| PAR2-dependent phosphorylation of TRPV4 at the trigeminal nerve terminals contributes to tongue cancer pain. | PAR2-dependent phosphorylation of TRPV4 at the trigeminal nerve terminals contributes to tongue cancer pain.
Akasaka R, Furukawa A, Hayashi Y, Hitomi S, Koyama R, Oshima E, Tamura M, Yonemoto M, Hojo Y, Takahashi R, Shibuta I, Iwata K, Yonehara Y, Shinoda M. | 11/16/2023 |
| Effects of PAR2 Gene Knockout on Visceral Sensitivity, Stress Behaviors, and Colonic Electrical Activities in Irritable Bowel Syndrome. | Effects of PAR2 Gene Knockout on Visceral Sensitivity, Stress Behaviors, and Colonic Electrical Activities in Irritable Bowel Syndrome.
Gu Q, Zhang H, Li J, He T, Lei Y, Song S. | 11/3/2023 |
| PAR2 Overexpression is Involved in the Occurrence of Hyperoxygen-Induced Bronchopulmonary Dysplasia in Rats. | PAR2 Overexpression is Involved in the Occurrence of Hyperoxygen-Induced Bronchopulmonary Dysplasia in Rats.
Shao C, Lu L. | 05/30/2023 |
| Endothelial PAR2 activation evokes resistance artery relaxation. | Endothelial PAR2 activation evokes resistance artery relaxation.
Zhang X, Lee MD, Buckley C, Hollenberg MD, Wilson C, McCarron JG., Free PMC Article | 04/19/2023 |
| Proteinase-activated receptor-2 (PAR2) on blood pressure and electrolyte handling in the late pregnant rat. | Proteinase-activated receptor-2 (PAR2) on blood pressure and electrolyte handling in the late pregnant rat.
West DA Jr, Beck SD, de Souza AMA, West CA. | 07/2/2022 |
| Knockdown of PAR2 alleviates cancer-induced bone pain by inhibiting the activation of astrocytes and the ERK pathway. | Knockdown of PAR2 alleviates cancer-induced bone pain by inhibiting the activation of astrocytes and the ERK pathway.
Tang Y, Chen Y, Yang M, Zheng Q, Li Y, Bao Y., Free PMC Article | 06/11/2022 |
| Trypsin-induced elevated contractile responses in a rat model of interstitial cystitis/bladder pain syndrome: Involvement of PAR2 and intracellular Ca(2+) release pathways. | Trypsin-induced elevated contractile responses in a rat model of interstitial cystitis/bladder pain syndrome: Involvement of PAR2 and intracellular Ca(2+) release pathways.
Denizalti M, Anjum I, Simsek G, Onder SC, Durlu-Kandilci NT. | 02/26/2022 |
| Teprenone ameliorates diclofenac-induced small intestinal injury via inhibiting protease activated receptors 1 and 2 activity. | Teprenone ameliorates diclofenac-induced small intestinal injury via inhibiting protease activated receptors 1 and 2 activity.
Chao G, Wang Z, Yang C, Qian Y, Zhang S. | 10/16/2021 |
| Effects of chitinase-3-like protein 1 on brain death-induced hepatocyte apoptosis via PAR2-JNK-caspase-3. | Effects of chitinase-3-like protein 1 on brain death-induced hepatocyte apoptosis via PAR2-JNK-caspase-3.
Li ZX, Yang DJ, Huo ZK, Wen PH, Hu BW, Wang ZH, Guo WZ, Zhang SJ. | 07/3/2021 |
| Pain responses to protease-activated receptor-2 stimulation in the spinal cord of naive and arthritic rats. | Pain responses to protease-activated receptor-2 stimulation in the spinal cord of naïve and arthritic rats.
Lucena F, McDougall JJ. | 05/1/2021 |
| The findings indicated that PAR2 deficiency markedly reduced cardiomyocyte apoptosis in the myocardial ischemia/reperfusion injury mouse model, as well as in rat myocardial H9c2 cells exposed to hypoxia/reoxygenation. | Proteinase‑activated receptor 2 deficiency is a protective factor against cardiomyocyte apoptosis during myocardial ischemia/reperfusion injury.
Wang M, Ma Y, Zhang T, Gao L, Zhang S, Chen Q., Free PMC Article | 02/22/2020 |
| PAR-2 is involved in glial scar formation via JNK signaling. | Protease-activated receptor-2 regulates glial scar formation via JNK signaling.
Li TZ, Deng H, Liu Q, Xia YZ, Darwazeh R, Yan Y. | 11/30/2019 |
| it concluded that the FAE was more susceptible to stress, and the mast cells and PAR2 signaling played crucial roles in this process. | Stress induces more serious barrier dysfunction in follicle-associated epithelium than villus epithelium involving mast cells and protease-activated receptor-2.
