cells In Vivo. | Secretome Analysis of Mesenchymal Stem Cell Factors Fostering Oligodendroglial Differentiation of Neural Stem Cells In Vivo.
Samper Agrelo I, Schira-Heinen J, Beyer F, Groh J, Bütermann C, Estrada V, Poschmann G, Bribian A, Jadasz JJ, Lopez-Mascaraque L, Kremer D, Martini R, Müller HW, Hartung HP, Adjaye J, Stühler K, Küry P., Free PMC Article | 02/20/2021 |
| MMP9 and TIMP-1 may have a role in tissue remodeling in a rat model of heart failure | Molecular evidence of tissue remodeling in an animal model of heart failure.
Nascimento LS, Tedesco LM, Araujo NS, Priviero FBM, Claudino MA, Priolli DG, Rocha T. | 05/23/2020 |
| The present study is the first to demonstrate that cold exposure exacerbates imbalance between MMP-9 and TIMP-1 by activating the RAS, which may be critical in the initiation of stroke during chronic hypertension | Renin-angiotensin system activation and imbalance of matrix metalloproteinase-9/tissue inhibitor of matrix metalloproteinase-1 in cold-induced stroke.
Su YY, Li HM, Yan ZX, Li MC, Wei JP, Zheng WX, Liu SQ, Deng YT, Xie HF, Li CG. | 09/21/2019 |
| These data provide a previously uncharacterized trophic action of TIMP-1 to regulate oligodendrocyte maturation via a CD63/beta1-integrin/Akt pathway mechanism. | TIMP-1 Promotes Oligodendrocyte Differentiation Through Receptor-Mediated Signaling.
Nicaise AM, Johnson KM, Willis CM, Guzzo RM, Crocker SJ., Free PMC Article | 08/17/2019 |
| Overexpression of prolyl-hydroxylase 2 (PHD2) transgene, a predominant isoform of PHDs in renal tubules, to reduce HIF-1alpha level significantly attenuated albumin-induced increases in TIMP-1 and collagen-I levels. These results suggest that albumin-induced oxidative stress inhibits PHD activity to accumulate HIF-1alpha, which mediates albumin-induced profibrotic effects in renal tubular cells | Hypoxia inducible factor-1α mediates the profibrotic effect of albumin in renal tubular cells.
Hu J, Wang W, Zhang F, Li PL, Boini KM, Yi F, Li N., Free PMC Article | 07/6/2019 |
| High TIMP1 expression is associated with myocardial fibrosis in cardiac hypertrophy. | Copper-induced reduction in myocardial fibrosis is associated with increased matrix metalloproteins in a rat model of cardiac hypertrophy.
Liu Y, Xiao Y, Liu J, Feng L, Kang YJ. | 01/19/2019 |
| Data suggest that increased blood pressure and decreased pup weight in ischemic model of pregnancy-induced hypertension are associated with decrease in Mmp9 homodimer and increase in Mmp9/Timp1 complex in placenta, uterus, and uterine artery; thus Mmp9 and Timp1 appear to be involved in uteroplacental/vascular remodeling in preeclampsia. (Mmp9 = matrix metalloproteinase 9; Timp1 = tissue inhibitor of metalloproteinase-1) | Decreased homodimerization and increased TIMP-1 complexation of uteroplacental and uterine arterial matrix metalloproteinase-9 during hypertension-in-pregnancy.
Chen J, Ren Z, Zhu M, Khalil RA., Free PMC Article | 07/29/2017 |
| The present study investigated rat models of Feeney's freefall-induced brain injury combined with Achilles tendon rupture-induced heterotopic ossification. It analyzed the altered curves of MMP-9, MMP-2 and tissue inhibitor of metalloproteinase-1 (TIMP-1) in addition to the curves of gene expression. | Dynamics of MMP‑9, MMP‑2 and TIMP‑1 in a rat model of brain injury combined with traumatic heterotopic ossification.
Shi WZ, Ju JY, Xiao HJ, Xue F, Wu J, Pan MM, Ni WF., Free PMC Article | 05/20/2017 |
| Alloxan-induced renal damage is associated with alterations of p53, TGF-beta1, and extracellular matrix metalloproteinases. | Renal damage following Alloxan-induced diabetes is associated with generation of reactive oxygen species, alterations of p53, TGF-β1, and extracellular matrix metalloproteinases in rats.
Abdel Aziz MA, Badary DM, Hussein MRA. | 05/6/2017 |
| These findings suggested that artesunate attenuates alveolitis and pulmonary fibrosis by regulating expression of collagen-IV, TIMP-1 and 2, as well as MMP-2 and -9, to reduce ECM accumulation. | Artesunate modulates expression of matrix metalloproteinases and their inhibitors as well as collagen-IV to attenuate pulmonary fibrosis in rats.
