| ERK1/2 Regulates Epileptic Seizures by Modulating the DRP1-Mediated Mitochondrial Dynamic. | ERK1/2 Regulates Epileptic Seizures by Modulating the DRP1-Mediated Mitochondrial Dynamic.
Chen T, Yang J, Zheng Y, Zhou X, Huang H, Zhang H, Xu Z. | 09/26/2024 |
| Inhibition of ERK1/2 or CRMP2 Disrupts Alcohol Memory Reconsolidation and Prevents Relapse in Rats. | Inhibition of ERK1/2 or CRMP2 Disrupts Alcohol Memory Reconsolidation and Prevents Relapse in Rats.
Rahamim N, Liran M, Aronovici C, Flumin H, Gordon T, Urshansky N, Barak S., Free PMC Article | 08/9/2024 |
| Exosomal miR-370-3p increases the permeability of blood-brain barrier in ischemia/reperfusion stroke of brain by targeting MPK1. | Exosomal miR-370-3p increases the permeability of blood-brain barrier in ischemia/reperfusion stroke of brain by targeting MPK1.
Gu C, Mo W, Wang K, Gao M, Chen J, Zhang F, Shen J., Free PMC Article | 08/10/2023 |
| Role of PI3K, ERK1/2, and JAK2 Kinases in the Cardioprotective Effect of Deltorphin II during Cardiac Reperfusion. | Role of PI3K, ERK1/2, and JAK2 Kinases in the Cardioprotective Effect of Deltorphin II during Cardiac Reperfusion.
Mukhomedzyanov AV, Popov SV, Maslov LN, Diez ER, Azev VN. | 06/29/2023 |
| Cyclic tensile force modifies calvarial osteoblast function via the interplay between ERK1/2 and STAT3. | Cyclic tensile force modifies calvarial osteoblast function via the interplay between ERK1/2 and STAT3.
Xiao X, Zou S, Chen J., Free PMC Article | 03/14/2023 |
| Blocking P2RX7 Attenuates Ferroptosis in Endothelium and Reduces HG-induced Hemorrhagic Transformation After MCAO by Inhibiting ERK1/2 and P53 Signaling Pathways. | Blocking P2RX7 Attenuates Ferroptosis in Endothelium and Reduces HG-induced Hemorrhagic Transformation After MCAO by Inhibiting ERK1/2 and P53 Signaling Pathways.
Liu C, Tian Q, Wang J, He P, Han S, Guo Y, Yang C, Wang G, Wei H, Li M. | 01/28/2023 |
| Diabetes Induces Permanent Deleterious Effects in the Olfactory Bulb Associated with Increased Tyrosine Hydroxylase Expression and ERK1/2 Phosphorylation. | Diabetes Induces Permanent Deleterious Effects in the Olfactory Bulb Associated with Increased Tyrosine Hydroxylase Expression and ERK1/2 Phosphorylation.
Jiménez A, Herrera-González A, Organista-Juárez D, Estudillo E, Velasco I, Guerrero-Vargas NN, Guzmán-Ruíz MA, Guevara-Guzmán R. | 10/15/2022 |
| Androgen receptor suppresses inflammatory response of airway epithelial cells in allergic asthma through MAPK1 and MAPK14. | Androgen receptor suppresses inflammatory response of airway epithelial cells in allergic asthma through MAPK1 and MAPK14.
Xia T, Ma J, Sun Y, Sun Y. | 08/27/2022 |
| Hotair and Malat1 Long Noncoding RNAs Regulate Bdnf Expression and Oligodendrocyte Precursor Cell Differentiation. | Hotair and Malat1 Long Noncoding RNAs Regulate Bdnf Expression and Oligodendrocyte Precursor Cell Differentiation.
Khani-Habibabadi F, Zare L, Sahraian MA, Javan M, Behmanesh M. | 06/11/2022 |
| The ERK phosphorylation levels in the amygdala predict anxiety symptoms in humans and MEK/ERK inhibition dissociates innate and learned defensive behaviors in rats. | The ERK phosphorylation levels in the amygdala predict anxiety symptoms in humans and MEK/ERK inhibition dissociates innate and learned defensive behaviors in rats.
de Carvalho CR, Lopes MW, Constantino LC, Hoeller AA, de Melo HM, Guarnieri R, Linhares MN, Bortolotto ZA, Prediger RD, Latini A, Lin K, Licinio J, Leal RB, Walz R. | 03/19/2022 |
| Wogonoside attenuates the articular cartilage injury and the infiltration of Th1/Th2-type cytokines in papain-induced osteoarthritis in rat model via inhibiting the NF-kappaB and ERK1/2 activation. | Wogonoside attenuates the articular cartilage injury and the infiltration of Th1/Th2-type cytokines in papain-induced osteoarthritis in rat model via inhibiting the NF-κB and ERK1/2 activation.
Liu J, Liu S, Pan W, Li Y. | 12/11/2021 |
| Knockdown of long non-coding RNA NEAT1 relieves the inflammatory response of spinal cord injury through targeting miR-211-5p/MAPK1 axis. | Knockdown of long non-coding RNA NEAT1 relieves the inflammatory response of spinal cord injury through targeting miR-211-5p/MAPK1 axis.