Zhang L, Song J, Bai T, Qian W, Hou XH., Free PMC Article | 01/19/2019 |
| Our study findings demonstrated that PAR2-induced relaxations of aortas of aged spontaneously hypertensive rats was impaired, and this impaired aortic relaxation may be attributed to decreased NO bioavailability rather than altered NO sensitivity unrelated to the Akt activity.PAR2 activation is a potential therapeutic target to improve chronic hypertension-associated vasculopathies. | Impairment of Protease-Activated Receptor 2-Induced Relaxation of Aortas of Aged Spontaneously Hypertensive Rat.
Ando M, Matsumoto T, Kobayashi S, Iguchi M, Taguchi K, Kobayashi T. | 09/29/2018 |
| The proteinase-activated receptor-2 signal in muscle sensory nerves contributes to the amplified exercise pressor reflex via TRPA1 mechanisms in rats with femoral artery ligation. | Proteinase-Activated Receptor-2 Sensitivity of Amplified TRPA1 Activity in Skeletal Muscle Afferent Nerves and Exercise Pressor Reflex in Rats with Femoral Artery Occlusion.
Xing J, Li J., Free PMC Article | 03/10/2018 |
| The results of this study suggest that PAR2 plays an important role in mediating renal injury induced by glomerulosclerosis. | Role of Protease-Activated Receptor 2 in Regulating Focal Segmental Glomerulosclerosis.
Wang Y, He Y, Wang M, Lv P, Liu J, Wang J. | 07/1/2017 |
| PAR1 and PAR2 play a critical role in Ang II-induced adventitial fibroblasts activation, and this may contribute to adventitia-related pathological changes. | Protease-activated receptor 1 and 2 contribute to angiotensin II-induced activation of adventitial fibroblasts from rat aorta.
He RQ, Tang XF, Zhang BL, Li XD, Hong MN, Chen QZ, Han WQ, Gao PJ. | 09/3/2016 |
| tryptase may directly damage IEC6 cells via PAR-2 and the downstream activation of ERK, and demonstrate that the signaling pathway requires beta-arrestin-2. | Intestinal mucosal injury induced by tryptase-activated protease-activated receptor 2 requires β-arrestin-2 in vitro.
Li S, Guan J, Ge M, Huang P, Lin Y, Gan X. | 08/27/2016 |
| PAR2 stimulation of NO production via an additional pathway that targets phosphorylation of Ser1177-eNOS suggests a regulatory mechanism for sustaining agonist-mediated vasodilation in metabolic syndrome. | Enhanced Nitric Oxide Synthase Activation via Protease-Activated Receptor 2 Is Involved in the Preserved Vasodilation in Aortas from Metabolic Syndrome Rats.
Maruyama K, Kagota S, McGuire JJ, Wakuda H, Yoshikawa N, Nakamura K, Shinozuka K. | 07/2/2016 |
| XZP significantly alleviates breast cancer-induced bone pain by inhibiting the PAR2 signaling pathway. | Topical treatment with Xiaozheng Zhitong Paste alleviates bone cancer pain by inhibiting proteinase-activated receptor 2 signaling pathway.
Bao Y, Wang G, Gao Y, Du M, Yang L, Kong X, Zheng H, Hou W, Hua B. | 05/14/2016 |
| The PAR-2 carboxyl tail was found to control the receptor localization, internalization, intracellular Ca(2+) responses and signaling to ERK and AKT. | The intracellular carboxyl tail of the PAR-2 receptor controls intracellular signaling and cell death.
Zhu Z, Stricker R, Li Ry, Zündorf G, Reiser G. | 11/21/2015 |
| Results provide evidence for a direct relationship between PAR-2 activation and peripheral sympathetic activity via the N-type Ca2+ channels. | Protease-activated receptor 2 activation inhibits N-type Ca2+ currents in rat peripheral sympathetic neurons.
Kim YH, Ahn DS, Kim MO, Joeng JH, Chung S., Free PMC Article | 08/1/2015 |
| PAR2-mediated relaxation is preserved in the small mesenteric arteries of rats with metabolic syndrome | Disturbance of vasodilation via protease-activated receptor 2 in SHRSP.Z-Lepr fa/IzmDmcr rats with metabolic syndrome.
Kagota S, Maruyama K, Wakuda H, McGuire JJ, Yoshikawa N, Nakamura K, Shinozuka K. | 07/4/2015 |
| Data suggest that the trypsin (TRP) generated during acute pancreatitis could be involved in the progression of lung injury through the activation of protease-activated receptor-2 (PAR-2) in alveolar macrophages. | Role of protease-activated receptor 2 in lung injury development during acute pancreatitis in rats.
de-Madaria E, del Mar Francés M, Gea-Sorlí S, Gutiérrez LM, Viniegra S, Pérez-Mateo M, Closa D, Lopez-Font I. | 04/25/2015 |
| These results suggest that the increased expression of PAR2 in the dorsal root ganglia may contribute to the development of mechanical allodynia and thermal hyperalgesia associated with bone cancer rats. | Involvement of protease-activated receptor 2 in nociceptive behavior in a rat model of bone cancer.
Bao Y, Hua B, Hou W, Shi Z, Li W, Li C, Chen C, Liu R, Qin Y. | 11/29/2014 |