Wang Y, Huang G, Mo B, Wang C. | 02/18/2017 |
| Data suggest that amlodipine and Atorvastatin could improve ventricular remodeling in SHR rats through intervention with the imbalance of MMP-2/TIMP-2 and MMP-9/TIMP-1 system. | Amlodipine and Atorvastatin Improved Hypertensive Cardiac Remodeling through Regulation of MMPs/TIMPs in SHR Rats.
Lu J, Hao J, Du H, Xiao B, Li Y, Yang X, Cui W. | 02/18/2017 |
| Data suggest that, as non-alcoholic fatty liver disease progresses, expression of miR-21 (mirn21 microRNA), Mmp-9 (matrix metalloproteinase 9), and Timp-1 (tissue inhibitor of metalloproteinase-1) is up-regulated in liver, peaking when liver fibrosis is first detected; miR-21 has potential as a plasma biomarker for hepatic fibrosis. | MicroRNA-21 is associated with fibrosis in a rat model of nonalcoholic steatohepatitis and serves as a plasma biomarker for fibrotic liver disease.
Takeuchi-Yorimoto A, Yamaura Y, Kanki M, Ide T, Nakata A, Noto T, Matsumoto M. | 02/18/2017 |
| upregulated expressions of MMP1/3 and downregulated expressions of TIMP1/3 at the messenger RNA (mRNA) and protein levels also appeared to be relevant to low Se intake. In conclusion, Se-deficient diet could cause low Se concentration in the liver, alterations of hepatocyte ultrastructure | Long-Term Selenium-Deficient Diet Induces Liver Damage by Altering Hepatocyte Ultrastructure and MMP1/3 and TIMP1/3 Expression in Growing Rats.
Han J, Liang H, Yi J, Tan W, He S, Wang S, Li F, Wu X, Ma J, Shi X, Guo X, Bai C. | 01/28/2017 |
| Tissue kallikrein 1 and TIMP1 expressed in a coexpression vector synergistically inhibited the proliferation of rat vascular smooth muscle cells. | Synergistic effect of a tissue kallikrein 1 and tissue inhibitor of matrix metalloproteinase 1 co‑expression vector on the proliferation of rat vascular smooth muscle cells.
Zhu P, Yu H, Huang S, Xiang H, Li F, Zheng W., Free PMC Article | 06/28/2016 |
| In a normoglycemic rat model of wound healing, pentoxifylline significantly increased TIMP-1 gene expression. | Pentoxifylline Accelerates Wound Healing Process by Modulating Gene Expression of MMP-1, MMP-3, and TIMP-1 in Normoglycemic Rats.
Babaei S, Bayat M. | 05/28/2016 |
| MMP-2 and MMP-9 activities and TIMP-1 and TIMP-2 expression were significantly reduced in the lateral prostatic lobe of the ethanol drinking animals. | MMP-2 and MMP-9 activities and TIMP-1 and TIMP-2 expression in the prostatic tissue of two ethanol-preferring rat models.
Fioruci-Fontanelli BA, Chuffa LG, Mendes LO, Pinheiro PF, Delella FK, Kurokawa CS, Felisbino SL, Martinez FE., Free PMC Article | 03/26/2016 |
| Our findings clearly demonstrate that despite their dramatic spatial rearrangement, cones and second-order neuron processes maintain their synaptic connections before and after TIMP-1 treatment. | TIMP-1 affects the spatial distribution of dendritic processes of second-order neurons in a rat model of Retinitis Pigmentosa.
Shin JA, Eom YS, Yu WQ, Grzywacz NM, Craft CM, Lee EJ. | 02/20/2016 |
| Angiotensin II regulates MMP-2, MMP-9, and TIMP-1 expression and affects collagen deposition. | Effects of angiotensin II intervention on MMP-2, MMP-9, TIMP-1, and collagen expression in rats with pulmonary hypertension.
Wang XM, Shi K, Li JJ, Chen TT, Guo YH, Liu YL, Yang YF, Yang S. | 02/13/2016 |
| Data indicate that adiponectin promoted tissue inhibitor of metalloproteinase-1 (TIMP-1) expression and limited hepatic stellate cell migration . | Adiponectin reduces hepatic stellate cell migration by promoting tissue inhibitor of metalloproteinase-1 (TIMP-1) secretion.
Ramezani-Moghadam M, Wang J, Ho V, Iseli TJ, Alzahrani B, Xu A, Van der Poorten D, Qiao L, George J, Hebbard L., Free PMC Article | 05/16/2015 |
| The immunohistochemistry demonstrated greater expression of MMP-2 than MMP-9 and MMP-14 in all masseter muscles and there were few differences in the staining of 4 TIMPs. | Histological, histochemical, and protein changes after induced malocclusion by occlusion alteration of Wistar rats.
Guerra Cde S, Carla Lara Pereira Y, Issa JP, Luiz KG, Guimarães EA, Gerlach RF, Iyomasa MM., Free PMC Article | 03/21/2015 |