| Activated Leukocyte Cell Adhesion Molecule Regulates the Expression of Interleukin-33 in RSV Induced Airway Inflammation by Regulating MAPK Signaling Pathways. | Activated Leukocyte Cell Adhesion Molecule Regulates the Expression of Interleukin-33 in RSV Induced Airway Inflammation by Regulating MAPK Signaling Pathways.
Baek SM, Kim MN, Kim EG, Lee YJ, Park CH, Kim MJ, Kim KW, Sohn MH. | 05/1/2024 |
| Osteomacs promote maintenance of murine hematopoiesis through megakaryocyte-induced upregulation of Embigin and CD166. | Osteomacs promote maintenance of murine hematopoiesis through megakaryocyte-induced upregulation of Embigin and CD166.
Mohamad SF, El Koussa R, Ghosh J, Blosser R, Gunawan A, Layer J, Zhang C, Karnik S, Davé U, Kacena MA, Srour EF., Free PMC Article | 04/24/2024 |
| ALCAM Deficiency Alleviates LPS-Induced Acute Lung Injury by Inhibiting Inflammatory Response. | ALCAM Deficiency Alleviates LPS-Induced Acute Lung Injury by Inhibiting Inflammatory Response.
Li R, Ren T, Zeng J, Xu H. | 03/24/2023 |
| A Novel Regulatory Role of Activated Leukocyte Cell-Adhesion Molecule in the Pathogenesis of Pulmonary Fibrosis. | A Novel Regulatory Role of Activated Leukocyte Cell-Adhesion Molecule in the Pathogenesis of Pulmonary Fibrosis.
Kim MN, Hong JY, Kim EG, Lee JW, Lee SY, Kim KW, Shim HS, Lee CG, Elias JA, Lee YJ, Sohn MH. | 04/9/2022 |
| The CD6/ALCAM pathway promotes lupus nephritis via T cell-mediated responses. | The CD6/ALCAM pathway promotes lupus nephritis via T cell-mediated responses.
Chalmers SA, Ayilam Ramachandran R, Garcia SJ, Der E, Herlitz L, Ampudia J, Chu D, Jordan N, Zhang T, Parodis I, Gunnarsson I, Ding H, Shen N, Petri M, Mok CC, Saxena R, Polu KR, Connelly S, Ng CT, Mohan C, Putterman C., Free PMC Article | 02/19/2022 |
| Activated leukocyte cell adhesion molecule regulates B lymphocyte migration across central nervous system barriers. | Activated leukocyte cell adhesion molecule regulates B lymphocyte migration across central nervous system barriers.
Michel L, Grasmuck C, Charabati M, Lécuyer MA, Zandee S, Dhaeze T, Alvarez JI, Li R, Larouche S, Bourbonnière L, Moumdjian R, Bouthillier A, Lahav B, Duquette P, Bar-Or A, Gommerman JL, Peelen E, Prat A. | 09/5/2020 |
| the cell adhesion molecule ALCAM (CD166) can act as an extracellular substrate to selectively promote the growth of murine midbrain dopamine neuron axons through a trans-heterophilic interaction with adhesion molecules | Axonal Growth of Midbrain Dopamine Neurons is Modulated by the Cell Adhesion Molecule ALCAM Through Trans-Heterophilic Interactions with L1cam, Chl1, and Semaphorins.
Bye CR, Rytova V, Alsanie WF, Parish CL, Thompson LH., Free PMC Article | 06/20/2020 |
| The ALCAM+ giant cell tumor of bone cells showed the stem cell properties of self renewal and had the capacity to differentiate. | ALCAM(+) stromal cells: role in giant cell tumor of bone progression.
Zhou Z, Li Y, Wang X, Hu J, Kuang M, Wang Z, Li S, Xu W, Xiao J., Free PMC Article | 10/26/2019 |
| These results indicate that ALCAM regulates food allergy by affecting T cell activation. | Activated leucocyte cell adhesion molecule (ALCAM/CD166) regulates T cell responses in a murine model of food allergy.
Kim YS, Kim MN, Lee KE, Hong JY, Oh MS, Kim SY, Kim KW, Sohn MH., Free PMC Article | 04/20/2019 |
| Our data demonstrate that ALCAM KO mice develop a more severe active experimental autoimmune encephalomyelitis, which can be explained by an increased permeability of their BBB. This loss in BBB integrity is due to a dysregulation of junctional molecules caused by the lack of ALCAM at the level of the TJ molecules. | Dual role of ALCAM in neuroinflammation and blood-brain barrier homeostasis.
Lécuyer MA, Saint-Laurent O, Bourbonnière L, Larouche S, Larochelle C, Michel L, Charabati M, Abadier M, Zandee S, Haghayegh Jahromi N, Gowing E, Pittet C, Lyck R, Engelhardt B, Prat A., Free PMC Article | 04/14/2018 |
| demonstrates for the first time the in vivo contribution of ALCAM to angiogenesis and reveals a novel role of stromally expressed ALCAM in supporting tumor growth and metastatic spread | Stromal Expression of Activated Leukocyte Cell Adhesion Molecule Promotes Lung Tumor Growth and Metastasis.
Willrodt AH, Beffinger M, Vranova M, Protsyuk D, Schuler K, Jadhav M, Heikenwalder M, van den Broek M, Borsig L, Halin C. | 12/2/2017 |
| Our results indicate that the loss of CD166 impacts hematopoietic stem cell numbers | Activated leukocyte cell adhesion molecule (ALCAM or CD166) modulates bone phenotype and hematopoiesis.