An Q, Zhou Z, Xie Y, Sun Y, Zhang H, Cao Y., Free PMC Article | 12/4/2021 |
| MAPKs Are Highly Abundant but Do Not Contribute to alpha1-Adrenergic Contraction of Rat Saphenous Arteries in the Early Postnatal Period. | MAPKs Are Highly Abundant but Do Not Contribute to α(1)-Adrenergic Contraction of Rat Saphenous Arteries in the Early Postnatal Period.
Gaynullina DK, Kudryashova TV, Vorotnikov AV, Schubert R, Tarasova OS., Free PMC Article | 07/17/2021 |
| Mechanism of long noncoding RNA metastasisassociated lung adenocarcinoma transcript 1 in lipid metabolism and inflammation in heart failure. | Mechanism of long non‑coding RNA metastasis‑associated lung adenocarcinoma transcript 1 in lipid metabolism and inflammation in heart failure.
Zhao P, Wang Y, Zhang L, Zhang J, Liu N, Wang H., Free PMC Article | 07/17/2021 |
| Activation Loop Dynamics Are Coupled to Core Motions in Extracellular Signal-Regulated Kinase-2. | Activation Loop Dynamics Are Coupled to Core Motions in Extracellular Signal-Regulated Kinase-2.
Iverson DB, Xiao Y, Jones DN, Eisenmesser EZ, Ahn NG., Free PMC Article | 03/13/2021 |
| Activation-induced substrate engagement in ERK signaling. | Activation-induced substrate engagement in ERK signaling.
Paul S, Yang L, Mattingly H, Goyal Y, Shvartsman SY, Veraksa A., Free PMC Article | 12/5/2020 |
| Calcium-Mediated Interactions Regulate the Subcellular Localization of Extracellular Signal-Regulated Kinases (ERKs). | Calcium-Mediated Interactions Regulate the Subcellular Localization of Extracellular Signal-Regulated Kinases (ERKs).
Chuderland D, Marmor G, Shainskaya A, Seger R. | 11/21/2020 |
| FGF6 enhances muscle regeneration after nerve injury via ERK1/ERK2 activation. | FGF6 enhances muscle regeneration after nerve injury by relying on ERK1/2 mechanism.
Cai Q, Wu G, Zhu M, Ge H, Xue C, Zhang Q, Cheng B, Xu S, Wu P. | 03/28/2020 |
| that STEP61 is the molecular brake that is lost following KCC2-dependent disinhibition and that the decrease in STEP61 activity drives the potentiation of excitatory GluN2B NMDAR responses in rodent and human models of pathological pain | Loss of STEP61 couples disinhibition to N-methyl-d-aspartate receptor potentiation in rodent and human spinal pain processing.
Dedek A, Xu J, Kandegedara CM, Lorenzo LÉ, Godin AG, De Koninck Y, Lombroso PJ, Tsai EC, Hildebrand ME., Free PMC Article | 03/14/2020 |
| Data indicate that ERK1/2 activation contributes to the visceral hypersensitivity evoked by craniofacial inflammation pain combined with stress. | Extracellular signal-regulated kinase activation in the spinal cord contributes to visceral hypersensitivity induced by craniofacial injury followed by stress.
Zhao YJ, Li JH, Hu B, Wang Y, Chang XF, Traub RJ, Cao DY. | 10/26/2019 |
| Results indicated matrix stiffness modulated the proliferation and differentiation of tendon derived stem cells, and the regulation effect could correlate to the activation of FAK or ERK1/2 | Matrix stiffness regulates the differentiation of tendon-derived stem cells through FAK-ERK1/2 activation.
Liu C, Luo JW, Liang T, Lin LX, Luo ZP, Zhuang YQ, Sun YL. | 09/28/2019 |
| Study shows that upregulation of hippocampal extracellular signal-regulated kinase (ERK)-2 induces antidepressant-like behavior in the rat forced swim test. | Upregulation of hippocampal extracellular signal-regulated kinase (ERK)-2 induces antidepressant-like behavior in the rat forced swim test.
Iñiguez SD, Parise LF, Lobo MK, Flores-Ramirez FJ, Garcia-Carachure I, Warren BL, Robison AJ., Free PMC Article | 07/27/2019 |
| MALAT1 knockdown gradually improved the hindlimb locomotor activity. | Long noncoding RNA MALAT1 contributes to inflammatory response of microglia following spinal cord injury via the modulation of a miR-199b/IKKβ/NF-κB signaling pathway.
Zhou HJ, Wang LQ, Wang DB, Yu JB, Zhu Y, Xu QS, Zheng XJ, Zhan RY. | 07/6/2019 |
| These data are consistent with a model in which IQGAP1 cleavage is regulated by acetylation of the cleavage sites. Activation of ERK1/2 by ceramide, known to increase lysine acetylation, appears to be mediated by acetylation-dependent stabilization of IQGAP1. | A novel mechanism of ERK1/2 regulation in smooth muscle involving acetylation of the ERK1/2 scaffold IQGAP1.
Vetterkind S, Lin QQ, Morgan KG., Free PMC Article | 04/20/2019 |
| ERK that interacts with and phosphorylates mGluR1a is involved in the regulation of the trafficking and signaling of mGluR1. | Synaptic ERK2 Phosphorylates and Regulates Metabotropic Glutamate Receptor 1 In Vitro and in Neurons.
Yang JH, Mao LM, Choe ES, Wang JQ., Free PMC Article | 12/22/2018 |