Hooker RA, Chitteti BR, Egan PH, Cheng YH, Himes ER, Meijome T, Srour EF, Fuchs RK, Kacena MA., Free PMC Article | 11/21/2015 |
| Data indicate that the CD166/AKT axis modulates tumorigenesis via promotion of phosphorylation and facilitation of degradation, ubiquitination and cytosolic accumulation of FOXO proteins in liver cancer cells. | CD166 plays a pro-carcinogenic role in liver cancer cells via inhibition of FOXO proteins through AKT.
Yu W, Wang J, Ma L, Tang X, Qiao Y, Pan Q, Yu Y, Sun F. | 02/14/2015 |
| ALCAM stably interacts with actin by binding to syntenin-1 and ezrin. | Syntenin-1 and ezrin proteins link activated leukocyte cell adhesion molecule to the actin cytoskeleton.
Tudor C, te Riet J, Eich C, Harkes R, Smisdom N, Bouhuijzen Wenger J, Ameloot M, Holt M, Kanger JS, Figdor CG, Cambi A, Subramaniam V., Free PMC Article | 06/28/2014 |
| CD166/ALCAM (ALCAM) is a close structural and functional homolog of RAGE; it shows that binding of S100B to CD166/ALCAM induces dose- and time-dependent expression of NF-kappaB family members in wild type and RAGE-deficient mouse endothelial cells. | CD166/ALCAM mediates proinflammatory effects of S100B in delayed type hypersensitivity.
von Bauer R, Oikonomou D, Sulaj A, Mohammed S, Hotz-Wagenblatt A, Gröne HJ, Arnold B, Falk C, Luethje D, Erhardt A, Stern DM, Bierhaus A, Nawroth PP., Free PMC Article | 09/21/2013 |
| Activated Leukocyte Cell Adhesion Molecule (ALCAM) or CD166 expression on osteoblasts is directly correlated with Runx2 expression and high hematopoiesis enhancing activity. | Hierarchical organization of osteoblasts reveals the significant role of CD166 in hematopoietic stem cell maintenance and function.
Chitteti BR, Cheng YH, Kacena MA, Srour EF., Free PMC Article | 09/7/2013 |
| Behavioral deficits caused by prolonged IFN alpha treatment were not prevented by blocking ALCAM, which is involved in immune cell entry to the brain. | Effects of complete vagotomy and blockage of cell adhesion molecules on interferon-α induced behavioral changes in mice.
Friebe A, Brünahl C, Karimi K, Schäfer M, Juckel G, Sakic B, Arck P. | 06/22/2013 |
| novel role for ALCAM in stabilizing LEC-LEC interactions and in the organization and function of the LV network. | Novel role for ALCAM in lymphatic network formation and function.
Iolyeva M, Karaman S, Willrodt AH, Weingartner S, Vigl B, Halin C. | 04/27/2013 |
| The presence of CD166 on prostate stem/progenitors and castration resistant sub-populations suggest that it is a cell surface molecule with the potential for targeted delivery of human prostate cancer therapeutics. | Identification of CD166 as a surface marker for enriching prostate stem/progenitor and cancer initiating cells.
Jiao J, Hindoyan A, Wang S, Tran LM, Goldstein AS, Lawson D, Chen D, Li Y, Guo C, Zhang B, Fazli L, Gleave M, Witte ON, Garraway IP, Wu H., Free PMC Article | 01/12/2013 |
| CD166 is highly expressed within the endogenous intestinal stem cell niche | Characterization of the intestinal cancer stem cell marker CD166 in the human and mouse gastrointestinal tract.
Levin TG, Powell AE, Davies PS, Silk AD, Dismuke AD, Anderson EC, Swain JR, Wong MH., Free PMC Article | 01/8/2011 |
| The higher adhesion molecules expression and higher BBB permeability contributed to the major inflammatory cell infiltration into the CNS of C57BL/6 mice that was not efficient to control the parasite. | Toxoplasma gondii: the severity of toxoplasmic encephalitis in C57BL/6 mice is associated with increased ALCAM and VCAM-1 expression in the central nervous system and higher blood-brain barrier permeability.
Silva NM, Manzan RM, Carneiro WP, Milanezi CM, Silva JS, Ferro EA, Mineo JR. | 08/30/2010 |
| ALCAM promotes medial extension of retinal ganglion cell axon branches by interacting with immunoglobulin superfamily adhesion molecule L1. | ALCAM regulates mediolateral retinotopic mapping in the superior colliculus.
Buhusi M, Demyanenko GP, Jannie KM, Dalal J, Darnell EP, Weiner JA, Maness PF., Free PMC Article | 02/1/2010 |
| ALCAM coordinates tissue growth and cell migration in a process involvnig L1CAM | Attenuation of melanoma invasion by a secreted variant of activated leukocyte cell adhesion molecule.
van Kilsdonk JW, Wilting RH, Bergers M, van Muijen GN, Schalkwijk J, van Kempen LC, Swart GW. | 01/21/2010 |
| These results indicate that cells retaining a potential to differentiate to the cardiac lineage are present in E8.5 yolk sacs and can be isolated as ALCAM high+, Flk-1- cells. | Isolation of cardiac cells from E8.5 yolk sac by ALCAM (CD166) expression.
Murakami Y, Hirata H, Miyamoto Y, Nagahashi A, Sawa Y, Jakt M, Asahara T, Kawamata S. | 01/21/2010 |
| expression by mesenchymal stem cells in perichondrium | Mesenchymal stem cells in perichondrium express activated leukocyte cell adhesion molecule and participate in bone marrow formation.
Arai F, Ohneda O, Miyamoto T, Zhang XQ, Suda T., Free PMC Article | 01/21/2010 |